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Showing 1-30 of 79 results for "sml0282" within Papers
Erica L L Warkus et al.
Toxicological sciences : an official journal of the Society of Toxicology, 149(1), 15-30 (2015-09-20)
In utero exposure to certain chemicals can impair embryo development, causing embryonic death, growth retardation, or severe birth defects. Establishment of effective in vitro tests is crucial for identifying developmental toxicants and for reducing the financial and ethical burden of
Siyu Wu et al.
Journal of cellular physiology, 236(5), 3929-3945 (2020-11-10)
Traumatic injuries of the central nervous system (CNS) are followed by the accumulation of cellular debris including proteins and lipids from myelinated fiber tracts. Insufficient phagocytic clearance of myelin debris influences the pathological process because it induces inflammation and blocks
Frits Kamp et al.
ACS chemical neuroscience, 9(7), 1702-1713 (2018-05-03)
Bexarotene is a pleiotropic molecule that has been proposed as an amyloid-β (Aβ)-lowering drug for the treatment of Alzheimer's disease (AD). It acts by upregulation of an apolipoprotein E (apoE)-mediated Aβ clearance mechanism. However, whether bexarotene induces removal of Aβ
Hailin Liu et al.
Neurochemical research, 44(12), 2809-2820 (2019-11-05)
Apolipoprotein E (APOE) is implicated not only in chronic degenerative neurological diseases, such as Alzheimer's disease, but also in acute brain disorders, including traumatic brain injury. Bexarotene, a selective agonist of the retinoid X receptor, has been reported to enhance
Li Li et al.
Drug delivery, 23(1), 79-87 (2014-05-03)
Bexarotene (Bex) is a synthetic retinoid that exhibits anti-tumor activities. However, the low solubility of the compound hinders its development. In this study, bexarotene nanocrystal was developed and its surface was modified to improve the dissolution and absorption of the
Yogita Dheer et al.
Molecular neurobiology, 55(12), 9043-9056 (2018-04-11)
Retinoid X-receptors (RXRs) are members of the ligand-dependent transcription factor family of nuclear receptors that have gained recent research focus as potential targets for neurodegenerative disorders. Bexarotene is an RXR pharmacological agonist that is shown to be neuroprotective through its
Che-Feng Chang et al.
Stroke, 51(2), 612-618 (2019-12-13)
Background and Purpose- Enhancement of erythrophagocytosis by macrophages in a timely manner can limit the toxic effects of erythrocyte metabolites and promote brain recovery after intracerebral hemorrhage (ICH). In the current study, we investigated the therapeutic effect of retinoid X
Behnam Rashidieh et al.
Cancers, 13(15) (2021-08-08)
The overexpression of BRF2, a selective subunit of RNA polymerase III, has been shown to be crucial in the development of several types of cancers, including breast cancer and lung squamous cell carcinoma. Predominantly, BRF2 acts as a central redox-sensing
María P Menéndez-Gutiérrez et al.
The Journal of clinical investigation, 125(2), 809-823 (2015-01-13)
Osteoclasts are bone-resorbing cells that are important for maintenance of bone remodeling and mineral homeostasis. Regulation of osteoclast differentiation and activity is important for the pathogenesis and treatment of diseases associated with bone loss. Here, we demonstrate that retinoid X
Yuko Murakami et al.
Microbes and infection, 16(2), 114-122 (2013-11-02)
Using a high-throughput screening system involving HCV JFH-1-Huh 7.5.1 cells, we determined that the ligands of class II nuclear receptors, retinoids and rexinoids inhibit HCV infection. Retinoids, ligands of retinoic acid receptor (RAR), and rexinoids, ligands of retinoid X receptor
Christina E Wells et al.
PloS one, 8(7), e68915-e68915 (2013-07-31)
Given the fundamental roles of histone deacetylases (HDACs) in the regulation of DNA repair, replication, transcription and chromatin structure, it is fitting that therapies targeting HDAC activities are now being explored as anti-cancer agents. In fact, two histone deacetylase inhibitors
Neuroprotective Effect of Bexarotene in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.
Javier Riancho et al.
Frontiers in cellular neuroscience, 9, 250-250 (2015-07-21)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive weakness and muscle atrophy related to the loss of upper and lower motor neurons (MNs) without a curative treatment. There is experimental evidence suggesting that retinoids may be involved
Jing Wang et al.
Neuron, 108(5), 876-886 (2020-10-28)
Myelination facilitates rapid axonal conduction, enabling efficient communication across different parts of the nervous system. Here we examined mechanisms controlling myelination after injury and during axon regeneration in the central nervous system (CNS). Previously, we discovered multiple molecular pathways and
Shawn C Owen et al.
ACS chemical biology, 7(8), 1429-1435 (2012-05-26)
Many small molecules, including bioactive molecules and approved drugs, spontaneously form colloidal aggregates in aqueous solution at micromolar concentrations. Though it is widely accepted that aggregation leads to artifacts in screens for ligands of soluble proteins, the effects of colloid
Jiang Zhu et al.
American journal of hypertension, 27(8), 1112-1124 (2014-03-08)
Retinoid X receptor (RXR) has been demonstrated to play an important role in cardiac development and has been implicated in cardiovascular diseases. This study aimed to examine the effects of RXRα agonist bexarotene on pathological left ventricular hypertrophy (LVH) in
Protective effects of retinoid x receptors on retina pigment epithelium cells
Ayala-Pena VB, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1863(6), 1134-1145 (2016)
Edilson Ribeiro de Oliveira Junior et al.
Drug delivery and translational research, 10(6), 1688-1699 (2020-07-03)
Intranasal administration of mucus-penetrating nanoparticles is an emerging trend to increase drug delivery to the brain. In order to overcome rapid nasal mucociliary clearance, low epithelial permeation, and local enzymatic degradation, we investigated the influence of PEGylation on nose-to-brain delivery
Yongguo Li et al.
Cell reports, 29(12), 4099-4113 (2019-12-19)
Recruitment of brite/beige cells, known as browning of white adipose tissue (WAT), is an efficient way to turn an energy-storing organ into an energy-dissipating one and may therefore be of therapeutic value in combating obesity. However, a comprehensive understanding of
Xin Zhou et al.
The Journal of clinical investigation, 130(5), 2220-2236 (2020-03-24)
Lipid-rich myelin forms electrically insulating, axon-wrapping multilayers that are essential for neural function, and mature myelin is traditionally considered metabolically inert. Surprisingly, we discovered that mature myelin lipids undergo rapid turnover, and quaking (Qki) is a major regulator of myelin
Angie C A Chiang et al.
Acta neuropathologica communications, 8(1), 193-193 (2020-11-14)
Frequently reported neurotoxic sequelae of cancer treatment include cognitive deficits and sensorimotor abnormalities that have long-lasting negative effects on the quality of life of an increasing number of cancer survivors. The underlying mechanisms are not fully understood and there is
Marianne Tawa et al.
Clinical journal of oncology nursing, 23(4), E73-E80 (2019-07-20)
Cutaneous T-cell lymphoma (CTCL), including subtypes mycosis fungoides (MF) and Sézary syndrome (SS), represents a rare group of non-Hodgkin lymphomas. Mogamulizumab is a first-in-class monoclonal antibody that selectively binds to C-C chemokine receptor 4, which is overexpressed on the surface
Li Tu et al.
Neurological research, 40(8), 702-708 (2018-04-25)
Objectives Early brain injury (EBI) is considered to be one of the main causes of poor outcome in subarachnoid hemorrhage (SAH) patients. Bexarotene is an agonist of retinoid X receptor and plays a protective role in central nervous system diseases.
M Maekawa et al.
Translational psychiatry, 7(9), e1229-e1229 (2017-09-06)
The risk of schizophrenia is increased in offspring whose mothers experience malnutrition during pregnancy. Polyunsaturated fatty acids (PUFAs) are dietary components that are crucial for the structural and functional integrity of neural cells, and PUFA deficiency has been shown to
Jui-Yu Chen et al.
Journal of the Chinese Medical Association : JCMA, 83(10), 923-930 (2020-10-04)
Thyroid tumors are the most frequent neoplasm of the endocrine system. The major treatment is surgical intervention followed by radioiodine therapy. The sodium/iodide symporter (NIS) has positive expression in thyroid carcinomas with good prognoses and plays a critical role in
Diana M Mitchell et al.
PLoS genetics, 11(8), e1005483-e1005483 (2015-08-22)
The signaling molecule retinoic acid (RA) regulates rod and cone photoreceptor fate, differentiation, and survival. Here we elucidate the role of RA in differential regulation of the tandemly-duplicated long wavelength-sensitive (LWS) cone opsin genes. Zebrafish embryos were treated with RA
Katherine D LaClair et al.
Molecular neurodegeneration, 8, 18-18 (2013-06-15)
Though the precise cause(s) of Alzheimer's disease (AD) remain unknown, there is strong evidence that decreased clearance of β-amyloid (Aβ) from the brain can contribute to the disease. Therapeutic strategies to promote natural Aβ clearance mechanisms, such as the protein
Allison M B Lehman et al.
Molecular pharmacology, 86(5), 570-579 (2014-08-30)
The retinoid X receptor (RXR) partners with numerous nuclear receptors, such as the peroxisome proliferator activated receptor (PPAR) family, liver X receptors (LXRs), and farnesoid X receptor (FXR). Although each heterodimer can be activated by specific ligands, a subset of
Dongdong Wang et al.
Biochemical pharmacology, 177, 114022-114022 (2020-05-22)
Increased cholesterol efflux from macrophage foam cells in the subendothelial space confers protection against atherosclerosis. Soraphen A, a myxobacterial macrolactone, is an inhibitor of acetyl coenzyme A carboxylases (ACC), which control fatty acid synthesis and oxidation. To assess a potential
Zita Hubler et al.
Nature, 560(7718), 372-376 (2018-07-27)
Regeneration of myelin is mediated by oligodendrocyte progenitor cells-an abundant stem cell population in the central nervous system (CNS) and the principal source of new myelinating oligodendrocytes. Loss of myelin-producing oligodendrocytes in the CNS underlies a number of neurological diseases
Lei Wang et al.
The Journal of investigative dermatology, 135(8), 2102-2108 (2015-04-01)
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of malignancies characterized by accumulation of malignant T-cells within the skin. Retinoids, metabolic derivatives, and synthetic analogs of vitamin A embody an effective CTCL therapy with over three decades of clinical use.
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