CN
Search Within
V900506
Applied Filters:
Keyword:'V900506'
Showing 1-30 of 63 results for "V900506" within Papers
E Olveti et al.
Fogorvosi szemle, 85(2), 57-62 (1992-02-01)
Apparent viscosity at different shear rates was measured for two types of saliva substitutes based on methocel and CMC, and was compared with that of human whole saliva. Results indicate, that fresh mixed human saliva is viscoelastic, exhibiting pseudoplasticity. Methocel
Liang Li et al.
Molecules (Basel, Switzerland), 18(1), 545-560 (2013-01-04)
Solid self-microemulsifying drug delivery systems (SMEDDS) have been used increasingly for improving the bioavailability of hydrophobic drugs. Labrasol® and Transcutol® are used widely as surfactant and solubilizer in the formulation of solid SMEDDS. We investigated the effects of spray-drying and
Navnit Shah et al.
Journal of pharmaceutical sciences, 102(3), 967-981 (2013-01-03)
The present work deals with improving the solubility of vemurafenib, a practically insoluble drug, by converting it into an amorphous-solid dispersion using a solvent-controlled precipitation process. The dispersion containing vemurafenib and hypromellose acetate succinate (HPMCAS), an enteric polymer, is termed
Guilherme L Alexandrino et al.
Analytica chimica acta, 765, 37-44 (2013-02-16)
Thin films loaded with the drug paracetamol were produced from polymer blends formed by hydroxypropylmethylcellulose (HPMC), polyvinylpyrrolidone (PVP) and polyethyleneglycol (PEG), at various mass ratios of polymers and drug defined by a D-optimal experimental design. NIR hyperspectral images were obtained
Chieh-Cheng Huang et al.
Biomaterials, 34(19), 4582-4591 (2013-03-27)
Based on a porcine model with surgically created myocardial infarction (MI) as a pre-clinical scheme, this study investigates the clinical translation of cell sheet fragments of autologous mesenchymal stem cells (MSCs) for cellular cardiomyoplasty. MSC sheet fragments retaining endogenous extracellular
Qiuna Zhou et al.
International journal of pharmaceutics, 454(1), 125-134 (2013-07-16)
The present study aimed to prepare a chemically and physically stable formulation of baicalein (Ba) in an in situ thermally sensitive hydrogel for vaginal administration. An inclusion complex of Ba and hydroxypropyl-γ-cyclodextrin (HP-γ-CD) was first developed to increase the stability
Hisham Al-Obaidi et al.
International journal of pharmaceutics, 446(1-2), 100-105 (2013-02-16)
The role of molecular interactions in ball milled solid dispersions in determining the aqueous solubility of the poorly water-soluble drug, griseofulvin (GF) has been examined. Ball milled solid dispersions of GF and hydroxypropylmethylcellulose acetate succinate (HPMCAS) and GF and polyvinylpyrrolidone
Amornset Tachaprutinun et al.
International journal of pharmaceutics, 441(1-2), 801-808 (2012-12-29)
The method to prepare mucosa-plates, glass slides covalently coated with mucin, is demonstrated. The use of the plate to evaluate mucoadhesion of nanocarriers made from different four polymeric materials, N-succinylchitosan (NS-chitosan), alginate (ALG), ethylcellulose (EC), and a blend of EC
Paula Judith Perez Espitia et al.
Carbohydrate polymers, 94(1), 199-208 (2013-04-03)
This work aimed to develop nanocomposite films of methyl cellulose (MC) incorporated with pediocin and zinc oxide nanoparticles (nanoZnO) using the central composite design and response surface methodology. This study evaluated film physical-mechanical properties, including crystallography by X-ray diffraction, mechanical
Mohamed H Fayed et al.
Pharmaceutical development and technology, 18(5), 971-981 (2011-06-07)
The objective of this study was to evaluate the potential of Carbopol(®) 71G-NF on the release of dextromethorphan hydrobromide (DM) from matrix tablets in comparison with hydroxypropyl methylcellulose (HPMC(®) K15M) and Eudragit(®) L100-55 polymers. Controlled release DM matrix tablets were
Eyal Zur
International journal of pharmaceutical compounding, 17(1), 10-22 (2013-05-01)
Compounding pharmacists throughout the world are compounding a special type of capsule called "slow-release." This type of capsule is a compounding pharmacy application of the commercial hydrophilic matrix tablets. It is a relatively simple system that allows formulating a robust
Kawthar Bouchemal et al.
International journal of pharmaceutics, 454(2), 649-652 (2013-03-19)
The miniCD4 M48U1 was formulated into thermosensitive and mucoadhesive pluronic(®) hydrogels as anti-HIV-1 microbicide. The release kinetics of M48U1 from F127/HPMC (20/1 wt%) and F127/F68/HPMC (22.5/2.5/1 wt%) studied during 24h by using Franz diffusion cells showed that HEC hydrogel (1.5
Rozina Kousar et al.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 22(1), 41-45 (2013-03-08)
The objective of this study was to assess the pharmacokinetic behavior of floating hydroxypropylmethylcellulose microparticles loaded with cimetidine (FMC) prepared using the non-solvent addition coacervation technique. Based on the physico-chemical characteristics of three formulations (FMC1, FMC2 and FMC3), FMC2 having
Matthew J Caicco et al.
Journal of controlled release : official journal of the Controlled Release Society, 166(3), 197-202 (2013-01-12)
Stimulation of endogenous neural stem/progenitor cells (NSPCs) with therapeutic factors holds potential for the treatment of stroke. Cyclosporin A (CsA) is a particularly promising candidate molecule because it has been shown to act as a survival factor for these cells
Hakan Karaca et al.
International journal of food microbiology, 179, 72-79 (2014-04-20)
Common food preservative agents were evaluated in in vitro tests for their antifungal activity against Monilinia fructicola, the most economically important pathogen causing postharvest disease of stone fruits. Radial mycelial growth was measured in Petri dishes of PDA amended with
Martina Bajerová et al.
Acta poloniae pharmaceutica, 70(2), 271-281 (2013-04-26)
Particles preparation from biodegradable polymers as carriers for the controlled release of drugs has been the focus of many investigations and the subject of a growing field of research in recent years. The aim of this study was to develop
May S Freag et al.
International journal of pharmaceutics, 454(1), 462-471 (2013-07-09)
Scanty solubility and permeability of diosmin (DSN) are perpetrators for its poor oral absorption and high inter-subject variation. This article investigated the potential of novel DSN nanosuspensions to improve drug delivery characteristics. Bottom-up nanoprecipitation technique has been employed for nanosuspension
Maryam Zadeh-Khorasani et al.
Journal of translational medicine, 11, 4-4 (2013-01-09)
Animal models of human inflammatory diseases have limited predictive quality for human clinical trials for various reasons including species specific activation mechanisms and the immunological background of the animals which markedly differs from the genetically heterogeneous and often aged patient
Andrea J Mothe et al.
Biomaterials, 34(15), 3775-3783 (2013-03-08)
Traumatic injury to the spinal cord causes cell death, demyelination, axonal degeneration, and cavitation resulting in functional motor and sensory loss. Stem cell therapy is a promising approach for spinal cord injury (SCI); however, this strategy is currently limited by
Feng Hong et al.
Biochemistry, 52(47), 8489-8500 (2013-10-23)
During activation of smooth muscle contraction, one myosin light chain kinase (MLCK) molecule rapidly phosphorylates many smooth muscle myosin (SMM) molecules, suggesting that muscle activation rates are influenced by the kinetics of MLCK-SMM interactions. To determine the rate-limiting step underlying
T Tinny et al.
Drug development and industrial pharmacy, 39(9), 1357-1363 (2012-08-31)
Chronotherapeutic drug delivery offers a new approach in the pharmacologic interventions design for the effective treatment in the diseases which follows circadian rhythm. In the present study chronotherapeutic tablets of indometacin was designed to match the timing of rheumatoid arthritis
Ana Salgado et al.
Pharmaceutical development and technology, 19(5), 618-622 (2013-07-23)
Dermatological inflammatory diseases often affect the scalp and the eyebrows. Common dosage forms available on the market for those situations are lotions; however, the presence of hair limits their use. Gels, for their consistency and adhesiveness, are a suitable alternative
Lu Xiao et al.
Drug development and industrial pharmacy, 39(9), 1284-1290 (2012-09-27)
A new self-microemulsifying mouth dissolving film (SMMDF) for poorly water-soluble drugs such as indomethacin was developed by incorporating self-microemulsifying components with solid carriers mainly containing microcrystalline cellulose, low-substituted hydroxypropyl cellulose and hypromellose. The uniformity of dosage units of the preparation
K S Sink et al.
Behavioural brain research, 243, 286-293 (2013-02-05)
Calcitonin gene-related peptide (CGRP) acting within the bed nucleus of the stria terminalis (BNST) increases anxiety as well as neural activation in anxiety-related structures, and mediates behavioral stress responses. Similar effects have been described following intra-ventricular as well as intra-BNST
Sajid Bashir et al.
Pakistan journal of pharmaceutical sciences, 26(6), 1229-1235 (2013-11-06)
This study involves the design and characterization of Nateglinide (NAT) microspheres to enhance patient compliance. Ionic gelation technique was used to prepare Nateglinide Microspheres by using rate controlling polymers Carbopol-940 and Hydroxypropylmethyl cellulose (HPMC). Shape and surface were evaluated with
Zbynek Sklenár et al.
Acta poloniae pharmaceutica, 70(4), 759-762 (2013-08-08)
Therapy of oral, esophageal and gastrointestinal candidiasis is still a common problem that can be solved by an administration of antimycotics. Major disadvantage of registered commercial antifungal medicinal products is their price, so the health care system and its payers
Daniele Ouellet et al.
Journal of pharmaceutical sciences, 102(9), 3100-3109 (2013-04-24)
Dabrafenib is a small-molecule inhibitor of BRAF kinase activity that is currently being developed for the treatment of BRAF V600 mutation-positive melanoma. This clinical, open-label, two-cohort (n = 14 per cohort), randomized study was designed to evaluate the effect of
Carmen Ferrero et al.
Journal of controlled release : official journal of the Controlled Release Society, 170(2), 175-182 (2013-06-04)
The two main purposes of this work were: (i) to critically consider the use of thermodynamic parameters of activation for elucidating the drug release mechanism from hydroxypropyl methylcellulose (HPMC) matrices, and (ii) to examine the effect of neutral (pH 6)
Liangmei Chen et al.
Die Pharmazie, 68(10), 796-799 (2013-11-28)
The objective of this research was to develop and evaluate sustained-release matrix tablets of BKP-01-041 (tilorone derivative) based on Hypromellose (hydroxypropyl methylcellulose, HPMC) as the matrix forming polymer. The sustained-release tablets were prepared by the wet granulation method. The influence
Lindsay A Wegiel et al.
Pharmaceutical development and technology, 19(8), 976-986 (2013-11-07)
We have investigated the physical stability of amorphous curcumin dispersions and the role of curcumin-polymer intermolecular interactions in delaying crystallization. Curcumin is an interesting model compound as it forms both intra and intermolecular hydrogen bonds in the crystal. A structurally
Page 1 of 3