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Showing 1-30 of 1260 results for "V900876" within Papers
James R Connor et al.
PloS one, 10(5), e0125272-e0125272 (2015-05-15)
There is a significant clinical need for effective treatment of iron deficiency. A number of compounds that can be administered intravenously have been developed. This study examines how the compounds are handled by macrophages and their relative potential to provoke
T-Y Kao et al.
Cell death & disease, 6, e1642-e1642 (2015-02-13)
Human Lon protease is a mitochondrial matrix protein with several functions, including protein degradation, mitochondrial DNA (mtDNA) binding, and chaperone activity. Lon is currently emerging as an important regulator of mitochondria-contributed tumorigenesis due to its overexpression in cancer cells. To
Christian M Hammer et al.
Journal of cataract and refractive surgery, 41(6), 1279-1288 (2015-07-21)
To assess the suitability of a new 345 nm ultraviolet (UV) femtosecond laser for refractive surgery. Department of Ophthalmology, University of Erlangen-Nürnberg, Erlangen, Germany. Experimental study. Twenty-five porcine corneas were used for stromal flap or lamellar bed creation (stromal depth
Law Jia Xian et al.
Cytotherapy, 17(3), 293-300 (2014-12-03)
Platelet-rich plasma (PRP) has been found to contain a high concentration of growth factors that are present during the process of healing. Studies conducted found that application of PRP accelerates wound healing. In this study, we characterized the skin cell
Ekta Lachmandas et al.
PloS one, 10(2), e0117941-e0117941 (2015-02-11)
Type 2 diabetes mellitus is an established risk factor for tuberculosis but the underlying mechanisms are largely unknown. We examined the effects of hyperglycaemia, a hallmark of diabetes, on the cytokine response to and macrophage infection with Mycobacterium tuberculosis. Increasing
M Melusova et al.
Neoplasma, 61(6), 690-699 (2014-10-25)
For several thousand years natural products were successfully used to treat a variety of diseases and to maintain health in humans, but until now it is not fully known what causes these medicinal effects. In our study we assessed the cytotoxic
Hong Wang et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(6), 5417-5425 (2014-02-13)
UNC5H4 is a newly identified member of the UNC5H receptor family. Previously, we have demonstrated that UNC5H4 expression is significantly higher in favorable neuroblastomas than in unfavorable ones, and higher UNC5H4 level is correlated with longer survival time. However, the
V Vukićević et al.
Molecular psychiatry, 20(8), 941-950 (2015-02-25)
The antiepileptic drug valproic acid (VPA) has been shown to influence the neural differentiation and neurite outgrowth of neural stem cells. Sympathoadrenal progenitor cells share properties with neural stem cells and are considered a potential cell source in the treatment
Jin-Ju Jeong et al.
Journal of medicinal food, 17(8), 849-854 (2014-07-02)
Abstract Acquired immunodeficiency syndrome patients treated with red ginseng, which contains protopanxadiol and protopanaxatriol ginsenosides as its main constituents, have been reported to remain healthy for >20 years in the absence of highly active antiretroviral therapy. Of these ginsenosides, ginsenoside
Young Lan Seo et al.
The Journal of general virology, 96(Pt 4), 822-832 (2014-12-24)
Infection with hepatitis C virus (HCV) is characterized by systemic oxidative stress that is caused by either viral core protein or chronic inflammation. It is well recognized that reactive oxygen species (ROS) such as H2O2 can induce apoptotic cell death
Darin C Bennett et al.
Poultry science, 94(9), 2288-2296 (2015-07-29)
Traditionally, native Australian aborigines have used emu oil for the treatment of inflammation and to accelerate wound healing. Studies on mice suggest that topically applied emu oil may have anti-inflammatory properties and may promote wound healing. We investigated the effects
Priyajit Chatterjee et al.
Molecular and cellular biochemistry, 405(1-2), 149-158 (2015-04-22)
Non-small cell lung cancer (NSCLC) is known to be a difficult cancer to treat because of its poor prognosis, limited option for surgery, and resistance to chemo or radiotherapy. In this study, we have demonstrated that suppression of rictor expression
Jara Majuelos-Melguizo et al.
Oncotarget, 6(7), 4790-4803 (2015-01-13)
Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and one of the most aggressive cancers. PARP-1 is a nuclear protein involved in multiple facets of DNA repair and transcriptional regulation. In this study we dissected the
Meiling Zhuang et al.
Materials science & engineering. C, Materials for biological applications, 55, 410-419 (2015-06-29)
Hollow fiber membrane (HFM) culture system is one of the most important bioreactors for the large-scale culture and expansion of therapeutic cells. However, enzymatic and mechanical treatments are traditionally applied to harvest the expanded cells from HFMs, which inevitably causes
H-D Chae et al.
Leukemia, 29(6), 1379-1389 (2014-12-30)
CREB (cyclic AMP response element-binding protein) is a transcription factor overexpressed in normal and neoplastic myelopoiesis and regulates cell cycle progression, although its oncogenic mechanism has not been well characterized. Replication factor C3 (RFC3) is required for chromatin loading of
Eileen McNeill et al.
Scientific reports, 5, 17404-17404 (2015-12-02)
Blockade of CC chemokines is an attractive yet under utilized therapeutic strategy. We report the in vivo pharmacokinetics of a broad-spectrum vaccinia virus CC chemokine binding protein (35 K) fused to human IgG1 Fc. We demonstrate that the in vivo efficacy
Marta Mellai et al.
Oncotarget, 6(14), 12452-12467 (2015-05-08)
The suppressor of Lin-12-like (C. elegans) (SEL1L) is involved in the endoplasmic reticulum (ER)-associated degradation pathway, malignant transformation and stem cells. In 412 formalin-fixed and paraffin-embedded brain tumors and 39 Glioblastoma multiforme (GBM) cell lines, we determined the frequency of
Ghulam Muhammad et al.
Acta neurobiologiae experimentalis, 75(2), 144-159 (2015-08-04)
Transplantation of mesenchymal stem cells (MSCs) has emerged as a promising strategy for the treatment of myriad human disorders, including several neurological diseases. Superparamagnetic iron oxide nanoparticles (SPION) and fluorine nanoemulsion (19F) are characterized by low toxicity and good sensitivity
Lu Yin et al.
Respiratory research, 15, 116-116 (2014-10-01)
Influenza virus infection causes significantly higher levels of morbidity and mortality in the elderly. Studies have shown that impaired immunity in the elderly contributes to the increased susceptibility to influenza virus infection, however, how aging affects the lung tissue damage
Blassan Plackal Adimuriyil George et al.
BioMed research international, 2015, 165037-165037 (2015-06-17)
Plants and plant derived products exert chemopreventive effects on various cancer cell lines by the induction of cell death mechanisms. The effects of root acetone extract of Rubus fairholmianus (RFRA) on the proliferation of human colorectal cancer (Caco-2) cells have
Shigeto Hamaguchi et al.
Mediators of inflammation, 2015, 614518-614518 (2015-08-15)
Recently, it has been reported that circulating free DNA (cf-DNA) in the blood is increased in various infectious diseases, including sepsis. Moreover, a relationship between cf-DNA and neutrophil extracellular traps (NETs) has been suggested. However, it is still unclear what
MiJung Kim et al.
Investigative ophthalmology & visual science, 55(5), 3247-3257 (2014-04-12)
The efficacy of therapeutic cross-linking of the cornea using riboflavin photochemistry (commonly abbreviated as CXL) has caused its use to become widespread. Because there are known chemical agents that cross-link collagenous tissues, it may be possible to cross-link tissue pharmacologically.
Hussain Arif et al.
International journal of molecular sciences, 16(11), 26754-26769 (2015-11-17)
Epidemiological studies have linked dietary consumption of plant polyphenols with lower incidence of various cancers. In particular, flavonoids (present in onion, tomato and other plant sources) induce apoptosis and cytotoxicity in cancer cells. These can therefore be used as lead
Qingchun Huang et al.
Environmental toxicology and chemistry, 34(7), 1675-1682 (2015-03-11)
To gain new insight into the mechanism of selective cytotoxicity of benzoylureas as insecticides, the in vitro mode of action of chlorfluazuron was investigated on lepidopteran Tn5B1-4 and Sf-21 cells and human Hek293 and HepG2 cells. Chlorfluazuron inhibited the proliferation
Burcu Bestas et al.
The Journal of clinical investigation, 124(9), 4067-4081 (2014-08-12)
X-linked agammaglobulinemia (XLA) is an inherited immunodeficiency that results from mutations within the gene encoding Bruton's tyrosine kinase (BTK). Many XLA-associated mutations affect splicing of BTK pre-mRNA and severely impair B cell development. Here, we assessed the potential of antisense
Elisa Crisci et al.
Molecular immunology, 63(2), 343-354 (2014-10-06)
Cellular therapies using immune cells and in particular dendritic cells (DCs) are being increasingly applied in clinical trials and vaccines. Their success partially depends on accurate delivery of cells to target organs or migration to lymph nodes. Delivery and subsequent
Ruixia Huang et al.
Anticancer research, 35(7), 3743-3753 (2015-07-01)
A low quantity of mitochondrial DNA (mtDNA) is a risk factor in a variety of tumor types. However, it is unclear how mtDNA reduction influences tumor behavior. mtDNA-deficient ovarian cancer cells were established by ethidium bromide (EtBr) treatment with additive
Yuliang Wang et al.
Molecular medicine reports, 11(5), 3361-3367 (2015-01-28)
Dendritic cell (DC)‑based cancer immunotherapy requires an immunogenic tumor‑associated antigen and an effective therapeutic strategy. Glypican 3 (GPC3) is a valuable diagnostic marker and a potential therapeutic target in hepatocellular carcinoma (HCC). The present study investigated whether DCs transduced with
Mikel Aristorena et al.
Journal of cell science, 127(Pt 12), 2723-2735 (2014-04-30)
Endoglin plays a crucial role in pathophysiological processes such as hereditary hemorrhagic telangiectasia (HHT), preeclampsia and cancer. Endoglin expression is upregulated during the monocyte-to-macrophage transition, but little is known about its regulation and function in these immune cells. Two different
Jon Hazeldine et al.
Injury, 46(6), 975-984 (2015-03-31)
Traumatic injury results in a systemic inflammatory response syndrome (SIRS), a phenomenon characterised by the release of pro-inflammatory cytokines into the circulation and immune cell activation. Released from necrotic cells as a result of tissue damage, damage associated molecular patterns
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