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Showing 1-30 of 183 results for "T6567" within Papers
Yousef I Hassan et al.
Archives of biochemistry and biophysics, 495(1), 35-41 (2009-12-23)
Holocarboxylase synthetase (HCS) catalyzes the binding of biotin to lysines in carboxylases and histones in two steps. First, HCS catalyzes the synthesis of biotinyl-5'-AMP; second, the biotinyl moiety is ligated to lysine residues. It has been proposed that step two
The Qb-SNARE Memb11 interacts specifically with Arf1 in the Golgi apparatus of Arabidopsis thaliana.
Claireline Marais et al.
Journal of experimental botany, 66(21), 6665-6678 (2015-07-26)
The SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins are critical for the function of the secretory pathway. The SNARE Memb11 is involved in membrane trafficking at the ER-Golgi interface. The aim of the work was to decipher molecular mechanisms
Lindsay A Parish et al.
Journal of proteome research, 10(11), 5150-5162 (2011-09-13)
Lipid raft microdomains, a component of detergent resistant membranes (DRMs), are routinely exploited by pathogens during host-cell entry. Multiple membrane-surface proteins mediate Plasmodium ookinete invasion of the Anopheles midgut, a critical step in the parasite life cycle that is successfully
Rachael M Cunningham et al.
ACS chemical biology, 12(11), 2737-2745 (2017-09-12)
Pt(II)-based anticancer drugs are widely used in the treatment of a variety of cancers, but their clinical efficacy is hindered by undesirable side effects and resistance. While much research has focused on Pt(II) drug interactions with DNA, there is increasing
Guillaume Serwe et al.
Nature communications, 14(1), 3560-3560 (2023-06-16)
Cell motility is a critical feature of invasive tumour cells that is governed by complex signal transduction events. Particularly, the underlying mechanisms that bridge extracellular stimuli to the molecular machinery driving motility remain partially understood. Here, we show that the
William O Slade et al.
Journal of the American Society for Mass Spectrometry, 26(4), 631-640 (2015-02-24)
Photosynthetic organisms use dynamic post-translational modifications to survive and adapt, which include reversible oxidative modifications of protein thiols that regulate protein structure, function, and activity. Efforts to quantify thiol modifications on a global scale have relied upon peptide derivatization, typically
Cindy Dieryckx et al.
Frontiers in plant science, 6, 859-859 (2015-11-04)
Using Botrytis cinerea we confirmed in the present work several previous studies showing that salicylic acid, a main plant hormone, inhibits fungal growth in vitro. Such an inhibitory effect was also observed for the two salicylic acid derivatives, methylsalicylic and
Divya Arunachalam et al.
Infection and immunity, 89(6) (2021-03-24)
Human corneal epithelial (HCE) cells play a significant role in the innate immune response by secreting cytokines and antimicrobial peptides when they encounter fungal pathogens. But the detailed mechanism of attachment and engulfment of the fungal conidia by HCE cells
Biomarkers of acute and chronic pancreatitis
Kaphalia BS
Biomarkers in Toxicology, 279-289 (2014)
Yoann Saucereau et al.
BMC genomics, 18(1), 635-635 (2017-08-20)
Aedes albopictus is a vector of arboviruses that cause severe diseases in humans such as Chikungunya, Dengue and Zika fevers. The vector competence of Ae. albopictus varies depending on the mosquito population involved and the virus transmitted. Wolbachia infection status
Jérémy Loehr et al.
Frontiers in molecular biosciences, 9, 831758-831758 (2022-04-12)
Cellular homeostasis requires the orderly expression of thousands of transcripts. Gene expression is regulated by numerous proteins that recognize post-translational modifications-in particular, the acetylation of lysine residues (Kac) on histones. In addition to affecting the general condensation state of the
Mohammad Anas et al.
The Biochemical journal, 477(18), 3625-3643 (2020-09-08)
Plasmodium falciparum, the human malaria parasite harbors a metastable proteome which is vulnerable to proteotoxic stress conditions encountered during its lifecycle. How parasite's chaperone machinery is able to maintain its aggregation-prone proteome in functional state, is poorly understood. As HSP70-40
Sina Nazifi et al.
Veterinary medicine and science, 8(6), 2646-2654 (2022-09-10)
Sertoli cells (SCs) as supportive cells in the seminiferous tubule play an essential role in the nutrition and development of adjacent cells by secreting several beneficial growth factors, stimulators and cytokines which can be conceived to improve the developmental competency
Robert M DeKroon et al.
Journal of proteome research, 10(4), 1632-1644 (2011-01-08)
To better elucidate temporal changes in protein oxidation resulting from aging and the Alzheimer's disease-associated Apolipoprotein E (ApoE), we developed a 2D-DIGE-based method for simultaneously detecting differential expression and carbonyl oxidation of proteins. Specifically, we examined changes in the levels
Narongsak Chaiyabutr et al.
The journal of venomous animals and toxins including tropical diseases, 28, 20210111-20210111 (2022-04-19)
Eastern Russell's viper (Daboia siamensis) is one of the most medically significant snakes responsible for the development of acute renal failure. However, variation of the clinical picture and renal pathophysiology following bites by young and adult D. siamensis have not
Pauline Floch et al.
Gut pathogens, 6, 20-20 (2014-07-06)
A gamma-glutamyl transpeptidase (GGT) is produced by up to 31% of strains of Campylobacter jejuni isolates. C. jejuni GGT is close to Helicobacter pylori GGT suggesting a conserved activity but unlike the latter, C. jejuni GGT has not been studied
Ombretta Repetto et al.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 24(3), 666-679 (2021-02-24)
Autoimmune atrophic gastritis (AAG) is a chronic disease that can progress to gastric cancer (GC). To better understand AAG pathology, this proteomics study investigated gastric proteins whose expression levels are altered in this disease and also in GC. Using two-dimensional
Achintya Kumar Dolui et al.
Scientific reports, 10(1), 15191-15191 (2020-09-18)
Rice bran is an underutilized agricultural by-product with economic importance. The unique phytochemicals and fatty acid compositions of bran have been targeted for nutraceutical development. The endogenous lipases and hydrolases are responsible for the rapid deterioration of rice bran. Hence
Marta Murgia et al.
Cell reports, 29(12), 3825-3834 (2019-12-19)
The mosaic distribution of cytochrome c oxidase+ (COX+) and COX- muscle fibers in mitochondrial disorders allows the sampling of fibers with compensated and decompensated mitochondrial function from the same individual. We apply laser capture microdissection to excise individual COX+ and
Hillary Andaluz Aguilar et al.
Nature protocols, 15(1), 161-180 (2019-12-22)
Extracellular vesicles (EVs) are increasingly being recognized as important vehicles for intercellular communication and as promising sources for biomarker discovery. Because the state of protein post-translational modifications (PTMs) such as phosphorylation and glycosylation can be a key determinant of cellular
Elena Hego et al.
Proteomics, 16(9), 1386-1397 (2016-02-24)
Changes in leaf soluble proteome were explored in 3-month-old plants of metallicolous (M) and nonmetallicolous (NM) Agrostis capillaris L. populations exposed to increasing Cu concentrations (1-50 μM) to investigate molecular mechanisms underlying plant responses to Cu excess and tolerance of M
Ricardo N Alves et al.
Food chemistry, 267, 15-27 (2018-06-24)
The oral bioaccessibility of several essential and toxic elements was investigated in raw and cooked commercially available seafood species from European markets. Bioaccessibility varied between seafood species and elements. Methylmercury bioaccessibility varied between 10 (octopus) and 60% (monkfish). Arsenic (>64%)
Labelling of proteins by use of iodination and detection by ICP-MS.
Jakubowski, N., et al.
Journal of Analytical Atomic Spectrometry, 23, 1487-1496 (2008)
Aurelien Dugourd et al.
Molecular systems biology, 17(1), e9730-e9730 (2021-01-28)
Multi-omics datasets can provide molecular insights beyond the sum of individual omics. Various tools have been recently developed to integrate such datasets, but there are limited strategies to systematically extract mechanistic hypotheses from them. Here, we present COSMOS (Causal Oriented
Rasmus Rydbirk et al.
Cellular and molecular life sciences : CMLS, 79(6), 336-336 (2022-06-04)
Multiple system atrophy (MSA) is a rare, progressive, neurodegenerative disorder presenting glia pathology. Still, disease etiology and pathophysiology are unknown, but neuro-inflammation and vascular disruption may be contributing factors to the disease progression. Here, we performed an ex vivo deep
Ralph Adams et al.
Frontiers in immunology, 14, 1170357-1170357 (2023-05-30)
Serum albumin binding is an established mechanism to extend the serum half-life of antibody fragments and peptides. The cysteine rich knob domains, isolated from bovine antibody ultralong CDRH3, are the smallest single chain antibody fragments described to date and versatile
Xiang-Rong Li et al.
Cell death discovery, 7(1), 11-11 (2021-01-16)
Besides their original regulating roles in the brain, spinal cord, retina, and peripheral nervous system for mediating fast excitatory synaptic transmission, glutamate receptors consisting of metabotropic glutamate receptors (GluRs) and ionotropic glutamate receptors (iGluRs) have emerged to have a critical
Devon Radford et al.
Frontiers in microbiology, 9, 2123-2123 (2018-09-27)
With the alarming proliferation of antibiotic resistance, it is important to understand the de novo development of bacterial adaptation to antibiotics in formerly susceptible lineages, in the absence of external genetic input from existing resistance pools. A strain of ceftiofur
Supeecha Kumkate et al.
Toxins, 12(1) (2020-01-23)
The two venomous pit vipers, Trimeresurus macrops and T. hageni, are distributed throughout Thailand, although their abundance varies among different areas. No species-specific antivenom is available for their bite victims, and the only recorded treatment method is a horse antivenom
Fei-Yan Deng et al.
Molecular & cellular proteomics : MCP, 10(11), M111-M111 (2011-08-06)
Low bone mineral density (BMD) is a risk factor of osteoporosis and has strong genetic determination. Genes influencing BMD and fundamental mechanisms leading to osteoporosis have yet to be fully determined. Peripheral blood monocytes (PBM) are potential osteoclast precursors, which
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