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Showing 1-30 of 133 results for "T3824" within Papers
Ayşe Türkhan et al.
Applied biochemistry and biotechnology, 192(2), 432-442 (2020-05-13)
Tyrosinase (T3824, Sigma) enzymes were immobilized onto SnO2: Sb thin films (ATO-TF) which were synthesized in laboratory conditions by spray pyrolysis technique. Immobilization of tyrosinase onto SnO2: Sb thin film (ATO-TF) was confirmed by scanning electron microscopy (SEM) and Fourier
Joel Ricky Steele et al.
Proteomes, 9(2) (2021-06-03)
Proteinopathies are protein misfolding diseases that have an underlying factor that affects the conformation of proteoforms. A factor hypothesised to play a role in these diseases is the incorporation of non-protein amino acids into proteins, with a key example being
EunA Choi et al.
Molecules (Basel, Switzerland), 27(6) (2022-03-27)
Broussonetia kazinoki has been used as a traditional medicine for the treatment of burns and acne, and its extracts have been found to show tyrosinase inhibitory and anticancer activities. In this study, the tyrosinase inhibitory and cytotoxic activities of B.
Qi Li et al.
PeerJ, 6, e4206-e4206 (2018-02-01)
Targeting tyrosinase is considered to be an effective way to control the production of melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin pigmentation, melanoma and neurodegenerative diseases. Herein, we report our results in identifying new tyrosinase
An Chi et al.
Journal of proteome research, 5(11), 3135-3144 (2006-11-04)
Melanin, which is responsible for virtually all visible skin, hair, and eye pigmentation in humans, is synthesized, deposited, and distributed in subcellular organelles termed melanosomes. A comprehensive determination of the protein composition of this organelle has been obstructed by the
Renwei Jing et al.
Experimental eye research, 119, 35-43 (2013-12-24)
The eye has pigmented cells of two different embryonic origins and therefore it is a good model for studying melanosome biogenesis and melanin production/deposition. Pale ear mice bear a mutation in the Hermansky-Pudlak syndrome type 1 (HPS-1) gene and exhibit
Yang Yao et al.
International journal of molecular sciences, 12(10), 7048-7058 (2011-11-11)
Phenolic acids have been identified in a variety of legumes including lima bean, broad bean, common bean, pea, jack bean, goa bean, adzuki bean, hyacinth bean, chicking vetch, garbanzo bean, dral, cow bean, rice bean, mung bean and soybean. The
Chee W How et al.
Biochimica et biophysica acta, 1838(5), 1215-1224 (2014-02-13)
Catechin flavonoids are the main components of green tea extracts which present broad potential physiological activities. Several of their biological activities seem to affect membrane-dependent cellular processes and it is known that some catechins interact with phospholipid membranes. In this
Xiaoyu Chen et al.
Oxidative medicine and cellular longevity, 2012, 534934-534934 (2013-01-11)
The chemotherapeutical treatment is very limited for malignant melanoma, a highly lethal disease occurs globally. Natural products derived from traditional Chinese medicine licorice are attractive in quest new treatments due to their anti-tumor activities. A new dietary flavonoid isoliquiritigenin (ISL)
B Bouchard et al.
The Journal of experimental medicine, 169(6), 2029-2042 (1989-06-01)
A distinguishing characteristic of cells of the melanocyte lineage is the expression of the melanosomal enzyme tyrosinase that catalyzes the synthesis of the pigment melanin. A tyrosinase cDNA clone, designated BBTY-1, was isolated from a library constructed from the pigmented
Sung Jin Bae et al.
Bioscience, biotechnology, and biochemistry, 77(1), 65-72 (2013-01-08)
We synthesized a novel series of (E)-2-((substituted phenyl)diazenyl)phenyl 4-methylbenzenesulfonate derivatives (2 and 3) and (E)-2-((substituted phenyl)diazenyl)phenol derivatives (4 and 5), and conducted an evaluation in order to determine their inhibitory effects on mushroom tyrosinase, with the aim of discovering a
Yun-Mi Jeong et al.
Bioscience, biotechnology, and biochemistry, 77(1), 119-125 (2013-01-08)
To our knowledge, there is no report that directly shows an inhibitory effect of ginsenoside on melanin synthesis in B16 melanoma cells. Hence, we investigated whether the aglycone of Rh(4) (A-Rh4) inhibits melanin synthesis in B16 melanoma cells, and determined
Hye-Eun Kim et al.
BMB reports, 45(12), 724-729 (2012-12-25)
In this study, we evaluated the anti-melanogenesis effects of Caffeoylserotonin (CaS) in B16 melanoma cells. Treatment with CaS reduced the melanin content and tyrosinase (TYR) activity in B16 melanoma cells in a dose-dependent manner. CaS inhibited the expression of melanogenesis-related
Patrick Sulem et al.
Nature genetics, 39(12), 1443-1452 (2007-10-24)
Hair, skin and eye colors are highly heritable and visible traits in humans. We carried out a genome-wide association scan for variants associated with hair and eye pigmentation, skin sensitivity to sun and freckling among 2,986 Icelanders. We then tested
Ampai Phrutivorapongkul et al.
Pakistan journal of pharmaceutical sciences, 26(6), 1071-1076 (2013-11-06)
The flowers of African marigold (Tagetes erecta L), a medicinal plant widely cultivated in Thailand, were subjected to evaluation for total phenolics, DPPH scavenging and thiobarbituric acid-reactive substance (TBARs) assays as well as tyrosinase inhibitory activity. In preliminary studies, the
B S Kwon et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(21), 7473-7477 (1987-11-01)
Screening of a lambda gt11 human melanocyte cDNA library with antibodies against hamster tyrosinase (monophenol, L-dopa:oxygen oxidoreductase, EC 1.14.18.1) resulted in the isolation of 16 clones. The cDNA inserts from 13 of the 16 clones cross-hybridized with each other, indicating
L M C Silva et al.
Environmental technology, 35(5-8), 1012-1017 (2014-03-22)
A simple and inexpensive biosensor based on lyophilized mushroom tissue (Agaricus bisporus) was developed for amperometric determination of phenol. This fungi tissue contains tyrosinase (EC 1.14.18.1) enzyme that catalysis two sequential oxidation reactions with phenolic substrates. Both reactions involve molecular
Tyrosinase: a comprehensive review of its mechanism.
A Sánchez-Ferrer et al.
Biochimica et biophysica acta, 1247(1), 1-11 (1995-02-22)
Hyun-E Lee et al.
Die Pharmazie, 68(3), 212-216 (2013-04-06)
Melanin plays major a role in pigmentation of hair, eyes, and skin in mammals. In this study, the inhibitory effects of MMS 1001 on alpha-MSH-stimulated melanogenesis were investigated in B16F10 melanoma cells. MMS 1001 did not show cytotoxic effects up
Neda Rafat et al.
Biosensors, 11(11) (2021-11-26)
A novel, integrated experimental and modeling framework was applied to an inhibition-based bi-enzyme (IBE) electrochemical biosensor to detect acetylcholinesterase (AChE) inhibitors that may trigger neurological diseases. The biosensor was fabricated by co-immobilizing AChE and tyrosinase (Tyr) on the gold working
Su-Tze Chou et al.
International journal of molecular sciences, 14(9), 19186-19201 (2013-09-21)
Essential oils extracted from aromatic plants exhibit important biological activities and have become increasingly important for the development of aromatherapy for complementary and alternative medicine. The essential oil extracted from Cinnamomum cassia Presl (CC-EO) has various functional properties; however, little
Wangsa T Ismaya et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 67(Pt 5), 575-578 (2011-05-06)
Tyrosinase catalyzes the conversion of tyrosine to dihydroxyphenylalanine quinone, which is the main precursor for the biosynthesis of melanin. The enzyme from Agaricus bisporus, the common button mushroom, was purified and crystallized in two different space groups. Crystals belonging to
Zong-Ping Zheng et al.
Fitoterapia, 84, 242-247 (2012-12-25)
The twigs of Cudrania tricuspidata were found to show strong tyrosinase inhibitory activity, and further detailed component analysis resulted in the isolation of a new flavanol glucoside, (2S,3S)-2,3-trans-dihydromorin-7-O-β-d-glucoside (1), plus twenty-seven known compounds (2-28). Their structures were elucidated on the
Epidermal growth factor and epidermal growth factor signaling attenuate laser-induced melanogenesis.
Woo Jin Yun et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 39(12), 1903-1911 (2013-10-18)
Epidermal growth factor (EGF) is a peptide that promotes cell growth by binding to its receptor (EGFR) on the cell surface. EGF has been used in cosmetics to whiten the skin and for the prevention of postinflammatory hyperpigmentation (PIH), presumably
Jakub Zdarta et al.
Biotechnology advances, 37(7), 107401-107401 (2019-05-28)
In the modern era, the use of sustainable, environmentally friendly alternatives for removal of recalcitrant pollutants in streams resulting from industrial processes is of key importance. In this context, biodegradation of phenolic compounds, pharmaceuticals and dyes in wastewater by using
Do Hyun Kim et al.
Drug design, development and therapy, 11, 827-836 (2017-03-30)
The authors designed and synthesized 17 (2-substituted phenyl-1,3-dithiolan-4-yl) methanol (PDTM) derivatives to find a new chemical scaffold, showing excellent tyrosinase-inhibitory activity. Their tyrosinase-inhibitory activities were evaluated against mushroom tyrosinase at 50 μM, and five of the PDTM derivatives (PDTM3, PDTM7-PDTM9
V Brichard et al.
The Journal of experimental medicine, 178(2), 489-495 (1993-08-01)
Lymphocytes of melanoma patients can be restimulated in vitro with autologous tumor cells to generate antitumor cytolytic T lymphocytes (CTL). Previous reports have indicated that, when such CTL are obtained from HLA-A2 melanoma patients, they often display broad reactivity on
Ching-Yi Lien et al.
TheScientificWorldJournal, 2014, 409783-409783 (2014-08-20)
We investigated the kinetics of 4N-acetyl-pentapeptides, Ac-P1, Ac-P2, Ac-P3, and Ac-P4, regarding inhibition of mushroom tyrosinase activity. The peptides sequences of Ac-P1, Ac-P2, Ac-P3, and Ac-P4 were Ac-RSRFK, Ac-KSRFR, Ac-KSSFR, and Ac-RSRFS, respectively. The 4N-acetyl-pentapeptides were able to reduce the
Shilpi Goenka et al.
Biomedicines, 8(10) (2020-10-18)
CMT-308 is a nonantimicrobial chemically-modified tetracycline (CMT), which we have previously shown exhibits antifungal activity and pleiotropic anti-inflammatory activities, including inhibition of the enzymatic activity of matrix metalloproteinases (MMPs). Based on its chemical structure, we hypothesized that CMT-308 could inhibit
Novel mutations of the tyrosinase (TYR) gene in type I oculocutaneous albinism (OCA1).
R A Spritz et al.
Human mutation, 10(2), 171-174 (1997-01-01)
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