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Showing 1-30 of 1260 results for "V900876" within Papers
E Muraro et al.
Journal of translational medicine, 13, 204-204 (2015-06-28)
Locally advanced HER2-overexpressing breast cancer (BC) patients achieve a high rate of pathological complete responses (pCR) after neoadjuvant chemotherapy (NC). The apparently unaltered immune proficiency of these patients together with the immune-modulating activities of NC drugs suggest a potential contribution
Joshua M Moreau et al.
Blood, 126(10), 1184-1192 (2015-07-15)
Systemic inflammation perturbs the bone marrow environment by evicting resident B cells and favoring granulopoiesis over lymphopoiesis. Despite these conditions, a subset of marrow B cell remains to become activated and produce potent acute immunoglobulin M (IgM) responses. This discrepancy
Rana Mroue et al.
PLoS genetics, 11(5), e1005235-e1005235 (2015-05-23)
Imprinted genes are expressed from only one parental allele and heterozygous loss involving the expressed allele is sufficient to produce complete loss of protein expression. Genetic alterations are common in tumorigenesis but the role of imprinted genes in this process
Paola Palumbo et al.
Journal of cellular physiology, 230(8), 1974-1981 (2015-03-05)
Nowadays, fat tissue transplantation is widely used in regenerative and reconstructive surgery. However, a shared method of lipoaspirate handling for ensuring a good quality fat transplant has not yet been established. The study was to identify a method to recover
Theodoros Eleftheriadis et al.
Experimental and therapeutic medicine, 10(5), 1959-1966 (2015-12-08)
Activated T cells rely on aerobic glycolysis and glutaminolysis in order to proliferate and differentiate into effector cells. Therefore, intervention in these metabolic pathways inhibits proliferation. The aim of the present study was to evaluate the effects of Krebs' cycle
Julia Hupfeld et al.
Biotechnology and bioengineering, 111(11), 2290-2302 (2014-06-04)
Mesenchymal stromal cells (MSCs) are promising candidates for cell therapy. Their therapeutic use requires extensive expansion to obtain a sufficiently high number of cells for clinical applications. State-of-the-art expansion systems, that is, primarily culture flask-based systems, are limited regarding scale-up
Claudia A Grillo et al.
Materials science & engineering. C, Materials for biological applications, 58, 372-380 (2015-10-20)
This work is focused on the processes occurring at the bioabsorbable metallic biomaterial/cell interfaces that may lead to toxicity. A critical analysis of the results obtained when degradable metal disks (pure Mg and rare earth-containing alloys (ZEK100 alloys)) are in
Xu Xu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(6), 2645-2654 (2014-03-07)
Alginate from marine seaweeds is receiving continuous attention owing to its wide physiological activities. Herein, we sought to elucidate possible effects of alginate-derived polyguluronate (PG) and unsaturated guluronate oligosaccharide (GOS) on antibacterial activities of macrophages. Our results showed that, in
Hairui Li et al.
Pharmaceutical research, 32(8), 2678-2689 (2015-02-19)
Copper peptide (GHK-Cu) plays an important role in skin regeneration and wound healing. However, its skin absorption remains challenging due to its hydrophilicity. Here we use polymeric microneedle array to pre-treat skin to enhance GHK-Cu skin penetration. Two in vitro
Eriko Yamamoto et al.
Biochemical and biophysical research communications, 453(1), 19-24 (2014-09-23)
Autophagy is a tightly regulated self-digestion system. As in other cell types, autophagy plays an essential role in the homeostasis of pancreatic beta cells. However, the mechanisms involved in the deterioration of beta cell function caused by autophagic failure have
Bertha Isabel Carvajal-Gamez et al.
PloS one, 9(9), e107293-e107293 (2014-09-25)
Polyamines are involved in the regulation of some Trichomonas vaginalis virulence factors such as the transcript, proteolytic activity, and cytotoxicity of TvCP65, a cysteine proteinase (CP) involved in the trichomonal cytotoxicity. In this work, we reported the putrescine effect on
D Stagos et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65(6), 843-852 (2015-01-03)
The aim of the present study was to investigate the antiangiogenic potential of a grape stem extract against tube formation by human endothelial cells (EA.hy926). The results showed that at low and non-cytotoxic concentrations (50 and 100 μg/ml) the grape
Christian M Karsten et al.
Journal of immunology (Baltimore, Md. : 1950), 194(4), 1841-1855 (2015-01-16)
Many of the biological properties of C5a are mediated through activation of its receptor (C5aR1), the expression of which has been demonstrated convincingly on myeloid cells, such as neutrophils, monocytes, and macrophages. In contrast, conflicting results exist regarding C5aR1 expression
Ding Yuan Oh et al.
PloS one, 10(3), e0118780-e0118780 (2015-03-05)
Ferrets are the preferred animal model to assess influenza virus infection, virulence and transmission as they display similar clinical symptoms and pathogenesis to those of humans. Measures of disease severity in the ferret include weight loss, temperature rise, sneezing, viral
Sanjay Kumar et al.
Stem cells and development, 24(11), 1332-1341 (2015-01-21)
Pharmacological preconditioning (PC) with tadalafil, a PDE5A inhibitor, enhances protein kinase G-1 (PKG-I) activity, resulting in stem cell survival. Protection by PC had two different phases, early (2 h) and late (24 h). However, the mechanism of protection during these phases remained
Sandy Eap et al.
Nanomedicine (London, England), 9(8), 1253-1261 (2013-11-28)
Implants triggering rapid, robust and durable tissue regeneration are needed to shorten recovery times and decrease risks of postoperative complications for patients. Here, we describe active living collagen implants with highly promising bone regenerative properties. Bioactivity of the implants is
Wei Feng et al.
Scientific reports, 5, 17422-17422 (2015-12-04)
Photothermal cancer therapy has attracted considerable interest for cancer treatment in recent years, but the effective photothermal agents remain to be explored before this strategy can be applied clinically. In this study, we therefore develop flower-like molybdenum disulfide (MoS2) nanoflakes
Sha Yi et al.
Annals of hematology, 94(2), 201-210 (2014-09-23)
Nucleophosmin (NPM1) is a multifunctional protein that functions as a molecular chaperone, shuttling between the nucleolus and the cytoplasm. In up to one third of patients with acute myeloid leukemia, mutation of NPM1 results in the aberrant cytoplasmic accumulation of
Zahra Davoudi et al.
Asian Pacific journal of cancer prevention : APJCP, 15(10), 4353-4358 (2014-06-18)
PI3/AKT and NF-kB signaling pathways are constitutively active in acute myeloid leukemia and cross-talk between the two has been shown in various cancers. However, their role in acute myeloid leukemia has not been completely explored. We therefore used cell penetrating
Wei-Jiunn Lee et al.
Archives of toxicology, 89(7), 1103-1117 (2014-08-21)
Quercetin is a plant-derived bioflavonoid that was recently shown to have multiple anticancer activities in various solid tumors. Here, novel molecular mechanisms through which quercetin exerts its anticancer effects in acute myeloid leukemia (AML) cells were investigated. Results from Western
Sung Tae Kim et al.
Developmental biology, 390(2), 160-169 (2014-04-05)
The absence of Discs-large 1 (DLG1), the mouse ortholog of the Drosophila discs-large tumor suppressor, results in congenital hydronephrosis characterized by urinary tract abnormalities, reduced ureteric bud branching, and delayed disconnection of the ureter from the common nephric duct (CND).
Bethany A Herbert et al.
PloS one, 10(5), e0125387-e0125387 (2015-05-07)
Osteoclasts (OCs) are bone-resorptive cells critical for maintaining skeletal integrity through coupled bone turnover. OC differentiation and activation requires receptor activator of NF-kB ligand (RANKL) signaling through the p38 MAPK pathway. However the role of the p38 MAPK substrate, MAPK-activated
Jung-Sen Liu et al.
Journal of cellular and molecular medicine, 19(7), 1697-1709 (2015-03-18)
The objectives of this study are to investigate antiproliferative effect and mechanisms of bioactive compounds from Gynostemma pentaphyllum (G. pentaphyllum) on lung carcinoma cell A549. Saponins, carotenoids and chlorophylls were extracted and fractionated by column chromatography, and were subjected to high-performance
Shun-Yao Ko et al.
Biochimie, 118, 8-14 (2015-07-28)
Diabetic cardiomyopathy is related to oxidative stress and correlated with the presence of advanced glycation end products (AGEs). In a clinical setting, AGEs can be detected in patients presenting diabetic cardiomyopathy; however, the underlying mechanism has yet to be elucidated.
Yolanda Córdova-Galaviz et al.
In vivo (Athens, Greece), 28(5), 819-825 (2014-09-06)
Acute myeloid leukaemia is a neoplastic disease of haematopoietic stem cells. Although there have been recent advances regarding its treatment, mortality remains high. Consequently, therapeutic alternatives continue to be explored. In the present report, we present evidence that sodium caseinate
Tânia Petta et al.
Enzyme and microbial technology, 58-59, 36-43 (2014-04-16)
Lipid mediators such as the leukotrienes, resolvins and protectins have been considered excellent models for the development of new anti-inflammatory drugs, due to their high potentiality. Nevertheless, only tiny amounts are available from natural sources and they have to be
Edyta Bajak et al.
Toxicology letters, 233(2), 187-199 (2014-12-20)
Higher efficacy and safety of nano gold therapeutics require examination of cellular responses to gold nanoparticles (AuNPs). In this work we compared cellular uptake, cytotoxicity and RNA expression patterns induced in Caco-2 cells exposed to AuNP (5 and 30nm). Cellular
Friedrich H Schmitz-Winnenthal et al.
Oncoimmunology, 4(4), e1001217-e1001217 (2015-07-03)
VEGFR-2 is expressed on tumor vasculature and a target for anti-angiogenic intervention. VXM01 is a first in kind orally applied tumor vaccine based on live, attenuated Salmonella bacteria carrying an expression plasmid, encoding VEGFR-2. We here studied the safety, tolerability
Chia-Chia Chao et al.
Pharmacological reports : PR, 66(4), 576-584 (2014-06-21)
Strong P2X7 receptor (P2X7R) activation causes Ca(2+) overload and consequent cell death. We previously showed that depletion of Ca(2+) stores and endoplasmic reticulum (ER) stress in differentiated NG108-15 neuronal cells contributed to P2X7R-mediated cytotoxicity. In this work, we assessed whether
Nicholas M Durham et al.
PloS one, 9(11), e109080-e109080 (2014-11-06)
Lymphocyte Activation Gene - 3 (LAG-3) is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. However, the molecular mechanisms underlying LAG-3's function are generally unknown. Using a model in which LAG-3 blockade or absence reliably augmented homeostatic
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