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Showing 1-30 of 65 results for "T1788" within Papers
Rolf Kemler et al.
Development (Cambridge, England), 131(23), 5817-5824 (2004-11-05)
Many components of the Wnt/beta-catenin signaling pathway are expressed during mouse pre-implantation embryo development, suggesting that this pathway may control cell proliferation and differentiation at this time. We find no evidence for a functional activity of this pathway in cleavage-stage
Ida Björkgren et al.
Frontiers in cell and developmental biology, 9, 710864-710864 (2021-09-28)
Mammalian female fertility is defined by a successful and strictly periodic ovarian cycle, which is under the control of gonadotropins and steroid hormones, particularly progesterone and estrogen. The latter two are produced by the ovaries that are engaged in controlled
Margot Van der Jeught et al.
Cellular reprogramming, 17(3), 170-180 (2015-06-09)
In mice, inhibition of both the fibroblast growth factor (FGF) mitogen-activated protein kinase kinase/extracellular-signal regulated kinase (MEK/Erk) and the Wnt signaling inhibitor glycogen synthase-3β (GSK3β) enables the derivation of mouse embryonic stem cells (mESCs) from nonpermissive strains in the presence
Qianhua Xu et al.
Nature genetics, 51(5), 844-856 (2019-05-02)
The oocyte epigenome plays critical roles in mammalian gametogenesis and embryogenesis. Yet, how it is established remains elusive. Here, we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse oocyte epigenome. Deficiency in Setd2
Sean Chen et al.
Cell reports, 27(13), 3780-3789 (2019-06-27)
Genetically engineered mouse models harboring large sequence insertions or modifications are critical for a wide range of applications including endogenous gene tagging, conditional knockout, site-specific transgene insertion, and gene replacement; however, existing methods to generate such animals remain laborious and
Yue Wang et al.
Biochemical and biophysical research communications, 527(1), 8-14 (2020-05-25)
Oocyte meiotic maturation failure and unfaithful chromosome segregation are major causes for female infertility. Here, we showed that CENP-W, a relatively novel member of the kinetochore protein family, was expressed in mouse oocytes from the germinal vesicle (GV) to metaphase
Guojing Chang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(7), 2760-2770 (2017-03-16)
During pregnancy, placental trophoblasts at the feto-maternal interface produce a broad repertoire of microRNA (miRNA) species. These species include miRNA from the primate-specific chromosome 19 miRNA cluster (C19MC), which is expressed nearly exclusively in the placenta. Trafficking of these miRNAs
Qian Zhou et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(7), 8990-9002 (2020-05-26)
Precise regulation of chromosome segregation during oocyte meiosis is of vital importance to mammalian reproduction. Anaphase promoting complex/cyclosome (APC/C) is reported to play an important role in metaphase-to-anaphase transition. Here we report that cell division cycle 23 (Cdc23, also known
Yoko Kakino Kurotaki et al.
Human reproduction (Oxford, England), 30(5), 1178-1187 (2015-03-06)
Is the poor development of embryos generated from round spermatid injection (ROSI) in humans and animals associated with abnormal active DNA demethylation? A significant proportion of ROSI-derived embryos failed to undergo active DNA demethylation. Active DNA demethylation is initiated by
Huanyu Qiao et al.
Molecular cell, 72(2), 211-221 (2018-10-03)
Oocyte quality control culls eggs with defects in meiosis. In mouse, oocyte death can be triggered by defects in chromosome synapsis and recombination, which involve repair of DNA double-strand breaks (DSBs) between homologous chromosomes. We show that RNF212, a SUMO
Liyan Sui et al.
Journal of cellular physiology, 235(10), 7030-7042 (2020-02-06)
Histone deacetylase 6 (HDAC6) participates in mouse oocyte maturation by deacetylating α-tubulin. However, how HDAC6 expression is regulated in oocytes remains unknown. In the present study, we discovered that mouse oocytes had a high level of HDAC6 expression and a
Qian-Qian Sha et al.
Nature communications, 11(1), 4917-4917 (2020-10-03)
Maternal mRNA clearance is an essential process that occurs during maternal-to-zygotic transition (MZT). However, the dynamics, functional importance, and pathological relevance of maternal mRNA decay in human preimplantation embryos have not yet been analyzed. Here we report the zygotic genome
Shunsuke Konno et al.
Development (Cambridge, England), 147(15) (2020-07-16)
The reason for the poor development of cloned embryos is not yet clear. Several reports have suggested that some nuclear remodeling/reprogramming factors (RRFs) are removed from oocytes at the time of enucleation, which might cause the low success rate of
Jian Yang et al.
Nature, 550(7676), 393-397 (2017-10-12)
Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and the germline but are excluded from the extra-embryonic tissues that are derived from the trophectoderm and the primitive endoderm upon reintroduction to the blastocyst. Here we
Eleonora Maino et al.
EMBO molecular medicine, 13(5), e13228-e13228 (2021-03-17)
Tandem duplication mutations are increasingly found to be the direct cause of many rare heritable diseases, accounting for up to 10% of cases. Unfortunately, animal models recapitulating such mutations are scarce, limiting our ability to study them and develop genome
Maryam Salimi et al.
Reports of biochemistry & molecular biology, 9(3), 357-365 (2021-03-03)
Currently, the efficient production of chimeric mice and their survival are still challenging. Recent researches have indicated that preimplantation embryo culture media and manipulation lead to abnormal methylation of histone in the H19/Igf2 promotor region and consequently alter their gene
Zhao-Yang Xu et al.
Scientific reports, 5, 16978-16978 (2015-11-20)
Cep55 is a relatively novel member of the centrosomal protein family. Here, we show that Cep55 is expressed in mouse oocytes from the germinal vesicle (GV) to metaphase II (MII) stages. Immuostaining and confocal microscopy as well as time lapse
Anastasiia Bondarieva et al.
Nature communications, 11(1), 3101-3101 (2020-06-20)
Orderly chromosome segregation is enabled by crossovers between homologous chromosomes in the first meiotic division. Crossovers arise from recombination-mediated repair of programmed DNA double-strand breaks (DSBs). Multiple DSBs initiate recombination, and most are repaired without crossover formation, although one or
Yao-Long Yan et al.
PLoS biology, 17(6), e3000324-e3000324 (2019-06-22)
The molecular mechanism controlling the zygotic genome activation (ZGA) in mammals remains poorly understood. The 2-cell (2C)-like cells spontaneously emerging from cultures of mouse embryonic stem cells (ESCs) share some key transcriptional and epigenetic programs with 2C-stage embryos. By studying
Tomonori Nakamura et al.
Scientific data, 4, 170067-170067 (2017-06-27)
In mammals, the development of pluripotency and specification of primordial germ cells (PGCs) have been studied predominantly using mice as a model organism. However, divergences among mammalian species for such processes have begun to be recognized. Between humans and mice
Lei Gao et al.
Cell, 173(1), 248-259 (2018-03-13)
The dynamics of the chromatin regulatory landscape during human early embryogenesis remains unknown. Using DNase I hypersensitive site (DHS) sequencing, we report that the chromatin accessibility landscape is gradually established during human early embryogenesis. Interestingly, the DHSs with OCT4 binding
Elie Akoury et al.
Human reproduction (Oxford, England), 30(1), 159-169 (2014-11-02)
What is the subcellular localization in human oocytes and preimplantation embryos, of the two maternal-effect proteins, NLRP7 and KHDC3L, responsible for recurrent hydatidiform moles (RHMs)? NLRP7 and KHDC3L localize to the oocyte cytoskeleton and are polar and absent from the
Sudarshan Gadadhar et al.
Science (New York, N.Y.), 371(6525) (2021-01-09)
Posttranslational modifications of the microtubule cytoskeleton have emerged as key regulators of cellular functions, and their perturbations have been linked to a growing number of human pathologies. Tubulin glycylation modifies microtubules specifically in cilia and flagella, but its functional and
Masahiro Sato et al.
Cells, 9(3) (2020-03-01)
Improved genome-editing via oviductal nucleic acid delivery (i-GONAD) is a technique capable of inducing genomic changes in preimplantation embryos (zygotes) present within the oviduct of a pregnant female. i-GONAD involves intraoviductal injection of a solution containing genome-editing components via a
Xukun Lu et al.
Science advances, 7(48), eabi6178-eabi6178 (2021-11-25)
[Figure: see text].
Alina Osychenko et al.
Experimental cell research, 389(1), 111887-111887 (2020-02-07)
The cell fusion is a widespread process, which takes place in many systems in vivo and in vitro. Fusion of cells is frequently related to tetraploidy, which can be found within natural physiological conditions, e.g., placentation, and in pathophysiological conditions
Marta N Shahbazi et al.
Nature, 552(7684), 239-243 (2017-12-01)
The foundations of mammalian development lie in a cluster of embryonic epiblast stem cells. In response to extracellular matrix signalling, these cells undergo epithelialization and create an apical surface in contact with a cavity, a fundamental event for all subsequent
Martin Kinisu et al.
Cell reports, 37(6), 109982-109982 (2021-11-11)
Early blastomeres of mouse preimplantation embryos exhibit bi-potential cell fate, capable of generating both embryonic and extra-embryonic lineages in blastocysts. Here we identify three major two-cell-stage (2C)-specific endogenous retroviruses (ERVs) as the molecular hallmark of this bi-potential plasticity. Using the
Yuki Kishimoto et al.
Scientific reports, 11(1), 8297-8297 (2021-04-17)
E26 avian leukemia oncogene 2, 3' domain (Ets2) has been implicated in various biological processes. An Ets2 mutant model (Ets2db1/db1), which lacks the DNA-binding domain, was previously reported to exhibit embryonic lethality caused by a trophoblast abnormality. This phenotype could
Zhongshuai Sun et al.
Cell death and differentiation, 25(9), 1686-1701 (2018-02-23)
TMCO1 (transmembrane and coiled-coil domains 1) is an endoplasmic reticulum (ER) transmembrane protein that actively prevents Ca2+ stores from overfilling. To characterize its physiological function(s), we generated Tmco1-/- knockout (KO) mice. In addition to the main clinical features of human
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