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Showing 1-30 of 5139 results for "V900419" within Papers
A E Rapp et al.
European cells & materials, 29, 22-34 (2015-01-02)
Mesenchymal stem cells (MSC) were shown to support bone regeneration, when they were locally transplanted into poorly healing fractures. The benefit of systemic MSC transplantation is currently less evident. There is consensus that systemically applied MSC are recruited to the
Tomas Fiedler et al.
Cancer biology & therapy, 16(7), 1047-1055 (2015-03-17)
Arginine auxotrophy constitutes a weak point of several tumors, among them glioblastoma multiforme (GBM). Hence, those tumors are supposed to be sensitive for arginine-depleting substances, such as arginine deiminase (ADI). Here we elucidated the sensitivity of patient-individual GBM cell lines
Anne des Rieux et al.
Journal of biomedical materials research. Part A, 102(7), 2345-2355 (2013-08-16)
We hypothesized that vascular endothelial growth factor (VEGF)-containing hydrogels that gelify in situ after injection into a traumatized spinal cord, could stimulate spinal cord regeneration. Injectable hydrogels composed of 0.5% Pronova UPMVG MVG alginate, supplemented or not with fibrinogen, were
Alix de Brogniez et al.
Journal of virology, 89(17), 8945-8956 (2015-06-19)
Viruses have coevolved with their host to ensure efficient replication and transmission without inducing excessive pathogenicity that would indirectly impair their persistence. This is exemplified by the bovine leukemia virus (BLV) system in which lymphoproliferative disorders develop in ruminants after
Themistoklis Spyridopoulos et al.
Journal of reconstructive microsurgery, 31(7), 516-526 (2015-07-01)
Dental pulp stem cells (DPSCs) present an exciting new tool in the field of peripheral nerve regeneration due to their close embryonic origin. In this study, we examined their potential in pigs, using biodegradable collagen conduits filled with DPSCs. To
Lingzhi Li et al.
Oncotarget, 6(14), 12009-12019 (2015-05-07)
We had previously reported that trivalent arsenic (As(3+)), a well-known environmental carcinogen, induces phosphorylation of several putative Akt substrates. In the present report, we characterized one of these substrates by immunoprecipitation and proteomics analysis. The results indicate that a cytoskeleton
C Oliver et al.
Journal of applied microbiology, 119(2), 365-376 (2015-05-29)
To produce and characterize egg yolk immunoglobulin (IgY) against the fish intracellular pathogen Piscirickettsia salmonis as well as to evaluate the antibacterial activity of IgY in vitro and the availability in the serum of fish immunized orally. Specific IgY was
Sanne de Wit et al.
Scientific reports, 5, 12270-12270 (2015-07-18)
EpCAM expressing circulating tumor cells, detected by CellSearch, are predictive of short survival in several cancers and may serve as a liquid biopsy to guide therapy. Here we investigate the presence of EpCAM(+) CTC detected by CellSearch and EpCAM(-) CTC
Sherry L Kurtz et al.
Clinical and vaccine immunology : CVI, 22(10), 1096-1108 (2015-08-14)
A critical hindrance to the development of a novel vaccine against Mycobacterium tuberculosis is a lack of understanding of protective correlates of immunity and of host factors involved in a successful adaptive immune response. Studies from our group and others
Xiaoli Zhang et al.
Reproductive biomedicine online, 30(5), 514-521 (2015-03-17)
We previously reported that bone morphogenetic protein 4/drosophila mothers against decapentaplegic protein (BMP4/Smad) signalling pathway initiated primordial follicle growth and prevented oocyte apoptosis via up-regulation of Sohlh2 and receptor for kit ligand (c-kit). The mechanism underlying this process was not
Emilie Bigorgne et al.
Ecotoxicology (London, England), 24(5), 1028-1039 (2015-03-18)
The health of tree swallows, Tachycineta bicolor, on the Upper Mississippi River (UMR) was assessed in 2010 and 2011 using biomarkers at six sites downriver of Minneapolis/St. Paul, MN metropolitan area, a tributary into the UMR, and a nearby lake.
Ulrike Mock et al.
Nucleic acids research, 43(11), 5560-5571 (2015-05-13)
Homozygosity for a natural deletion variant of the HIV-coreceptor molecule CCR5, CCR5Δ32, confers resistance toward HIV infection. Allogeneic stem cell transplantation from a CCR5Δ32-homozygous donor has resulted in the first cure from HIV ('Berlin patient'). Based thereon, genetic disruption of
Anke Vanderstraeten et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 38(6), 239-249 (2015-06-08)
Survivin is an antiapoptotic protein, not expressed in terminally differentiated adult tissues, yet overexpressed in several tumors. Therefore, it is an interesting target for immunotherapeutic strategies. In addition to specific overexpression in tumors, tumor survival is mediated by survivin and
Fanny Tzelepis et al.
The Journal of clinical investigation, 125(2), 752-768 (2015-01-07)
The phagocytosis of apoptotic cells and associated vesicles (efferocytosis) by DCs is an important mechanism for both self tolerance and host defense. Although some of the engulfment ligands involved in efferocytosis have been identified and studied in vitro, the contributions
Jelena Stanisavljevic et al.
Cancer research, 75(2), 284-295 (2014-12-10)
Crosstalk between tumor and stromal cells in the tumor microenvironment alter its properties in ways that facilitate the invasive behavior of tumor cells. Here, we demonstrate that cancer-associated fibroblasts (CAF) increase the stiffness of the extracellular matrix (ECM) and promote
Lisa M Johansen et al.
Science translational medicine, 7(290), 290ra89-290ra89 (2015-06-05)
Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical resource for potential
Depu Zhang et al.
Cancer letters, 348(1-2), 100-108 (2014-03-25)
The present study aims to determine the role of γ-aminobutyric acid (GABA) signaling molecules in breast cancer metastasis. Our results reveal that GABAergic system exists in breast cancer cells. Both the GABA synthetic enzyme. (GAD65/67) and GABAB receptor are expressed
Amy H Buck et al.
Nature communications, 5, 5488-5488 (2014-11-26)
In mammalian systems RNA can move between cells via vesicles. Here we demonstrate that the gastrointestinal nematode Heligmosomoides polygyrus, which infects mice, secretes vesicles containing microRNAs (miRNAs) and Y RNAs as well as a nematode Argonaute protein. These vesicles are
Joanne Muter et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(4), 1603-1614 (2015-01-13)
Implantation requires coordinated interactions between the conceptus and surrounding decidual cells, but the involvement of clock genes in this process is incompletely understood. Circadian oscillations are predicated on transcriptional-translational feedback loops, which balance the activities of the transcriptional activators CLOCK
Nathella P Kumar et al.
Immunology, 144(4), 677-686 (2014-11-05)
Type 2 diabetes mellitus (DM) is associated with expanded frequencies of mycobacterial antigen-specific CD4(+) T helper type 1 (Th1) and Th17 cells in individuals with active pulmonary tuberculosis (TB). No data are available on the role of CD8(+) T and
K Mizrahi et al.
Bone marrow transplantation, 49(7), 942-949 (2014-04-30)
The influence of TNF-α and Fas-ligand (FasL) on viability and function was evaluated in fresh- and expanded-umbilical cord blood (UCB) cells. CD34(+) progenitors and T cells display outstanding survival, whereas ~30% and >50% B lymphocytes and myeloid cells undergo spontaneous
Ype P de Jong et al.
Science translational medicine, 6(254), 254ra129-254ra129 (2014-09-19)
In most exposed individuals, hepatitis C virus (HCV) establishes a chronic infection; this long-term infection in turn contributes to the development of liver diseases such as cirrhosis and hepatocellular carcinoma. The role of antibodies directed against HCV in disease progression
Simon Fischer et al.
RNA biology, 12(3), 238-247 (2015-04-01)
Understanding the multifaceted nature of microRNA (miRNA) function in mammalian cells is still a challenge. Commonly accepted principles of cooperativity and multiplicity of miRNA function imply that individual mRNAs can be targeted by several miRNAs whereas a single miRNA may
Catchia Hermes-Uliana et al.
Digestive diseases and sciences, 59(5), 937-948 (2013-12-29)
Diabetes and its complications appear to be multifactorial. Substances with antioxidant potential have been used to protect enteric neurons in experimental diabetes. This study evaluated the effects of supplementation with L-glutamine and L-glutathione on enteric neurons in the jejunum in
Sean O Ryan et al.
Journal of immunology (Baltimore, Md. : 1950), 192(12), 5561-5570 (2014-05-06)
Common variable immunodeficiency (CVID), the most frequent symptomatic primary immune deficiency in humans, is a heterogeneous group of immunologic disorders estimated to affect 1:10,000-1:50,000. Although a clear disease etiology remains elusive, a common characteristic of CVID is deficient IgG Ab
Huda Omar Ali et al.
Thrombosis research, 134(1), 138-143 (2014-05-03)
Oestrogens influence the pathophysiology and development of hormone-sensitive cancers, such as breast cancer. Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation pathway and has recently been associated with breast cancer cell development. Moreover, reduced
Katia Falasca et al.
Nutrients, 7(10), 8335-8347 (2015-10-02)
Inflammation persists in patients infected with HIV. Reduction of inflammatory cytokines and microbial translocation might be one way that this could be managed. The anti-inflammatory properties of certain probiotic strains prompted us to investigate whether a probiotic could reduce the
Alexandra Jaeger et al.
International journal of biological sciences, 11(9), 1006-1015 (2015-07-30)
The beta-2 adrenergic receptor (beta-2 AR) modulates metabolic processes in skeletal muscle, liver, and adipose tissue in response to catecholamine stimulation. We showed previously that expression of the porcine beta-2 AR gene (ADRB2) is affected by cis-regulatory polymorphisms. These are
A S Menko et al.
Molecular biology of the cell, 25(6), 776-790 (2014-01-31)
Mock cataract surgery provides a unique ex vivo model for studying wound repair in a clinically relevant setting. Here wound healing involves a classical collective migration of the lens epithelium, directed at the leading edge by an innate mesenchymal subpopulation
Haitian Fang et al.
Canadian journal of microbiology, 59(6), 374-379 (2013-06-12)
A major problem when pyrimidine de novo biosynthesis is used for cytidine production is the existence of many negative regulatory factors. Cytidine biosynthesis in Bacillus amyloliquefaciens proceeds via a pathway that is controlled by uridine monophosphate (UMP) through feedback inhibition
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