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Showing 1-30 of 210 results for "V900323" within Papers
Alberto Alvarez-Larrán et al.
Annals of hematology, 93(12), 2037-2043 (2014-07-02)
Therapeutic options for patients with polycythemia vera (PV) and essential thrombocythemia (ET) resistant or intolerant to hydroxyurea are limited. Busulfan is effective as first-line therapy, but there is scarce information on this drug as second-line treatment. The efficacy of busulfan
Naseema Gangat et al.
European journal of haematology, 94(1), 31-36 (2014-06-04)
Vascular events in essential thrombocythemia (ET) are associated with advanced age and thrombosis history. Recent information suggests additional effect from the presence of specific mutations. To examine the influence of age and thrombosis history on the reported association between mutational
Nina Saban et al.
Cancer chemotherapy and pharmacology, 64(2), 213-221 (2009-04-08)
Hydroxyurea has been used for decades and it is still valuable for the treatment of some types of cancer. It inhibits ribonucleotide reductase (RNR) enzyme known to be crucial in the conversion of ribonucleotides into deoxyribonucleotides. However, nowadays the main
Douglas R Mackay et al.
Molecular biology of the cell, 26(12), 2217-2226 (2015-04-24)
Aurora B regulates cytokinesis timing and plays a central role in the abscission checkpoint. Cellular events monitored by this checkpoint are beginning to be elucidated, yet signaling pathways upstream of Aurora B in this context remain poorly understood. Here we
Zhao Wei et al.
Free radical biology & medicine, 79, 1-13 (2014-12-03)
Tumor suppressor p53 is known to regulate the level of intracellular reactive oxygen species (ROS). It can either alleviate oxidative stress under physiological and mildly stressed conditions or exacerbate oxidative stress under highly stressed conditions. We here report that a
H Jia et al.
Oncogene, 34(27), 3568-3581 (2014-09-10)
The DNA damage response (DDR) helps to maintain genome integrity, suppress tumorigenesis and mediate the radiotherapeutic and chemotherapeutic effects on cancer. Here we report that p57Kip2, a cyclin-dependent kinase (CDK) inhibitor implicated in the development of tumor-prone Beckwith-Wiedemann syndrome, is
Flavia Rubia Pallis et al.
British journal of haematology, 164(2), 286-295 (2014-01-05)
Inflammation, leucocyte and red cell adhesion to the endothelium contribute to the pathogenesis of sickle cell anaemia. Neutrophils appear to be important for vaso-occlusion, however, eosinophils may also participate in this phenomenon. The role of eosinophils in the pathophysiology of
Choon-Ho Park et al.
Biochimica et biophysica acta, 1853(7), 1738-1748 (2015-04-23)
Vaccinia-related kinase 3 (VRK3) is known as a pseudokinase that is catalytically inactive due to changes in motifs that are essential for kinase activity. Although VRK3 has been regarded as a genuine pseudokinase from structural and biochemical studies, recent reports
Nabil Matmati et al.
The Journal of biological chemistry, 288(24), 17272-17284 (2013-04-27)
Recent studies showed that deletion of ISC1, the yeast homologue of the mammalian neutral sphingomyelinase, resulted in an increased sensitivity to hydroxyurea (HU). This raised an intriguing question as to whether sphingolipids are involved in pathways initiated by HU. In
Jana Peremartí et al.
Toxicological sciences : an official journal of the Society of Toxicology, 142(1), 93-104 (2014-08-06)
Chronic arsenic exposure is known to enhance the genotoxicity/carcinogenicity of other DNA-damaging agents by inhibiting DNA repair activities. Interference with nucleotide excision repair and base excision repair are well documented, but interactions with other DNA repair pathways are poorly explored
Hydroxyurea-induced leg ulceration in a patient with a homozygous MTHFR polymorphism misdiagnosed as pyoderma gangrenosum.
Sunita C Crittenden et al.
JAMA dermatology, 150(7), 780-781 (2014-03-07)
Gui-Zhen Wang et al.
Cancer science, 106(7), 902-908 (2015-04-22)
The Fanconi anemia (FA) pathway plays a key role in interstrand crosslink (ICL) repair and maintenance of the genomic stability, while inhibition of this pathway may sensitize cancer cells to DNA ICL agents and ionizing radiation (IR). The active FA
Benjamin D Landry et al.
The EMBO journal, 33(9), 1044-1060 (2014-04-10)
To maintain genome stability, regulators of chromosome segregation must be expressed in coordination with mitotic events. Expression of these late cell cycle genes is regulated by cyclin-dependent kinase (Cdk1), which phosphorylates a network of conserved transcription factors (TFs). However, the
Sapna Oberoi et al.
Journal of pediatric hematology/oncology, 36(3), e140-e144 (2013-11-28)
Compound heterozygous HbSD-Punjab is an uncommon hemoglobinopathy encountered in Indians. Limited literature is available about its clinical course. The aim of this study was to describe the clinical and hematological profile of HbSD-Punjab patients from North India. HbSD-Punjab patients diagnosed
Nancy S Green et al.
Pediatric blood & cancer, 56(2), 177-181 (2010-09-11)
Fetal hemoglobin (HbF) levels are generally inversely proportional to severity of sickle cell disease (SCD) for given sickle phenotypes. Molecular regulation of HbF occurs through complex interactions cis and trans to the beta globin gene locus. Novel insights made through
Nnenna Ukachi et al.
Pediatrics, 132(3), 547-551 (2013-08-21)
Two of the most ethically complex situations in pediatrics are those involving families whose religious beliefs preclude the provision of life-sustaining treatment and those involving young adults who have reached the age of legal majority and who face decisions about
Dominga Iacobazzi et al.
Antioxidants & redox signaling, 21(11), 1591-1604 (2014-02-12)
Vascular wall-resident progenitor cells hold great promise for cardiovascular regenerative therapy. This study evaluates the impact of oxidative stress on the viability and functionality of adventitia-derived progenitor cells (APCs) from vein remnants of coronary artery bypass graft (CABG) surgery. We
Toru Nakayashiki et al.
Journal of bacteriology, 195(9), 2039-2049 (2013-03-05)
We have performed a screening of hydroxyurea (HU)-sensitive mutants using a single-gene-deletion mutant collection in Escherichia coli K-12. HU inhibits ribonucleotide reductase (RNR), an enzyme that catalyzes the formation of deoxyribonucleotides. Unexpectedly, seven of the mutants lacked genes that are
Laifeng Ren et al.
Biochemical and biophysical research communications, 436(2), 192-198 (2013-06-04)
Smu1 is an evolutionarily conserved gene that encodes a member of the WD40-repeat protein family. Disruption of Smu1 function leads to multiple cellular defects including chromosomal instability, aberrant DNA replication and alternative RNA splicing events. In this paper, we show
Zhe Meng et al.
Urology, 82(6), 1452-1452 (2013-12-04)
To investigate the expression of 5-lipoxygenase (5-LOX) in metastatic prostate cancer and whether zileuton, the inhibitor of 5-LOX, plays a role in the metastasis of prostate cancer. An enzyme-linked immunosorbent assay was used to measure 5-hydroxyeicosatetraenoic acid (5-HETE) in patient
Medical management of beta-thalassaemia without blood transfusion: a myth or a reality?
Tahir Shamsi et al.
JPMA. The Journal of the Pakistan Medical Association, 63(3), 304-305 (2013-08-07)
Veronika Anyigoh Atemnkeng et al.
PloS one, 8(3), e58318-e58318 (2013-03-19)
Primaquine, an 8-aminoquinoline, is the only drug which cures the dormant hypnozoites of persistent liver stages from P. vivax. Increasing resistance needs the discovery of alternative pathways as drug targets to develop novel drug entities. Deoxyhypusine hydroxylase (DOHH) completes hypusine
Min Zhu et al.
Nucleic acids research, 42(21), 13074-13081 (2014-10-19)
CLASPIN is an essential mediator in the DNA replication checkpoint, responsible for ATR (ataxia telangiectasia and Rad3-related protein)-dependent activation of CHK1 (checkpoint kinase 1). Here we found a dynamic signaling pathway that regulates CLASPIN turn over. Under unperturbed conditions, the
Katherine S Lawrence et al.
PLoS genetics, 11(4), e1005150-e1005150 (2015-04-22)
Errors in replication or segregation lead to DNA damage, mutations, and aneuploidies. Consequently, cells monitor these events and delay progression through the cell cycle so repair precedes division. The DNA damage response (DDR), which monitors DNA integrity, and the spindle
Akiko Hori et al.
Molecular biology of the cell, 26(11), 2005-2019 (2015-04-03)
Centriolar satellites are numerous electron-dense granules dispersed around the centrosome. Mutations in their components are linked to various human diseases, but their molecular roles remain elusive. In particular, the significance of spatial communication between centriolar satellites and the centrosome is
Sickle cell anemia: time for personalized prescription of hydroxyurea? Focus on "Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics".
Courtney D Thornburg
American journal of physiology. Cell physiology, 305(12), C1209-C1210 (2013-09-06)
I A Lagunju et al.
The Nigerian postgraduate medical journal, 20(3), 181-187 (2013-11-30)
To compare the outcome after a first clinical stroke, following treatment with and without hydroxyurea (HU). A retrospective review of a cohort of Nigerian children with SCD, who had suffered a first stroke, was carried out. Outcomes in the group
Linyu Deng et al.
The Cochrane database of systematic reviews, 1(1), CD005196-CD005196 (2013-02-27)
This is an update of the original review that was published in The Cochrane Database of Systematic Reviews, 2009, Issue 2. Gestational trophoblastic neoplasia (GTN) are malignant disorders of the placenta that include invasive hydatidiform mole, choriocarcinoma, placental-site trophoblastic tumour
Raoul Tibes et al.
Expert opinion on emerging drugs, 18(3), 393-404 (2013-08-24)
Polycythemia vera (PV) patients suffer from disease-related constitutional symptoms, cardiovascular complications and risk of transformation into myelofibrosis and acute leukemia. Clinical and molecular aspects and current therapies will be described to provide clinical and molecular background to understand the natural
David C Zebrowski et al.
eLife, 4 (2015-08-08)
Mammalian cardiomyocytes become post-mitotic shortly after birth. Understanding how this occurs is highly relevant to cardiac regenerative therapy. Yet, how cardiomyocytes achieve and maintain a post-mitotic state is unknown. Here, we show that cardiomyocyte centrosome integrity is lost shortly after
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