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Showing 1-30 of 329 results for "T1426" within Papers
The Src-ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage.
Lin, et al.
The Journal of Experimental Medicine, 220 (2023)
Functional and structural characterization of Vibrio cholerae extracellular serine protease B, VesB.
Shilpa Gadwal et al.
The Journal of biological chemistry, 289(12), 8288-8298 (2014-01-25)
The chymotrypsin subfamily A of serine proteases consists primarily of eukaryotic proteases, including only a few proteases of bacterial origin. VesB, a newly identified serine protease that is secreted by the type II secretion system in Vibrio cholerae, belongs to
Jeffrey R Whiteaker et al.
Molecular & cellular proteomics : MCP, 10(4), M110-M110 (2011-01-20)
Stable isotope standards and capture by antipeptide antibodies (SISCAPA) couples affinity enrichment of peptides with stable isotope dilution and detection by multiple reaction monitoring mass spectrometry to provide quantitative measurement of peptides as surrogates for their respective proteins. In this
Eitan Erez Zahavi et al.
Science signaling, 11(529) (2018-05-10)
Tropomyosin-related tyrosine kinase B (TrkB) is the receptor for brain-derived neurotrophic factor (BDNF) and provides critical signaling that supports the development and function of the mammalian nervous system. Like other receptor tyrosine kinases (RTKs), TrkB is thought to signal as
Oleg V Petrov et al.
Magnetic resonance in medicine, 81(5), 2858-2868 (2018-12-12)
The multi-exponential character of T1 relaxation in bovine articular cartilage was investigated at low magnetic fields below 0.5 T. The ultimate aim was to identify a parameter based on the T1 relaxation time distribution as a biomarker to biochemical features
Acacia White et al.
Frontiers in pharmacology, 13, 841068-841068 (2022-03-31)
The endoplasmic reticulum (ER) is a key organelle involved in homeostatic functions including protein synthesis and transport, and the storage of free calcium. ER stress potentiates neuroinflammation and neurodegeneration and is a key contributor to the pathogenesis of neurogenic hypertension.
Caterina Peña et al.
Tissue & cell, 54, 72-79 (2018-10-13)
The up-regulation of HLA antigens is important during heart inflammatory events and myofibroblasts may modulate the expression of this molecule in tissues. To test this possibility, the effect of cardiac myofibroblast:macrophage contact and the production of myofibroblast inhibitor factor(s) on
J Fréderique de Graaf et al.
Heliyon, 8(7), e09915-e09915 (2022-07-26)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor clinical prognosis and is usually a metastatic disease. In the last decades, oncolytic viro-immunotherapy has shown a promise as treatment strategy with encouraging results for a variety of tumors. Newcastle Disease
D F Jelinek et al.
Journal of immunology (Baltimore, Md. : 1950), 139(4), 1005-1013 (1987-08-15)
Human peripheral blood, spleen, and lymph node B cells were stimulated with Cowan I Staphylococcus aureus (SA) or F(ab')2 fragments of anti-mu antibody (anti-mu) and various lymphokines and were analyzed for proliferation and generation of Ig-secreting cells (ISC). SA alone
Isabel Gómez et al.
The Biochemical journal, 459(2), 383-396 (2014-01-25)
Cry proteins from Bacillus thuringiensis are insecticidal PFTs (pore-forming toxins). In the present study, we show that two distinct functional pre-pores of Cry1Ab are formed after binding of the protoxin or the protease-activated toxin to the cadherin receptor, but before
Dibyendu Dana et al.
Bioorganic chemistry, 85, 505-514 (2019-02-26)
Human cathepsin L is a ubiquitously expressed endopeptidase and is known to play critical roles in a wide variety of cellular signaling events. Its overexpression has been implicated in numerous human diseases, including highly invasive forms of cancer. Inhibition of
Tian-Yu Feng et al.
Oxidative medicine and cellular longevity, 2020, 5954635-5954635 (2021-01-26)
Spermatogonial stem cells (SSCs) are the only adult stem cells that pass genes to the next generation and can be used in assisted reproductive technology and stem cell therapy. SSC cryopreservation is an important method for the preservation of immature
N N Kostin et al.
Fish & shellfish immunology, 81, 99-107 (2018-07-15)
Serpins are a family of serine protease inhibitors that are involved in numerous physiological processes and are known to regulate innate immunity pathways. To advance our understanding of their role in P. camtschaticus, a commercially significant species, we cloned and
J S Yokhana et al.
Poultry science, 95(3), 550-559 (2015-11-18)
Two experiments were conducted to study effects of dietary insoluble fiber (IF) on digestive enzyme function in layer poultry. In Experiment 1, 8 wk old pullets were fed a control diet (Group C) or a diet (Group IF) supplemented with
Erik Rössler et al.
Magnetic resonance in medicine, 73(5), 2005-2014 (2014-05-16)
Cross-relaxation of protons with (14) N nuclei in proteins enhances relaxivity in the quadrupolar dip range of typically 2-3 MHz Larmor frequency. The magnitude of these dips was suggested as a means of assessing the degeneracy of articular cartilage during
András Szabó et al.
The Journal of biological chemistry, 289(8), 4753-4761 (2014-01-10)
Human cationic trypsinogen, precursor of the digestive enzyme trypsin, can be rapidly degraded to protect the pancreas when pathological conditions threaten, while trypsin itself is impressively resistant to degradation. For either form, degradation is controlled by two necessary initial proteolytic
Joshua K Endow et al.
PloS one, 11(12), e0167802-e0167802 (2016-12-10)
PolyGly is present in many proteins in various organisms. One example is found in a transmembrane β-barrel protein, translocon at the outer-envelope-membrane of chloroplasts 75 (Toc75). Toc75 requires its N-terminal extension (t75) for proper localization. t75 comprises signals for chloroplast
William T Yewdell et al.
Cell reports, 37(6), 109961-109961 (2021-11-11)
Following infection or immunization, memory B cells (MBCs) and long-lived plasma cells provide humoral immunity that can last for decades. Most principles of MBC biology have been determined with hapten-protein carrier models or fluorescent protein immunizations. Here, we examine the
Xuemei Li et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 29(3), 284-286 (2013-05-07)
To identify the epitope of von Willebrand factor (vWF) recognized by monoclonal antibody SZ-125 (mAb SZ-125) using immune-affinity matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) assay in combination with peptide synthesis and amino acid site-mutagenesis technology. Recombinant vWF A3
Sebastian Kreimendahl et al.
BMC biology, 18(1), 156-156 (2020-10-31)
The uptake of newly synthesized nuclear-encoded mitochondrial proteins from the cytosol is mediated by a complex of mitochondrial outer membrane proteins comprising a central pore-forming component and associated receptor proteins. Distinct fractions of proteins initially bind to the receptor proteins
Bram Van Den Eeckhout et al.
NPJ vaccines, 5, 64-64 (2020-07-28)
Annual administration and reformulation of influenza vaccines is required for protection against seasonal infections. However, the induction of strong and long-lasting T cells is critical to reach broad and potentially lifelong antiviral immunity. The NLRP3 inflammasome and its product interleukin-1β
A vast amount of enzyme activity fails to be absorbed within the human pancreas: implications for cost-effective islet isolation procedures.
Andrew S Friberg et al.
Transplantation, 95(6), e36-e38 (2013-03-20)
Christelle Dubois et al.
Journal of proteome research, 19(2), 914-925 (2020-01-09)
Well-characterized prognostic biomarkers and reliable quantitative methods are key in sepsis management. Among damage-associated molecular patterns, S100A8/S100A9 complexes are reported to be markers for injured cells and to improve the prediction of death in septic shock patients. In view of
Mikhail M Vorob'ev
International journal of molecular sciences, 23(15) (2022-07-29)
The opening of protein substrates during degradation by proteases and the corresponding exposure of their internal peptide bonds for a successful enzymatic attack, the so-called demasking effect, was studied for β-lactoglobulin (β-LG) and β-casein (β-CN) hydrolyzed by trypsin. Demasking was
B Mazel-Sanchez et al.
Journal of virology, 92(11) (2018-03-23)
Highly pathogenic influenza A viruses (IAV) from avian hosts were first reported to directly infect humans 20 years ago. However, such infections are rare events, and our understanding of factors promoting or restricting zoonotic transmission is still limited. One accessory
Melisha R Kenedy et al.
Journal of bacteriology, 196(4), 859-872 (2013-12-10)
The Borrelia burgdorferi outer membrane (OM) contains numerous surface-exposed lipoproteins but a relatively low density of integral OM proteins (OMPs). Few membrane-spanning OMPs of B. burgdorferi have been definitively identified, and none are well characterized structurally. Here, we provide evidence
Ching-Wen Tan et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(20), 5199-5204 (2018-05-02)
Obligate symbioses occur when organisms require symbiotic relationships to survive. Some parasitic wasps of caterpillars possess obligate mutualistic viruses called "polydnaviruses." Along with eggs, wasps inject polydnavirus inside their caterpillar hosts where the hatching larvae develop inside the caterpillar. Polydnaviruses
Shunyi Zhu et al.
Molecular immunology, 45(9), 2531-2536 (2008-02-22)
The cathelin-like domain (CLD) of the antimicrobial cathelicidin family constitutes a unique protein family with structural similarity to cystatins, the cysteine protease inhibitors. CLDs are derived from the processed amino-terminal prosequence of the cathelicidin precursors with conservation across the vertebrate
Shunsuke Ohnishi et al.
Molecular imaging, 4(3), 172-181 (2005-10-01)
Intraoperative near-infrared (NIR) fluorescence imaging provides the surgeon with real-time image guidance during cancer and other surgeries. We have previously reported the use of NIR fluorescent quantum dots (QDs) for sentinel lymph node (SLN) mapping. However, because of concerns over
Chuanming Xu et al.
American journal of physiology. Renal physiology, 313(3), F641-F656 (2016-07-22)
(Pro)renin receptor (PRR) is highly expressed in the distal nephron, but it has an unclear functional implication. The present study was conducted to explore a potential role of renal PRR during high K+ (HK) loading. In normal Sprague-Dawley rats, a
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