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Showing 1-30 of 158 results for "SRP4037" within Papers
Chih-Jung Yao et al.
Integrative cancer therapies, 13(6), 541-554 (2014-11-02)
High-grade gliomas are the most common and invasive malignant brain tumors in adults, and they are almost universally fatal because of drug resistance and recurrence. In spite of the progress in adjuvant therapy (like temozolomide) and irradiation after surgery, no
Kazumichi Yoshida et al.
Cancer medicine, 4(9), 1322-1333 (2015-06-17)
CD47 is an antiphagocytic molecule that acts via ligation to signal regulatory protein alpha on phagocytes; its enhanced expression and therapeutic targeting have recently been reported for several malignancies. However, CD47 expression in gastric cancer is not well documented. Immunohistochemical
Wenchao Xu et al.
Molecular carcinogenesis, 54 Suppl 1, E148-E161 (2014-09-25)
Lung cancer is the leading cause of cancer mortality worldwide. A common interest in lung cancer research is the identification of biomarkers for early diagnosis and accurate prognosis. There is increasing evidence that microRNAs (miRNAs) are involved in lung cancer.
Role of microRNA?503 in the suppression of osteosarcoma cell proliferation and migration via modulation of fibroblast growth factor 2.
Wu B and Bi W
Molecular Medicine Reports, 12, 7433-7438 (2015)
Guo-Fang Guan et al.
Molecular medicine reports, 12(3), 4352-4357 (2015-06-18)
The presence of cancer stem cells (CSCs) has major implications in the choice of cancer treatment strategy and is responsible for tumor relapse. CSCs have been isolated and characterized in several types of cancer; however, studies concerning the CSCs from
Yasemin Kartal et al.
Implant dentistry, 23(4), 463-470 (2014-07-23)
The aim of this study was to evaluate the implant stability with the addition of local application of basic fibroblast growth factor (bFGF) during the osseointegration of 2 different dental implant surfaces using rabbit tibia model. Fifty-six dental implants, 28
Debbie M Figueroa et al.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 23(4), 733-752 (2015-07-21)
On the male X and female active X chromosome (Xa), the macrosatellite repeat (MSR) DXZ4 is packaged into constitutive heterochromatin characterized by CpG methylation and histone H3 tri-methylated at lysine-9 (H3K9me3). In contrast, DXZ4 on the female inactive X chromosome
Manasi Bhoj et al.
Journal of endodontics, 41(7), 1100-1107 (2015-05-11)
A living, self-supporting pulp tissue replacement in vitro and for transplantation is an attractive yet unmet bioengineering challenge. Our aim is to create 3-dimensional alginate-based microenvironments that replicate the shape of gutta-percha and comprise key elements for the proliferation of
Sandrine Cornaz-Buros et al.
Cancer research, 74(22), 6610-6622 (2014-09-28)
Plasticity in cancer stem-like cells (CSC) may provide a key basis for cancer heterogeneity and therapeutic response. In this study, we assessed the effect of combining a drug that abrogates CSC properties with standard-of-care therapy in a Ewing sarcoma family
Kenichiro Ito et al.
Nature communications, 6, 6373-6373 (2015-03-12)
Hepatocyte growth factor (HGF) receptor, also known as Met, is a member of the receptor tyrosine kinase family. The Met-HGF interaction regulates various signalling pathways involving downstream kinases, such as Akt and Erk. Met activation is implicated in wound healing
Fabien Chevalier et al.
Stem cell research, 12(3), 703-715 (2014-04-01)
Human circulating endothelial progenitor cells isolated from peripheral blood generate in culture cells with features of endothelial cells named late-outgrowth endothelial colony-forming cells (ECFC). In adult blood, ECFC display a constant quantitative and qualitative decline during life span. Even after
Emmy L D de Mare-Bredemeijer et al.
Stem cells and development, 24(12), 1436-1447 (2015-03-07)
After organ transplantation, recipient T cells contribute to graft rejection. Mesenchymal stromal cells from the bone marrow (BM-MSCs) are known to suppress allogeneic T-cell responses, suggesting a possible clinical application of MSCs in organ transplantation. Human liver grafts harbor resident
Jason Spina et al.
Veterinary surgery : VS, 43(6), 750-760 (2014-03-13)
To determine the in vitro effects of differing growth factor treatments on the fibrochondrogenic potential of fibroblast-like synoviocytes from cruciate ligament deficient femorotibial joints of dogs. In vitro study. Synoviocytes from dogs (n = 8) with naturally occurring cruciate ligament insufficiency. Synoviocytes
Chul Soon Park et al.
Cells, 9(10) (2020-10-03)
The increased interest in organoid research in recent years has contributed to an improved understanding of diseases that are currently untreatable. Various organoids, including kidney, brain, retina, liver, and spinal cord, have been successfully developed and serve as potential sources
Mingming Hu et al.
PloS one, 11(1), e0147374-e0147374 (2016-01-30)
Basic fibroblast growth factor (bFGF) is known to stimulate angiogenesis and thus to influence the proliferation, migration and survival of tumor cells. Many studies examined the relationship between human bFGF overexpression and survival in lung cancer patients, but the results
Cassandra L Weaver et al.
Advanced healthcare materials, 4(9), 1408-1416 (2015-05-07)
Neural stem cell (NSC) transplantation has the potential to restore function to diseased or damaged nervous tissue, but poor control over cell survival, differentiation, and maturation limits therapeutic prospects. Engineered scaffolds that have the ability to drive neural stem cell
A R Fernandes et al.
Integrative biology : quantitative biosciences from nano to macro, 6(9), 855-861 (2014-07-16)
Evaluating the uptake and handling of biomedically relevant nanoparticles by cells of the nervous system critically underpins the effective use of nanoparticle platforms for neuro-regenerative therapies. The lack of biologically relevant and 'neuromimetic' models for nanomaterials testing (that can simulate
Masataka Hosoi et al.
Experimental hematology, 42(9), 816-825 (2014-05-27)
Induced pluripotent stem cells (iPS) derived from disease cells are expected to provide a new experimental material, especially for diseases from which samples are difficult to obtain. In this study, we generated iPS from samples from patients with primary and
Colette A Bichsel et al.
Tissue engineering. Part A, 21(15-16), 2166-2176 (2015-04-22)
The formation of blood vessels is a complex tissue-specific process that plays a pivotal role during developmental processes, in wound healing, cancer progression, fibrosis, and other pathologies. To study vasculogenesis and vascular remodeling in the context of the lung, we
Shun Yamamuro et al.
International journal of oncology, 47(1), 91-96 (2015-05-09)
Glioma stem-like cells (GSCs) could have potential for tumorigenesis, treatment resistance, and tumor recurrence (GSC hypothesis). However, the mechanisms underlying such potential has remained elusive and few ultrastructural features of the cells have been reported in detail. We therefore undertook
Jisun Oh et al.
Biotechnology journal, 9(7), 921-933 (2014-05-23)
Adult hippocampal progenitor cells (AHPCs) are generally maintained as a dispersed monolayer population of multipotent neural progenitors. To better understand cell-cell interactions among neural progenitors and their influences on cellular characteristics, we generated free-floating cellular aggregates, or neurospheres, from the
G Riddick et al.
The pharmacogenomics journal, 15(4), 347-353 (2014-12-03)
Cancer stem cells (CSCs) are thought to promote resistance to chemotherapeutic drugs in glioblastoma, the most common and aggressive primary brain tumor. However, the use of high-throughput drug screens to discover novel small-molecule inhibitors for CSC has been hampered by
Chih-Hung Chiang et al.
Cell transplantation, 24(3), 541-559 (2015-02-11)
Acute hepatic failure (AHF) is a severe liver injury leading to sustained damage and complications. Induced pluripotent stem cells (iPSCs) may be an alternative option for the treatment of AHF. In this study, we reprogrammed human dental pulp-derived fibroblasts into
Dongmei Lai et al.
Scientific reports, 5, 10014-10014 (2015-05-08)
Culture conditions that support the growth of undifferentiated human embryonic stem cells (hESCs) have already been established using primary human amnion epithelial cells (hAECs) as an alternative to traditional mitotically inactivated mouse embryonic fibroblasts (MEFs). In the present work, inner
Nuno Jorge Lamas et al.
PloS one, 9(10), e110324-e110324 (2014-10-23)
Human motor neurons derived from embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are a potentially important tool for studying motor neuron survival and pathological cell death. However, their basic survival requirements remain poorly characterized. Here, we sought to
Matthias Ilmer et al.
Molecular cancer therapeutics, 14(12), 2712-2721 (2015-10-31)
The substance P (SP)/NK-1 receptor (NK1R) complex represents an intriguing anticancer target for a variety of tumors, including hepatoblastoma (HB). Therefore, NK1R antagonists, such as the clinical drug aprepitant, recently have been proposed as potent anticancer agents. However, very little
Kirsten S Evonuk et al.
Journal of immunology (Baltimore, Md. : 1950), 195(2), 450-463 (2015-06-14)
T cell infiltration into the CNS is a significant underlying pathogenesis in autoimmune inflammatory demyelinating diseases. Several lines of evidence suggest that glutamate dysregulation in the CNS is an important consequence of immune cell infiltration in neuroinflammatory demyelinating diseases; yet
Shang Song et al.
Acta biomaterialia, 18, 100-111 (2015-03-05)
Critical failures associated with current engineered bone grafts involve insufficient induction of osteogenesis of the implanted cells and lack of vascular integration between graft scaffold and host tissue. This study investigated the combined effects of surface microtextures and biochemical supplements
Marta Kumorek et al.
PloS one, 10(5), e0125484-e0125484 (2015-05-07)
In a typical cell culture system, growth factors immobilized on the cell culture surfaces can serve as a reservoir of bio-signaling molecules, without the need to supplement them additionally into the culture medium. In this paper, we report on the
Evelyne Tassone et al.
Journal of cellular physiology, 230(2), 366-377 (2014-07-06)
Membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14), a transmembrane proteinase with an extracellular catalytic domain and a short cytoplasmic tail, degrades extracellular matrix components and controls diverse cell functions through proteolytic and non-proteolytic interactions with extracellular, intracellular, and transmembrane proteins. Here
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