T0251

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Showing 1-30 of 251 results for "T0251" within Papers

ARE-binding protein ZFP36L1 interacts with CNOT1 to directly repress translation via a deadenylation-independent mechanism.

Hiroshi Otsuka et al.

Biochimie, 174, 49-56 (2020-04-21)

Eukaryotic gene expression can be spatiotemporally tuned at the post-transcriptional level by cis-regulatory elements in mRNA sequences. An important example is the AU-rich element (ARE), which induces mRNA destabilization in a variety of biological contexts in mammals and can also

Tristetraprolin disables prostate cancer maintenance by impairing proliferation and metabolic function.

Anders E Berglund et al.

Oncotarget, 7(50), 83462-83475 (2016-11-09)

Tristetraprolin (TTP) is an RNA-binding protein that post-transcriptionally suppresses gene expression by delivering mRNA cargo to processing bodies (P-bodies) where the mRNA is degraded. TTP functions as a tumor suppressor in a mouse model of B cell lymphoma, and in

Repeated measures dose-finding design with time-trend detection in the presence of correlated toxicity data.

Jun Yin et al.

Clinical trials (London, England), 14(6), 611-620 (2017-08-03)

Phase I trials are designed to determine the safety, tolerability, and recommended phase 2 dose of therapeutic agents for subsequent testing. The dose-finding paradigm has thus traditionally focused on identifying the maximum tolerable dose of an agent or combination therapy

De novo DNA methylation drives 5hmC accumulation in mouse zygotes.

Rachel Amouroux et al.

Nature cell biology, 18(2), 225-233 (2016-01-12)

Zygotic epigenetic reprogramming entails genome-wide DNA demethylation that is accompanied by Tet methylcytosine dioxygenase 3 (Tet3)-driven oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC; refs 1-4). Here we demonstrate using detailed immunofluorescence analysis and ultrasensitive LC-MS-based quantitative measurements that the initial

Translational studies within the TAMRAD randomized GINECO trial: evidence for mTORC1 activation marker as a predictive factor for everolimus efficacy in advanced breast cancer.

I Treilleux et al.

Annals of oncology : official journal of the European Society for Medical Oncology, 26(1), 120-125 (2014-11-02)

Everolimus is an agent frequently associated with specific toxicities. Predictive markers of efficacy are needed to help define which patients could benefit from it. The goal of this exploratory study was to identify potential predictive biomarkers in the mammalian target

Impact of Concurrent PIK3CA Mutations on Response to EGFR Tyrosine Kinase Inhibition in EGFR-Mutant Lung Cancers and on Prognosis in Oncogene-Driven Lung Adenocarcinomas.

Juliana Eng et al.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 10(12), 1713-1719 (2015-09-04)

In patients with epidermal growth factor receptor (EGFR)-mutant or KRAS-mutant lung adenocarcinomas, the prognostic impact of a concurrent PIK3CA mutation remains unclear. Although preclinical data suggest that sensitivity to EGFR tyrosine kinase inhibition (TKI) is decreased in EGFR-mutant lung cancers

Screening Approaches for Targeting Ribonucleoprotein Complexes: A New Dimension for Drug Discovery.

Vito Giuseppe D'Agostino et al.

SLAS discovery : advancing life sciences R & D, 24(3), 314-331 (2019-01-09)

RNA-binding proteins (RBPs) are pleiotropic factors that control the processing and functional compartmentalization of transcripts by binding primarily to mRNA untranslated regions (UTRs). The competitive and/or cooperative interplay between RBPs and an array of coding and noncoding RNAs (ncRNAs) determines

A scoutRNA Is Required for Some Type V CRISPR-Cas Systems.

Lucas B Harrington et al.

Molecular cell, 79(3), 416-424 (2020-07-10)

CRISPR-Cas12c/d proteins share limited homology with Cas12a and Cas9 bacterial CRISPR RNA (crRNA)-guided nucleases used widely for genome editing and DNA detection. However, Cas12c (C2c3)- and Cas12d (CasY)-catalyzed DNA cleavage and genome editing activities have not been directly observed. We

The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3.

Natalia Ronkina et al.

Journal of immunology (Baltimore, Md. : 1950), 203(8), 2291-2300 (2019-09-19)

Tristetraprolin (TTP) is an RNA-binding protein and an essential factor of posttranscriptional repression of cytokine biosynthesis in macrophages. Its activity is temporally inhibited by LPS-induced p38MAPK/MAPKAPK2/3-mediated phosphorylation, leading to a rapid increase in cytokine expression. We compared TTP expression and

A dual-function oligonucleotide-based ratiometric fluorescence sensor for ATP detection.

Yao-Yao Fan et al.

Talanta, 219, 121349-121349 (2020-09-06)

Adenosine triphosphate (ATP) is the main energy currency of life that plays a vital role in supporting physiological activities in living organisms, including humans. Therefore, accurate and sensitive detection of ATP concentration is necessary in biochemical research and clinical diagnosis.

Tumor suppressing effects of tristetraprolin and its small double-stranded RNAs in bladder cancer.

Wen Jiang et al.

Cancer medicine, 10(1), 269-285 (2020-12-02)

Bladder cancer (BCa) is a common malignant tumor of urinary system with few treatments, so more useful therapeutic targets are still needed. Antitumor effects of tristetraprolin (TTP) have been explored in many type tumors, but its roles in bladder cancer

Thrombotic thrombocytopenic purpura - analysis of clinical features, laboratory characteristics and therapeutic outcome of 24 patients treated at a Tertiary Care Center in Saudi Arabia.

Shahid Iqbal et al.

Pakistan journal of medical sciences, 32(6), 1494-1499 (2017-01-14)

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease. The primary aim was overall response rate (ORR) assessment in the treated patients. This retrospective study included 24 patients treated during 2006-2015. TTP patients with microangiopathic hemolysis (MAHA) and thrombocytopenia were included.

FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression.

Esperanza Fernández et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(25), 9402-9408 (2015-06-26)

In brain, specific RNA-binding proteins (RBPs) associate with localized mRNAs and function as regulators of protein synthesis at synapses exerting an indirect control on neuronal activity. Thus, the Fragile X Mental Retardation protein (FMRP) regulates expression of the scaffolding postsynaptic

Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway.

Qimeng Wang et al.

International journal of molecular medicine, 41(2), 868-876 (2017-12-06)

The pathogenesis of inflammatory bowel disease (IBD) is believed to be associated with the abnormal expression of inflammatory factors. The aryl hydrocarbon receptor (AhR) is a ligand‑dependent transcription factor, which can suppress the inflammatory response and attenuate experimental colitis. However, the

Inhibition of DNA replication by an anti-PCNA aptamer/PCNA complex.

Ewa Kowalska et al.

Nucleic acids research, 46(1), 25-41 (2017-12-01)

Proliferating cell nuclear antigen (PCNA) is a multifunctional protein present in the nuclei of eukaryotic cells that plays an important role as a component of the DNA replication machinery, as well as DNA repair systems. PCNA was recently proposed as

MAPKAPK2 plays a crucial role in the progression of head and neck squamous cell carcinoma by regulating transcript stability.

Sourabh Soni et al.

Journal of experimental & clinical cancer research : CR, 38(1), 175-175 (2019-04-27)

Head and neck squamous-cell carcinoma (HNSCC) ranks sixth among cancers worldwide. Though several molecular mechanisms of tumor initiation and progression of HNSCC are known, others remain unclear. Significance of p38/MAPKAPK2 (Mitogen-activated protein kinase-activated protein kinase-2) pathway in cell stress and

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope.

Till Schoofs et al.

Immunity, 50(6), 1513-1529 (2019-05-28)

Broadly neutralizing antibodies (bNAbs) against HIV-1 envelope (Env) inform vaccine design and are potential therapeutic agents. We identified SF12 and related bNAbs with up to 62% neutralization breadth from an HIV-infected donor. SF12 recognized a glycan-dominated epitope on Env's silent

Complications and Outcomes of Temporary Transvenous Pacing: An Analysis of > 360,000 Patients From the National Inpatient Sample.

Thomas S Metkus et al.

Chest, 155(4), 749-757 (2018-12-14)

The incidence of complications and the outcomes of temporary transvenous pacemaker (TTP) placement in the modern era are not well established. To determine the current incidence of pericardial complications and the outcomes of patients undergoing TTP, we performed an analysis

Effects of tristetraprolin on doxorubicin (adriamycin)-induced experimental kidney injury through inhibiting IL-13/STAT6 signal pathway.

Qian Zhang et al.

American journal of translational research, 12(4), 1203-1221 (2020-05-02)

To study the effects of Tristetraprolin (TTP) on Doxorubicin (DOX)-induced experimental kidney injury (KI). DOX was used to induce kidney injury in Balb/c male mice (in vivo) and in human kidney proximal tubular epithelial cell line (HK-2) and normal rat

Association Between Cerebral Hypoperfusion and Cognitive Impairment in Patients With Chronic Vertebra-Basilar Stenosis.

Yiming Deng et al.

Frontiers in psychiatry, 9, 455-455 (2018-10-16)

Objective: This study aimed to investigate the association between cognitive impairment and cerebral haemodynamic changes in patients with chronic vertebra-basilar (VB) stenosis. Methods: Patients with severe posterior circulation VB stenosis and infarction or a history of infarction for more than

RNA-binding proteins regulate cell respiration and coenzyme Q biosynthesis by post-transcriptional regulation of COQ7.

María V Cascajo et al.

RNA biology, 13(7), 622-634 (2015-12-23)

Coenzyme Q (CoQ) is a key component of the mitochondrial respiratory chain carrying electrons from complexes I and II to complex III and it is an intrinsic component of the respirasome. CoQ concentration is highly regulated in cells in order

Pseudo-RNA-Binding Domains Mediate RNA Structure Specificity in Upstream of N-Ras.

Nele Merret Hollmann et al.

Cell reports, 32(3), 107930-107930 (2020-07-23)

RNA-binding proteins (RBPs) commonly feature multiple RNA-binding domains (RBDs), which provide these proteins with a modular architecture. Accumulating evidence supports that RBP architectural modularity and adaptability define the specificity of their interactions with RNA. However, how multiple RBDs recognize their

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Patrick Sin-Chan et al.

Cancer cell, 36(1), 51-67 (2019-07-10)

Embryonal tumors with multilayered rosettes (ETMRs) are highly lethal infant brain cancers with characteristic amplification of Chr19q13.41 miRNA cluster (C19MC) and enrichment of pluripotency factor LIN28A. Here we investigated C19MC oncogenic mechanisms and discovered a C19MC-LIN28A-MYCN circuit fueled by multiple

Time to blood culture positivity as a predictor of clinical outcomes and severity in adults with bacteremic pneumococcal pneumonia.

Catia Cillóniz et al.

PloS one, 12(8), e0182436-e0182436 (2017-08-09)

We aimed to investigate the association between the time to positivity of blood culture (TTP) with clinical outcome and severity of pneumococcal bacteremic pneumonia. Prospective observational study carried out in 278 hospitalized adult CAP patients with positive blood culture for

Mitochondrial disorders of DNA polymerase γ dysfunction: from anatomic to molecular pathology diagnosis.

Linsheng Zhang et al.

Archives of pathology & laboratory medicine, 135(7), 925-934 (2011-07-08)

Primary mitochondrial dysfunction is one of the most common causes of inherited disorders predominantly involving the neuromuscular system. Advances in the molecular study of mitochondrial DNA have changed our vision and our approach to primary mitochondrial disorders. Many of the

Alteration of Mature Nucleocapsid and Enhancement of Covalently Closed Circular DNA Formation by Hepatitis B Virus Core Mutants Defective in Complete-Virion Formation.

Xiuji Cui et al.

Journal of virology, 89(19), 10064-10072 (2015-07-24)

Assembly of hepatitis B virus (HBV) begins with packaging of the pregenomic RNA (pgRNA) into immature nucleocapsids (NC), which are converted to mature NCs containing the genomic relaxed circular (RC) DNA as a result of reverse transcription. Mature NCs have

ATP-Induced Increase in Intracellular Calcium Levels and Subsequent Activation of mTOR as Regulators of Skeletal Muscle Hypertrophy.

Naoki Ito et al.

International journal of molecular sciences, 19(9) (2018-09-21)

Intracellular signaling pathways, including the mammalian target of rapamycin (mTOR) and the mitogen-activated protein kinase (MAPK) pathway, are activated by exercise, and promote skeletal muscle hypertrophy. However, the mechanisms by which these pathways are activated by physiological stimulation are not

Outcomes with two different schedules of bortezomib, melphalan, and prednisone (VMP) for previously untreated multiple myeloma: matched pair analysis using long-term follow-up data from the phase 3 VISTA and PETHEMA/GEM05 trials.

Maria-Victoria Mateos et al.

Annals of hematology, 95(12), 2033-2041 (2016-11-04)

Bortezomib-melphalan-prednisone (VMP) is a standard-of-care for previously untreated, transplant-ineligible multiple myeloma (MM). Here, we compared outcomes between VMP regimens in the VISTA trial (9-cycle VMP schedule, including 4 cycles of twice weekly bortezomib) and the PETHEMA/GEM05 trial (less intensive 6-cycle

A Subset of Mycobacteria-Specific CD4+ IFN-γ+ T Cell Expressing Naive Phenotype Confers Protection against Tuberculosis Infection in the Lung.

Jinyun Yuan et al.

Journal of immunology (Baltimore, Md. : 1950), 203(4), 972-980 (2019-06-30)

Failure of the most recent tuberculosis (TB) vaccine trial to boost bacillus Calmette-Guérin-mediated anti-TB immunity despite the induction of Th1-specific central memory cell and effector memory cell responses highlights the importance of identifying optimal T cell targets for protective vaccines.

Targeted cofactor quantification in metabolically engineered E. coli using solid phase extraction and hydrophilic interaction liquid chromatography-mass spectrometry.

Zhucui Li et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1014, 107-115 (2016-02-20)

Quantification of energy and redox cofactors is of great value to synthetic biologists to infer the balance of energy metabolism in engineered microbial strains and assess each strain's potential for further improvement. Most currently used methods for intracellular cofactor measurement

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