SCC111

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Showing 1-12 of 12 results for "SCC111" within Papers

Jemila C Kester et al.

Antimicrobial agents and chemotherapy, 64(4) (2020-01-29)

A clinically relevant risk factor for Clostridioides difficile-associated disease (CDAD) is recent antibiotic treatment. Although broad-spectrum antibiotics have been shown to disrupt the structure of the gut microbiota, some antibiotics appear to increase CDAD risk without being highly active against

SnapShot: Growing Organoids from Stem Cells.

Toshiro Sato et al.

Cell, 161(7), 1700-1700 (2015-06-20)

Tissue stem cells require unique niche microenvironments. In the presence of specific combinations of niche factors, mouse and human epithelial tissues from stomach, small intestine, colon, pancreas duct, and liver bile duct efficiently form stereotypic organoids. The platform of epitheloid

Coculture of primary human colon monolayer with human gut bacteria.

Jianbo Zhang et al.

Nature protocols, 16(8), 3874-3900 (2021-06-30)

The presence of microbes in the colon impacts host physiology. Therefore, microbes are being evaluated as potential treatments for colorectal diseases. Humanized model systems that enable robust culture of primary human intestinal cells with bacteria facilitate evaluation of potential treatments.

Optimized 3D Culture of Hepatic Cells for Liver Organoid Metabolic Assays.

Christian Moya Gamboa et al.

Cells, 10(12) (2021-12-25)

The liver is among the principal organs for glucose homeostasis and metabolism. Studies of liver metabolism are limited by the inability to expand primary hepatocytes in vitro while maintaining their metabolic functions. Human hepatic three-dimensional (3D) organoids have been established

Establishment and Long-Term Culture of Organoids Derived from Human Biliary Tract Carcinoma.

Yoshimasa Saito et al.

STAR protocols, 1(1), 100009-100009 (2020-10-29)

This protocol is a procedure for establishment and culture of cancer and non-cancer organoids using tissues from biliary tract carcinoma (BTC) patients. These BTC organoids can be used for various biological analyses and drug screening. One challenge in establishing and

Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids.

Martin Trapecar et al.

Cell systems, 10(3), 223-239 (2020-03-20)

Although the association between the microbiome and IBD and liver diseases is known, the cause and effect remain elusive. By connecting human microphysiological systems of the gut, liver, and circulating Treg and Th17 cells, we created a multi-organ model of

Establishing Bipotential Human Lung Organoid Culture System and Differentiation to Generate Mature Alveolar and Airway Organoids.

Chiu, et al.

Bio-protocol, 13, e4657-e4657 (2023)

Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications.

Toshiro Sato et al.

Science (New York, N.Y.), 340(6137), 1190-1194 (2013-06-08)

Recent examples have highlighted how stem cells have the capability to initiate morphogenesis in vitro; that is, to generate complex structures in culture that closely parallel their in vivo counterparts. Lgr5, the receptor for the Wnt-agonistic R-spondins, marks stem cells

Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.

Martin Trapecar et al.

Science advances, 7(5) (2021-01-31)

Slow progress in the fight against neurodegenerative diseases (NDs) motivates an urgent need for highly controlled in vitro systems to investigate organ-organ- and organ-immune-specific interactions relevant for disease pathophysiology. Of particular interest is the gut/microbiome-liver-brain axis for parsing out how

Chicken-derived RSPO1 and WNT3 contribute to maintaining longevity of chicken intestinal organoid cultures.

Miriam J Oost et al.

Scientific reports, 12(1), 10563-10563 (2022-06-23)

Intestinal organoids are advanced cellular models, which are widely used in mammalian studies to mimic and study in vivo intestinal function and host-pathogen interactions. Growth factors WNT3 and RSPO1 are crucial for the growth of intestinal organoids. Chicken intestinal organoids

Initiation, Expansion, and Cryopreservation of Human Primary Tissue-Derived Normal and Diseased Organoids in Embedded Three-Dimensional Culture.

James Clinton et al.

Current protocols in cell biology, 82(1), e66-e66 (2018-09-29)

Organoids are primary patient-derived micro tissues grown within a three-dimensional extracellular matrix that better represents in vivo physiology and genetic diversity than existing two-dimensional cell lines. Organoids rely on the self-renewal and differentiation of tissue-resident stem cells that expand in

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche.

Akifumi Ootani et al.

Nature medicine, 15(6), 701-706 (2009-04-29)

The in vitro analysis of intestinal epithelium has been hampered by a lack of suitable culture systems. Here we describe robust long-term methodology for small and large intestinal culture, incorporating an air-liquid interface and underlying stromal elements. These cultures showed

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