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Showing 1-30 of 124 results for "w302600" within Papers
Margie N Sutton et al.
Autophagy, 14(4), 637-653 (2018-01-26)
Among the 3 GTPases in the DIRAS family, DIRAS3/ARHI is the best characterized. DIRAS3 is an imprinted tumor suppressor gene that encodes a 26-kDa GTPase that shares 60% homology to RAS and RAP. DIRAS3 is downregulated in many tumor types
Guoqiang Liu et al.
Small (Weinheim an der Bergstrasse, Germany), 11(23), 2807-2816 (2015-02-05)
A facile route to fabricate a nanocomposite of Fe3O4@poly[N-isopropylacrylamide (NIPAM)-co-2-(dimethylamino)ethyl methacrylate (DMAEMA)]@Au (Fe3O4@PND@Au) is developed for magnetically recyclable and thermally tunable catalysis. The negatively charged Au nanoparticles with an average diameter of 10 nm are homogeneously loaded onto positively charged
Madhusudhan Srinivasan et al.
Cell, 173(6), 1508-1519 (2018-05-15)
As predicted by the notion that sister chromatid cohesion is mediated by entrapment of sister DNAs inside cohesin rings, there is perfect correlation between co-entrapment of circular minichromosomes and sister chromatid cohesion. In most cells where cohesin loads without conferring
Geovanny Nic-Can et al.
Plant methods, 9(1), 47-47 (2013-12-18)
Epigenetic mechanisms can be highly dynamic, but the cross-talk among them and with the genome is still poorly understood. Many of these mechanisms work at different places in the cell and at different times of organism development. Covalent histone modifications
Jeffrey A Kline et al.
Thrombosis research, 136(4), 769-774 (2015-09-05)
Pulmonary embolism (PE) can cause intracardiac hemolysis and increased plasma hemoglobin and arginase-1, which can worsen pulmonary vasoconstriction. We test the hypothesis that patients with PE that causes tricuspid regurgitation (TR), indicative of higher pulmonary arterial pressures, have decreased leukocyte
Didem Rodoplu et al.
Current pharmaceutical design, 21(37), 5389-5400 (2015-09-18)
Magnetic nanoparticles are considered as the ideal substrate to selectively isolate target molecules or organisms from sample solutions in a wide variety of applications including bioassays, bioimaging and environmental chemistry. The broad array of these applications in fields requires the
Mudasir Bhat et al.
Environmental monitoring and assessment, 187(7), 398-398 (2015-06-04)
Dissipation patterns were studied following two applications of difenoconazole (score 25% EC) at 300 and 600 g ai ha(-1) as single and double dose respectively on Golden Delicious and Starkrimson cultivars of apple. Samples were collected at 0, 3, 6
Arutselvan Natarajan et al.
Molecular imaging, 14 (2015-03-13)
Manufacturing of 64Cu-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-rituximab injection under good manufacturing practices (GMP) was validated for imaging of patients with CD20+ B-cell non-Hodgkin lymphoma. Rituximab was purified by size exclusion high performance liquid chromatography (HPLC) and conjugated to DOTA-mono-(N-hydroxysuccinimidyl) ester. 64CuCl2, buffers
Shengtao Yu et al.
Scientific reports, 5, 13600-13600 (2015-09-05)
This report investigates the influence of surface chemistry (or wettability) on the evaporation performance of free-standing double-layered thin film on the surface of water. Such newly developed evaporation system is composed of top plasmonic light-to-heat conversion layer and bottom porous
João Conde et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(11), E1278-E1287 (2015-03-04)
Multidrug resistance (MDR) in cancer cells is a substantial limitation to the success of chemotherapy. Here, we describe facile means to overcome resistance by silencing the multidrug resistance protein 1 (MRP1), before chemotherapeutic drug delivery in vivo with a single
Eric Dugat-Bony et al.
PloS one, 10(4), e0124360-e0124360 (2015-04-14)
Cheese ripening is a complex biochemical process driven by microbial communities composed of both eukaryotes and prokaryotes. Surface-ripened cheeses are widely consumed all over the world and are appreciated for their characteristic flavor. Microbial community composition has been studied for
Partha Pratim Bose et al.
Acta tropica, 152, 208-214 (2015-09-24)
Visceral form of leishmaniasis (also known as Kala-azar) is a fatal neglected tropical disease affecting 95 countries worldwide. Recently, substantial proportion of resistance related treatment failure cases have been reported against its first line drug, sodium-antimony gluconate (SAG). We report
Caterina Fede et al.
Microvascular research, 97, 147-155 (2014-12-03)
A new in vitro model system, adding advection and shear stress associated with a flowing medium, is proposed for the investigation of nanoparticles uptake and toxicity towards endothelial cells, since these processes are normally present when nanoparticles formulations are intravenously
Jason Palladino et al.
Developmental cell, 52(3), 379-394 (2020-02-13)
Centromeres are essential for accurate chromosome segregation and are marked by centromere protein A (CENP-A) nucleosomes. Mis-targeted CENP-A chromatin has been shown to seed centromeres at non-centromeric DNA. However, the requirements for such de novo centromere formation and transmission in vivo
Héctor Rodríguez-Rodríguez et al.
Small (Weinheim an der Bergstrasse, Germany), 11(13), 1555-1561 (2014-12-03)
3D remote control of multifunctional fluorescent up-converting nanoparticles (UCNPs) using optical forces is being required for a great variety of applications including single-particle spectroscopy, single-particle intracellular sensing, controlled and selective light-activated drug delivery and light control at the nanoscale. Most
Anderson G M da Silva et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(35), 12314-12320 (2015-08-01)
New AgAu tadpole nanocrystals were synthesized in a one-step reaction involving simultaneous galvanic replacement between Ag nanospheres and AuCl4(-)(aq.) and AuCl4(-)(aq.) reduction to Au in the presence of citrate. The AgAu tadpoles display nodular polycrystalline hollow heads, while their undulating
Maciej J Zelazowski et al.
Cell, 171(3), 601-614 (2017-09-26)
Faithful chromosome segregation in meiosis requires crossover (CO) recombination, which is regulated to ensure at least one CO per homolog pair. We investigate the failure to ensure COs in juvenile male mice. By monitoring recombination genome-wide using cytological assays and
Raphael V Gayet et al.
Nature protocols, 15(9), 3030-3063 (2020-08-19)
Materials that sense and respond to biological signals in their environment have a broad range of potential applications in drug delivery, medical devices and diagnostics. Nucleic acids are important biological cues that encode information about organismal identity and clinically relevant
Andrea J Clark et al.
Frontiers in cell and developmental biology, 4, 120-120 (2016-11-20)
This protocol describes the methods and steps involved in performing biomarker ratio imaging microscopy (BRIM) using formalin fixed paraffin-embedded (FFPE) samples of human breast tissue. The technique is based on the acquisition of two fluorescence images of the same microscopic
Chenchen Bao et al.
Scientific reports, 5, 12297-12297 (2015-07-21)
Gold nanobeacons can be used as a powerful tool for cancer theranostics. Here, we proposed a nanomaterial platform based on gold nanobeacons to detect, target and inhibit the expression of a mutant Kras gene in an in vivo murine gastric
Rasmus I Jølck et al.
Advanced healthcare materials, 3(10), 1680-1687 (2014-04-16)
External beam radiation therapy relies on the ability to deliver high radiation doses to tumor cells with minimal exposure to surrounding healthy tissue. Advanced irradiation techniques, including image-guided radiation therapy (IGRT), rely on the ability to locate tumors to optimize
Benesh Joseph et al.
Nature protocols, 14(8), 2344-2369 (2019-07-07)
Observation of structure and conformational dynamics of membrane proteins at high resolution in their native environments is challenging because of the lack of suitable techniques. We have developed an approach for high-precision distance measurements in the nanometer range for outer-membrane
Alternative QuEChERS-based modular approach for pesticide residue analysis in food of animal origin.
Karolina Lichtmannegger et al.
Analytical and bioanalytical chemistry, 407(13), 3727-3742 (2015-03-17)
The approach for pesticide residue analysis in food of animal origin differs strongly from the one established for food of plant origin, as laboratories mainly focus on conventional methods for the analysis of non-polar pesticides known to accumulate in fatty
Shuang Yang et al.
Nature protocols, 12(6), 1229-1244 (2017-05-19)
Glycosylation has a pivotal role in a diverse range of biological activities, modulating the structure and function of proteins. Glycogens coupled to the nitrogen atom (N-linked) of asparagine side chains or to the oxygen atom (O-linked) of serine and threonine
Chaofan Li et al.
Immunity, 51(3), 491-507 (2019-09-19)
Tissue-resident memory CD8+ T (Trm) cells share core residency gene programs with tumor-infiltrating lymphocytes (TILs). However, the transcriptional, metabolic, and epigenetic regulation of Trm cell and TIL development and function is largely undefined. Here, we found that the transcription factor
Giovanni Bellomo et al.
PloS one, 11(11), e0165730-e0165730 (2016-11-11)
Prostate cancer (PCa) is the most common non-cutaneous cancer in male subjects and the second leading cause of cancer-related death in developed countries. The necessity of a non-invasive technique for the diagnosis of PCa in early stage has grown through
Haijian Luo et al.
Molecular and cellular biochemistry, 397(1-2), 215-222 (2014-08-28)
Granulocyte colony-stimulating factor (G-CSF) is a controversial chemical in cardiac cell therapy. Myocardial homing of mobilized bone marrow-derived cells is thought to play a critical role in observed G-CSF-induced cardiac repair; meanwhile, the activation of proliferative potential of cardiac stem
Elena G Zemtsova et al.
Nanomaterials (Basel, Switzerland), 11(10) (2021-10-24)
The development of new composites with improved functional properties is the important task of modern materials science. The composites must be structurally organized to provide improved properties. For metal-ceramic composites, there is a need for a uniform distribution of the
Delphine Balmer et al.
PloS one, 8(9), e74162-e74162 (2013-09-26)
Glucose is an important metabolic substrate of the retina and diabetic patients have to maintain a strict normoglycemia to avoid diabetes secondary effects, including cardiovascular disease, nephropathy, neuropathy and retinopathy. Others and we recently demonstrated the potential role of hypoglycemia
Lakshminarayana Polavarapu et al.
Small (Weinheim an der Bergstrasse, Germany), 10(15), 3065-3071 (2014-05-03)
The translation of a technology from the laboratory into the real world should meet the demand of economic viability and operational simplicity. Inspired by recent advances in conductive ink pens for electronic devices on paper, we present a "pen-on-paper" approach
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