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Showing 1-30 of 5139 results for "V900419" within Papers
S C Zainathan et al.
Journal of fish diseases, 38(8), 739-754 (2014-08-19)
Molecular (PCR) diagnostic tests for the detection and identification of aquareovirus in general, and Tasmanian Atlantic salmon reovirus (TSRV) specifically, were developed, and their diagnostic sensitivity and specificity were determined and compared with virus isolation in cell culture. Intralaboratory and
P Mabeta
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(5), 611-617 (2014-04-30)
The phosphoinositide 3-kinase (PI3k) signaling pathway is involved in the regulation of numerous cellular activities. The pathway has also been implicated in the development of various tumors. In the context of vascular tumors, the role of the PI3k signaling still
Fernanda Visioli et al.
PloS one, 9(6), e101053-e101053 (2014-06-26)
This study was designed to investigate the activation of the unfolded protein response (UPR) in tumor associated endothelial cells (TECs) and its association with chemoresistance during acidic pH stress. Endothelial cells from human oral squamous cell carcinomas (OSCC) were excised
Zichun Wang et al.
Immunogenetics, 67(8), 447-461 (2015-07-02)
Although immune pressure exerted by MHC class I-restricted cytotoxic T lymphocytes (CTL) are an important determinant of outcome in pathogenic HIV and SIV infection, lack of data on MHC class I genes has hampered study of its role in natural
Haibo Feng et al.
Immunological investigations, 44(3), 288-308 (2015-03-17)
This study was conducted to evaluate the adjuvant potential of sulfated Radix Cyathulae officinalis Kuan polysaccharides (sRCPS) and their effects on specific cellular and humoral immune responses to hepatitis B subunit vaccine in mice. Our data demonstrated that sRCPS significantly
Katarina Turáková et al.
Anticancer research, 35(5), 2627-2634 (2015-05-13)
P-glycoprotein (Pgp) expression in neoplastic cells is known to reduce cell sensitivity to several cytotoxic Pgp substrates. A member of the ABC transporter family, Pgp, represents the most frequently described membrane efflux pump and its expression in neoplastic cells is
Lei Zhang et al.
International journal of clinical and experimental medicine, 8(4), 5591-5600 (2015-07-02)
To investigate the roles of matrine in regulating immune functions and its effect on the proliferation of leukemic cells. Human leukemia K562, OUN-1, HL-60, U937, K562/AO2 cell lines and primary leukemic cells were used to detect the NKG2D ligands (NKG2DL)
Jennifer Martinez et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9281-9289 (2014-07-11)
Neurons in the CNS do not regenerate following injury; regeneration is blocked by inhibitory proteins in myelin, such as myelin-associated glycoprotein (MAG). Elevating neuronal levels of the second messenger cAMP overcomes this blocked axonal outgrowth. One way to elevate cAMP
Hai Lin et al.
American journal of rhinology & allergy, 29(1), e18-e23 (2015-01-16)
The pathogenesis of human chronic rhinosinusitis (CRS) remains controversial. Recent evidence has suggested that interleukin (IL)-9 is vital in eliciting inflammatory response, stimulating cell proliferation and preventing apoptosis, through binding to the IL-9 receptor (IL-9R). However, little is known about
Harriët Schellekens et al.
ACS chemical neuroscience, 6(7), 1186-1197 (2015-03-03)
Understanding the intricate pathways that modulate appetite and subsequent food intake is of particular importance considering the rise in the incidence of obesity across the globe. The serotonergic system, specifically the 5-HT2C receptor, has been shown to be of critical
Ming-Hsien Chien et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(20), 4719-4732 (2015-06-17)
Kelch-like ECH-associated protein 1 (Keap1) is an E3 ligase participated in the cellular defense response against oxidative stress through nuclear factor erythroid-2-related factor 2 (Nrf2). However, the role of Keap1 in regulating cancer motility is still controversial. We investigated the
M Shah et al.
European cells & materials, 29, 155-175 (2015-03-05)
Osteogenic behaviour of osteoblasts from trabecular, cortical and subchondral bone were examined to determine any bone type-selective differences in samples from both osteoarthritic (OA) and osteoporotic (OP) patients. Cell growth, differentiation; alkaline phosphatase (TNAP) mRNA and activity, Runt-related transcription factor-2
Matthias Schröder et al.
Biological chemistry, 396(6-7), 795-802 (2015-02-27)
FTY720 (Fingolimod; Gilenya®) is an immune-modulatory prodrug which, after intracellular phosphorylation by sphingosine kinase 2 (SphK2) and export, mimics effects of the endogenous lipid mediator sphingosine-1-phosphate. Fingolimod has been introduced to treat relapsing-remitting multiple sclerosis. However, little has been published
Zhifa Wang et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(6), 1204-1216 (2014-10-21)
To analyze the effects of platelet-rich fibrin (PRF) on mesenchymal stem cells (MSCs) in vitro and investigate in vivo bone formation by MSC sheets with PRF. Cell proliferation and expression of osteogenesis-related genes within MSC sheets were assessed upon exposure
Hui Quan et al.
PloS one, 10(5), e0127885-e0127885 (2015-05-29)
Recent studies have suggested that 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) increases macrophage phagocytosis through adenosine monophosphate-activated protein kinase (AMPK). However, little information is available on the effects of AICAR on the clearance of apoptotic cells by macrophages, known as efferocytosis, which is essential
Pyrene is a Novel Constitutive Androstane Receptor (CAR) Activator and Causes Hepatotoxicity by CAR.
Xiao-Jie Zhang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(2), 436-445 (2015-07-15)
Polycyclic aromatic hydrocarbons (PAHs) are a class of ubiquitous persistent environmental pollutants which are primarily formed from the incomplete combustion of organic materials. Many potential sources of human exposure to PAHs exist, including daily exposures from the ambient environment or
Samantha Jardon-Xicotencatl et al.
Toxins, 7(10), 4294-4314 (2015-10-30)
Aflatoxins, a group of extremely toxic mycotoxins produced by Aspergillus flavus, A. parasiticus and A. nomius, can occur as natural contaminants of certain agricultural commodities, particularly maize. These toxins have been shown to be hepatotoxic, carcinogenic, mutagenic and cause severe
G Fichi et al.
Diseases of aquatic organisms, 115(2), 147-156 (2015-07-24)
The common octopus Octopus vulgaris Cuvier, 1798 is extremely important in fisheries and is a useful protein source in most Mediterranean countries. Here we investigated pathogens associated with skin lesions in 9 naturally deceased specimens that included both cultured and
Valerio Leoni et al.
Clinical chemistry and laboratory medicine, 42(2), 186-191 (2004-04-06)
24S-Hydroxycholesterol (24OHC) and 27-hydroxycholesterol (27OHC) are two structurally similar oxysterols of different origins--the former almost exclusively formed in the brain and the latter formed to a lesser extent in the brain than in most other organs. HYPOTHESIS TO BE TESTED:
H J Pegram et al.
Leukemia, 29(2), 415-422 (2014-07-10)
Disease relapse or progression is a major cause of death following umbilical cord blood (UCB) transplantation (UCBT) in patients with high-risk, relapsed or refractory acute lymphoblastic leukemia (ALL). Adoptive transfer of donor-derived T cells modified to express a tumor-targeted chimeric
Aurore Le Bescont et al.
Antioxidants & redox signaling, 23(1), 1-14 (2014-02-12)
Ectopic activation of tissue-specific genes accompanies malignant transformation in many cancers. Prolactin (PRL) aberrant activation in lung cancer was investigated here to highlight its value as a biomarker. PRL is ectopically activated in a subset of very aggressive lung tumors
Satyanarayana R Pondugula et al.
Toxicology letters, 232(3), 580-589 (2014-12-30)
Activation of human pregnane X receptor (hPXR)-regulated expression of cytochrome P450 3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1) plays an important role in mediating adverse drug interactions. Given the common use of natural products as part of adjunct human
Alba A Chavez-Dozal et al.
Eukaryotic cell, 14(7), 684-697 (2015-05-24)
The yeast exocyst is a multiprotein complex comprised of eight subunits (Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84) which orchestrates trafficking of exocytic vesicles to specific docking sites on the plasma membrane during polarized secretion. To study SEC6
Dayong Liu et al.
Stem cells (Dayton, Ohio), 33(8), 2523-2536 (2015-04-02)
Mesenchymal stem cell (MSC)-mediated periodontal tissue regeneration is considered a promising method for periodontitis treatment. The molecular mechanism underlying directed differentiation and anti-inflammatory actions remains unclear, thus limiting potential MSC application. We previously found that insulin-like growth factor binding protein
Rostyslav Zvanych et al.
Molecular bioSystems, 11(1), 97-104 (2014-09-12)
Streptococcus mutans, a Gram-positive human commensal and pathogen, is commonly recognized as a primary causative agent in dental caries. Metabolic activity of this strain results in the creation of acids and secreted products are recognized as pathogenic factors and agents
Huaqiong Huang et al.
Immunology and cell biology, 93(2), 126-135 (2014-10-01)
Respiratory syncytial virus (RSV) infection remains a significant global health burden disproportionately affecting infants and leading to long-term lung disease. Interleukin (IL)-17A has been shown to be involved in regulating viral and allergic lung inflammatory responses, which has led to
Eva Hagforsen et al.
Experimental dermatology, 24(7), 516-521 (2015-03-27)
Mast cells are known to have a detrimental impact on numerous types of inflammatory skin diseases such as contact dermatitis, atopic eczema and cutaneous mastocytosis. Regimens that dampen skin mast cell-mediated activities can thus offer an attractive therapeutic option under
Melissa M Coughlin et al.
Vaccine, 33(36), 4540-4547 (2015-07-21)
Disposable-syringe jet injectors (DSJIs) with single-use, auto disable, needle-free syringes offer the opportunity to avoid hazards associated with injection using a needle and syringe. Clinical studies have evaluated DSJIs for vaccine delivery, but most studies have focused on inactivated, subunit
Steven J Conrad et al.
Journal of experimental & clinical cancer research : CR, 34, 19-19 (2015-04-19)
Colorectal cancers are significant causes of morbidity and mortality and existing therapies often perform poorly for individuals afflicted with advanced disease. Oncolytic virotherapy is an emerging therapeutic modality with great promise for addressing this medical need. Herein we describe the
Shuo Tang et al.
PloS one, 9(9), e107517-e107517 (2014-09-13)
Neural stem cells (NSCs) have emerged as a potential source for cell replacement therapy following spinal cord injury (SCI). However, poor survival and low neuronal differentiation remain major obstacles to the use of NSCs. Biomaterials with neurotrophic factors are promising
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