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Showing 1-30 of 73 results for "T4444" within Papers
Qian Wang et al.
iScience, 24(11), 103393-103393 (2021-11-09)
We compared the functional properties of spike (S) glycoproteins from the original SARS-CoV-2 strain (D614) (Wuhan, China), the globally dominant D614G strain, and emerging geographic variants: B.1.1.7 (United Kingdom), B.1.351 (South Africa), P.1 (Brazil), and B.1.1.248 (Brazil/Japan). Compared with D614G
Minsun Choi et al.
Experimental neurobiology, 31(1), 29-41 (2022-03-09)
Abnormal aggregation of α-synuclein is a key element in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease (PD), dementia with Lewy bodies, and multiple system atrophy. α-synuclein aggregation spreads through various brain regions during the course of disease progression
Robert Mills-Goodlet et al.
Nanoscale, 13(48), 20508-20520 (2021-12-03)
A detailed description of the changes that occur during the formation of protein corona represents a fundamental question in nanoscience, given that it not only impacts the behaviour of nanoparticles but also affects the bound proteins. Relevant questions include whether
Sebastian Jäger et al.
Methods in molecular biology (Clifton, N.J.), 2070, 267-287 (2019-10-19)
Anti-hapten antibodies are widely used as specific immunochemical detection tools in a variety of clinical and environmental analyses. The sensitivity, however, is limited due to the resulting antibody affinities to the haptens which, in turn, leads to a high demand
Kate M Smith et al.
Nature communications, 9(1), 3703-3703 (2018-09-14)
Seven human isoforms of importin α mediate nuclear import of cargo in a tissue- and isoform-specific manner. How nuclear import adaptors differentially interact with cargo harbouring the same nuclear localisation signal (NLS) remains poorly understood, as the NLS recognition region is
Yihong Guan et al.
Communications biology, 3(1), 493-493 (2020-09-09)
Loss-of-function TET2 mutations (TET2MT) are common in myeloid neoplasia. TET2, a DNA dioxygenase, requires 2-oxoglutarate and Fe(II) to oxidize 5-methylcytosine. TET2MT thus result in hypermethylation and transcriptional repression. Ascorbic acid (AA) increases dioxygenase activity by facilitating Fe(III)/Fe(II) redox reaction and
Diana J Vaca et al.
Microbiology spectrum, 10(3), e0059822-e0059822 (2022-04-19)
Bacterial adhesion to the host is the most decisive step in infections. Trimeric autotransporter adhesins (TAA) are important pathogenicity factors of Gram-negative bacteria. The prototypic TAA Bartonella adhesin A (BadA) from human-pathogenic Bartonella henselae mediates bacterial adherence to endothelial cells
Philip J M Brouwer et al.
Cell, 184(5), 1188-1200 (2021-02-13)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a
Robin Avanthay et al.
PLoS pathogens, 20(8), e1012393-e1012393 (2024-08-08)
Live-attenuated influenza vaccines (LAIV) offer advantages over the commonly used inactivated split influenza vaccines. However, finding the optimal balance between sufficient attenuation and immunogenicity has remained a challenge. We recently developed an alternative LAIV based on the 2009 pandemic H1N1
E6 and E7 Antibody Levels Are Potential Biomarkers of Recurrence in Patients with Advanced-Stage Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma.
Matthew E Spector et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(11), 2723-2729 (2016-11-23)
Tilde Andersson et al.
Frontiers in cellular and infection microbiology, 10, 571578-571578 (2020-12-18)
Stapylococcus aureus is a common infectious agent in e.g. sepsis, associated with both high mortality rates and severe long-term effects. The cytolytic protein α-hemolysin has repeatedly been shown to enhance the virulence of S. aureus. Combined with an unhindered spread
Jeonghyo Kim et al.
ACS central science, 7(11), 1898-1907 (2021-11-30)
The coronavirus disease 2019 (COVID-19) pandemic has proved the importance of fast and widespread diagnostic testing to prevent serious epidemics timely. The first-line weapon against rapidly transmitted disease is a quick and massive screening test to isolate patients immediately, preventing
Runhong Zhou et al.
EBioMedicine, 75, 103762-103762 (2021-12-24)
Vaccines in emergency use are efficacious against COVID-19, yet vaccine-induced prevention against nasal SARS-CoV-2 infection remains suboptimal. Since mucosal immunity is critical for nasal prevention, we investigated the efficacy of an intramuscular PD1-based receptor-binding domain (RBD) DNA vaccine (PD1-RBD-DNA) and
Elizabeth A Odundo et al.
mSphere, 7(3), e0102021-e0102021 (2022-05-26)
Diarrheal diseases are a leading cause of global morbidity and mortality, disproportionately affecting children in resource-limited settings. Although improvements in hygiene and access to clean water are helpful, vaccines are considered essential due to the low infectious dose of Shigella
Marco Catalano et al.
Analytical chemistry, 92(15), 10822-10829 (2020-07-04)
The availability of reliable methods for the characterization of the binding of small molecule ligands to protein targets is crucially important for drug discovery. We have adapted a method, routinely used for the characterization of monoclonal antibodies (enzyme-linked immunosorbent assay
Philip J M Brouwer et al.
Cell host & microbe, 30(12), 1759-1772 (2022-11-19)
The Lassa virus is endemic in parts of West Africa, and it causes hemorrhagic fever with high mortality. The development of a recombinant protein vaccine has been hampered by the instability of soluble Lassa virus glycoprotein complex (GPC) trimers, which
K Arias-Alpízar et al.
Biosensors & bioelectronics, 215, 114513-114513 (2022-08-03)
A point-of-care (POC) device is reported for highly sensitive and selective detection of Plasmodium falciparum lactate dehydrogenase (Pf-LDH), a biomarker of malaria infection, based on a single-step magneto-immunoassay, a single-use microfluidic paper device and a customized hand-held fluorescence reader. The
Emmanuel J Favaloro et al.
Methods in molecular biology (Clifton, N.J.), 1646, 403-416 (2017-08-15)
von Willebrand disease (VWD) is reportedly the most common inherited bleeding disorder and can also arise as an acquired syndrome (AVWS). These disorders arise due to defects and/or deficiency of the plasma protein von Willebrand factor (VWF). Laboratory testing for
Kate M Smith et al.
Biochimica et biophysica acta. Molecular cell research, 1865(8), 1114-1129 (2018-05-12)
Nuclear import involves the recognition by importin (IMP) superfamily members of nuclear localization signals (NLSs) within protein cargoes destined for the nucleus, the best understood being recognition of classical NLSs (cNLSs) by the IMPα/β1 heterodimer. Although the cNLS consensus [K-(K/R)-X-(K/R)
Measurement of 11-dehydrocorticosterone in mice, rats and songbirds: Effects of age, sex and stress.
Jordan E Hamden et al.
General and comparative endocrinology, 281, 173-182 (2019-05-31)
Glucocorticoids (GCs) are secreted into the blood by the adrenal glands and are also locally-produced by organs such as the lymphoid organs (bone marrow, thymus, and spleen). Corticosterone is the primary circulating GC in many species, including mice, rats and
Mitch Brinkkemper et al.
iScience, 27(5), 109719-109719 (2024-05-06)
Zoonotic events by sarbecoviruses have sparked an epidemic (severe acute respiratory syndrome coronavirus [SARS-CoV]) and a pandemic (SARS-CoV-2) in the past two decades. The continued risk of spillovers from animals to humans is an ongoing threat to global health and
Ian Wilkinson et al.
PloS one, 16(12), e0260954-e0260954 (2021-12-22)
Elimination of the binding of immunoglobulin Fc to Fc gamma receptors (FcγR) is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins. Many different approaches have been described in the literature but none of
David A Lawrence et al.
Viruses, 16(6) (2024-06-27)
Multisystem Inflammatory Syndrome in Children (MIS-C) is a potentially life-threatening complication of COVID-19. The pathophysiological mechanisms leading to severe disease are poorly understood. This study leveraged clinical samples from a well-characterized cohort of children hospitalized with COVID-19 or MIS-C to
Runhong Zhou et al.
Immunity, 53(4), 864-877 (2020-08-14)
The SARS-CoV-2 pandemic has resulted in millions of infections, yet the role of host immune responses in early COVID-19 pathogenesis remains unclear. By investigating 17 acute and 24 convalescent patients, we found that acute SARS-CoV-2 infection resulted in broad immune
María C López
Toxicology and applied pharmacology, 333, 84-91 (2017-08-28)
The effect of ethanol (EtOH) on the gut immune system was analyzed using an experimental model previously described, where EtOH was provided ad libitum in the drinking water in a 20% w/v concentration for up to 12weeks. Dendritic cells, T
María Luisa Rodríguez de la Concepción et al.
Life science alliance, 4(9) (2021-07-30)
The use of high-dose of intravenous immunoglobulins (IVIGs) as immunomodulators for the treatment of COVID-19-affected individuals has shown promising results. IVIG reduced inflammation in these patients, who progressively restored respiratory function. However, little is known about how they may modulate
Soma Mohammed et al.
Methods in molecular biology (Clifton, N.J.), 1646, 461-472 (2017-08-15)
Von Willebrand disease (VWD) is reportedly the most common inherited bleeding disorder and can also arise as an acquired syndrome (AVWS). These disorders develop due to defects and/or deficiency of the plasma protein von Willebrand factor (VWF). Laboratory testing for
E Brandon Strong et al.
Scientific reports, 9(1), 7-7 (2019-01-11)
Microfluidic paper-based analytical devices (microPADs) are emerging as cost-effective and portable platforms for point-of-care assays. A fundamental limitation of microPAD fabrication is the imprecise nature of most methods for patterning paper. The present work demonstrates that paper patterned via wax
Nicole A Datson et al.
Nucleic acid therapeutics, 30(1), 50-65 (2019-12-11)
Duchenne muscular dystrophy (DMD) is a severe childhood muscle disease primarily caused by the lack of functional dystrophin at the muscle fiber membranes. Multiple therapeutic approaches are currently in (pre)clinical development, aimed at restoring expression of (truncated) dystrophin. Key questions
Discovery of antivirulence agents against methicillin-resistant Staphylococcus aureus
Khodaverdian V, et al.
Antimicrobial agents and chemotherapy, 57(8), 3645-3652 (2013)
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