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Showing 1-30 of 32 results for "T6764" within Papers
Rahul Dev et al.
AAPS PharmSciTech, 13(1), 174-183 (2011-12-21)
The aim of the present study was to develop asymmetric membrane (AM) tablets for controlled delivery of highly water-soluble antihistaminic drug triprolidine hydrochloride. The solubility of triprolidine hydrochloride was modulated through the incorporation of coated sodium chloride crystals encapsulated with
Johan De Houwer et al.
Angewandte Chemie (International ed. in English), 51(11), 2745-2748 (2012-02-01)
Sustainable Oxidations: an oxidation method to transform aryl(di)azinylmethanes into aryl(di)azinyl ketones is described. Base metals (copper and iron) as catalysts in combination with O(2) as the oxidant are used, which makes this method sustainable. The utility of this method is
Andrew D Whyment et al.
Journal of neurophysiology, 95(4), 2492-2500 (2005-12-16)
The role of histamine in regulating excitability of sympathetic preganglionic neurons (SPNs) and the expression of histamine receptor mRNA in SPNs was investigated using whole-cell patch-clamp electrophysiological recording techniques combined with single-cell reverse transcriptase polymerase chain reaction (RT-PCR) in transverse
A I Kuzmin et al.
European journal of pharmacology, 378(3), 311-316 (1999-09-24)
The effects of pretreatment with selective histamine receptor antagonists on changes in sympathoadrenal activity and haemodynamics, induced by 60-min immobilization stress, were studied in conscious rats. Using adrenomedullary microdialysis, it was shown that ranitidine (5 mg/kg, i.v.), a histamine H2
Jung Yeon Kim et al.
Biomedical chromatography : BMC, 29(3), 465-474 (2014-08-01)
The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged from 1.5 to 2.5
Y Kurose et al.
Brain research, 828(1-2), 115-118 (1999-05-13)
Histamine is one of the neurotransmitters suppressing appetite, but the interactions of histaminergic neurons with other neurons in satiety centers have not been clarified. Noradrenaline in the para-ventricular nucleus (PVN) has been shown to stimulate feeding. This study was designed
["Of snakes and crocodiles": central side effects of nose drops and facts about rhinitis medicamentosa].
Jens Bielenberg
Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 30(10), 406-408 (2011-10-28)
Mohamed O Amin et al.
Mikrochimica acta, 186(8), 503-503 (2019-07-05)
The use of carbon black-Fe3O4 magnetic nanocomposite (CB-Fe3O4) as a probe for surface-enhanced laser desorption ionization mass spectrometry (SELDI-MS) with a high extraction efficiency and sensitive detection is described. The magnetic nanocomposite was synthesized and fully characterized using X-ray photoelectron
Madison Elle Walsh et al.
PLoS neglected tropical diseases, 14(3), e0007790-e0007790 (2020-03-14)
Trypanosoma brucei are unicellular parasites endemic to Sub-Saharan Africa that cause fatal disease in humans and animals. Infection with these parasites is caused by the bite of the tsetse fly vector, and parasites living extracellularly in the blood of infected
Tao Luo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(23), 7845-7852 (2010-06-11)
Long-term potentiation (LTP) in hippocampal CA1 depends on the behavioral state of LTP induction. We hypothesize that histaminergic activity in the septohippocampal system, which is active during walking compared with other behavioral states, is responsible for the behavioral dependence of
Tiina-Kaisa Kukko-Lukjanov et al.
Epilepsy research, 90(1-2), 8-15 (2010-04-03)
The central histaminergic neuronal system is a powerful modulator of brain activity, and its functional disturbance is related to e.g. epilepsy. We have recently shown in the slice culture system that histaminergic neurons attenuate kainic acid (KA)-induced epileptiform activity and
Y-N Song et al.
Neuroscience, 140(1), 33-43 (2006-03-15)
Previous studies have revealed a direct histaminergic projection from the tuberomamillary nucleus of hypothalamus to the cerebellum and a postsynaptic excitatory effect of histamine on the cerebellar interpositus nucleus neurons via histamine H(2) receptors in vitro, indicating that the histaminergic
C Gex-Collet et al.
Journal of investigational allergology & clinical immunology, 16(3), 156-161 (2006-06-21)
Petasin (Ze 339) was recently introduced on the market as a potent herbal antiallergic drug for treatment of respiratory allergies such as hay fever. Few clinical studies have been performed so far addressing the clinical effectiveness of Ze 339. To
General anesthesia and ascending arousal pathways.
Anna Y Zecharia et al.
Anesthesiology, 111(4), 695-696 (2009-08-27)
Feifei Feng et al.
The Journal of pharmacy and pharmacology, 72(4), 507-518 (2020-02-08)
Ketotifen (K) and its active metabolite norketotifen (N) exist as optically active atropisomers. They both have antihistaminic and anti-inflammatory properties but the S-atropisomer of N (SN) causes less sedation than K and RN in rodents. This study investigated whether this
Benjamin R Collins et al.
Journal of pharmaceutical and biomedical analysis, 43(1), 293-297 (2006-08-26)
An automated solid-phase extraction method was developed for the determination of the H1-antihistamine acrivastine in plasma samples. Acrivastine was analyzed at the wavelength of 254 nm using a reversed-phase HPLC assay. Both extraction procedure and analytical condition were optimized and
Ashok K Shakya et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(32), 4071-4078 (2009-11-21)
A highly efficient, selective and specific method for simultaneous quantitation of triprolidine and pseudoephedrine in human plasma by liquid chromatography-ion trap-tandem mass spectrometry coupled with electro spray ionization (LC-ESI-ion trap-tandem MS) has been validated and successfully applied to a clinical
S I M Zayed et al.
Farmaco (Societa chimica italiana : 1989), 60(6-7), 621-625 (2005-06-14)
The electrochemical behavior of antihistaminic drug, viz. triprolidine hydrochloride (TripCl), at a hanging mercury drop electrode (HMDE) is investigated. Chemical and electrical parameters affecting the adsorptive voltammetric measurements are optimized. Different modes of sweep, viz. direct current DC, normal pulse
Chikako Gemba et al.
Journal of neurophysiology, 113(10), 3720-3735 (2015-04-24)
Histamine receptors are densely expressed in the mesencephalic trigeminal nucleus (MesV) and trigeminal motor nucleus. However, little is known about the functional roles of neuronal histamine in controlling oral-motor activity. Thus, using the whole-cell recording technique in brainstem slice preparations
Amr M Badawey et al.
Journal of AOAC International, 89(1), 46-52 (2006-03-04)
A simple and sensitive spectrophotometric method is suggested for analysis of 3 antihistaminic drugs, acrivastine (I), mequitazine (II), and dimethindene maleate (III). The method is based on reaction of the drugs with 7,7,8,8-tetracyanoquinodimethane (TCNQ) in acetonitrile to form highly stable
Gianluigi Tanda et al.
Journal of neurochemistry, 106(1), 147-157 (2008-03-28)
The pattern of activation of dopamine (DA) neurotransmission in the nucleus accumbens (NAc) of rats produced by H(1) histamine antagonists which have behavioral effects like those of psychostimulant drugs was examined. Diphenhydramine and (+)-chlorpheniramine were compared with triprolidine, a potent
Bradley J Shaw et al.
Journal of pharmaceutical and biomedical analysis, 63, 151-159 (2012-02-22)
Palladium (Pd) is extensively used in pharmaceutical small molecule drug substance processes, however it must be removed prior to release of the active pharmaceutical ingredient (API). Evaluation of four TXRF instruments and configurations were compared to ICP-MS instrumentation for trace
Karunya K Kandimalla et al.
International journal of pharmaceutics, 302(1-2), 133-144 (2005-08-18)
Hydroxyzine and triprolidine have both been reported to reach the CNS following nasal administration. The objective of this study was to investigate their in vitro permeation across bovine olfactory mucosa in order to further characterize the biological and physicochemical parameters
Sang-Chul Shin et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 61(1-2), 14-19 (2005-07-12)
The bioavailability of triprolidine from the ethylene vinyl acetate (EVA) matrix system containing polyoxyethylene-2-oleyl ether was studied to determine the feasibility of enhanced transdermal delivery of triprolidine in rabbits. The antihistamine effects were also confirmed to determine the percutaneous absorption
B Sandhya et al.
Journal of pharmaceutical and biomedical analysis, 54(5), 1180-1186 (2011-01-11)
The interaction between triprolidine hydrochloride (TRP) to serum albumins viz. bovine serum albumin (BSA) and human serum albumin (HSA) has been studied by spectroscopic methods. The experimental results revealed the static quenching mechanism in the interaction of TRP with protein.
Iustin V Tabarean
PloS one, 7(10), e47700-e47700 (2012-10-20)
Thermoregulatory neurons of the median preoptic nucleus (MnPO) represent a target at which histamine modulates body temperature. The mechanism by which histamine excites a population of MnPO neurons is not known. In this study it was found that histamine activated
Involvement of the organic cation transporters in histamine uptake into human vascular endothelial cells.
K Cerne et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 58 Suppl 1, 61-62 (2009-03-10)
Tiina-Kaisa Kukko-Lukjanov et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(4), 1088-1097 (2006-01-27)
The central histaminergic neuron system inhibits epileptic seizures, which is suggested to occur mainly through histamine 1 (H1) and histamine 3 (H3) receptors. However, the importance of histaminergic neurons in seizure-induced cell damage is poorly known. In this study, we
Adnan Manassra et al.
Journal of pharmaceutical and biomedical analysis, 51(4), 991-993 (2009-12-04)
An HPLC method using UV detection is proposed for the simultaneous determination of pseudophedrine hydrochloride, codeine phosphate, and triprolidine hydrochloride in liquid formulation. C18 column (250mmx4.0mm) is used as the stationary phase with a mixture of methanol:acetate buffer:acetonitrile (85:5:10, v/v)
Karl E Peace et al.
Journal of biopharmaceutical statistics, 19(2), 324-331 (2009-02-13)
Clinical trials often identify two endpoints or response measures of interest. Depending on the drugs and the disease, the endpoints may be correlated or uncorrelated, reflect efficacy or safety, or one or both may be considered as primary. For visualization
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