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Showing 1-30 of 6329 results for "V900859" within Papers
Ana Gil-Bona et al.
Journal of proteome research, 14(1), 142-153 (2014-11-05)
The commensal fungus Candida albicans secretes a considerable number of proteins and, as in different fungal pathogens, extracellular vesicles (EVs) have also been observed. Our report contains the first proteomic analysis of EVs in C. albicans and a comparative proteomic
Saifeldin N Shehata et al.
The Biochemical journal, 469(3), 409-420 (2015-07-25)
PCTAIRE-1 [also known as cyclin-dependent kinase 16 (CDK16)] is implicated in various physiological processes such as neurite outgrowth and vesicle trafficking; however, its molecular regulation and downstream targets are largely unknown. Cyclin Y has recently been identified as a key
Syed Z Sultan et al.
Infection and immunity, 83(5), 1765-1777 (2015-02-19)
Borrelia burgdorferi must migrate within and between its arthropod and mammalian hosts in order to complete its natural enzootic cycle. During tick feeding, the spirochete transmits from the tick to the host dermis, eventually colonizing and persisting within multiple, distant
Marcia A Shirakawa et al.
Journal of environmental management, 157, 160-167 (2015-04-25)
Sub-aerial biofilm (SAB) development on solar panels was studied in São Paulo. After 6, 12 and 18 months' exposure, photovoltaic panels were covered by increasing proportions of organic matter (42%, 53% and 58%, respectively). Fungi were an important component of
Sahayog N Jamdar et al.
Archives of biochemistry and biophysics, 587, 18-30 (2015-10-13)
Three members of peptidase family M20D from Burkholderia cepacia (BcepM20D; Uniprot accession no. A0A0F7GQ23), Deinococcus radiodurans R1 (DradM20D; Uniprot accession no. Q9RTP6) and Staphylococcus aureus (HmrA; Uniprot accession no. Q99Q45) were characterized in terms of their preference for various substrates.
Amar S More et al.
Journal of cardiovascular pharmacology, 64(3), 209-217 (2014-09-06)
This study examined the vascular effects of bradykinin in health and vascular inflammation comparing responses of isolated pig coronary arteries in the absence and presence of endotoxins. Bradykinin induced contractions in lipopolysaccharide-treated, but not untreated, arterial rings without endothelium. The
Maria F S D Rodrigues et al.
Medicine, 93(28), e192-e192 (2014-12-20)
Homeobox genes are a family of transcription factors that play a pivotal role in embryogenesis. Prospero homeobox 1 (PROX1) has been shown to function as a tumor suppressor gene or oncogene in various types of cancer, including oral squamous cell
Xiaoli Yang et al.
Molecular and cellular biochemistry, 407(1-2), 69-76 (2015-05-24)
MicroRNAs (miRNAs) play vital roles in the regulation of cell cycle, cell growth, apoptosis, and tumorigenesis. Our previous studies showed that miR-526a positively regulated innate immune response by suppressing CYLD expression, however, the functional relevance of miR-526a expression and cell
Milica Jovicic et al.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 16(5), 301-311 (2015-03-10)
To develop a structural equation model of negative affectivity (NA) that involves interaction of glucocorticoid receptor (GR) signaling, personality dimensions and recent stressful life events. Seventy participants - 35 diagnosed with major depression and 35 healthy controls, were enrolled in
Aristeidis Chiotellis et al.
Amino acids, 46(8), 1947-1959 (2014-05-08)
Amino acid transport is an attractive target for oncologic imaging. Despite a high demand of cancer cells for cationic amino acids, their potential as PET probes remains unexplored. Arginine, in particular, is involved in a number of biosynthetic pathways that
Yong Yu et al.
Nucleic acids research, 43(6), 3208-3218 (2015-03-05)
Mutations in FUS cause amyotrophic lateral sclerosis (ALS), but the molecular pathways leading to neurodegeneration remain obscure. We previously found that U1 snRNP is the most abundant FUS interactor. Here, we report that components of the U1 snRNP core particle
Kosha Mehta et al.
Blood cells, molecules & diseases, 55(2), 110-118 (2015-07-05)
Iron overload coupled with low hepcidin levels are characteristics of hereditary haemochromatosis. To understand the role of transferrin receptor (TFR) and intracellular iron in hepcidin secretion, Chinese hamster ovary transferrin receptor variant (CHO TRVb-1) cells were used that express iron-response-element-depleted
Daniela Sorriento et al.
Journal of cardiovascular translational research, 8(8), 493-502 (2015-08-01)
G protein coupled receptor kinase type 2 (GRK2) plays an important role in the development and maintenance of cardiac hypertrophy and heart failure even if its exact role is still unknown. In this study, we assessed the effect of GRK2
Douglas A Simonetto et al.
Hepatology (Baltimore, Md.), 61(2), 648-659 (2014-08-22)
Chronic passive hepatic congestion (congestive hepatopathy) leads to hepatic fibrosis; however, the mechanisms involved in this process are not well understood. We developed a murine experimental model of congestive hepatopathy through partial ligation of the inferior vena cava (pIVCL). C57BL/6
Fang Liu et al.
Molecular medicine reports, 11(5), 3349-3353 (2015-01-22)
Non‑small cell lung cancer (NSCLC) remains the leading cause of cancer‑related mortality despite the fact that great advances have been made in therapeutic treatment methods. Therefore, in the present study, the role of adenovirus-mediated retinoblastoma 94 (Ad‑RB94) gene therapy in
Eduardo Parra et al.
Oncology reports, 33(1), 413-418 (2014-10-30)
Inhibition of basal Jun kinase (JNK) activity by small interfering RNAs (siRNAs) enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. Although the JNK pathway has been extensively studied in recent years, little is known concerning the signaling
Woojung Lee et al.
International journal of molecular medicine, 36(2), 527-533 (2015-06-03)
In the present study, the anti-diabetic effects of amorphastilbol (APH) from Amorpha fruticosa (AF) were evaluated in high-fat-diet (HFD) mice. HFD-induced blood glucose and insulin levels are significantly reduced in AF extract or APH treatment groups. HFD-induced weight gain was
Ana M Matas-Cobos et al.
Pancreas, 44(3), 429-433 (2014-11-26)
Toll-like receptors (TLRs) are damage-associated molecular patterns receptors, which are essential in the activation of the inflammasome cascade, required for the initiation of inflammation. We hypothesized that changes in the function of these receptors caused by genetic polymorphisms in their
Susana Matamouros et al.
mBio, 6(3), e00616-e00615 (2015-05-28)
HAMP domains are α-helical coiled coils that often transduce signals from extracytoplasmic sensing domains to cytoplasmic domains. Limited structural information has resulted in hypotheses that specific HAMP helix movement changes downstream enzymatic activity. These hypotheses were tested by mutagenesis and
E D N S Abeyrathne et al.
Poultry science, 94(9), 2280-2287 (2015-07-22)
Ovomucoid is well known as a "trypsin inhibitor" and is considered to be the main food allergen in egg. However, the negative functions of ovomucoid can be eliminated if the protein is cut into small peptides. The objectives of this
Hieng-Ming Ting et al.
Molecular plant, 8(3), 454-466 (2015-01-20)
Plants produce numerous terpenes and much effort has been dedicated to the identification and characterization of the terpene biosynthetic genes. However, little is known about how terpenes are transported within the cell and from the cell into the apoplast. To
Siao-Syun Guan et al.
Oncotarget, 6(34), 36139-36155 (2015-10-09)
Hypoxic microenvironment is a common situation in solid tumors. Carbonic anhydrase IX (CA9) is one of the reliable cellular biomarkers of hypoxia. The role of CA9 in colorectal cancer (CRC) remains to be clarified. CA9 inhibitor such as sulfonamides is
Zhaoxing Dong et al.
BMC pulmonary medicine, 15, 13-13 (2015-04-19)
Interleukin-27 (IL-27) is a multifunctional cytokine with both pro-inflammatory and immunoregulatory functions. At present, the role of IL-27 in pulmonary fibrosis remains unknown. In this study, we observed the expression of IL-27/IL-27R in a mouse model of bleomycin (BLM)-induced pulmonary
Emiley A Eloe-Fadrosh et al.
mBio, 6(2) (2015-04-16)
A mechanistic understanding of the purported health benefits conferred by consumption of probiotic bacteria has been limited by our knowledge of the resident gut microbiota and its interaction with the host. Here, we detail the impact of a single-organism probiotic
Louise M Collins et al.
Molecular neurobiology, 51(3), 1432-1442 (2014-07-30)
Small molecule histone deacetylase inhibitors (HDIs) hold much promise as pharmacological modifiers of the epigenetic status of the central nervous system (CNS), given their ability to cross the blood-brain barrier. This is particularly relevant given the lack of disease-modifying therapies
Henriette Franz et al.
Oncotarget, 6(7), 4773-4789 (2015-03-10)
The histone code reader Spindlin1 (SPIN1) has been implicated in tumorigenesis and tumor growth, but the underlying molecular mechanisms remain poorly understood. Here, we show that reducing SPIN1 levels strongly impairs proliferation and increases apoptosis of liposarcoma cells in vitro
Peter S Hasenhuetl et al.
Molecular pharmacology, 88(1), 12-18 (2015-04-16)
The membrane transporters for the monoamines serotonin (SERT) and dopamine (DAT) are prominent targets of various psychoactive substances, including competitive inhibitors, such as tricyclic antidepressants, methylphenidate, and cocaine. Upon rapid application of a substrate, SERT and DAT display an inwardly
Munetsugu Hara et al.
Scientific reports, 5, 11204-11204 (2015-06-16)
Methyl-CpG-binding protein 2 (MeCP2) is an epigenetic regulator of gene expression that is essential for normal brain development. Mutations in MeCP2 lead to disrupted neuronal function and can cause Rett syndrome (RTT), a neurodevelopmental disorder. Previous studies reported cardiac dysfunction
Orwa Aboud et al.
Frontiers in cellular neuroscience, 9, 103-103 (2015-04-11)
Reports from neural cell cultures and experimental animal studies provide evidence of age- and disease-related changes in retrograde transport of spent or misfolded proteins destined for degradation or recycling. However, few studies address these issues in human brain from those
Jin Hee Shin et al.
Biochimica et biophysica acta, 1839(9), 826-836 (2014-07-08)
Ischemic cerebral stroke is one of the leading global causes of mortality and morbidity. Ischemic preconditioning (IPC) refers to a sublethal ischemia and resulting in tolerance to subsequent severe ischemic injury. Although several pathways are reportedly involved in IPC-mediated neuroprotection
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