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Showing 1-30 of 287 results for "V900067" within Papers
Jing Zhang et al.
Biomaterials, 35(34), 9322-9331 (2014-08-19)
Bone morphogenetic proteins (BMPs) play an important role in regulating osteoblastic differentiation and bone formation. But the diffuse of BMPs into muscle tissues around bone injury sites often leads to heterotopic ossification, which has been regarded as one of major
Sooho Lee et al.
Biochemical pharmacology, 85(7), 965-976 (2013-01-23)
Glycogen synthase kinase 3 (GSK-3) plays a central role in cellular energy metabolism, and dysregulation of GSK-3 activity is implicated in a variety of metabolic disorders, including obesity, type 2 diabetes, and cancer. Hence, GSK-3 has emerged as an attractive
Nikolaos T Georgopoulos et al.
Journal of cell science, 127(Pt 13), 2967-2982 (2014-05-13)
By operating as both a subunit of the cadherin complex and a key component of Wnt signalling, β-catenin acts as the lynchpin between cell-cell contact and transcriptional regulation of proliferation, coordinating epithelial tissue homeostasis and regeneration. The integration of multiple
Hung-Chieh Lee et al.
The FEBS journal, 281(19), 4367-4383 (2014-07-25)
Glycogen synthase kinase 3 beta (Gsk3b) acts as a negative modulator in endothelial cells through the Wnt/β-catenin/PI3K/AKT/Gsk3b axis in cancer-induced angiogenesis. However, the function of Gsk3b during embryonic angiogenesis remains unclear. Here, either gsk3b knockdown by morpholino or Gsk3b loss
Hongquan Dong et al.
Journal of neuroinflammation, 11, 140-140 (2014-08-15)
Lithium, an effective mood stabilizer for the treatment of bipolar disorders, has been recently suggested to have a role in neuroprotection during neurodegenerative diseases. The pathogenesis of neurological disorders often involves the activation of microglia and associated inflammatory processes. Thus
Guangzhen Hu et al.
PloS one, 9(9), e107016-e107016 (2014-09-10)
Long noncoding RNAs (lncRNAs) are important regulators of transcription; however, their involvement in protein translation is not well known. Here we explored whether the lncRNA GAS5 is associated with translation initiation machinery and regulates translation. GAS5 was enriched with eukaryotic
G Cebrián et al.
International journal of food microbiology, 188, 67-74 (2014-08-05)
The NaCl MNICs (maximum non-inhibitory concentrations) and MICs (minimum inhibitory concentrations) for growth of various strains of six bacterial species were determined and then compared with those obtained for seven other solutes. The influence of prior growth conditions on the
Walter Besio et al.
Epilepsy & behavior : E&B, 28(3), 432-436 (2013-07-28)
Experiments were conducted to evaluate the effects of transcranial focal electrical stimulation (TFS) applied via tripolar concentric ring electrodes, alone and associated with a sub-effective dose of diazepam (DZP) on the expression of status epilepticus (SE) induced by lithium-pilocarpine (LP)
A M Petrosyan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 105, 623-625 (2013-02-07)
We argue that the recently reported crystals "L-threonine formate" as well as "L-alanine lithium chloride" and "bis L-alanine lithium chloride" actually are the well-known crystals L-threonine and L-alanine, respectively.
Arash Nikoubashman et al.
ACS nano, 8(8), 8015-8026 (2014-08-12)
We study thin films of homopolymers (PS) and monolayers of cylinder-forming diblock copolymers (PS–PHMA) under shear. To this end, we employed both experiments and computer simulations that correctly take into account hydrodynamic interactions and chain entanglements. Excellent quantitative agreement for
Tae Kwang Ha et al.
Applied microbiology and biotechnology, 98(22), 9239-9248 (2014-08-19)
Lithium chloride (LiCl), which is a specific inhibitor of glycogen synthase kinase-3β, is known to induce cell cycle arrest at the G2/M phase and to regulate apoptosis. To determine the potential of LiCl as a chemical additive to enhance specific
N-C Liang et al.
Neuroscience, 235, 149-158 (2013-02-06)
Stress activates the hypothalamus-pituitary-adrenal (HPA) axis leading to the release of glucocorticoids (GC). Increased activity of the HPA axis and GC exposure has been suggested to facilitate the development of obesity and metabolic syndrome. Nonetheless, different stressors can produce distinct
Rémi Legastelois et al.
PloS one, 10(5), e0127408-e0127408 (2015-05-21)
The STriatal-Enriched protein tyrosine Phosphatase (STEP) is a brain-specific phosphatase whose dysregulation in expression and/or activity is associated with several neuropsychiatric disorders. We recently showed that long-term excessive consumption of ethanol induces a sustained inhibition of STEP activity in the
Zhonggui Li et al.
Journal of molecular neuroscience : MN, 57(4), 510-518 (2015-08-02)
Epilepsy is one of the most common, chronic, neurological diseases. The pathology of epilepsy is based on abnormal synchronization of neuronal discharges. Epithelial sodium channels, which are constitutively active, non-voltage-gated, highly selective sodium channels belonging to the epithelial sodium channel/degenerin
Akiva P Novetsky et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 23(2), 361-366 (2013-01-09)
Lithium chloride (LiCl) has been shown to demonstrate anticancer properties at supratherapeutic doses. This study was designed to determine whether LiCl, as a single agent or in combination with cytotoxic agents, reduces ovarian cancer cell growth and metabolic activity at
Eric Röttinger et al.
PLoS genetics, 8(12), e1003164-e1003164 (2013-01-10)
Understanding the functional relationship between intracellular factors and extracellular signals is required for reconstructing gene regulatory networks (GRN) involved in complex biological processes. One of the best-studied bilaterian GRNs describes endomesoderm specification and predicts that both mesoderm and endoderm arose
Bofan Yu et al.
Journal of chromatography. A, 1356, 221-229 (2014-07-07)
For the expanded application area, fast trace analysis of certain high boiling point (i.e., 150-250 °C) volatile organic compounds (HVOCs) in water, a large volume-direct aqueous injection-gas chromatography (LV-DAI-GC) method was optimized for the following parameters: packed sorbent for sample
Naoki Okumura et al.
Investigative ophthalmology & visual science, 55(10), 6861-6869 (2014-10-04)
To evaluate the effect of Roof plate-specific spondin 1 (R-spondin1) on the proliferation of corneal endothelial cells (CECs) and to determine whether the Wnt/β-catenin pathway is involved in the activities of R-spondin1. The proliferation of rabbit CECs (RCECs) and human
Rao Fu et al.
BMC neuroscience, 15, 84-84 (2014-07-06)
During the clinical treatment of the brachial plexus root avulsion (BPRA), reimplantation surgery can not completely repair the motor function of the hand because the axonal growth velocity of the spinal motoneurons (MNs) is too slow to re-innervate the intrinsic
Darcy Young et al.
PloS one, 10(6), e0130381-e0130381 (2015-06-26)
Fungal lignocellulolytic enzymes are promising agents for oxidizing pollutants. This study investigated degradation of Number 6 "Bunker C" fuel oil compounds by the white-rot fungi Irpex lacteus, Trichaptum biforme, Phlebia radiata, Trametes versicolor, and Pleurotus ostreatus (Basidiomycota, Agaricomycetes). Averaging across
A Briolay et al.
Biochemical and biophysical research communications, 430(3), 1072-1077 (2012-12-26)
Although anti-tumor necrosis factor (TNF)-α treatments efficiently block inflammation in ankylosing spondylitis (AS), they are inefficient to prevent excessive bone formation. In AS, ossification seems more prone to develop in sites where inflammation has resolved following anti-TNF therapy, suggesting that
Guadalupe Villarreal et al.
Investigative ophthalmology & visual science, 55(11), 7433-7440 (2014-10-30)
Canonical Wnt signaling has emerged as a critical regulator of aqueous outflow facility and intraocular pressure (IOP). In this study, we examine the role of canonical Wnt signaling on extracellular matrix (ECM) expression in the trabecular meshwork (TM) and explore
Qi Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(36), 14765-14770 (2013-08-22)
Diphtheria toxin-mediated, acute ablation of hypothalamic neurons expressing agouti-related protein (AgRP) in adult mice leads to anorexia and starvation within 7 d that is caused by hyperactivity of neurons within the parabrachial nucleus (PBN). Because NMDA glutamate receptors are involved
Yijun Zhang et al.
RNA (New York, N.Y.), 20(12), 1878-1889 (2014-10-23)
The TATA box represents one of the most prevalent core promoters where the pre-initiation complexes (PICs) for gene transcription are assembled. This assembly is crucial for transcription initiation and well regulated. Here we show that some cellular microRNAs (miRNAs) are
Ker Y Cheah et al.
PloS one, 9(6), e98921-e98921 (2014-06-07)
Grape seed procyanidins (PC) are flavan-3-ol oligomers and polymers known for their biological activity in the gut. Grape seed extract (GSE) have been reported to reduce intestinal injury in a rat model of mucositis. We sought to investigate effects of
Otilia Zarnescu et al.
Micron (Oxford, England : 1993), 46, 66-75 (2013-01-29)
In the present study we examined the effects of lithium chloride on the Corydoras aeneus caudal fin regeneration. After caudal fin amputation, the fish were exposed 3h daily to 35 mM lithium chloride for 9 days. The effects of lithium
Ruud Zwart et al.
The Journal of pharmacology and experimental therapeutics, 355(2), 247-254 (2015-09-02)
The citric acid cycle intermediate citrate plays a crucial role in metabolic processes such as fatty acid synthesis, glucose metabolism, and β-oxidation. Citrate is imported from the circulation across the plasma membrane into liver cells mainly by the sodium-dependent citrate
Shun-Mei Lu et al.
Brain research bulletin, 114, 31-41 (2015-04-04)
Though the pathogenesis of postoperative cognitive dysfunction (POCD) remains unclear, evidence is accumulating for a pivotal role of neuroinflammation in the disease process. Advanced age and severe surgical trauma are two main risk factors for POCD. Lithium, a neuroprotective agent
Hyo Geun Kim et al.
Journal of ethnopharmacology, 171, 196-204 (2015-06-13)
A growing body of literature supports the concept that antiaging herbs may be potential candidates for use in treating age-related neurodegeneration, including Alzheimer׳s disease (AD). Mori Fructus is a well-known traditional herbal medicine, food, and dietary supplement. This study employed
Karla M Acevedo et al.
The Journal of biological chemistry, 289(16), 11007-11019 (2014-03-13)
Amyloid precursor protein (APP) undergoes post-translational modification, including O- and N-glycosylation, ubiquitination, and phosphorylation as it traffics through the secretory pathway. We have previously reported that copper promotes a change in the cellular localization of APP. We now report that
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