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Showing 1-30 of 103 results for "T2265" within Papers
Brett J Hilton et al.
Neuron, 110(1), 51-69 (2021-10-28)
Axons in the adult mammalian central nervous system fail to regenerate after spinal cord injury. Neurons lose their capacity to regenerate during development, but the intracellular processes underlying this loss are unclear. We found that critical components of the presynaptic
Sébastien Dilly et al.
Biochemical pharmacology, 85(4), 560-569 (2012-12-29)
Valine residues in the pore region of SK2 (V366) and SK3 (V520) were replaced by either an alanine or a phenylalanine to evaluate the impact on the interactions with the allosteric blocker apamin. Unlike TEA which showed high sensitivity to
Yu Zhang et al.
European journal of pharmacology, 736, 55-62 (2014-05-06)
Although it is known that general anesthetics can suppress cortical neurons׳ activity, the underlying mechanisms are still poorly understood, especially the kinetic changes of voltage-gated Na(+) channels, which are mostly related to neuronal excitability. Some general anesthetics have been reported
Qian-Ru Zhao et al.
Journal of neurochemistry, 147(1), 40-57 (2018-06-20)
Neuritin is a neurotrophic factor that is activated by neural activity and neurotrophins. Its major function is to promote neurite growth and branching; however, the underlying mechanisms are not fully understood. To address this issue, this study investigated the effects
Andreas Pippow et al.
Cell calcium, 46(2), 87-98 (2009-06-24)
Information processing in neurons depends on highly localized Ca2+ signals. The spatial and temporal dynamics of these signals are determined by a variety of cellular parameters including the calcium influx, calcium buffering and calcium extrusion. Our long-term goal is to
Kevin A Guttenplan et al.
Cell reports, 31(12), 107776-107776 (2020-06-25)
Glaucoma is a neurodegenerative disease that features the death of retinal ganglion cells (RGCs) in the retina, often as a result of prolonged increases in intraocular pressure. We show that preventing the formation of neuroinflammatory reactive astrocytes prevents the death
Fernanda S Gravina et al.
PloS one, 9(10), e111307-e111307 (2014-10-23)
The pacemaker mechanisms activating phasic contractions of vaginal and cervical smooth muscle remain poorly understood. Here, we investigate properties of pacemaking in vaginal and cervical tissues by determining whether: 1) functional pacemaking is dependent on the phase of the estrus
Liberty François-Moutal et al.
Pain, 156(7), 1247-1264 (2015-03-19)
Targeting proteins within the N-type voltage-gated calcium channel (CaV2.2) complex has proven to be an effective strategy for developing novel pain therapeutics. We describe a novel peptide aptamer derived from the collapsin response mediator protein 2 (CRMP2), a CaV2.2-regulatory protein.
Abdelmoneim Eshra et al.
eLife, 10 (2021-10-07)
The Ca2+-dependence of the priming, fusion, and replenishment of synaptic vesicles are fundamental parameters controlling neurotransmitter release and synaptic plasticity. Despite intense efforts, these important steps in the synaptic vesicles' cycle remain poorly understood due to the technical challenge in
Y P Tan et al.
The Journal of physiology, 520 Pt 1, 65-78 (1999-10-12)
1. Action potential-evoked [Ca2+]i rises in basket cell axons of rat cerebellar slices were studied using two-photon laser scanning microscopy and whole-cell recording, to identify the K+ channels controlling the shape of the axonal action potential. 2. Whole-cell recordings of
Evgeniya Trofimenko et al.
eLife, 10 (2021-10-30)
Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules. The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based screening, we discovered that KCNQ5, KCNN4, and KCNK5 potassium channels positively modulate cationic CPP direct translocation into cells
Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction
Sordi R, et al.
British Journal of Pharmacology, 163(6), 1289-1301 (2011)
Dissociation enzyme effects on the potassium currents of inner hair cells isolated from guinea-pig cochlea
Kimitsuki T, et al.
Hearing Research, 199(1-2), 135-139 (2005)
Min Shen et al.
Vascular pharmacology, 58(1-2), 64-70 (2012-07-24)
Evidence has indicated that resveratrol (Res) produces vasorelaxation and may decrease the coronary heart disease mortality. However, several pathways involved in the mechanism of vasorelaxation are still unclear. This study was designed, therefore, to test the probable ion channels or
Takahiro Shibayama et al.
Pharmaceutical research, 32(9), 2937-2949 (2015-03-21)
Unstirred water layers (UWLs) present an unavoidable complication to the measurement of transport kinetics in cultured cells, and the high rates of transport achieved by overexpressing heterologous transporters exacerbate the UWL effect. This study examined the correlation between measured Jmax
Philippe Jean et al.
Nature communications, 11(1), 3208-3208 (2020-06-27)
Inner hair cells (IHCs) are the primary receptors for hearing. They are housed in the cochlea and convey sound information to the brain via synapses with the auditory nerve. IHCs have been thought to be electrically and metabolically independent from
Guillermo J Pérez et al.
American journal of physiology. Cell physiology, 304(3), C280-C286 (2012-12-01)
We studied principal neurons from canine intracardiac (IC) ganglia to determine whether large-conductance calcium-activated potassium (BK) channels play a role in their excitability. We performed whole cell recordings in voltage- and current-clamp modes to measure ion currents and changes in
Xiao-Wen Lu et al.
Electromagnetic biology and medicine, 34(4), 285-292 (2014-04-10)
To study the effects of static magnetic fields (SMF) on the electrophysiological properties of voltage-gated sodium and calcium channels on trigeminal ganglion (TRG) neurons. Acutely dissociated TRG neurons of neonatal SD rats were exposed to 125-mT and 12.5-mT SMF in
Tetraethylammonium enhances the rectal and colonic motility in rats and human in vitro
Li Z, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 384(2), 147-155 (2011)
Yi Cheng et al.
Journal of integrative neuroscience, 18(2), 163-172 (2019-07-20)
In this paper, the modulation of ascending commissural interneurons by N-methyl-D-aspartate was investigated in neonatal rats by using retrograde labeling and whole-cell patch clamp. Data shows these interneurons can be divided into three types (single spike, phasic, and tonic) based
Eunkyung Lie et al.
Communications biology, 4(1), 1138-1138 (2021-10-01)
Many synaptic adhesion molecules positively regulate synapse development and function, but relatively little is known about negative regulation. SALM4/Lrfn3 (synaptic adhesion-like molecule 4/leucine rich repeat and fibronectin type III domain containing 3) inhibits synapse development by suppressing other SALM family
Gonzalo Budelli et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(41), 16657-16662 (2013-09-27)
High-conductance Ca(2+)- and voltage-activated K(+) (Slo1 or BK) channels (KCNMA1) play key roles in many physiological processes. The structure of the Slo1 channel has two functional domains, a core consisting of four voltage sensors controlling an ion-conducting pore, and a
Emre Aslan et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(12), 4585-4589 (2015-02-05)
The electrochemical deposition of Cu nanoparticles with an average diameter of approximately 25-35 nm has been reported at liquid-liquid interfaces by using the organic-phase electron-donor decamethylferrocene (DMFc). The electrodeposited Cu nanoparticles display excellent catalytic activity for the hydrogen evolution reaction (HER);
Yi Cheng et al.
Frontiers in neural circuits, 15, 657445-657445 (2021-04-24)
Serotonergic (5-HT) neurons in the medulla play multiple functional roles associated with many symptoms and motor activities. The descending serotonergic pathway from medulla is essential for initiating locomotion. However, the ionic properties of 5-HT neurons in the medulla remain unclear.
Takeo Yamaguchi et al.
Biological & pharmaceutical bulletin, 35(11), 2088-2091 (2012-11-06)
Recently, we have found that pressure-induced hemolysis is enhanced by inhibiting water transport via aquaporin-1 (AQP1), as seen in p-chloromercuribenzoate (pCMB)-treated erythrocytes. So, using this method we reinvestigated the functions as AQP1 inhibitors of drugs and chemicals such as acetazolamide
Ying Lv et al.
American journal of physiology. Lung cellular and molecular physiology, 305(11), L856-L865 (2013-10-01)
Chronic hypoxia pulmonary hypertension (CH-PHT) in adulthood is likely to be of fetal origin following intrauterine growth retardation (IUGR). Oxygen (O₂)-sensitive voltage-gated potassium channels (Kv channels) in resistance pulmonary artery smooth muscle cells (PASMCs) play an important role in scaling
Bart Pauwels et al.
The journal of sexual medicine, 11(7), 1664-1674 (2014-05-21)
Erectile dysfunction (ED), as well as many cardiovascular diseases, is associated with impaired nitric oxide (NO) bioavailability. Recently, oxime derivatives have emerged as vasodilators due to their NO-donating capacities. However, whether these oximes offer therapeutic perspectives as an alternative NO
Satomi Iwata et al.
Brain research bulletin, 93, 39-46 (2012-11-24)
Neurosteroids such as allopregnanolone (Allo) are widely distributed in the brain and may modulate neuronal excitability under physiological or pathological states. Allo modulates GABAA receptor responses, and in this study we investigated the functional effects of Allo on presynaptic GABAA
Peroxynitrite-induced relaxation in isolated rat aortic rings and mechanisms of action
Li J, et al.
Toxicology and Applied Pharmacology, 209(3), 269-276 (2005)
S Yoon et al.
Cell death & disease, 5, e1494-e1494 (2014-10-31)
Apoptosis, which is anti-inflammatory, and necrosis, which is pro-inflammatory, represent the extremes of the cell death spectrum. Cell death is complex and both apoptosis and necrosis can be observed in the same cells or tissues. Here, we introduce a novel
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