W274518

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Showing 1-30 of 75 results for "W274518" within Papers

G protein-coupled estrogen receptor regulates mammary tumorigenesis and metastasis.

Nicole A Marjon et al.

Molecular cancer research : MCR, 12(11), 1644-1654 (2014-07-18)

The role of 17β-estradiol (E2) in breast cancer development and tumor growth has traditionally been attributed exclusively to the activation of estrogen receptor-α (ERα). Although targeted inhibition of ERα is a successful approach for patients with ERα(+) breast cancer, many

Drug permeation through skin is inversely correlated with carrier gel rigidity.

Duc-Viet Nguyen et al.

Molecular pharmaceutics, 12(2), 444-452 (2014-12-17)

Controlled release plays an essential role in formulating topical and transdermal drug delivery systems. In this study, we correlated the skin permeation of Sesamin, a lipophilic drug, with the rheological properties of two different organogel carriers, i.e., low molecular weight

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Lourdes Santana et al.

Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives

Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis.

Jian-ping Wang et al.

Journal of ethnopharmacology, 137(3), 1089-1094 (2011-07-30)

Siegesbeckia orientalis has been traditionally used as a topical anti-inflammatory and analgesic agent. Current study was designed to explore the topical anti-inflammatory and analgesic effects of a constituent isolated from Siegesbeckia orientalis (Compositae), in order to validate its folk use.

Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion.

Taraka R Donti et al.

Disease models & mechanisms, 7(2), 271-280 (2013-11-26)

Mutations in subunits of succinyl-CoA synthetase/ligase (SCS), a component of the citric acid cycle, are associated with mitochondrial encephalomyopathy, elevation of methylmalonic acid (MMA), and mitochondrial DNA (mtDNA) depletion. A FACS-based retroviral-mediated gene trap mutagenesis screen in mouse embryonic stem

The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis.

X Lu et al.

Oncogene, 33(20), 2655-2664 (2013-06-19)

Nanog is a transcription factor required for maintaining the pluripotency of embryonic stem cells, and is not expressed in most normal adult tissues. However, recent studies have indicated that Nanog is overexpressed in many types of human cancers, including breast

What happens if people start drinking mouthwash as surrogate alcohol? A quantitative risk assessment.

Dirk W Lachenmeier et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 51, 173-178 (2012-10-09)

Mouthwash ingestion has been observed in settings of restricted availability to alcoholic beverages such as in hospitals, prisons or military establishments. The literature offers limited evidence that ingredients of mouthwash may have health effects above the effects of ethanol. This

Evaluation of drug release profile from patches based on styrene-isoprene-styrene block copolymer: the effect of block structure and plasticizer.

ChengXiao Wang et al.

AAPS PharmSciTech, 13(2), 556-567 (2012-04-06)

We prepared pressure-sensitive adhesive (PSA) patches based on styrene-isoprene-styrene (SIS) thermoplastic elastomer using hot-melt coating method. The liquid paraffine is added in the PSA matrices as a plasticizer to moderate the PSA properties. Three drugs, methyl salicylate, capsaicin, and diphenhydramine

Red:far-red light conditions affect the emission of volatile organic compounds from barley (Hordeum vulgare), leading to altered biomass allocation in neighbouring plants.

Wouter Kegge et al.

Annals of botany, 115(6), 961-970 (2015-04-09)

Volatile organic compounds (VOCs) play various roles in plant-plant interactions, and constitutively produced VOCs might act as a cue to sense neighbouring plants. Previous studies have shown that VOCs emitted from the barley (Hordeum vulgare) cultivar 'Alva' cause changes in

Potential dangers from topical preparations containing methyl salicylate.

T Y Chan

Human & experimental toxicology, 15(9), 747-750 (1996-09-01)

Methyl salicylate (oil of wintergreen) is widely available in many over-the-counter liniments, ointments, lotions or medicated oils for the relief of musculoskeletal aches and pains. Ingestion of methyl salicylate poses the threat of severe, rapid-onset salicylate poisoning because of its

Immunological shielding by induced recruitment of regulatory T-lymphocytes delays rejection of islets transplanted in muscle.

Evelina Vågesjö et al.

Cell transplantation, 24(2), 263-276 (2014-02-01)

The only clinically available curative treatment of type 1 diabetes mellitus is replacement of the pancreatic islets by allogeneic transplantation, which requires immunosuppressive therapies. Regimens used today are associated with serious adverse effects and impaired islet engraftment and function. The

Design, synthesis and antileishmanial in vitro activity of new series of chalcones-like compounds: a molecular hybridization approach.

Ticiano P Barbosa et al.

Bioorganic & medicinal chemistry, 19(14), 4250-4256 (2011-06-21)

The chalcone-like series 1a-1g was efficiently synthesized from Morita-Baylis-Hillman reaction (52-74% yields). Compounds 1a-1g were designed by molecular hybridization based on the anti-inflammatory drug methyl salicylate (3) and the antileishmanial moiety of the Morita-Baylis-Hillman adducts 2a-2g. The 1a-1g compounds were

A role for site-specific phosphorylation of mouse progesterone receptor at serine 191 in vivo.

Sandra L Grimm et al.

Molecular endocrinology (Baltimore, Md.), 28(12), 2025-2037 (2014-10-22)

Progesterone receptors (PRs) are phosphorylated on multiple sites, and a variety of roles for phosphorylation have been suggested by cell-based studies. Previous studies using PR-null mice have shown that PR plays an important role in female fertility, regulation of uterine

Comparison of mandibular first molar mesial root canal morphology using micro-computed tomography and clearing technique.

Yeun Kim et al.

Acta odontologica Scandinavica, 73(6), 427-432 (2014-11-12)

Micro-computed tomography (MCT) with alternative image reformatting techniques shows complex and detailed root canal anatomy. This study compared two-dimensional (2D) and 3D MCT image reformatting with standard tooth clearing for studying mandibular first molar mesial root canal morphology. Extracted human

Sequence comparisons of odorant receptors among tortricid moths reveal different rates of molecular evolution among family members.

Colm Carraher et al.

PloS one, 7(6), e38391-e38391 (2012-06-16)

In insects, odorant receptors detect volatile cues involved in behaviours such as mate recognition, food location and oviposition. We have investigated the evolution of three odorant receptors from five species within the moth genera Ctenopseustis and Planotrotrix, family Tortricidae, which

Time-dependent density functional theory (TD-DFT) study on the excited-state intramolecular proton transfer (ESIPT) in 2-hydroxybenzoyl compounds: significance of the intramolecular hydrogen bonding.

Xin Lan et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102, 281-285 (2012-12-12)

The excited-state properties of intramolecular hydrogen bonding (IMHB) in methyl salicylate (MS) and its effects on the excited-state intramolecular proton transfer (ESIPT) have been investigated using theoretical methods. From the geometric optimization and IR spectra in the ground and excited

Vaccines against human HER2 prevent mammary carcinoma in mice transgenic for human HER2.

Carla De Giovanni et al.

Breast cancer research : BCR, 16(1), R10-R10 (2014-01-24)

The availability of mice transgenic for the human HER2 gene (huHER2) and prone to the development of HER2-driven mammary carcinogenesis (referred to as FVB-huHER2 mice) prompted us to study active immunopreventive strategies targeting the human HER2 molecule in a tolerant

A randomized clinical study of the heated lidocaine/tetracaine patch versus subacromial corticosteroid injection for the treatment of pain associated with shoulder impingement syndrome.

Richard Radnovich et al.

Journal of pain research, 7, 727-735 (2014-12-20)

Treatment for pain due to shoulder impingement syndrome (SIS) typically begins conservatively with nonsteroidal anti-inflammatory drugs and physical therapy and can include subacromial injection of corticosteroids, particularly in patients unresponsive to conservative measures. The heated lidocaine/tetracaine (HLT) patch has been

Hyperspectral imaging signatures detect amyloidopathy in Alzheimer's mouse retina well before onset of cognitive decline.

Swati S More et al.

ACS chemical neuroscience, 6(2), 306-315 (2014-10-30)

Amyloidopathic disorders such as Alzheimer's disease present symptomology years after the entrenchment of amyloidogenic imbalance. The pathologic α-helix → β-strand conversion of amyloid β(1-42) and amyloid β(1-40) peptides causes neuronal death in the vicinity. Symptomology often presents only after significant

A hard-wired priority map in the superior colliculus shaped by asymmetric inhibitory circuitry.

Peter O Bayguinov et al.

Journal of neurophysiology, 114(1), 662-676 (2015-05-23)

The mammalian superior colliculus (SC) is a laminar midbrain structure that translates visual signals into commands to shift the focus of attention and gaze. The SC plays an integral role in selecting targets and ultimately generating rapid eye movements to

Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.

Jochen Pauwels et al.

Journal of pharmaceutical and biomedical analysis, 60, 51-58 (2011-11-19)

Capsaicinoids, salicylic acid, methyl and ethyl salicylate, glycol monosalicylate, camphor and l-menthol are widely used in topical formulations to relieve local pain. For each separate compound or simple mixtures, quantitative analysis methods are reported. However, for a mixture containing all

The floral transcriptome of Eucalyptus grandis.

Kelly J Vining et al.

The New phytologist, 206(4), 1406-1422 (2014-10-30)

As a step toward functional annotation of genes required for floral initiation and development within the Eucalyptus genome, we used short read sequencing to analyze transcriptomes of floral buds from early and late developmental stages, and compared these with transcriptomes

Detection of volatile organic compounds indicative of human presence in the air.

Jae Kwak et al.

Journal of separation science, 38(14), 2463-2469 (2015-05-07)

Volatile organic compounds were collected and analyzed from a variety of indoor and outdoor air samples to test whether human-derived compounds can be readily detected in the air and if they can be associated with human occupancy or presence. Compounds

Aphid antixenosis in cotton is activated by the natural plant defence elicitor cis-jasmone.

Mahabaleshwar Hegde et al.

Phytochemistry, 78, 81-88 (2012-04-21)

Upon insect herbivory, plants can release blends of volatile organic compounds (VOCs) that modify herbivore and natural enemy behaviour. We have shown recently that cotton, Gossypium hirsutum, emits a blend of defence VOCs that repels the cotton aphid, Aphis gossypii

Scalable ionic gelation synthesis of chitosan nanoparticles for drug delivery in static mixers.

Yuancai Dong et al.

Carbohydrate polymers, 94(2), 940-945 (2013-04-03)

The purpose of this study is to synthesize chitosan (CS) nanoparticles (NPs) by ionic gelation with tripolyphosphate (TPP) as crossslinker in static mixers. The proposed static mixing technique showed good control over the ionic gelation process and 152-376 nm CS

Differences in volatile profiles of turnip plants subjected to single and dual herbivory above- and belowground.

Prisca S Pierre et al.

Journal of chemical ecology, 37(4), 368-377 (2011-03-31)

Plants attacked by herbivorous insects emit volatile organic compounds that are used by natural enemies to locate their host or prey. The composition of the blend is often complex and specific. It may vary qualitatively and quantitatively according to plant

Neurons of self-defence: neuronal innervation of the exocrine defence glands in stick insects.

Konrad Stolz et al.

Frontiers in zoology, 12, 29-29 (2015-10-27)

Stick insects (Phasmatodea) use repellent chemical substances (allomones) for defence which are released from so-called defence glands in the prothorax. These glands differ in size between species, and are under neuronal control from the CNS. The detailed neural innervation and

Volatile flavor components of sapodilla fruit (Achras sapota L).

MacLeod AJ & Gonzales de Troconis N.

Journal of Agricultural and Food Chemistry, 30(3), 515-517 (1982)

Mosquito odorant receptor for DEET and methyl jasmonate.

Pingxi Xu et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(46), 16592-16597 (2014-10-29)

Insect repellents are important prophylactic tools for travelers and populations living in endemic areas of malaria, dengue, encephalitis, and other vector-borne diseases. DEET (N,N-diethyl-3-methylbenzamide) is a 6-decade-old synthetic repellent, which is still considered the gold standard of mosquito repellents. Mosquitoes

Transcriptome analysis of the hormone-sensing cells in mammary epithelial reveals dynamic changes in early pregnancy.

Duvini De Silva et al.

BMC developmental biology, 15, 7-7 (2015-01-28)

Alveoli, the milk-producing units of the mammary gland, are generated during pregnancy by collaboration of different epithelial cell types. We present the first analysis of transcriptional changes within the hormone sensing population during pregnancy. Hormone-receptor positive (HR+) cells play a

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