W287806

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Concentration-dependent effect of platelet-rich plasma on keratinocyte and fibroblast wound healing.

Law Jia Xian et al.

Cytotherapy, 17(3), 293-300 (2014-12-03)

Platelet-rich plasma (PRP) has been found to contain a high concentration of growth factors that are present during the process of healing. Studies conducted found that application of PRP accelerates wound healing. In this study, we characterized the skin cell

Covalent adduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal and phloretin.

Andreas Üllen et al.

Biochemical pharmacology, 93(4), 470-481 (2015-01-13)

Hypochlorous acid added as reagent or generated by the myeloperoxidase (MPO)-H2O2-Cl(-) system oxidatively modifies brain ether-phospholipids (plasmalogens). This reaction generates a sn2-acyl-lysophospholipid and chlorinated fatty aldehydes. 2-Chlorohexadecanal (2-ClHDA), a prototypic member of chlorinated long-chain fatty aldehydes, has potent neurotoxic potential

Hemangioblastic foci in human first trimester placenta: Distribution and gestational profile.

John D Aplin et al.

Placenta, 36(10), 1069-1077 (2015-09-01)

The human placenta is a site of both hematopoiesis and vasculogenesis. There are reports of hemangioblastic foci (HAF) in the first trimester placenta, but little published information about their spatiotemporal incidence. We have used semi-thin sections and whole mount staining

Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice†.

Can Tepeköylü et al.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47(3), e80-e90 (2014-11-26)

Tissue-engineered xenografts represent a promising treatment option in heart valve disease. However, inflammatory response leading to graft failure and incomplete in vitro repopulation with recipient cells remain challenging. Shock waves (SWs) were shown to modulate inflammation and to enhance re-epithelialization.

Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.

David R Colquhoun et al.

Proteomics, 15(12), 2066-2077 (2015-04-29)

Protein acylation plays a critical role in protein localization and function. Acylation is essential for human immunodeficiency virus 1 (HIV-1) assembly and budding of HIV-1 from the plasma membrane in lipid raft microdomains and is mediated by myristoylation of the

Valproic acid enhances neuronal differentiation of sympathoadrenal progenitor cells.

V Vukićević et al.

Molecular psychiatry, 20(8), 941-950 (2015-02-25)

The antiepileptic drug valproic acid (VPA) has been shown to influence the neural differentiation and neurite outgrowth of neural stem cells. Sympathoadrenal progenitor cells share properties with neural stem cells and are considered a potential cell source in the treatment

CD4(+) FoxP3(+) regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection.

Bianca Schulze et al.

European journal of immunology, 44(12), 3596-3604 (2014-09-05)

The opportunistic fungal pathogen Cryptococcus neoformans causes lung inflammation and fatal meningitis in immunocompromised patients. Regulatory T (Treg) cells play an important role in controlling immunity and homeostasis. However, their functional role during fungal infection is largely unknown. In this

Ionizing radiation increases primary cilia incidence and induces multiciliation in C2C12 myoblasts.

Alžběta Filipová et al.

Cell biology international, 39(8), 943-953 (2015-03-27)

Primary cilia act as physical-chemical sensors and their functions include the perception of the extracellular milieu, regulation of organogenesis, and cell polarity. In general, these cells are monociliated and the single cilium possesses diverse receptors and channels which are involved

Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro- and in vivo-induced murine osteoarthritis.

Laurent-Emmanuel Monfoulet et al.

Experimental biology and medicine (Maywood, N.J.), 240(7), 854-866 (2015-01-15)

Osteoarthritis (OA) is an age-related degenerative joint disease. To date, its management is focused on symptoms (pain and inflammation). Studies suggest that fatty acids can reduce the expression of inflammatory and catalytic mediators, and improve in vivo joint function. Free fatty

Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins.

Alfonso Pérez-Garrido et al.

Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the molecular structure of the compounds under investigation

Biomass Yield and Steviol Glycoside Production in Callus and Suspension Culture of Stevia rebaudiana Treated with Proline and Polyethylene Glycol.

Pratibha Gupta et al.

Applied biochemistry and biotechnology, 176(3), 863-874 (2015-05-06)

Enhanced production of steviol glycosides (SGs) was observed in callus and suspension culture of Stevia rebaudiana treated with proline and polyethylene glycol (PEG). To study their effect, yellow-green and compact calli obtained from in vitro raised Stevia leaves were sub-cultured

Induction of immune-related gene expression in Ctenopharyngodon idella kidney cells by secondary metabolites from immunostimulatory Alcaligenes faecalis FY-3.

Z-F Wu et al.

Scandinavian journal of immunology, 76(2), 131-140 (2012-05-23)

This study was undertaken to isolate active secondary metabolites from immunostimulatory Alcaligenes faecalis FY-3 and evaluate their activities using grass carp Ctenopharyngodon idella kidney (CIK) cells. By applying chromatography techniques and successive recrystallization, three purified metabolites were obtained and identified

Mechanical load and mechanical integrity of lung cells - experimental mechanostimulation of epithelial cell- and fibroblast-monolayers.

Katharina Gamerdinger et al.

Journal of the mechanical behavior of biomedical materials, 40, 201-209 (2014-09-23)

Experimental mechanostimulation of soft biologic tissue is widely used to investigate cellular responses to mechanical stress or strain. Reactions on mechanostimulation are investigated in terms of morphological changes, inflammatory responses and apoptosis/necrosis induction on a cellular level. In this context

Expression analysis of all protease genes reveals cathepsin K to be overexpressed in glioblastoma.

Urška Verbovšek et al.

PloS one, 9(10), e111819-e111819 (2014-10-31)

Cancer genome and transcriptome analyses advanced our understanding of cancer biology. We performed transcriptome analysis of all known genes of peptidases also called proteases and their endogenous inhibitors in glioblastoma multiforme (GBM), which is one of the most aggressive and

The effects of the fungicides fenhexamid and myclobutanil on SH-SY5Y and U-251 MG human cell lines.

David A Nagel et al.

Environmental toxicology and pharmacology, 38(3), 968-976 (2014-12-03)

Mixtures of pesticides in foodstuffs and the environment are ubiquitous in the developed world and although agents are usually exhaustively tested individually, the toxicological implications of pesticide mixtures are underreported. In this study, the effects of two fungicides, fenhexamid and

Inhibition of indoleamine 2,3-dioxygenase activity enhances the anti-tumour effects of a Toll-like receptor 7 agonist in an established cancer model.

Hiroyasu Ito et al.

Immunology, 144(4), 621-630 (2014-10-18)

Toll-like receptor (TLR) agonists have been shown to have anti-tumour activity in basic research and clinical studies. However, TLR agonist monotherapy does not sufficiently eliminate tumours. Activation of the innate immune response by TLR agonists is effective at driving adaptive

miR-34c regulates the permeability of blood-tumor barrier via MAZ-mediated expression changes of ZO-1, occludin, and claudin-5.

Lini Zhao et al.

Journal of cellular physiology, 230(3), 716-731 (2014-09-10)

The purposes of this study were to investigate the potential roles of miR-34c in regulating blood-tumor barrier (BTB) functions and its possible molecular mechanisms. The over-expression of miR-34c significantly impaired the integrity and increased the permeability of BTB, which were

Cross-Presentation of the Oncofetal Tumor Antigen 5T4 from Irradiated Prostate Cancer Cells--A Key Role for Heat-Shock Protein 70 and Receptor CD91.

Josephine Salimu et al.

Cancer immunology research, 3(6), 678-688 (2015-02-14)

Immune responses contribute to the success of radiotherapy of solid tumors; however, the mechanism of triggering CD8(+) T-cell responses is poorly understood. Antigen cross-presentation from tumor cells by dendritic cells (DC) is a likely dominant mechanism to achieve CD8(+) T-cell

Plasma concentrations of phenyllactic acid in phenylketonuria.

P C Clemens et al.

Journal of inherited metabolic disease, 13(2), 227-228 (1990-01-01)

Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53.

Ivanildce Cristiane Ireno et al.

Carcinogenesis, 35(10), 2273-2282 (2014-08-03)

Synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) and homologous recombination (HR) repair pathways have been exploited for the development of novel mono- and combination cancer therapies. The tumor suppressor p53 was demonstrated to exhibit indirect and direct regulatory activities

Diagnostic and prognostic potential of serum miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429 in ovarian cancer patients.

Xiaodan Meng et al.

British journal of cancer, 113(9), 1358-1366 (2015-09-24)

Owing to late diagnosis in advanced disease stages, prognosis of patients with epithelial ovarian cancer (EOC) is poor. The quantification of deregulated levels of microRNAs could facilitate earlier diagnosis and improve prognosis of EOC. Seven microRNAs (miR-7, miR-16, miR-25, miR-93

Vitamin D limits chemokine expression in adipocytes and macrophage migration in vitro and in male mice.

Esma Karkeni et al.

Endocrinology, 156(5), 1782-1793 (2015-03-03)

Vitamin D (VD) displays immunoregulatory effects and reduces adipocyte inflammation, which may participate to a reduction of adipose tissue macrophage infiltration in the context of obesity-associated low-grade inflammation. These observations have been described mainly in vitro, through the evaluation of

Plasma amino acid profile on nocturnal hemodialysis.

D S Raj et al.

Blood purification, 18(2), 97-102 (2000-06-06)

The purpose of this study was to examine the effect of nocturnal hemodialysis (NHD) on serum amino acid (AA) profile. In a cross-over trial, we studied the AA profile in 11 patients who were switched from conventional hemodialysis to NHD.

Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins.

Uwe Mamat et al.

Microbial cell factories, 14, 57-57 (2015-04-19)

Lipopolysaccharide (LPS), also referred to as endotoxin, is the major constituent of the outer leaflet of the outer membrane of virtually all Gram-negative bacteria. The lipid A moiety, which anchors the LPS molecule to the outer membrane, acts as a

MicroRNA-199b Modulates Vascular Cell Fate During iPS Cell Differentiation by Targeting the Notch Ligand Jagged1 and Enhancing VEGF Signaling.

Ting Chen et al.

Stem cells (Dayton, Ohio), 33(5), 1405-1418 (2014-12-24)

Recent ability to derive endothelial cells (ECs) from induced pluripotent stem (iPS) cells holds a great therapeutic potential for personalized medicine and stem cell therapy. We aimed that better understanding of the complex molecular signals that are evoked during iPS

Lignosus rhinocerotis (Cooke) Ryvarden mimics the neuritogenic activity of nerve growth factor via MEK/ERK1/2 signaling pathway in PC-12 cells.

Syntyche Ling-Sing Seow et al.

Scientific reports, 5, 16349-16349 (2015-11-07)

The traditional application of the sclerotium of Lignosus rhinocerotis (tiger's milk mushroom) by the indigenous folks as tonic and remedy to treat a variety of ailments has been documented in Malaysia. Indigenous communities claimed to have consumed the decoction to

Up-regulation of programmed cell death 1 ligand 1 on neutrophils may be involved in sepsis-induced immunosuppression: an animal study and a prospective case-control study.

Jia-Feng Wang et al.

Anesthesiology, 122(4), 852-863 (2014-12-02)

Recent studies have shown that neutrophils may display an antigen-presenting function and inhibit lymphocyte proliferation by expressing programmed cell death 1 ligand 1 (PD-L1). The current study was performed to investigate the effect of neutrophils and their pathophysiological significance during

New insights into the molecular and epigenetic effects of antitumor Pt(IV)-valproic acid conjugates in human ovarian cancer cells.

Vojtech Novohradsky et al.

Biochemical pharmacology, 95(3), 133-144 (2015-04-19)

Substitutionally inert Pt(IV) prodrugs, combining bioactive axial ligands with Pt(IV) derivatives of antitumor Pt(II) compounds, represent a new generation of anticancer drugs. The rationale behind these prodrugs is to release, by reductive elimination inside the cancer cell, an active Pt(II)

Schistosome infection aggravates HCV-related liver disease and induces changes in the regulatory T-cell phenotype.

E Loffredo-Verde et al.

Parasite immunology, 37(2), 97-104 (2015-01-07)

Schistosome infections are renowned for their ability to induce regulatory networks such as regulatory T cells (Treg) that control immune responses against homologous and heterologous antigens such as allergies. However, in the case of co-infections with hepatitis C virus (HCV)

Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening.

Gerrit Erdmann et al.

Genome medicine, 7(1), 46-46 (2015-06-30)

Mesenchymal stem cells (MSCs) are promising candidates for cellular therapies ranging from tissue repair in regenerative medicine to immunomodulation in graft versus host disease after allogeneic transplantation or in autoimmune diseases. Nonetheless, progress has been hampered by their enormous phenotypic

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