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Showing 1-30 of 329 results for "T1426" within Papers
Bas Sleumer et al.
Analytical and bioanalytical chemistry, 414(20), 6187-6200 (2022-07-16)
The human growth hormone GH1 (22 kDa) is a commonly measured biomarker for diagnosis and during treatment of growth disorders, but its quantification by ligand binding assays may be compromised by the occurrence of a number of isoforms. These can interfere
Iselin Vildmyren et al.
Food & nutrition research, 66 (2022-11-08)
Documentation of health effects of residuals after fish filleting may motivate both consumers and producers to increase the use of this under-utilised protein source. The primary objective of the present study was to investigate the effects of a diet containing
Päivi Ylä-Anttila et al.
Autophagy, 11(10), 1833-1848 (2015-09-02)
RAB24 belongs to a family of small GTPases and has been implicated to function in autophagy. Here we confirm the intracellular localization of RAB24 to autophagic vacuoles with immuno electron microscopy and cell fractionation, and show that prenylation and guanine
Salvatore J Scaffidi et al.
Bio-protocol, 11(10), e4038-e4038 (2021-06-22)
Surface proteins of Staphylococcus aureus and other Gram-positive bacteria play essential roles in bacterial colonization and host-microbe interactions. Surface protein precursors containing a YSIRK/GXXS signal peptide are translocated across the septal membrane at mid-cell, anchored to the cell wall peptidoglycan
Gilda Aiello et al.
Journal of agricultural and food chemistry, 65(47), 10174-10184 (2017-11-04)
The seed of industrial hemp is an underexploited protein source. In view of a possible use in functional foods, a hempseed protein concentrate was hydrolyzed with pepsin, trypsin, pancreatin, or a mixture of these enzymes. A detailed peptidomic analysis using
Niels Wicke et al.
Communications biology, 4(1), 960-960 (2021-08-13)
Protein-based targeting reagents, such as antibodies and non-antibody scaffold proteins, are rapidly inactivated in the upper gastrointestinal (GI) tract. Hydrochloric acid in gastric juice denatures proteins and activates pepsin, concentrations of which reach 1 mg/mL in the mammalian stomach. Two stable
Xiu-Wen Wu et al.
Die Pharmazie, 68(10), 805-810 (2013-11-28)
The Caco-2 cell monolayer model is widely used in drug absorption studies. Dulbecco's Modified Eagle's Medium (DMEM) and Minimum Essential Medium (MEM) have been used alternatively in the development of this model, although they are different in composition which may
Georgios Amanakis et al.
Cardiovascular research, 117(1), 212-223 (2020-03-05)
Cyclophilin-D is a well-known regulator of the mitochondrial permeability transition pore (PTP), the main effector of cardiac ischaemia/reperfusion injury. However, the binding of CypD to the PTP is poorly understood. Cysteine 202 (C202) of CypD is highly conserved among species
Kun Han et al.
Cell proliferation, 55(1), e13169-e13169 (2021-12-28)
Implantation failure is a major cause of prenatal mortality. The uterine lumen closure contributes to embryo adhesion to the uterus, but its underlying mechanisms are largely unknown. Our previous study has reported that endometrial fold extension can lead to uterine
Jianze Xu et al.
Cell reports, 38(12), 110540-110540 (2022-03-24)
The DSB machinery, which induces the programmed DNA double-strand breaks (DSBs) in the leptotene and zygotene stages during meiosis, is suppressed before the onset of the pachytene stage. However, the biological significance and underlying mechanisms remain largely unclear. Here, we
Kinin B1 Receptor Mediates Bidirectional Interaction between Neuroinflammation and Oxidative Stress.
Drew Theobald et al.
Antioxidants (Basel, Switzerland), 12(1) (2023-01-22)
Hypertension is associated with increased expression of kinin B1 receptors (B1R) and increased levels of pro-inflammatory cytokines within the neurons. We previously reported that angiotensin II (Ang II) upregulates B1R expression and can induce neuroinflammation and oxidative stress in primary
Yanchao Wang et al.
Food chemistry, 188, 170-176 (2015-06-05)
Protein isolate was prepared from defatted Antarctic krill (Euphausia superba) byproducts by 0.1 M NaOH extraction. Maximum yield of krill protein isolate reached 28.66% by precipitation at pH 4.6. Krill protein isolate demonstrated its excellent nutritional values through amino acid
Martial Caillaud et al.
Frontiers in neuroscience, 16, 1062253-1062253 (2023-01-24)
The enteric nervous system (ENS) is the intrinsic nervous system that innervates the entire digestive tract and regulates major digestive functions. Recent evidence has shown that functions of the ENS critically rely on enteric neuronal connectivity; however, experimental models to
Kyu Kwang Kim et al.
PloS one, 15(5), e0232253-e0232253 (2020-05-05)
Proteases have been implicated in the tumorigenesis and aggressiveness of a variety of cancer types. In fact, proteases have proven to be very clinically useful as tumor biomarkers in the blood of patients. Proteases are typically involved in complex systems
Fragment-based computational design of antibodies targeting structured epitopes.
Aguilar Rangel, et al.
Science Advances, 8, eabp9540-eabp9540 (2023)
Yao-Yun Fan et al.
Biomolecules, 9(8) (2019-08-25)
System-wide quantitative characterization of human neonatal Fc receptor (FcRn) properties is critical for understanding and predicting human PK (pharmacokinetics) as well as the distribution of mAbs and Fc-fusion proteins using PBPK (physiologically-based pharmacokinetic) modeling. To this end, tissue-specific FcRn expression
F Fiedler
European journal of biochemistry, 163(2), 303-312 (1987-03-02)
Kinetic constants for the hydrolysis by porcine tissue beta-kallikrein B and by bovine trypsin of a number of peptides related to the sequence of kininogen (also one containing a P2 glycine residue instead of phenylalanine) and of a series of
Nima Rajabi et al.
ACS medicinal chemistry letters, 11(10), 1886-1892 (2020-10-17)
The sirtuin enzymes are potential drug targets for intervention in a series of diseases. Efforts to inhibit enzymes of this class with thioamide- and thiourea-containing, substrate-mimicking entities have produced a number of high-affinity binders. However, less attention has been dedicated
Alice Prigent et al.
Journal of neurochemistry, 148(6), 746-760 (2018-12-28)
The protein alpha-synuclein whose expression is strongly implicated in Parkinson's disease (PD) is not only expressed in the CNS but also in the enteric nervous system (ENS). The growing body of evidence suggesting that gastrointestinal inflammation is involved in the
Rohan Umesh Parekh et al.
Scientific reports, 11(1), 21050-21050 (2021-10-28)
Brain orexin system hyperactivity contributes to neurogenic hypertension. We previously reported upregulated neuronal kinin B1 receptor (B1R) expression in hypertension. However, the role of central B1R activation on the orexin system in neurogenic hypertension has not been examined. We hypothesized
Lucelia Cabral et al.
Nature communications, 13(1), 629-629 (2022-02-04)
The largest living rodent, capybara, can efficiently depolymerize and utilize lignocellulosic biomass through microbial symbiotic mechanisms yet elusive. Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty
Andreas P Frei et al.
Nature protocols, 8(7), 1321-1336 (2013-06-15)
Physiological responses to ligands such as peptides, proteins, pharmaceutical drugs or whole pathogens are generally mediated through interactions with specific cell surface protein receptors. Here we describe the application of TRICEPS, a specifically designed chemoproteomic reagent that can be coupled
Ariel Ionescu et al.
Methods in molecular biology (Clifton, N.J.), 2431, 145-161 (2022-04-13)
The molecular communication mechanisms within the Motor Neurons (MN) distant axon and its soma, as well as between MN and their neighboring cells and extracellular environment are of keen interest for our understanding of neurodevelopment and neurodegenerative diseases. One tool
Thomas Masetto et al.
International journal of molecular sciences, 24(13) (2023-07-14)
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The fast and accurate diagnosis of sepsis by procalcitonin (PCT) has emerged as an essential tool in clinical medicine. Although in use in the clinical laboratory
Guofu Zhu et al.
British journal of pharmacology, 179(8), 1716-1731 (2021-11-20)
The Dll4-Notch1 signalling pathway plays an important role in sprouting angiogenesis, vascular remodelling and arterial or venous specificity. Genetic or pharmacological inhibition of Dll4-Notch1 signalling leads to excessive sprouting angiogenesis. However, transcriptional inhibitors of Dll4-Notch1 signalling have not been described.
Emily A McGlade et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(5), e21563-e21563 (2021-04-06)
One of the endogenous estrogens, 17β-estradiol (E2 ) is a female steroid hormone secreted from the ovary. It is well established that E2 causes biochemical and histological changes in the uterus. However, it is not completely understood how E2 regulates
Daniel T Tresnak et al.
Applied and environmental microbiology, 86(22) (2020-09-13)
Class IIa bacteriocin antimicrobial peptides (AMPs) are a compelling alternative to current antimicrobials because of potential specific activity toward antibiotic-resistant bacteria, including vancomycin-resistant enterococci. Engineering of these molecules would be enhanced by a better understanding of AMP sequence-activity relationships to
Emma-Karin I Millers et al.
PloS one, 8(1), e54104-e54104 (2013-01-22)
Textilinin-1 is a Kunitz-type serine protease inhibitor from Australian brown snake venom. Its ability to potently and specifically inhibit human plasmin (K(i) = 0.44 nM) makes it a potential therapeutic drug as a systemic anti-bleeding agent. The crystal structures of
Ling Wang et al.
PloS one, 10(11), e0143431-e0143431 (2015-11-19)
The purpose of this study was to identify the key factors involved in patulin adsorption by heat-inactivated lactic acid bacteria (LAB) cells. For preventing bacterial contamination, a sterilization process was involved in the adsorption process. The effects of various physical
Paola Palumbo et al.
Oncotarget, 8(15), 25582-25598 (2017-04-21)
Nitric oxide has been implicated in biology and progression of glioblastoma (GBM) being able to influence the cellular signal depending on the concentration and duration of cell exposure. NOS2 (inducible nitric oxide synthase) have been proposed as a component of
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