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Showing 1-30 of 1542 results for "u6504" within Papers
Lars Malmström et al.
Journal of proteomics, 129, 98-107 (2015-09-19)
The increasing number of bacterial genomes in combination with reproducible quantitative proteome measurements provides new opportunities to explore how genetic differences modulate proteome composition and virulence. It is challenging to combine genome and proteome data as the underlying genome influences
E G Lauchnor et al.
Journal of applied microbiology, 118(6), 1321-1332 (2015-03-27)
Ureolysis drives microbially induced calcium carbonate precipitation (MICP). MICP models typically employ simplified urea hydrolysis kinetics that do not account for cell density, pH effect or product inhibition. Here, ureolysis rate studies with whole cells of Sporosarcina pasteurii aimed to
Sameh Magdeldin et al.
Journal of proteome research, 14(2), 943-952 (2014-11-16)
The purpose of this study is to determine the behavioral and proteomic consequences of shock-induced stress in zebrafish (Danio rerio) as a vertebrate model. Here we describe the behavioral effects of exposure to predictable and unpredictable electric shock, together with
Sun-Jin Kim et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(20), 4630-4641 (2015-06-25)
The objective of the study was to determine whether astrocytes and brain endothelial cells protect glioma cells from temozolomide through an endothelin-dependent signaling mechanism and to examine the therapeutic efficacy of the dual endothelin receptor antagonist, macitentan, in orthotopic models
Arpana Dutta et al.
Biochemistry, 53(46), 7160-7169 (2014-10-01)
Rhodopsin is a model system for understanding membrane protein folding. Recently, conditions that allow maximally denaturing rhodopsin without causing aggregation have been determined, opening the door to the first structural characterization of denatured states of rhodopsin by nuclear magnetic resonance
Fredrick Matongo et al.
Archives of medical research, 45(7), 540-546 (2014-09-23)
Pathogenic effects associated with Helicobacter pylori infection include peptic ulcer. Pathogenicity is mediated by the bacteria ureases. The emerging resistance of H. pylori to clarithromycin used in combination with amoxicillin in the treatment of H. pylori infection has necessitated the
J T Richeson et al.
Journal of animal science, 93(8), 4089-4097 (2015-10-07)
Growth implant efficacy may be affected when administered to nutritionally stressed calves, whereas the procedure may alter health or the humoral immune response to respiratory vaccination. The study objective was to determine the effect of different administration times (d 0
Kazuyuki Mizunoya et al.
Masui. The Japanese journal of anesthesiology, 62(10), 1214-1217 (2013-11-16)
Uncontrolled hyperthyroidism is a risk factor of perioperative thyrotoxic crisis. We report a case of a 61-year-old woman with thyrotoxicosis diagnosed with unstable angina pectoris. She needed to have an early scheduled coronay artery bypass grafting surgery, because percutaneous intervention
Jolanta Malyszko et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 21(1), 145-152 (2005-09-06)
Renal function affects thyroid function and adipocytokines in many ways. We aimed to assess the adipocytokines adiponectin and leptin in relation to thyroid function in patients with chronic renal failure treated conservatively, in haemodialysed patients and in kidney allograft recipients.
Anton Khmelinskii et al.
Nature, 516(7531), 410-413 (2014-12-19)
The nuclear envelope is a double membrane that separates the nucleus from the cytoplasm. The inner nuclear membrane (INM) functions in essential nuclear processes including chromatin organization and regulation of gene expression. The outer nuclear membrane is continuous with the
Jing Wang et al.
Proteomics, 14(11), 1393-1402 (2014-03-13)
The rhesus macaque is similar to humans both anatomically and physiologically as a primate, and has therefore been used extensively in medical and biological research, including reproductive physiology. Despite sequencing of the macaque genome, limited postgenomic studies have been performed
Stephanie Dille et al.
PloS one, 9(7), e103220-e103220 (2014-07-30)
Chlamydia grows inside a cytosolic vacuole (the inclusion) that is supplied with nutrients by the host through vesicular and non-vesicular transport. It is unclear in many respects how Chlamydia organizes this transport. One model posits that the Chlamydia-induced fragmentation of
Rahel S Spindler et al.
Transplantation, 99(5), 935-941 (2015-02-13)
This study investigated the potential use of N-octanoyl dopamine (NOD) in donor management to ameliorate the damage caused by brain death and ischemia-reperfusion injury in a rat model of kidney and heart transplantation. Brain-dead Fisher rats were treated for 6
Chi Young Shim et al.
American journal of physiology. Endocrinology and metabolism, 307(12), E1097-E1104 (2014-10-23)
Skeletal muscle microvascular blood flow (MBF) increases in response to physiological hyperinsulinemia. This vascular action of insulin may facilitate glucose uptake. We hypothesized that epoxyeicosatrienoic acids (EETs), a family of arachadonic, acid-derived, endothelium-derived hyperpolarizing factors, are mediators of insulin's microvascular
Yuqin Li et al.
World journal of microbiology & biotechnology, 31(5), 773-783 (2015-03-01)
A structured heterotrophic-iron (II) induction (HII) strategy was proposed to enhance lipid accumulation in oleaginous Chlorella protothecoides. C. protothecoides subjected to heterotrophic-iron (II) induction achieved a favorable lipid accumulation up to 62 % and a maximum lipid productivity of 820.17 mg/day
Junya Awata et al.
Molecular biology of the cell, 26(15), 2788-2800 (2015-06-13)
The nexin-dynein regulatory complex (N-DRC), which is a major hub for the control of flagellar motility, contains at least 11 different subunits. A major challenge is to determine the location and function of each of these subunits within the N-DRC.
Wilfredo D Mansilla et al.
The Journal of nutrition, 145(6), 1163-1169 (2015-05-01)
Nitrogen absorption from the large intestine is considered of limited value for supporting body protein synthesis in animals and humans, but it may be of benefit when the dietary supply of nitrogen for synthesis of dispensable amino acids (DAAs) is
Verena Paulitschke et al.
Molecular cancer therapeutics, 14(3), 757-768 (2015-01-24)
The FDA-approved BRAF inhibitor vemurafenib achieves outstanding clinical response rates in patients with melanoma, but early resistance is common. Understanding the pathologic mechanisms of drug resistance and identification of effective therapeutic alternatives are key scientific challenges in the melanoma setting.
Iain W Chalmers et al.
PLoS neglected tropical diseases, 9(7), e0003920-e0003920 (2015-07-07)
The heptalaminate-covered, syncytial tegument is an important anatomical adaptation that enables schistosome parasites to maintain long-term, intravascular residence in definitive hosts. Investigation of the proteins present in this surface layer and the immune responses elicited by them during infection is
Karolina Laskowska-Macios et al.
Molecular brain, 8, 48-48 (2015-08-15)
Binocular pattern deprivation from eye opening (early BD) delays the maturation of the primary visual cortex. This delay is more pronounced for the peripheral than the central visual field representation within area 17, particularly between the age of 2 and
Aaron A Witham et al.
Chemical research in toxicology, 28(6), 1346-1356 (2015-05-26)
Certain phenoxyl radicals can attach covalently to the C8-site of 2'-deoxyguanosine (dG) to afford oxygen-linked C8-dG adducts. Such O-linked adducts can be chemically synthesized through a nucleophilic displacement reaction between a phenolate and a suitably protected 8-Br-dG derivative. This permits
Hai-Guang Xin et al.
Molecular and cellular biochemistry, 392(1-2), 117-124 (2014-03-22)
In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of renal disease. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant
Erik L de Graaf et al.
Journal of proteome research, 14(7), 2906-2914 (2015-05-27)
We report a straightforward strategy to comprehensively monitor signal transduction pathway dynamics in mammalian systems. Combining targeted quantitative proteomics with highly selective phosphopeptide enrichment, we monitor, with great sensitivity, phosphorylation dynamics of the PI3K-mTOR and MAPK signaling networks. Our approach
Mariana Díaz-Zaragoza et al.
Immunobiology, 220(9), 1050-1058 (2015-06-01)
The early detection of cancer is one of the most promising approaches to reduce its growing burden and develop a curative treatment before the tumor is established. The early diagnosis of breast cancer is the most demanding of all tumors
Mathieu Cayla et al.
PLoS pathogens, 10(9), e1004347-e1004347 (2014-09-19)
Protozoan pathogens of the genus Leishmania have evolved unique signaling mechanisms that can sense changes in the host environment and trigger adaptive stage differentiation essential for host cell infection. The signaling mechanisms underlying parasite development remain largely elusive even though
Pinkesh G Sutariya et al.
Talanta, 147, 590-597 (2015-11-26)
A new, simple, ultra-sensitive and selective approach has been reported for the "on spot" colorimetric detection of creatinine based on calix[4]arene functionalized gold nanoparticles (AuNPs) with excellent discrimination in the presence of other biomolecules. The lower detection limit of the
Freimut Schliess et al.
Hepatology (Baltimore, Md.), 60(6), 2040-2051 (2014-03-29)
The impairment of hepatic metabolism due to liver injury has high systemic relevance. However, it is difficult to calculate the impairment of metabolic capacity from a specific pattern of liver damage with conventional techniques. We established an integrated metabolic spatial-temporal
Jeannine Gruse et al.
The Journal of nutrition, 145(11), 2486-2495 (2015-09-25)
Inadequate colostrum supply results in insufficient intake of macronutrients and bioactive factors, thereby impairing gastrointestinal development and the maturation of glucose metabolism in neonatal calves. The flavonoid quercetin has been shown to have health-promoting properties, including effects in diabetic animals.
Colette J Shen et al.
BMC cancer, 14, 532-532 (2014-07-24)
Ionizing radiation (IR) is a mainstay of cancer therapy, but irradiation can at times also lead to stress responses, which counteract IR-induced cytotoxicity. IR also triggers cellular secretion of vascular endothelial growth factor, transforming growth factor β and matrix metalloproteinases
Qi Chen et al.
Biosensors & bioelectronics, 74, 504-511 (2015-07-16)
In this study, we described a novel impedance biosensor combining immunomagnetic separation with urease catalysis for sensitive detection of foodborne bacteria using Listeria monocytogenes as model and an immobilization-free microelectrode as detector. The monoclonal antibodies (MAbs) were immobilized on the
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