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Showing 1-30 of 64 results for "T4444" within Papers
Emmanuel J Favaloro et al.
Methods in molecular biology (Clifton, N.J.), 1646, 417-433 (2017-08-15)
Von Willebrand disease (VWD) is reportedly the most common inherited bleeding disorder and can also arise as an acquired syndrome (AVWS). These disorders develop due to defects and/or deficiency of the plasma protein von Willebrand factor (VWF). Laboratory testing for
Manel Ben Ismail et al.
Analytica chimica acta, 999, 144-154 (2017-12-20)
Magnetic beads (MB) and signal amplifiers, such as horseradish peroxidase polymers (poly-HRP), have been used before for the production of highly sensitive immunoassays. However, most of the examples reported previously entailed long and tedious multi-step procedures, which were not necessarily
Can Wang et al.
Frontiers in pharmacology, 12, 734603-734603 (2021-10-26)
Background: Berberine (BBR), a natural product, was reported to inhibit platelet aggregation; however, the molecular mechanisms remain unclear. This study aims to investigate the effects and mechanisms of BBR in inhibiting platelet activation and thrombus formation. Methods: Flow cytometry, immunofluorescence
Mitch Brinkkemper et al.
iScience, 25(12), 105649-105649 (2022-11-29)
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants poses continuous challenges in combating the virus. Here, we describe vaccination strategies to broaden SARS-CoV-2 and sarbecovirus immunity by combining spike proteins based on different viruses or viral strains
Mohammad Suhail Khan et al.
Pharmaceutics, 15(12) (2023-12-23)
Currently deployed SARS-CoV-2 vaccines all require storage at refrigerated or sub-zero temperatures. We demonstrate that after month-long incubation at 37 °C, solubilization, and formulation with squalene-in-water emulsion adjuvant, a stabilized receptor binding domain retains immunogenicity and protective efficacy. We also
Antigen discovery by bioinformatics analysis and peptide microarray for the diagnosis of cystic echinococcosis.
Batisti Biffignandi, et al.
PLoS Neglected Tropical Diseases, 17, e0011210-e0011210 (2023)
Federico Pratesi et al.
Frontiers in immunology, 13, 879946-879946 (2022-06-14)
The currently devastating pandemic of severe acute respiratory syndrome known as coronavirus disease 2019 or COVID-19 is caused by the coronavirus SARS-CoV-2. Both the virus and the disease have been extensively studied worldwide. A trimeric spike (S) protein expressed on
Qian Wang et al.
Cell reports, 39(11), 110924-110924 (2022-06-07)
The recently emerged B.1.1.529 (Omicron) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant has a highly divergent spike (S) glycoprotein. We compared the functional properties of B.1.1.529 BA.1 S with those of previous globally prevalent SARS-CoV-2 variants, D614G and B.1.617.2. Relative to
Perla Ugalde-Muñiz et al.
Oxidative medicine and cellular longevity, 2020, 4807179-4807179 (2020-02-06)
Systemic inflammation is a crucial factor for microglial activation and neuroinflammation in neurodegeneration. This work is aimed at assessing whether previous exposure to systemic inflammation potentiates neurotoxic damage by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and how chronic systemic inflammation participates in
Anna Dąbrowska et al.
Food chemistry, 302, 125350-125350 (2019-08-16)
The aim of the study was to investigate the use of serine protease from Yarrowia lipolytica yeast for reduction of milk proteins allergenicity. Whey protein concentrate (WPC-80), αs-casein and their hydrolysates were analyzed for the capacity to bind IgE and
Martina Iulini et al.
Frontiers in toxicology, 4, 814050-814050 (2022-03-18)
The development of new low molecular weight drugs has many chances of failure and is an expensive process. Currently, there are no screening methods and/or models to assess the hazard of hypersensitivity reactions to drugs (DHRs) in the preclinical phase.
The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination
Karousou E, et al.
The Journal of Biological Chemistry, 285(31), 23647-23654 (2010)
Michael P Horn et al.
Allergy, 77(7), 2090-2103 (2022-01-06)
Serological tests are a powerful tool in the monitoring of infectious diseases and the detection of host immunity. However, manufacturers often provide diagnostic accuracy data generated through biased studies, and the performance in clinical practice is essentially unclear. We aimed
Yihong Guan et al.
The Journal of clinical investigation, 132(4) (2022-01-28)
Eltrombopag, an FDA-approved non-peptidyl thrombopoietin receptor agonist, is clinically used for the treatment of aplastic anemia, a disease characterized by hematopoietic stem cell failure and pancytopenia, to improve platelet counts and stem cell function. Eltrombopag treatment results in a durable
Anna-Karin Haylock et al.
Oncotarget, 8(39), 65152-65170 (2017-10-17)
The aim of this study was to generate and characterize scFv antibodies directed to human CD44v6, as well as to radiolabel and evaluate top candidates Phage display selections were used to isolate CD44v6-specific scFvs. A chain shuffling strategy was employed
Syrian hamster convalescence from prototype SARS-CoV-2 confers measurable protection against the attenuated disease caused by the Omicron variant.
Ryan, et al.
PLoS Pathogens, 19, e1011293-e1011293 (2023)
Daniel Brigger et al.
Allergy, 76(3), 853-865 (2020-10-01)
Serological immunoassays that can identify protective immunity against SARS-CoV-2 are needed to adapt quarantine measures, assess vaccination responses, and evaluate donor plasma. To date, however, the utility of such immunoassays remains unclear. In a mixed-design evaluation study, we compared the
Ruud van den Bos et al.
Behavioural pharmacology, 30(2 and 3-Spec Issue), 260-271 (2019-02-07)
Maternal stress and early life stress affect development. Zebrafish (Danio rerio) are ideally suited to study this, as embryos develop externally into free-feeding larvae. The objective of this study was therefore to assess the effects of increased levels of cortisol
Elke Gossla et al.
International journal of molecular sciences, 22(17) (2021-09-11)
The replacement of damaged or degenerated articular cartilage tissue remains a challenge, as this non-vascularized tissue has a very limited self-healing capacity. Therefore, tissue engineering (TE) of cartilage is a promising treatment option. Although significant progress has been made in
Caroline S Bruikman et al.
Arteriosclerosis, thrombosis, and vascular biology, 40(2), 462-472 (2019-12-06)
Netrin-1 has been shown to play a role in the initiation of atherosclerosis in mice models. However, little is known about the role of Netrin-1 in humans. We set out to study whether Netrin-1 is associated with different stages of
Theodoros T Karalis et al.
Matrix biology : journal of the International Society for Matrix Biology, 78-79, 118-138 (2018-04-21)
The malignant phenotype of various cancers is linked to enhanced expression of hyaluronan, a pro-angiogenic glycosaminoglycan whose expression is suppressed by 4-methylumbelliferone (4-MU), a non-toxic oral agent used as a dietary supplement to improve health and combat prostate cancer. In
Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses.
RadiA?, et al.
iScience, 26, 106540-106540 (2023)
Xiaofeng Zhai et al.
Nature communications, 15(1), 622-622 (2024-01-21)
Alphaviruses are arboviruses transmitted by mosquitoes and are pathogenic to humans and livestock, causing a substantial public health burden. So far, several receptors have been identified for alphavirus entry; however, they cannot explain the broad host range and tissue tropism
Maedeh Moghadam et al.
Frontiers in cellular and infection microbiology, 12, 972929-972929 (2022-10-08)
Hashimoto's thyroiditis (HT) is an autoimmune disorder of the thyroid gland that can cause hypothyroidism. As HT is a multifactorial disorder, activation of immune responses in genetically predisposed individuals exposed to some environmental factors can contribute to it. Microorganisms, as
Yuan Chen et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(18), e2101155-e2101155 (2021-07-20)
Accessible and adaptable nucleic acid diagnostics remains a critical challenge in managing the evolving COVID-19 pandemic. Here, an integrated molecular nanotechnology that enables direct and programmable detection of SARS-CoV-2 RNA targets in native patient specimens is reported. Termed synergistic coupling
Vanesa S Marín Viegas et al.
Biotechnology and bioengineering, 119(9), 2505-2517 (2022-06-12)
Plants are economical and sustainable factories for the production of recombinant proteins. Currently, numerous proteins produced using different plant-based systems with applications as cosmetic and tissue culture ingredients, research and diagnostic reagents, and industrial enzymes are marketed worldwide. In this
Jean Paul Ten Klooster et al.
Archives of biochemistry and biophysics, 644, 81-92 (2018-03-13)
Currently, there is a worldwide increase of patients with type 2 diabetes (T2D). During the progression of healthy obese to T2D status, there is an influx of immune cells, in particular macrophages, into visceral adipose tissue, accompanied by an increase
Theodoros Karalis et al.
Cancers, 14(23) (2022-12-12)
Breast cancer is a common cancer in women. Breast cancer cells synthesize large amounts of hyaluronan to assist their proliferation, survival, migration and invasion. Accumulation of hyaluronan and overexpression of its receptor CD44 and hyaluronidase TMEM2 in breast tumors correlate
Heidi Gytz Olesen et al.
Journal of innate immunity, 1-21 (2022-05-14)
Damage and disease of nerves activates the complement system. We demonstrated that activation of the terminal pathway of the complement system leads to the formation of the membrane attack complex (MAC) and delays regeneration in the peripheral nervous system. Animals
Abdelhadi Djaïleb et al.
Frontiers in immunology, 13, 1052424-1052424 (2023-02-07)
Early in the COVID-19 pandemic, reagent availability was not uniform, and infrastructure had to be urgently adapted to undertake COVID-19 surveillance. Before the validation of centralized testing, two enzyme-linked immunosorbent assays (ELISA) were established independently at two decentralized sites using
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