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Showing 1-30 of 94 results for "V0100000" within Papers
Two cases of cluster headache effectively treated with levetiracetam.
Antonio Palermo et al.
Functional neurology, 28(1), 63-64 (2013-06-05)
V Sridhar et al.
Phytotherapy research : PTR, 28(5), 699-705 (2013-07-25)
The effects of hesperetin on the pharmacokinetics and the role of P-glycoprotein (P-gp) in the transport of felodipine were investigated in rats and in vitro. Felodipine was administered orally (10 mg/kg) without or with hesperetin (25, 50 and 100 mg/kg) to rats
Sibylle Neuhoff et al.
Journal of pharmaceutical sciences, 102(9), 3161-3173 (2013-05-21)
Digoxin is the recommended substrate for assessment of P-glycoprotein (P-gp)-mediated drug-drug interactions (DDIs) in vivo. The overall aim of our study was to investigate the inhibitory potential of both verapamil and norverapamil on the P-gp-mediated efflux of digoxin in both
Ling-Jun Li et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(6), 894-898 (2013-05-31)
To study in situ intestinal absorption kinetics of baicalin contained in Tiangou Jiangya capsules, and the effect of different intestinal segments, pH value, drug concentration and P-gp inhibitor on the absorption. The in situ intestinal perfusion test was adopted, and
Weidong Jia et al.
Cancer chemotherapy and pharmacology, 71(6), 1585-1590 (2013-04-17)
This study was designed to evaluate efficacy, toxicity, and adverse effects of combination of chemotherapy drugs and intraperitoneal perfusion of verapamil in the treatment of malignant ascites. Seventy-two patients with malignant ascites were divided into two study groups. Patients in
Cheryl C Y Loh et al.
PloS one, 9(10), e110800-e110800 (2014-10-25)
Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole. Chloroquine accumulation studies have traditionally relied on
Esther Bridges et al.
Cancer cell, 27(1), 7-9 (2015-01-15)
In this issue of Cancer Cell, Wong and colleagues describe a novel approach of increasing the number of functional blood vessels in tumors using a low-dose therapy regimen of Cilengtide and Verapamil. This method enhanced gemcitabine delivery, uptake, and metabolism
Tianxing Wang et al.
Biosensors & bioelectronics, 49, 9-13 (2013-05-28)
Drug-induced cardiotoxicity greatly endangers the human health and results in resource waste. Also, it is a leading attribution to drug withdrawal and late-stage attrition in pharmaceutical industry. In the study, a dual function cardiomyocyte-based biosensor was introduced for rapid drug
Masato Ishigami et al.
Biochimica et biophysica acta, 1831(4), 683-690 (2013-01-12)
Although human MDR1 and MDR3 share 86% similarity in their amino acid sequences and are predicted to share conserved domains for drug recognition, their physiological transport substrates are quite different: MDR1 transports xenobiotics and confers multidrug resistance, while MDR3 exports
Matylda Resztak et al.
Acta poloniae pharmaceutica, 70(3), 395-401 (2013-06-14)
A stereospecific capillary zone electrophoresis (CZE) method was developed for the determination of verapamil (VER) and its main metabolite norverapamil (NOR) in human plasma. Optimal temperature, cyclodextrin selectors (CDs), pH of background electrolyte (BGE) and voltage were established to obtain
Ping-Pui Wong et al.
Cancer cell, 27(1), 123-137 (2015-01-15)
Increasing chemotherapy delivery to tumors, while enhancing drug uptake and reducing side effects, is a primary goal of cancer research. In mouse and human cancer models in vivo, we show that coadministration of low-dose Cilengitide and Verapamil increases tumor angiogenesis, leakiness
Masanobu Tsubaki et al.
Leukemia research, 38(1), 121-130 (2013-11-19)
The calcium channel blocker verapamil inhibits the transport function of multidrug resistance protein 1 (MDR1). Although verapamil acts to reverse MDR in cancer cells, the underlying mechanism remains unclear. In the present study, we investigated the mechanism of reversing MDR
Rashmi Mehta et al.
International journal of chronic obstructive pulmonary disease, 8, 159-167 (2013-04-10)
The combination of umeclidinium (UMEC), a long-acting muscarinic receptor antagonist, and vilanterol (VI), a selective long-acting β₂ agonist, is in development for the treatment of chronic obstructive pulmonary disease (COPD). This study evaluated the pharmacokinetics, safety and tolerability, and pharmacodynamics
Michael Levine et al.
Annals of emergency medicine, 62(3), 252-258 (2013-05-07)
Verapamil or diltiazem overdose can cause severe morbidity and death, and there exist limited human data describing management and outcome of a large number of such patients. This article describes the management and outcome of patients with nondihydropyridine calcium-channel blocker
Avi Stein et al.
Harefuah, 151(11), 638-640 (2013-02-02)
Peyronie's disease may be idiopatic or secondary to sexual intercourse. Medical treatment includes vitamin E, colchicine and tamoxifen, which provide a very limited solution. Lately, intralesional injection of verapamil and other substances have achieved a reasonable effect. The best cosmetic
Gerald H Jordan et al.
BJU international, 114(1), 16-24 (2014-01-23)
Peyronie's disease (PD) is often physically and psychologically devastating for patients, and the goal of treatment is to improve symptoms and sexual function without adding treatment-related morbidity. The potential for treatment-related morbidity after more invasive interventions, e.g. surgery, creates a
Combination therapy to reduce conjunctival scarring after glaucoma surgery.
Marco A Zarbin
JAMA ophthalmology, 131(9), 1123-1123 (2013-07-13)
Golam Kibria et al.
Biological & pharmaceutical bulletin, 37(12), 1926-1935 (2014-12-03)
Multi-drug resistance (MDR) of cancers to chemotherapy including doxorubicin (DOX) is mediated by several factors. To design an effective therapy for the treatment of chemotherapy-resistant cancers, it is essential to explore the elements responsible for mediating MDR. However, exploring these
Tuba Incecayir et al.
Molecular pharmaceutics, 10(3), 958-966 (2013-01-19)
The purpose of this study was to investigate labetalol as a potential high permeability reference standard for the application of Biopharmaceutics Classification Systems (BCS). Permeabilities of labetalol and metoprolol were investigated in animal intestinal perfusion models and Caco-2 cell monolayers.
Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges".
Yoonseok Kam et al.
International journal of cancer, 136(4), E188-E196 (2014-08-27)
ATP-binding cassette (ABC) drug transporters consuming ATPs for drug efflux is a common mechanism by which clinical cancers develop multidrug resistance (MDR). We hypothesized that MDR phenotypes could be suppressed by administration of "ersatzdroges," nonchemotherapy drugs that are, nevertheless, ABC
Lian Duan et al.
International journal of pharmaceutics, 445(1-2), 134-140 (2013-02-14)
The aim of the study was to observe the characteristic of permeation of capsaicin across jejunum, ileum and colon in the rat, and to investigate the role of transient receptor potential cation channel (TRPV1). The interaction of capsaicin with P-glycoprotein
Chin-Chuan Hung et al.
PloS one, 8(3), e59419-e59419 (2013-03-26)
Methadone is a widely used substitution therapy for opioid addiction. Large inter-individual variability has been observed in methadone maintenance dosages and P-glycoprotein (P-gp) was considered to be one of the major contributors. To investigate the mechanism of P-gp's interaction with
Yong Yu et al.
Die Pharmazie, 68(9), 732-743 (2013-10-24)
Raltitrexed (RTX) has shown clinical activity in a variety of advanced solid tumours. Its oral bioavailability is low and its intestinal absorption mechanism is not clear. In the present study, the absorption mechanism of RTX in the small intestine was
Alice Ban Ke et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(3), 437-446 (2013-01-30)
Through PET imaging, our laboratory has studied the dynamic biodistribution of (11)C-verapamil, a P-gp substrate, in the nonhuman primate Macaca nemestrina. To gain detailed insight into the kinetics of verapamil transport across the blood-brain barrier (BBB) and the blood-placental barrier
Amit Singhal et al.
Science translational medicine, 6(263), 263ra159-263ra159 (2014-11-21)
The global burden of tuberculosis (TB) morbidity and mortality remains immense. A potential new approach to TB therapy is to augment protective host immune responses. We report that the antidiabetic drug metformin (MET) reduces the intracellular growth of Mycobacterium tuberculosis
Jiu Wang et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(9), 1500-1507 (2013-03-05)
The aim of this study was to load Verapamil Hydrochloride to carboxylated multi-walled carbon nanotubes( c-CNTs) and discuss the mechanism of drug release which could act as an effective basis for c-MWNTs used as drug carriers of controlled and sustained
Dasha Palmer et al.
Colloids and surfaces. B, Biointerfaces, 104, 174-180 (2013-01-15)
The ability of anionic polymer sodium carboxymethylcellulose to influence the release of four model cationic drugs (chlorpheniramine maleate, venlafaxine hydrochloride, propranolol hydrochloride and verapamil hydrochloride) from extended release (ER) hydrophilic matrices based on non-ionic polymer polyethylene oxide was investigated by
Hasan Salman Siddiqi et al.
Journal of cardiovascular pharmacology, 64(2), 151-163 (2014-04-01)
This study was aimed to offer a possible pharmacological basis regarding the remedial utilization of Wrightia tinctoria in hypertension and dyslipidemia in certain South Asian traditional systems of medicine, using in vivo and in vitro assays. The aqueous methanolic extract
Yasuo Uchida et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 578-588 (2014-06-21)
The aim of this study was to investigate whether in vivo drug distribution in brain in monkeys can be reconstructed by integrating four factors: protein expression levels of P-glycoprotein (P-gp)/multidrug resistance protein 1 at the blood-brain barrier (BBB), in vitro
Shashank Gupta et al.
American journal of respiratory and critical care medicine, 188(5), 600-607 (2013-06-29)
A major priority in tuberculosis (TB) is to reduce effective treatment times and emergence of resistance. Recent studies in macrophages and zebrafish show that inhibition of mycobacterial efflux pumps with verapamil reduces the bacterial drug tolerance and may enhance drug
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