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Showing 1-30 of 153 results for "SITRAN-RO" within Papers
Shanshan Li et al.
Prostaglandins & other lipid mediators, 93(1-2), 60-74 (2010-07-06)
Sub-acute hypoxia causes pulmonary vasoconstriction (HPV) is associated with increased intracellular Ca(2+) concentration ([Ca(2+)](i)) and contraction of pulmonary arterial smooth muscle cells (PASMCs). We previous have demonstrated that 15-hydroxyeicosatetraenoic acid (15-HETE), a metabolite of arachidonic acid by 15-lipoxygenase (15-LO), causes
Taku Chibazakura et al.
Molecular and cellular biology, 31(2), 248-255 (2010-11-17)
Cyclin A is known to promote S-phase entry in mammals, but its critical targets in this process have not been defined. We derived a novel human cyclin A mutant (CycA-C1), which can activate cyclin-dependent kinase but cannot promote S-phase entry
Hiroshi Hirata et al.
Carcinogenesis, 31(9), 1620-1626 (2010-06-18)
Endometrial cancer (EC) is a steroid hormone-dependent cancer. Uridine 5'-diphospho-glucuronosyltransferase enzymes conjugate and detoxify endogenous and exogenous steroid hormones and environmental carcinogens. Among these enzymes, the function of UGT2B17 is unknown except for glucuronidation. The messenger RNA expression of UGT2B17
Kristina Kapinas et al.
The Journal of biological chemistry, 285(33), 25221-25231 (2010-06-17)
Differentiation of human mesenchymal stem cells into osteoblasts is controlled by extracellular cues. Canonical Wnt signaling is particularly important for maintenance of bone mass in humans. Post-transcriptional regulation of gene expression, mediated by microRNAs, plays an essential role in the
Jean-Christophe Pignon et al.
Cancer research, 69(7), 2941-2949 (2009-03-26)
EGFR or ERBB2 contributes to prostate cancer (PCa) progression by activating the androgen receptor (AR) in hormone-poor conditions. Here, we investigated the mechanisms by which androgens regulate EGFR and ERBB2 expression in PCa cells. In steroid-depleted medium (SDM), EGFR protein
W Zundel et al.
Genes & development, 12(13), 1941-1946 (1998-07-03)
The initiation of apoptosis often transpires in the presence of agents that regulate cell survival. This study evaluated the effects of stress-induced ceramide on the anti-apoptotic activity of the phosphoinositide-3 kinase [PI(3)K] pathway. PI(3)K activity is directly down-regulated by stress-induced
Andrew J Smith et al.
The Journal of physiology, 588(Pt 12), 2033-2045 (2010-04-28)
The voltage-gated Cl(-) channel (CLC) family comprises cell surface Cl(-) channels and intracellular Cl(-)/H(+) exchangers. CLCs in organelle membranes are thought to assist acidification by providing a passive chloride conductance that electrically counterbalances H(+) accumulation. Following recent descriptions of Cl(-)/H(+)
Minnkyong Lee et al.
The Journal of biological chemistry, 285(49), 38014-38022 (2010-09-28)
Parathyroid hormone (PTH) regulates the transcription of many genes involved in bone remodeling in osteoblasts. One of these genes is matrix metalloproteinase-13 (MMP-13), which is involved in bone remodeling and early stages of endochondral bone formation. We have previously shown
Andrea Kopp et al.
Endocrinology, 151(11), 5267-5278 (2010-08-27)
Proteins secreted by adipocytes (adipokines) play an important role in the pathophysiology of type 2 diabetes mellitus and the associated chronic and low-grade state of inflammation. It was the aim to characterize the antiinflammatory potential of the new adipocytokine, C1q/TNF-related
Yali Wang et al.
Journal of biochemistry, 147(5), 751-764 (2010-02-09)
It has been previously reported by us that hypoxia activates lung 15-lipoxygenase (15-LO), which catalyzes arachidonic acid to 15-hydroxyeicosatetraenoic acid (15-HETE), leading to the constriction of pulmonary artery (PA). Rho-associated serine/threonine kinase (ROK), a downstream effector of small GTPase RhoA
Diana M Lim et al.
American journal of physiology. Gastrointestinal and liver physiology, 297(6), G1172-G1180 (2009-09-26)
Despite its position at the front line against ingested pathogens, very little is presently known about the role of the esophageal epithelium in host innate immune defense. As a key player in the innate immune response, Toll-like receptor (TLR) signaling
Hongping Xia et al.
Biochemical and biophysical research communications, 380(2), 205-210 (2009-01-13)
MicroRNAs (miRNAs) are non-protein-coding RNAs that function as post-transcriptional gene regulators. Recent evidence has shown that miRNA plays a pivotal role in the development of many cancers including glioma, a lethal brain cancer. We have recently compared the miRNA expression
Donghong Zhao et al.
Molecular cancer research : MCR, 6(12), 1819-1829 (2008-12-17)
Hypoxia is a critical aspect of the microenvironment in glioma and generally signifies unfavorable clinical outcome. Effective targeting of hypoxic areas in gliomas remains a significant therapeutic challenge. New therapeutic platforms using neural stem cells (NSC) for tumor-targeted drug delivery
Said Akli et al.
Cancer research, 71(9), 3377-3386 (2011-03-10)
Cyclin E activates Cdk2, controls centrosome duplication, and regulates histone gene transcription. Cyclin E is deregulated in cancer and appears as low-molecular-weight (LMW) isoforms that correlate strongly with decreased survival in breast cancer patients. Transgenic mice overexpressing LMW-cyclin E have
Xingjia Wang et al.
Endocrinology, 149(2), 851-857 (2007-11-17)
The cyclooxygenase-2 (COX2)-dependent inhibition of Leydig cell steroidogenesis has been demonstrated. To understand the mechanism for this effect of COX2, the present study examined the role of an enzyme downstream of COX2, namely thromboxane A synthase (TBXAS), in steroidogenesis. Inhibition
Hon-Wai Koon et al.
The American journal of pathology, 173(2), 400-410 (2008-07-05)
Substance P (SP) regulates important intestinal functions, such as mucosal permeability, motility, chloride secretion, and inflammation via the neurokinin-1 receptor (NK-1R). Previous reports showed that vascularization and expression of angiogenic factors are evident in the colonic mucosa of rats with
Kenji Ishimoto et al.
The Journal of biological chemistry, 284(33), 22195-22205 (2009-06-26)
Lipin 1 plays a crucial role in lipid metabolism in adipose tissue, skeletal muscle, and liver. Its physiological role involves two cellular functions: regulation of phosphatidate phosphatase activity and regulation of fatty acid oxidation. In this study, we have demonstrated
Tetsuo Yamazaki et al.
Biochemical and biophysical research communications, 362(4), 971-975 (2007-09-04)
To determine the contribution of the endoplasmic reticulum (ER) to cell fate decision, we focused on BRI3-binding protein (BRI3BP) residing in this organelle. BRI3BP, when overexpressed, augmented the apoptosis of human embryonic kidney 293T cells challenged with drugs including the
Kentaro Matsumura et al.
Anticancer research, 28(2A), 709-714 (2008-05-30)
Dietary genistein, a phytoestrogen derived from soybean, has been suggested as a chemopreventive agent for prostate cancer. Genistein has been reported to exert its anticancer effects via a variety of functional pathways, but the upstream signaling of molecules regulated by
Malka Cohen-Armon et al.
Molecular cell, 25(2), 297-308 (2007-01-25)
PolyADP-ribose polymerases (PARPs) catalyze a posttranslational modification of nuclear proteins by polyADP-ribosylation. The catalytic activity of the abundant nuclear protein PARP-1 is stimulated by DNA strand breaks, and PARP-1 activation is required for initiation of DNA repair. Here we show
M Lv et al.
Neuroscience, 176, 162-172 (2010-12-25)
Microglial activation is one of the causative factors of neuroinflammation in cerebral ischemia. Activation via Toll-like receptors (TLRs) causes increased proinflammatory cytokine expression, such as interleukin-23 (IL-23) and interleukin-17 (IL-17), leading to inflammatory immune responses and neuronal damage. In this
Hiroaki Shime et al.
Journal of immunology (Baltimore, Md. : 1950), 180(11), 7175-7183 (2008-05-21)
IL-23 is a proinflammatory cytokine consisting of a p19 subunit and a p40 subunit that is shared with IL-12. IL-23 is overexpressed in and around tumor tissues, where it induces local inflammation and promotes tumor development. Many tumor cells produce
Jung Ha Kim et al.
Cellular signalling, 22(9), 1341-1349 (2010-05-15)
Nuclear factor of activated T cells (NFAT) c1 plays a key role in receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclast differentiation and function via induction of osteoclast-specific target genes including osteoclast-associated receptor (OSCAR), cathepsin K, and tartrate-resistant acid
Yasushi Inoue et al.
Virology, 410(1), 38-47 (2010-11-26)
To identify the host factors implicated in the regulation of hepatitis C virus (HCV) genome replication, we performed comparative proteome analyses of HCV replication complex (RC)-rich membrane fractions prepared from cells harboring genome-length bicistronic HCV RNA at the exponential and
Takako Hattori et al.
Nucleic acids research, 36(9), 3011-3024 (2008-04-09)
Sox9 is a transcription factor of the SRY family required for several steps of chondrogenesis. It activates the expression of various chondrocyte-specific genes, but the mechanisms and role of cofactors involved in Sox9-regulated gene transcription are not fully understood. Here
Z Lu et al.
Molecular human reproduction, 14(6), 357-366 (2008-05-06)
Homeobox (HOX) A10 is essential for fertility as demonstrated in transgenic mice, specifically affecting implantation and decidualization. Its role in human decidualization, however, remains unknown. In this study, we used gene silencing followed by microarray analysis to decipher the role
Martin Lange et al.
Genes & development, 22(17), 2370-2384 (2008-09-04)
Chromatin remodeling and histone modifications facilitate access of transcription factors to DNA by promoting the unwinding and destabilization of histone-DNA interactions. We present DPF3, a new epigenetic key factor for heart and muscle development characterized by a double PHD finger.
Tomoko Mabuchi et al.
Gene, 397(1-2), 94-100 (2007-06-05)
Transcription factor IIA (TFIIA) is one of the general transcription factors for RNA polymerase II and composed of three subunits, TFIIAalpha, TFIIAbeta and TFIIAgamma. TFIIAalpha and TFIIAbeta are encoded by a single gene (TFIIAalphabeta) and mature through internal cleavage of
Capucine Van Rechem et al.
The Journal of biological chemistry, 286(35), 30462-30470 (2011-07-16)
Chromatin-modifying enzymes play a fundamental role in regulating chromatin structure so that DNA replication is spatially and temporally coordinated. For example, the lysine demethylase 4A/Jumonji domain-containing 2A (KDM4A/JMJD2A) is tightly regulated during the cell cycle. Overexpression of JMJD2A leads to
Hon Wai Koon et al.
Gastroenterology, 141(5), 1852-1863 (2011-07-19)
Cathelicidin (encoded by Camp) is an antimicrobial peptide in the innate immune system. We examined whether macrophages express cathelicidin in colons of mice with experimental colitis and patients with inflammatory bowel disease, and we investigated its signaling mechanisms. Quantitative, real-time
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