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Showing 1-30 of 36 results for "W241504" within Papers
Wen Hu et al.
Biochimie, 94(3), 656-661 (2011-10-04)
Papain as a sustainable and inexpensive biocatalyst was used for the first time to catalyze the Knoevenagel reactions in DMSO/water. A wide range of aromatic, hetero-aromatic and α,β-unsaturated aldehydes could react with less active methylene compounds acetylacetone and ethyl acetoacetate.
Jinbao Xiang et al.
Molecular diversity, 16(1), 173-181 (2011-12-06)
Highly substituted novel 4H-pyrimido[1,6-a] pyrimidines were prepared by a trifluoromethanesulfonic acid catalyzed one-pot three-component condensation of 4-aminopyrimidines, aldehydes, and β-ketoesters. A preliminary feasibility study was undertaken on these compounds, to assess the potential production of a library of further diversified
António G B Castro et al.
Nanotechnology, 25(36), 365701-365701 (2014-08-21)
Metallic implants and devices are widely used in the orthopedic and orthodontic clinical areas. However, several problems regarding their adhesion with the living tissues and inflammatory responses due to the release of metallic ions to the medium have been reported.
Hyperpolarized [1,3-13C2 ]ethyl acetoacetate is a novel diagnostic metabolic marker of liver cancer.
Pernille R Jensen et al.
International journal of cancer, 136(4), E117-E126 (2014-08-27)
An increased prevalence of liver diseases such as hepatitis C and nonalcoholic fatty liver results in an augmented incidence of the most common form of liver cancer, hepatocellular carcinoma (HCC). HCC is most often found in the cirrhotic liver and
Nicholas E Leadbeater et al.
Nature protocols, 3(1), 1-7 (2008-01-15)
The progress of microwave-promoted reactions can be monitored by interfacing a Raman spectrometer with a scientific microwave unit. The apparatus is assembled from commercially available components. It is used in this protocol to follow the base-catalyzed reaction of salicylaldehyde with
Gui-Rong Qu et al.
Organic letters, 11(8), 1745-1748 (2009-03-20)
A novel approach to the synthesis of purines bearing functionalized carbon substituents or methyl in position 6 was developed. Under different reaction conditions, 6-halopurine derivatives could react with ethyl acetoacetate efficiently to yield 2-(purin-6-yl)acetoacetic acid ethyl esters, (purin-6-yl)acetates and 6-methylpurines
Jae Hoon Bahn et al.
Nature communications, 6, 6355-6355 (2015-03-10)
Adenosine deaminases acting on RNA (ADARs) are the primary factors underlying adenosine to inosine (A-to-I) editing in metazoans. Here we report the first global study of ADAR1-RNA interaction in human cells using CLIP-seq. A large number of CLIP sites are
Debasish Bandyopadhyay et al.
Molecules (Basel, Switzerland), 17(3), 2643-2662 (2012-03-07)
The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for
P Priscilla Lui
Psychological bulletin, 141(2), 404-446 (2014-12-22)
Among immigrant Asian and Latino groups, the contrast between collectivism in traditional heritage and individualism in the mainstream American cultures presents unique challenges for their family relationships. This systematic review was designed to answer 3 fundamental questions: to what extent
Jing-Jing Xia et al.
Molecules (Basel, Switzerland), 17(5), 5339-5345 (2012-05-09)
Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the
David E Leib et al.
Cell reports, 13(6), 1081-1089 (2015-11-04)
Animals cannot synthesize nine essential amino acids (EAAs) and must therefore obtain them from food. Mice reportedly reject food lacking a single EAA within the first hour of feeding. This remarkable phenomenon is proposed to involve post-ingestive sensing of amino
Junguo Xin et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 14(10), 3177-3181 (2008-02-05)
An enantioselective Biginelli reaction that proceeds by a dual-activation route has been developed by using a combined catalyst of a readily available trans-4-hydroxyproline-derived secondary amine and a Brønsted acid. Aromatic, heteroaromatic, and fused-ring aldehydes were found to be suitable substrates
Hassan Valizadeh et al.
Molecular diversity, 15(1), 233-237 (2010-07-24)
In this study, a three-component one-pot synthesis of select 5-amino-6-cyano-3-hydroxybenzo[c]coumarin compounds derived from salicylaldehydes, malononitrile, and ethyl acetoacetate is reported. The reaction is conducted on grinding over MgO at room temperature resulting in good yields.
Siniša Sić et al.
Journal of chromatography. A, 1408, 93-100 (2015-07-18)
Investigation of oligosaccharides attached to proteins as post-translational modification remains an important research field in the area of glycoproteomics as well as in biotechnology. The development of new tools for qualitative and quantitative analysis of glycans has gained high importance
Igor R Costa et al.
Nutrients, 7(1), 1-16 (2014-12-30)
Essential amino acids (EAA) consist of a group of nine amino acids that animals are unable to synthesize via de novo pathways. Recently, it has been found that most metazoans lack the same set of enzymes responsible for the de
Erwin A Aguilar et al.
The American journal of the medical sciences, 350(5), 357-363 (2015-10-31)
Contemporary estimates of the prevalence of diagnosed osteoporosis among long-term care facility residents are limited. This chart review collected data between April 1, 2012 and August 31, 2013 for adult (age ≥ 30 years) residents of 11 long-term care facilities
Javier Silva et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 65(1-2), 1-9 (2010-04-02)
Bioreduction of several prochiral carbonylic compounds such as acetophenone (1), ethyl acetoacetate (2) and ethyl phenylpropionate (3) to the corresponding optically active sec-alcohols 1a-3a was performed using wild-type strains of Pichia pastoris UBB 1500, Rhodotorula sp., and Saccharomyces cerevisiae. The
Jer Yiing Houng et al.
Journal of biotechnology, 100(3), 239-250 (2002-11-22)
This study examined the characteristics and operational parameters of the asymmetric reduction of ethyl 4-chloro acetoacetate by bakers' yeast in order to produce S-4-chloro-3-hydroxybutyric acid ethyl ester. Eight operational variables were also optimized using the Taguchi method with consideration of
Zhong-Hua Yang et al.
Journal of industrial microbiology & biotechnology, 39(6), 835-841 (2012-02-11)
Microalgal photo-biocatalysis is a green technique for asymmetric synthesis. Asymmetric reduction of nonnatural prochiral ketones to produce chiral alcohols by microalgal photo-biocatalysis was studied in this work. Acetophenone (ACP) and ethyl acetoacetate (EAA) were chosen as model substrates for aromatic
Arne T Dickschat et al.
Chemical communications (Cambridge, England), 49(22), 2195-2197 (2013-02-09)
Bifunctional mesoporous silica nanoparticles (MSNs) bearing Pd-complexes and additional basic sites were prepared and tested as cooperative active catalysts in the Tsuji-Trost allylation of ethyl acetoacetate. Functionalization of the MSNs was realized by postmodification using click-chemistry. The selectivity of mono
Jasmin Shah et al.
Journal of fluorescence, 21(6), 2155-2163 (2011-07-13)
A new spectrofluorimetric method has been developed and validated for the quantification of ceftriaxone in bulk powder, pharmaceutical formulations and spiked human plasma. The developed method is reproducible, accurate, sensitive and cost effective. In this method, ceftriaxone was converted into
Zhonghao Li et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60(5), 1055-1059 (2004-04-16)
Tautomerism equilibrium of ethyl acetoacetate (EAA) in compressed CO2 + methanol and CO2 + ethanol mixtures was studied by UV-Vis spectroscopy at 308.15 K and different pressures. The volume expansion coefficient (alpha) of the solvents at different pressures was also
Günter E Jeromin
Biotechnology letters, 31(11), 1717-1721 (2009-07-01)
A new immobilisate of alcohol dehydrogenase (ADH) is described in which all components for the reaction, i.e. enzyme, the coenzyme NADP(+), the buffer and other cofactors (trace elements), are immobilized together. It is an all-inclusive catalyst. The support is a
Quentin L Sciascia et al.
PloS one, 10(7), e0134323-e0134323 (2015-08-01)
The objectives of this study were to (1) identify changes in plasma and mammary intracellular amino acid (AA) profiles in dairy cows treated with growth hormone (GH), and (2) evaluate the expression of mammary gland genes involved in the transport
Ying-Hui Sun et al.
Journal of biochemical and biophysical methods, 70(6), 850-856 (2008-01-19)
Bacterial beta-ketoacyl-ACP reductase (FabG) and the beta-ketoacyl reductase domain in mammalian fatty acid synthase (FAS) have the same function and both are rendered as the novel targets for drugs. Herein we developed a convenient method, using an available compound ethyl
Ruth Milkereit et al.
Nature communications, 6, 7250-7250 (2015-05-23)
Mammalian target of rapamycin 1 (mTORC1), a master regulator of cellular growth, is activated downstream of growth factors, energy signalling and intracellular essential amino acids (EAAs) such as Leu. mTORC1 activation occurs at the lysosomal membrane, and involves V-ATPase stimulation
Ramakrishnan Ganesan et al.
Langmuir : the ACS journal of surfaces and colloids, 25(16), 8888-8893 (2009-09-02)
A diazoketo-functionalized alkoxysilane compound was synthesized, and its self-assembled monolayer (SAM) formation was studied on glass and silicon substrates. Infrared spectroscopy was employed to follow the photoreaction in this system, which proved that carboxylic groups were generated from diazoketo groups
Gérard Coureaud et al.
Current biology : CB, 16(19), 1956-1961 (2006-10-10)
Mammalian neonates depend on their mother's food supply and use a defined sequence of actions to find her mammary area. Their behavior is initially uncertain and demanding but rapidly becomes optimal. Efficient learning is thus operating in newborns. For instance
Adel A A Emara et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 77(3), 594-604 (2010-08-07)
New mixed-ligand copper(II) complexes containing the bidentate dinitrogen ligands [N,N,N',N'-tetramethylethylenediamine (tmen), 2,2'-bipyridine (bipy) and 1,10-phenanthroline (phen)] and the bidentate dioxygen ligands [diethylmalonate (DEM), ethylacetoacetate (EAA) and ethylbenzoylacetate (EBA)] were prepared. The complexes were characterized by elemental analysis, infrared, mass and
Jian Wu et al.
Molecules (Basel, Switzerland), 17(5), 5139-5150 (2012-05-05)
Sixteen novel pyrazole acyl thiourea derivatives 6 were synthesized from monomethylhydrazine (phenylhydrazine) and ethyl acetoacetate. The key 5-chloro-3-methyl-1-substituted-1H-pyrazole-4-carbonyl chloride intermediates 4 were first generated in four steps through cyclization, formylation, oxidation and acylation. Thess were then reacted with ammonium thiocyanate
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