SCC163

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Showing 1-13 of 13 results for "SCC163" within Papers

George H De Vries et al.

Neurochemical research, 35(12), 1978-2000 (2010-12-04)

The importance and essential functions of glial cells in the nervous system are now beginning to be understood and appreciated. Glial cell lines have been instrumental in the elucidation of many of these properties. In this Overview, the origin and

Iron Bioavailability in the Extracellular Environment Is More Relevant Than the Intracellular One in Viability and Gene Expression: A Lesson from Oligodendroglioma Cells.

Stefania Braidotti et al.

Biomedicines, 11(11) (2023-11-25)

Oligodendroglioma (OG) is a brain tumor that contributes to <1% of brain tumor diagnoses in the pediatric population. Unfortunately, pediatric OG remains without definitive molecular characteristics to aid in diagnosis, and little is known about the tumor microenvironment. Tumor cells'

The Protective Role and Mechanism of Mild Therapeutic Hypothermia Protection on Brain Cells.

Suixin Liang et al.

Neuropsychiatric disease and treatment, 19, 1625-1631 (2023-07-24)

Moderate therapeutic hypothermia is protective against several cellular stressors. However, the mechanisms behind this protection are not entirely known. In the current investigation, we investigated that therapeutic hypothermia at 33°C administered following peroxide-induced oxidative stress might protect human oligodendroglioma cells

The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy.

Marcos Herrera-Vaquero et al.

Biochimica et biophysica acta. Molecular basis of disease, 1865(11), 165513-165513 (2019-07-19)

Multiple system atrophy (MSA) is a fatal, adult-onset neurodegenerative disorder that has no cure and very limited treatment options. MSA is characterized by deposition of fibrillar α-synuclein (α-syn) in glial cytoplasmic inclusions in oligodendrocytes. Similar to other synucleinopathies, α-syn self-assembly

Impaired myelin production due to an intrinsic failure of oligodendrocytes in mTORpathies.

Victoria-Elisabeth Gruber et al.

Neuropathology and applied neurobiology, 47(6), 812-825 (2021-06-27)

We aim to evaluate if the myelin pathology observed in epilepsy-associated focal cortical dysplasia type 2B (FCD2B) and-histologically indistinguishable-cortical tubers of tuberous sclerosis complex (TSC) is primarily related to the underlying malformation or constitutes a secondary phenomenon due to the

Characterization of three human oligodendroglial cell lines as a model to study oligodendrocyte injury: morphology and oligodendrocyte-specific gene expression.

M Buntinx et al.

Journal of neurocytology, 32(1), 25-38 (2003-11-18)

Oligodendrocytes, the myelin-forming cells of the central nervous system, are the target of pathogenic immune responses in multiple sclerosis. Primary cultures of human oligodendrocytes have been used to unravel the cellular and molecular mechanisms of immune-mediated injury of oligodendrocytes. However

Regulation of carbachol- and histamine-induced inositol phospholipid hydrolysis in a human oligodendroglioma.

G R Post et al.

Glia, 5(2), 122-130 (1992-01-01)

A stable cell line derived from a human oligodendroglioma (HOG) was used to study the regulation of muscarinic- and histamine receptor-mediated phosphoinositide hydrolysis. Both carbachol and histamine increased inositol monophosphate (InsP) accumulation in a dose- and time-dependent manner in the

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.

Yingyue Zhou et al.

Nature medicine, 26(1), 131-142 (2020-01-15)

Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD risk, and activation of disease-associated microglia (DAM) is dependent on TREM2 in mouse models of AD.

In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies.

Ulises Gómez-Pinedo et al.

Cells, 12(11) (2023-06-10)

The implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or differentiate into myelin-forming

Characterization of a cell line derived from a human oligodendroglioma.

G R Post et al.

Molecular and chemical neuropathology, 16(3), 303-317 (1992-06-01)

A novel clonal cell line derived from a human glioma (HOG) was found to express some oligodendrocyte-specific proteins including a 15-kDa form of myelin basic protein (MBP) and high 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) activity. Expression of the myelin lipids galactosylceramide

Alterations in oligodendrocyte transcriptional networks reveal region-specific vulnerabilities to neurological disease.

Dario Tommasini et al.

iScience, 26(4), 106358-106358 (2023-03-31)

Neurological disease is characterized the by dysfunction of specific neuroanatomical regions. To determine whether region-specific vulnerabilities have a transcriptional basis at cell-type-specific resolution, we analyzed gene expression in mouse oligodendrocytes across various brain regions. Oligodendrocyte transcriptomes cluster in an anatomical

Pectin-based bioinks for 3D models of neural tissue produced by a pH-controlled kinetics.

Marta Merli et al.

Frontiers in bioengineering and biotechnology, 10, 1032542-1032542 (2023-01-10)

Introduction: In the view of 3D-bioprinting with cell models representative of neural cells, we produced inks to mimic the basic viscoelastic properties of brain tissue. Moving from the concept that rheology provides useful information to predict ink printability, this study

SARS-CoV-2 entry sites are present in all structural elements of the human glossopharyngeal and vagal nerves: Clinical implications.

Lynn Vitale-Cross et al.

EBioMedicine, 78, 103981-103981 (2022-04-08)

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections result in the temporary loss of smell and taste in about one third of confirmed cases. We used immunohistochemistry to confirm the presence of ACE2, NRP1 and TMPRSS2 in two cranial nerves (IX

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