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Showing 1-30 of 195 results for "V900688" within Papers
Zhaogang Sun et al.
Microbial drug resistance (Larchmont, N.Y.), 20(6), 525-532 (2014-06-19)
Drug-resistance to ofloxacin (OFX) in Mycobacterium tuberculosis is due to missense mutations in gyrA and other factors, such as alterations in the activity of drug efflux pumps. In this study, we identified 8 extensively drug resistant tuberculosis (XDR-TB), 40 multidrug
[Tubercular abscess of the chest wall in the child].
Rachid El Barni et al.
The Pan African medical journal, 14, 9-9 (2013-03-19)
Stephen H Gillespie et al.
The New England journal of medicine, 371(17), 1577-1587 (2014-09-10)
Early-phase and preclinical studies suggest that moxifloxacin-containing regimens could allow for effective 4-month treatment of uncomplicated, smear-positive pulmonary tuberculosis. We conducted a randomized, double-blind, placebo-controlled, phase 3 trial to test the noninferiority of two moxifloxacin-containing regimens as compared with a
Vicente Reyes-Puerta et al.
PLoS computational biology, 11(6), e1004121-e1004121 (2015-06-23)
The manner in which populations of inhibitory (INH) and excitatory (EXC) neocortical neurons collectively encode stimulus-related information is a fundamental, yet still unresolved question. Here we address this question by simultaneously recording with large-scale multi-electrode arrays (of up to 128
Gurpreet Kaur et al.
Journal of pharmaceutical sciences, 104(7), 2203-2212 (2015-05-09)
A microemulsion has been formulated to coencapsulate antituberculosis drugs to solve the issue of stability of rifampicin (RIF) in the presence of isoniazid (INH) and pyrazinamide (PZA). The structural transition, solubilization locus, and quantitative release of drugs without interference have
Joveria Qais Farooqi et al.
JPMA. The Journal of the Pakistan Medical Association, 62(8), 767-772 (2013-07-19)
To assess the efficacy of a line-probe assay delta (LiPA) as rapid diagnostic test for early detection of drug-resistant tuberculosis compared to conventional susceptibility methods in Pakistan. Resistance to rifampicin (RIF) and isoniazid (INH) in 108 smear-positive pulmonary tuberculosis samples
Elwira Sieniawska et al.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 24(6), 527-532 (2015-09-19)
The aim of this study was to evaluate the antimycobacterial activity of the essential oil (EO) of Mutellina purpurea L. and its main constituents against the M. tuberculosis H37Ra strain. The M. purpurea EO was obtained by hydrodistillation, while its
Adherence and acquired drug-resistance in tuberculosis: wisdom stood on its head.
Tamilarasu Kadhiravan
The Indian journal of chest diseases & allied sciences, 55(1), 9-10 (2013-06-27)
Lokender Kumar et al.
The Journal of the Association of Physicians of India, 59, 733-735 (2012-05-24)
A case of isoniazid induced gynecomastia is being reported in an 18-year old male, who received a re-treatment regimen for the relapse of pulmonary tuberculosis (TB). At the end of two months of the treatment, the patient developed a painless
Sultan Tousif et al.
The Journal of biological chemistry, 289(44), 30190-30195 (2014-09-10)
Tuberculosis (TB) remains the second highest killer from a single infectious disease worldwide. Current therapy of TB is lengthy and consists of multiple expensive antibiotics, in a strategy referred to as Directly Observed Treatment, Short Course (DOTS). Although this therapy
Courtney M Yuen et al.
The Pediatric infectious disease journal, 32(5), e217-e226 (2013-01-26)
Isoniazid resistance is an obstacle to the treatment of tuberculosis disease and latent tuberculosis infection in children. We aim to summarize the literature describing the risk of isoniazid-resistant tuberculosis among children with tuberculosis disease. We did a systematic review of
Verónica Ramírez-Alcántara et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(11), G1002-G1010 (2014-04-20)
Pharmacotherapy based on 5-aminosalicylic acid (5-ASA) is a preferred treatment for ulcerative colitis, but variable patient response to this therapy is observed. Inflammation can affect therapeutic outcomes by regulating the expression and activity of drug-metabolizing enzymes; its effect on 5-ASA
B K Kishore Reddy et al.
Antimicrobial agents and chemotherapy, 58(6), 3312-3326 (2014-04-02)
Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenate, the first committed and rate-limiting step toward coenzyme A (CoA) biosynthesis. In our earlier reports, we had established that the type I isoform encoded by the coaA gene is an essential pantothenate
A fresh look at the mechanism of isoniazid-induced hepatotoxicity.
I G Metushi et al.
Clinical pharmacology and therapeutics, 89(6), 911-914 (2011-03-18)
A trial of mass isoniazid preventive therapy for tuberculosis control.
Kingsley N Ukwaja et al.
The New England journal of medicine, 370(17), 1661-1661 (2014-04-25)
Andrew D Kerkhoff et al.
PloS one, 7(11), e49928-e49928 (2012-12-05)
People living with HIV (PLWH) who have positive tuberculin skin tests (TST) benefit from isoniazid preventive therapy (IPT) whereas those testing TST-negative do not. Revised World Health Organization guidelines explicitly state that assessment of TST is not a requirement for
Saori Kamachi et al.
FEBS letters, 589(1), 131-137 (2014-12-06)
Isoniazid (INH) is a pro-drug that has been extensively used to treat tuberculosis. INH is activated by the heme enzyme catalase-peroxidase (KatG), but the mechanism of the activation is poorly understood, in part because the INH binding site has not
R Wood et al.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 104(3), 174-177 (2014-06-06)
Worldwide, South Africa (SA) has the worst tuberculosis (TB) epidemic. In SA, there are > 6.1 million people living with HIV (PLWH) and the country now has the largest antiretroviral treatment programme with > 2 million people receiving combination therapy.
Peng Liu et al.
Biomedical chromatography : BMC, 27(9), 1150-1156 (2013-05-01)
Medications compounded with isoniazid (INH) are usually applied to surgical sites at the completion of surgery to locally kill postoperative residual tubercle bacilli. However, the distribution and elimination of INH in the vertebrae in vivo are not known. In this
Samantha Ellis et al.
Molecular pharmacology, 85(2), 269-278 (2013-11-19)
The rise in drug-resistant strains of Mycobacterium tuberculosis is a major threat to human health and highlights the need for new therapeutic strategies. In this study, we have assessed whether high-affinity iron chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class
Julie Bertrand et al.
The Journal of infectious diseases, 209(3), 399-408 (2013-08-31)
We investigated the population pharmacokinetics and pharmacogenetics of efavirenz in 307 patients coinfected with human immunodeficiency virus and tuberculosis and included in the Cambodian Early vs Late Initiation of Antiretrovirals trial (CAMELIA) in Cambodia. Efavirenz (600 mg/d) and stavudine plus
Kara Mitchell et al.
Public health reports (Washington, D.C. : 1974), 130(6), 623-631 (2015-11-12)
The need for public health laboratories (PHLs) to prioritize resources has led to increased interest in sharing diagnostic services. To address this concept for tuberculosis (TB) testing, the New York State Department of Health Wadsworth Center and the Rhode Island
David W Dowdy et al.
Journal of acquired immune deficiency syndromes (1999), 66(5), 552-558 (2014-05-24)
The potential epidemiological impact of isoniazid preventive therapy (IPT), delivered at levels that could be feasibly scaled up among people living with HIV (PLHIV) in modern, moderate-burden settings, remains uncertain. We used routine surveillance and implementation data from a cluster-randomized
Tomoshige Matsumoto et al.
Kekkaku : [Tuberculosis], 88(3), 291-296 (2013-05-16)
Multidrug resistance (MDR) involves resistance to both isoniazid and rifampicin, which makes the treatment of tuberculosis very difficult. Extensive drug resistance (XDR) occurs when, in addition to isoniazid and rifampicin resistance, the microorganisms are resistant to a fluoroquinolone and an
Priti Kambli et al.
Diagnostic microbiology and infectious disease, 82(1), 49-53 (2015-03-10)
This study correlates MICs of rifampicin (RIF) and isoniazid (INH) with GenoType MTBDRplus assay results for drug-resistant Mycobacterium tuberculosis (MTB) clinical isolates. MICs of RIF and INH were established for 84 and 90 isolates, respectively, testing 7 concentrations of each
Michael L Wilson
Archives of pathology & laboratory medicine, 137(6), 812-819 (2013-06-01)
The global control of tuberculosis remains a challenge from the standpoint of diagnosis, detection of drug resistance, and treatment. This is an area of special concern to the health of women and children, particularly in regions of the world with
Yuling Chen et al.
PloS one, 10(6), e0127788-e0127788 (2015-06-04)
Tuberculosis, caused by the pathogen Mycobacterium tuberculosis, is a worldwide public health threat. Mycobacterium tuberculosis is capable of resisting various stresses in host cells, including high levels of ROS and copper ions. To better understand the resistance mechanisms of mycobacteria
S O Simons et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(10), 1015-1020 (2014-06-04)
There is an urgent need for rapid and accurate diagnosis of pyrazinamide-resistant multidrug-resistant tuberculosis (MDR-TB). No diagnostic algorithm has been validated in this population. We hypothesized that pncA sequencing added to rpoB mutation analysis can accurately identify patients with pyrazinamide-resistant
I Porvaznik et al.
Advances in experimental medicine and biology, 835, 15-22 (2014-09-26)
Tuberculosis currently belongs to rare respiratory diseases in Slovakia. However, the emergence and spread of multi-drug resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) are major challenges for global tuberculosis control, since the treatment of resistant forms creates both medical
Isoniazid hepatotoxicity requiring liver transplantation.
Edward Sheen et al.
Digestive diseases and sciences, 59(7), 1370-1374 (2014-02-28)
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