T4661

Applied Filters:

Keyword:'T4661'

Showing 1-30 of 463 results for "T4661" within Papers

Quantitative Characterization of E-selectin Interaction with Native CD44 and P-selectin Glycoprotein Ligand-1 (PSGL-1) Using a Real Time Immunoprecipitation-based Binding Assay.

Dina B AbuSamra et al.

The Journal of biological chemistry, 290(35), 21213-21230 (2015-07-01)

Selectins (E-, P-, and L-selectins) interact with glycoprotein ligands to mediate the essential tethering/rolling step in cell transport and delivery that captures migrating cells from the circulating flow. In this work, we developed a real time immunoprecipitation assay on a

Characterization of the recognition specificity of BH2, a monoclonal antibody prepared against the HLA-B27 heavy chain.

Hui-Chun Yu et al.

International journal of molecular sciences, 16(4), 8142-8150 (2015-04-15)

BH2, a monoclonal antibody prepared against the denatured human leukocytic antigen-B27 heavy chain (HLA-B27 HC), can immunoprecipitate the misfolded HLA-B27 HC complexed with Bip in the endoplasmic reticulum and recognize the homodimerized HLA-B27 HC that is often observed on the

Combination comet/micronucleus assay validation performed by BioReliance under the JaCVAM initiative.

Kamala Pant et al.

Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 87-97 (2015-07-28)

In the international validation study of the in vivo rat alkaline comet assay (comet assay), the Japanese Center for the Validation of Alternative Methods (JaCVAM) provided three coded chemicals to BioReliance, 1,3-dichloropropene, ethionamide and busulfan, to be tested in a

Betulinic acid derivatives NVX-207 and B10 for treatment of glioblastoma--an in vitro study of cytotoxicity and radiosensitization.

Matthias Bache et al.

International journal of molecular sciences, 15(11), 19777-19790 (2014-11-02)

Betulinic acid (BA), a pentacyclic triterpene, represents a new therapeutic substance that has potential benefits for treating glioblastoma. Recently, new strategies for producing BA derivatives with improved properties have evolved. However, few studies have examined the combination of BA or

[Treatment and metaphylaxis of urate and mixed urolithiasis].

V P Avdoshin et al.

Urologiia (Moscow, Russia : 1999), (3)(3), 7-8 (2012-10-19)

We estimated the efficacy of combined treatment and metaphylaxis of urate and mixed urolithiasis in 87 patients aged 18-87 years. The patients were divided into two groups: 68 patients of group 1 (the size of the concrements between 5-25 mm)

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Zhichao Liu et al.

PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated

Nutraceutic Potential of Two Allium Species and Their Distinctive Organosulfur Compounds: A Multi-Assay Evaluation.

Zahira Fernández-Bedmar et al.

Foods (Basel, Switzerland), 8(6) (2019-06-27)

This study aimed to evaluate the biological activities of two Allium species (garlic and onion) as well as diallyl disulphide (DADS) and dipropyl disulphide (DPDS) as their representative bioactive compounds in a multi-assay experimental design. The genotoxic, antigenotoxic, and lifespan

Binocular pattern deprivation interferes with the expression of proteins involved in primary visual cortex maturation in the cat.

Karolina Laskowska-Macios et al.

Molecular brain, 8, 48-48 (2015-08-15)

Binocular pattern deprivation from eye opening (early BD) delays the maturation of the primary visual cortex. This delay is more pronounced for the peripheral than the central visual field representation within area 17, particularly between the age of 2 and

Assembly of poly(dopamine)/poly(acrylamide) mixed coatings by a single-step surface modification strategy and its application to the separation of proteins using capillary electrophoresis.

Lijuan Chen et al.

Journal of separation science, 38(16), 2915-2923 (2015-05-29)

In this work, a facile approach was developed to modify a fused-silica capillary inner surface based on poly(dopamine) and poly(acrylamide) mixed coatings for protein separation by capillary electrophoresis. The surface morphology, thickness, and chemical components of poly(dopamine)/poly(acrylamide) mixed coatings on

Spectrofluorometric and thermal gravimetric study on binding interaction of thiabendazole with hemoglobin on epoxy-functionalized magnetic nanoparticles.

Esra Maltas et al.

Materials science & engineering. C, Materials for biological applications, 54, 43-49 (2015-06-06)

The interaction of thiabendazole (Tbz) with hemoglobin (Hb) on epoxy-functionalized iron oxide nanoparticles was presented in this study. The binding capacity of Tbz was determined by measuring at an excitation wavelength of 299 nm using fluorescence spectroscopy. The thermodynamic parameters

BCRP and P-gp relay overexpression in triple negative basal-like breast cancer cell line: a prospective role in resistance to Olaparib.

Robin Dufour et al.

Scientific reports, 5, 12670-12670 (2015-08-04)

The triple negative basal-like (TNBL) breast carcinoma is an aggressive and unfavorable prognosis disease. Inhibitors of poly(ADP-ribose) polymerase such as Olaparib could represent a promising targeted therapy but their sensitivity against Multidrug Resistance proteins (MDR), which causes resistance, is not

Intrinsic and extrinsic apoptotic pathways are involved in rat testis by cold water immersion-induced acute and chronic stress.

Adriana Lizbeth Juárez-Rojas et al.

Systems biology in reproductive medicine, 61(4), 211-221 (2015-04-14)

Testicular apoptosis is activated by stress, but it is not clear which signaling pathway is activated in response to stress. The aim of this study was to investigate whether intrinsic, extrinsic, or both apoptotic signaling pathways are activated by acute

Placental immune response to apple allergen in allergic mothers.

Martina Sandberg Abelius et al.

Journal of reproductive immunology, 106, 100-109 (2014-07-23)

The immunological milieu in the placenta may be crucial for priming the developing foetal immune system. Early imbalances may promote the establishment of immune-mediated diseases in later life, including allergies. The initial exposure to allergens seems to occur in utero

Structural insights into the benzophenanthridines binding to human glycine transporter GlyT1.

Frantisek Jursky et al.

European journal of pharmacology, 765, 1-6 (2015-08-15)

We previously identified cysteine 475 as a key residue for the inhibitory action of sanguinarine on the human glycine transporter GlyT1c. To define potential benzophenanthridine binding pocket more closely, we created a structural homology model of GlyT1 and also mutated

miR-145 suppress the androgen receptor in prostate cancer cells and correlates to prostate cancer prognosis.

Olivia Larne et al.

Carcinogenesis, 36(8), 858-866 (2015-05-15)

Androgen signalling through the androgen receptor (AR) is essential for prostate cancer initiation, progression and transformation to the lethal castration-resistant state. The aim of this study was to characterize the mechanisms by which miR-145 deregulation contribute to prostate cancer progression.

Acquisition strategy to reduce cerebrospinal fluid partial volume effects for improved DTI tractography.

Corey A Baron et al.

Magnetic resonance in medicine, 73(3), 1075-1084 (2014-04-12)

An acquisition method that does not increase scan time or specific absorption rate is investigated for reducing the deleterious effects of cerebrospinal fluid (CSF) partial volume effects on diffusion tensor imaging (DTI) tractography. It is based on using a shorter

The hydrolysed products of iridoid glycosides can enhance imatinib mesylate-induced apoptosis in human myeloid leukaemia cells.

Min-Beom Kim et al.

Phytotherapy research : PTR, 29(3), 434-443 (2015-01-15)

Several studies have demonstrated that deregulated activation of signal transducer and activator of transcription 3 (STAT3) has been associated with survival, proliferation, chemoresistance and angiogenesis of tumour cells. Thus, inhibition of STAT3 expression could be a potent therapeutic approach for

Extracorporeal Life Support in "Awake" Patients as a Bridge to Lung Transplant.

Prashant N Mohite et al.

The Thoracic and cardiovascular surgeon, 63(8), 699-705 (2015-03-06)

Traditionally, patients on extracorporeal membrane oxygenation (ECMO) are sedated and mechanically ventilated, which increases risk of complications related to immobility and mechanical ventilation. The purpose of this study was to assess the feasibility and highlight the benefits of a bridge

Evidence That Base-pairing Interaction between Intron and mRNA Leader Sequences Inhibits Initiation of HAC1 mRNA Translation in Yeast.

Leena Sathe et al.

The Journal of biological chemistry, 290(36), 21821-21832 (2015-07-16)

The Hac1 transcription factor in yeast up-regulates a collection of genes that control protein homeostasis. Base-pairing interactions between sequences in the intron and the 5'-untranslated region (5' UTR) of the HAC1 mRNA represses Hac1 protein production under basal conditions, whereas

Irisin, a unique non-inflammatory myokine in stimulating skeletal muscle metabolism.

Roger A Vaughan et al.

Journal of physiology and biochemistry, 71(4), 679-689 (2015-09-25)

Exercise offers several benefits for health, including increased lean body mass and heightened energy expenditure, which may be partially attributable to secretory factors known as myokines. Irisin, a recently identified myokine, was shown to increase metabolic rate and mitochondrial content

Ketorolac tromethamine: an oral/injectable nonsteroidal anti-inflammatory for postoperative pain control.

R J Redden

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 50(12), 1310-1313 (1992-12-01)

Ketorolac tromethamine is a new injectable/oral nonsteroidal anti-inflammatory analgesic with no apparent opiate receptor activity that has been administered alone and in combination with other opiate analgesics for the treatment of postoperative pain. The drug has shown promise in analgesic

Moisture dipole over the Tibetan Plateau during the past five and a half centuries.

Qi-Bin Zhang et al.

Nature communications, 6, 8062-8062 (2015-08-22)

The South Asian Monsoon and mid-latitude Westerlies are two important controls on Tibetan Plateau (TP) fresh water resources. Understanding their interaction requires long-term information on spatial patterns in moisture variability on the TP. Here we develop a network of 23

Complementary mass spectrometric techniques for the quantification of the protein corona: a case study on gold nanoparticles and human serum proteins.

Nerea Fernández-Iglesias et al.

Nanoscale, 7(34), 14324-14331 (2015-08-06)

Once nanoparticles enter a biological system, it is known that their surface is instantly covered by the biomolecules present with preference to proteins. This protein corona has been a subject of numerous studies in order to reveal its composition. Besides

Utilisation of the isobole methodology to study dietary peptide-drug and peptide-peptide interactive effects on dipeptidyl peptidase IV (DPP-IV) inhibition.

Alice B Nongonierma et al.

Food & function, 6(1), 313-320 (2014-12-06)

Inhibition of dipeptidyl peptidase-IV (DPP-IV) is used as a means to regulate post-prandial serum glucose in type 2 diabetics. The effect of drug (Sitagliptin®)/peptide and binary peptide mixtures on DPP-IV inhibition was studied using an isobole approach. Five peptides (Ile-Pro-Ile-Gln-Tyr

Photodiode array to charged aerosol detector response ratio enables comprehensive quantitative monitoring of basic drugs in blood by ultra-high performance liquid chromatography.

Jenni Viinamäki et al.

Analytica chimica acta, 865, 1-7 (2015-03-04)

Quantitative screening for a broad range of drugs in blood is regularly required to assess drug abuse and poisoning within analytical toxicology. Mass spectrometry-based procedures suffer from the large amount of work required to maintain quantitative calibration in extensive multi-compound

Hypomorphic variants of cationic amino acid transporter 3 in males with autism spectrum disorders.

Caroline Nava et al.

Amino acids, 47(12), 2647-2658 (2015-07-29)

Cationic amino acid transporters (CATs) mediate the entry of L-type cationic amino acids (arginine, ornithine and lysine) into the cells including neurons. CAT-3, encoded by the SLC7A3 gene on chromosome X, is one of the three CATs present in the

Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS).

Jennifer E Gilda et al.

PloS one, 10(8), e0135392-e0135392 (2015-08-20)

Western blotting is a commonly used technique in biological research. A major problem with Western blotting is not the method itself, but the use of poor quality antibodies as well as the use of different experimental conditions that affect the

Comparison of endocrine changes, timing of ovulations, ovarian follicular growth, and efficacy associated with Estradoublesynch and Heatsynch protocols in Murrah buffalo cows (Bubalus bubalis).

R Mirmahmoudi et al.

Theriogenology, 82(7), 1012-1020 (2014-08-26)

Poor estrus expression and the difficulty encountered in predicting the time of ovulation compromise the reproductive efficiency of Murrah buffalo cows. Synchronization of ovulation and timed artificial insemination are able to precisely control the time of ovulation and thus avoid

Profiling of drug binding proteins by monolithic affinity chromatography in combination with liquid chromatography-tandem mass spectrometry.

Xuepei Zhang et al.

Journal of chromatography. A, 1359, 84-90 (2014-07-30)

A new approach for proteome-wide profiling drug binding proteins by using monolithic capillary affinity chromatography in combination with HPLC-MS/MS is reported. Two immunosuppresive drugs, namely FK506 and cyclosporin A, were utilized as the experimental models for proof-of-concept. The monolithic capillary

Receptor mediated disruption of retinal pigment epithelium function in acute glycated-albumin exposure.

Mohammad Dahrouj et al.

Experimental eye research, 137, 50-56 (2015-06-14)

Diabetic macular edema (DME) is a major cause of visual impairment. Although DME is generally believed to be a microvascular disease, dysfunction of the retinal pigment epithelium (RPE) can also contribute to its development. Advanced glycation end-products (AGE) are thought

Page 1 of 16