W368401

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The Gardenia jasminoides extract and its constituent, geniposide, elicit anti-allergic effects on atopic dermatitis by inhibiting histamine in vitro and in vivo.

Yoon-Young Sung et al.

Journal of ethnopharmacology, 156, 33-40 (2014-08-26)

Gardenia jasminoides Ellis has been used in traditional medicine for treatment of inflammation, edema, and dermaitis. The aim of this study was to investigate the mechanism by which Gardenia jasminoides extract (GJE) elicits anti-allergic effects in mast cells and in

Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.

Michael Murphy et al.

The Journal of biological chemistry, 290(31), 19218-19232 (2015-06-18)

Endotoxin tolerance reprograms Toll-like receptor (TLR) 4-mediated macrophage responses by attenuating induction of proinflammatory cytokines while retaining expression of anti-inflammatory and antimicrobial mediators. We previously demonstrated deficient TLR4-induced activation of IL-1 receptor-associated kinase (IRAK) 4, IRAK1, and TANK-binding kinase (TBK)

DJ-1 plays an important role in caffeic acid-mediated protection of the gastrointestinal mucosa against ketoprofen-induced oxidative damage.

Yu-Ting Cheng et al.

The Journal of nutritional biochemistry, 25(10), 1045-1057 (2014-07-20)

Ketoprofen is widely used to alleviate pain and inflammation in clinical medicine; however, this drug may cause oxidative stress and lead to gastrointestinal (GI) ulcers. We previously reported that nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role

Isolation and culture of human oligodendrocyte precursor cells from neurospheres.

Yabin Lu et al.

Brain research bulletin, 118, 17-24 (2015-09-01)

Culture of human oligodendrocyte precursor cells (OPCs) can help understand the regulatory mechanism of differentiation and myelination of oligodendrocytes. However, existing culture methods have limitations, particularly the lack of a source of human donor tissue and high cost. We sorted

High-throughput transcriptomics reveals common and strain-specific responses of human macrophages to infection with Mycobacterium abscessus Smooth and Rough variants.

Anna Aulicino et al.

BMC genomics, 16, 1046-1046 (2015-12-15)

Mycobacterium abscessus (MAB) is an emerging pathogen causing pulmonary infections in those with inflammatory lung disorders, such as Cystic Fibrosis (CF), and is associated with the highest fatality rate among rapidly growing mycobacteria (RGM). Phenotypically, MAB manifests as either a

Pretreatment of Mesenchymal Stem Cells Manipulates Their Vasculoprotective Potential While Not Altering Their Homing Within the Injured Gut.

Dean P J Kavanagh et al.

Stem cells (Dayton, Ohio), 33(9), 2785-2797 (2015-07-01)

Mesenchymal stem cells (MSCs) have shown therapeutic promise in many experimental and clinical models of inflammation. However, a commonly reported feature of MSC transplantation is poor homing to injured tissues. Previously, we have shown that pretreatment with cytokines/chemical factors enhances

Imaging the Interaction of Pancreatic Cancer and Stellate Cells in the Tumor Microenvironment during Metastasis.

Atsushi Suetsugu et al.

Anticancer research, 35(5), 2545-2551 (2015-05-13)

Pancreatic stellate cells are involved in fibrosis of pancreatic cancer termed desmoplasia, which may contribute to both pancreatic cancer growth and metastasis, as well as to drug resistance. A better understanding of pancreatic cancer-cell interactions with stellate cells is therefore

Proteomic analysis of Pteropus alecto kidney cells in response to the viral mimic, Poly I:C.

Lawrence Mok et al.

Proteome science, 13, 25-25 (2015-11-05)

Bats are recognised as an important reservoir for a number of highly pathogenic zoonotic viruses. While many of these viruses cause severe and often fatal disease in humans, bats are able to coexist with these viruses without clinical signs of

ACSL1 Is Associated With Fetal Programming of Insulin Sensitivity and Cellular Lipid Content.

Roy Joseph et al.

Molecular endocrinology (Baltimore, Md.), 29(6), 909-920 (2015-04-29)

Individuals who are born small for gestational age (SGA) have a risk to develop various metabolic diseases during their life course. The biological memory of the prenatal state of growth restricted individuals may be reflected in epigenetic alterations in stem

EGF potentiation of VEGF production is cell density dependent in H292 EGFR wild type NSCLC cell line.

Daniel J Ranayhossaini et al.

International journal of molecular sciences, 15(10), 17686-17704 (2014-10-02)

Non-small cell lung cancer (NSCLC) affects millions of patients each year worldwide. Existing therapies include epidermal growth factor receptor (EGFR) inhibition using small molecules or antibodies with good efficacy. Unfortunately, intrinsic and acquired resistance to EGFR therapy remains a persistent

Confrontation of fibroblasts with cancer cells in vitro: gene network analysis of transcriptome changes and differential capacity to inhibit tumor growth.

Andrey Alexeyenko et al.

Journal of experimental & clinical cancer research : CR, 34, 62-62 (2015-06-18)

There is growing evidence that emerging malignancies in solid tissues might be kept under control by physical intercellular contacts with normal fibroblasts. Here we characterize transcriptional landscapes of fibroblasts that confronted cancer cells. We studied four pairs of in vitro

Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo.

Hironao Nakayama et al.

Scientific reports, 5, 11789-11789 (2015-07-15)

Semaphorin 3F (SEMA3F) provides neuronal guidance cues via its ability to bind neuropilin 2 (NRP2) and Plexin A family molecules. Recent studies indicate that SEMA3F has biological effects in other cell types, however its mechanism(s) of function is poorly understood.

Induction of primordial germ cell-like cells from mouse embryonic stem cells by ERK signal inhibition.

Tohru Kimura et al.

Stem cells (Dayton, Ohio), 32(10), 2668-2678 (2014-07-06)

Primordial germ cells (PGCs) are embryonic germ cell precursors. Specification of PGCs occurs under the influence of mesodermal induction signaling during in vivo gastrulation. Although bone morphogenetic proteins and Wnt signaling play pivotal roles in both mesodermal and PGC specification

Leptin Effect on Acetylation and Phosphorylation of Pgc1α in Muscle Cells Associated With Ampk and Akt Activation in High-Glucose Medium.

Francisco García-Carrizo et al.

Journal of cellular physiology, 231(3), 641-649 (2015-07-29)

Leptin is crucial in energy metabolism, including muscle regulation. Peroxisome proliferator activated receptor gamma co-activator 1α (PGC1α) orchestrates energy metabolism and is tightly controlled by post-translational covalent modifications such as phosphorylation and acetylation. We aimed to further the knowledge of

An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux.

Mark A Gillespie et al.

The EMBO journal, 34(9), 1244-1258 (2015-03-11)

LXR-cofactor complexes activate the gene expression program responsible for cholesterol efflux in macrophages. Inflammation antagonizes this program, resulting in foam cell formation and atherosclerosis; however, the molecular mechanisms underlying this antagonism remain to be fully elucidated. We use promoter enrichment-quantitative

An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation.

Maria Sol Degese et al.

The Biochemical journal, 467(1), 77-90 (2015-01-15)

Mitogen-activated protein kinase (MAPK) pathways constitute key regulatory elements linking extracellular stimuli to nuclear gene expression. Immediate-early responsive genes (IEGs) of the activator protein 1 (AP-1) family, such as fos, achieve peak expression levels shortly after cells are stimulated with

Gram-scale synthesis of single-crystalline graphene quantum dots with superior optical properties.

Liang Wang et al.

Nature communications, 5, 5357-5357 (2014-10-29)

Graphene quantum dots (GQDs) have various alluring properties and potential applications, but their large-scale applications are limited by current synthetic methods that commonly produce GQDs in small amounts. Moreover, GQDs usually exhibit polycrystalline or highly defective structures and thus poor

MicroRNAs are part of the regulatory network that controls EGF induced apoptosis, including elements of the JAK/STAT pathway, in A431 cells.

Ibrahim Alanazi et al.

PloS one, 10(3), e0120337-e0120337 (2015-03-18)

MiRNAs are known to regulate gene expression and in the context of cancer have been shown to regulate metastasis, cell proliferation and cell death. In this report we describe potential miRNA regulatory roles with respect to induction of cell death

The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity.

Widyawilis Selamat et al.

PloS one, 10(6), e0129634-e0129634 (2015-06-13)

The serine/threonine kinase PAK4 is a Cdc42 effector whose role is not well understood; overexpression of PAK4 has been associated with some cancers, and there are reports that correlate kinase level with increased cell migration in vitro. Here we report

Down-Regulation of miR-129-5p and the let-7 Family in Neuroendocrine Tumors and Metastases Leads to Up-Regulation of Their Targets Egr1, G3bp1, Hmga2 and Bach1.

Kristina B V Døssing et al.

Genes, 6(1), 1-21 (2014-12-30)

Expression of miRNAs in Neuroendocrine Neoplasms (NEN) is poorly characterized. We therefore wanted to examine the miRNA expression in Neuroendocrine Tumors (NETs), and identify their targets and importance in NET carcinogenesis. miRNA expression in six NEN primary tumors, six NEN

Inhibition of SGK1 enhances mAR-induced apoptosis in MCF-7 breast cancer cells.

Guilai Liu et al.

Cancer biology & therapy, 16(1), 52-59 (2014-11-27)

Functional membrane androgen receptors (mAR) have previously been described in MCF-7 breast cancer cells. Their stimulation by specific testosterone albumin conjugates (TAC) activate rapidly non-genomic FAK/PI3K/Rac1/Cdc42 signaling, trigger actin reorganization and inhibit cell motility. PI3K stimulates serum and glucocorticoid inducible

In vitro metabolism of testosterone in the horse liver and involvement of equine CYPs 3A89, 3A94 and 3A95.

A Schmitz et al.

Journal of veterinary pharmacology and therapeutics, 37(4), 338-347 (2014-02-01)

Testosterone (TES) 6-β-hydroxylation is a significant metabolic step in the biotransformation of TES in human liver microsomes and reflects cytochrome P450 (CYP) 3A4/5 specific metabolic activity. Several CYP3A enzymes have been annotated in the horse genome, but functional characterization is

Suppression of BRCA1 sensitizes cells to proteasome inhibitors.

Y Gu et al.

Cell death & disease, 5, e1580-e1580 (2014-12-19)

BRCA1 is a multifunctional protein best known for its role in DNA repair and association with breast and ovarian cancers. To uncover novel biologically significant molecular functions of BRCA1, we tested a panel of 198 approved and experimental drugs to

Immune responses to oral vaccination with Salmonella-delivered avian pathogenic Escherichia coli antigens and protective efficacy against colibacillosis.

John Hwa Lee et al.

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 79(3), 229-234 (2015-07-02)

In this study, the immune responses to and protective efficacy of a live attenuated Salmonella-delivered vaccine candidate secreting the papA, papG, iutA, and clpG antigens of Escherichia coli were evaluated against infection with avian pathogenic E. coli (APEC) in layer

Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography.

Shanice V Hudson et al.

Cancer research, 74(21), 6271-6279 (2014-09-14)

Detection of orthotopic xenograft tumors is difficult due to poor spatial resolution and reduced image fidelity with traditional optical imaging modalities. In particular, light scattering and attenuation in tissue at depths beyond subcutaneous implantation hinder adequate visualization. We evaluate the

Secretome of gingival epithelium in response to subgingival biofilms.

N Bostanci et al.

Molecular oral microbiology, 30(4), 323-335 (2015-03-20)

Periodontitis is the chronic inflammatory destruction of periodontal tissues as a result of bacterial biofilm formation on the tooth surface. Proteins secreted by the gingival epithelium challenged by subgingival biofilms represent an important initial response for periodontal inflammation. The aim

Treatment of osteosarcoma with microwave thermal ablation to induce immunogenic cell death.

Zhe Yu et al.

Oncotarget, 5(15), 6526-6539 (2014-08-26)

Microwave ablation (MWA) has been used as a classical hyperthermic ablation method for decades with the intention to induce direct killing of tumor cells or modulation of tumor architecture. The purpose of this study was to explore whether MWA induced

Inverse relationship between raft LRP1 localization and non-raft ERK1,2/MMP9 activation in idiopathic dilated cardiomyopathy: potential impact in ventricular remodeling.

Santiago Roura et al.

International journal of cardiology, 176(3), 805-814 (2014-08-19)

Idiopathic dilated cardiomyopathy (IDCM) is characterized by adverse ventricular remodeling attributed to altered activity of extracellular matrix metalloproteinase (MMP). MMP overactivation is linked to changes in extracellular signal-regulated kinases (ERK), reportedly modulated by the low-density lipoprotein receptor-related protein 1 (LRP1)

Hybrid multiphoton volumetric functional imaging of large-scale bioengineered neuronal networks.

Hod Dana et al.

Nature communications, 5, 3997-3997 (2014-06-06)

Planar neural networks and interfaces serve as versatile in vitro models of central nervous system physiology, but adaptations of related methods to three dimensions (3D) have met with limited success. Here, we demonstrate for the first time volumetric functional imaging

Taurine resumed neuronal differentiation in arsenite-treated N2a cells through reducing oxidative stress, endoplasmic reticulum stress, and mitochondrial dysfunction.

Chien-Te Chou et al.

Amino acids, 47(4), 735-744 (2014-12-31)

The goal of the study is to investigate the preventive effect of taurine against arsenite-induced arrest of neuronal differentiation in N2a cells. Our results revealed that taurine reinstated the neurite outgrowth in arsenite-treated N2a cells. Meanwhile, arsenite-induced oxidative stress and

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