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Showing 1-30 of 50 results for "W402826" within Papers
Pavel Ostašov et al.
Chemistry and physics of lipids, 167-168, 62-69 (2013-03-08)
HEK293 cells stably expressing δ-opioid receptor were labeled first with fluorescent analog of cholesterol, 22-NBD-cholesterol, exposed to cholesterol-depleting agent β-cyclodextrin (β-CDX) and analyzed by fluorescence lifetime imaging microscopy (FLIM). In accordance with chemical analysis of cholesterol level, the total cellular
Saurabh Gautam et al.
Biochemistry, 53(25), 4081-4083 (2014-06-17)
Aggregation of α-synuclein has been implicated in Parkinson's disease (PD). While many compounds are known to inhibit α-synuclein aggregation, dissolution of aggregates into their constituent monomers cannot be readily achieved. In this study, using a range of techniques, we have
Jia-Ming Liu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102, 1-6 (2012-12-04)
β-CD-HMTA-L-Tyr complex, formed in the host guest inclusion reaction carried out between host molecule β-cyclodextrin (β-CD) in β-CD-HMTA (HMTA is methenamine) and guest molecule L-tryptophan (L-Tyr), possessing the characteristic of room temperature phosphorescence (RTP). Bovine serum albumin (BSA) reacted with
Industrial applications of cyclodextrins.
Hedges AR.
Process Biochemistry (Oxford, United Kingdom), 98(5), 2035-2044 (1998)
Andreas Kranawetvogl et al.
Toxicology letters, 222(2), 164-170 (2013-08-03)
Cyclodextrins (CD) are promising small molecular scavengers showing favourable degradation of extremely toxic organophosphorus compounds (OP) such as tabun (GA), soman (GD) or cyclosarin (GF). For β-CD derivatives as potential OP antidotes with low intrinsic toxicity it is of great
Anne-Catherine Servais et al.
Methods in molecular biology (Clifton, N.J.), 970, 289-295 (2013-01-04)
The enantioseparation of acidic and neutral compounds can be successfully achieved in capillary electrophoresis (CE) using dual cyclodextrin (CD) systems. This chapter describes how to separate the enantiomers of acidic or neutral substances using dual CD systems made up of
Andreas Lambertz et al.
The Journal of surgical research, 192(2), 312-316 (2014-08-26)
The systemic palliative chemotherapy of locally extended gastrointestinal and hepatobiliary tumors is associated with a considerable burden for the patient. The aim of this project was to develop a new drug release system to improve the local stent therapy in
Maha Nasr et al.
Pharmaceutical development and technology, 18(5), 1078-1088 (2012-06-05)
The aim of this study was to investigate the effect of two mechanistically different porogens, namely: the hydrophilic hydroxy-propyl-β-cyclodextrin and the hydrophobic porogens (mineral oil and corn oil) in producing open/closed pored engineered polylactide-co-glycolic-acid microspheres suitable for pulmonary delivery of
Fernanda Pérez-Cruz et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102, 226-234 (2012-12-12)
A new nitrooxoisoaporphine derivative was synthetized and characterized by cyclic voltammetry and electron spin resonance. Its aqueous solubility was improved by complexes formation with β-cyclodextrin, heptakis(2,6-di-O-methyl)-β-cyclodextrin and (2-hydroxypropyl)-β-cyclodextrin. In order to assess the inclusion degree reached by nitrooxoisoaporphine in cyclodextris
Biotechnological applications of cyclodextrins.
Singh M, et al.
BioTechnology: An Indian Journal, 20(5), 341-359 (2002)
Zhi Chen et al.
Journal of pharmaceutical sciences, 98(1), 229-238 (2008-04-23)
A high-throughput method has been developed to measure drug-cyclodextrin binding constants. It measures the distribution ratio of a drug between a polymer film [polyvinyl chloride (PVC) with 67% (w/w) dioctyl sebacate (DOS)] and a cyclodextrin-containing buffer in a 96-well format.
Cheng Fang et al.
Biosensors & bioelectronics, 42, 632-639 (2012-12-25)
We demonstrate the selective detection of endocrine disruptor chemicals (EDCs) from river water using surface enhanced Raman scattering (SERS). By means of nanosphere lithography, the SERS substrate was prepared via the initial deposition of a monolayer of silica nanospheres (with
A review on the use of cyclodextrins in foods.
Astray G, et al.
Food Hydrocolloids, 23(7), 1631-1640 (2009)
Yuanqi Lu et al.
Pakistan journal of pharmaceutical sciences, 27(3), 487-490 (2014-05-09)
A method was proposed to determine kaempferol and quercetin in Hippophae rhamnoides L medicinal preparation xindakang tablet by β-cyclodextrin modified micellar electrokinetic capillary chromatography. Under the optimized conditions: buffer solution of 20 mmol/L Na(2)B(4)O(7)-KH(2)PO(4) (pH 9.0)-20mmol/L SDS-6mmol/L β-CD-5%(v/v) MeCN, applied
Jinping Lai et al.
ACS nano, 7(3), 2741-2750 (2013-03-01)
We describe the development of a versatile fluorescence resonance energy transfer (FRET)-based real-time monitoring system, consisting of (a) coumarin-labeled-cysteine tethered mesoporous silica nanoparticles (MSNs) as the drug carrier, (b) a fluorescein isothiocyanate-β-cyclodextrin (FITC-β-CD) as redox-responsive molecular valve blocking the pores
Heather Eng et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(9), 842-848 (2014-03-05)
Glucagon-like peptide-1 (GLP-1)(7-36)amide is a 30-amino acid peptide hormone that is secreted from intestinal enteroendocrine L-cells in response to nutrients. GLP-1(7-36)amide possesses potent insulinotropic actions in the augmentation of glucose-dependent insulin secretion. GLP-1(7-36)amide is rapidly metabolized by dipeptidyl peptidase-IV to
Kaori Yasuda et al.
Biochemical and biophysical research communications, 434(2), 311-315 (2013-04-04)
CYP2R1 is known to be a physiologically important vitamin D 25-hydroxylase. We have successfully expressed human CYP2R1 in Saccharomyces cerevisiae to reveal its enzymatic properties. In this study, we examined production of 25-hydroxylated vitamin D using whole recombinant yeast cells
Renée Onnainty et al.
The journal of physical chemistry. B, 117(1), 206-217 (2012-12-15)
Hydrochlorothiazide (HCT) is one of the most commonly prescribed antihypertensive drugs. In an attempt to gain an insight into the physicochemical and molecular aspects controlling the complex architecture of native β-cyclodextrin (β-CD) with HCT, we performed multiple-temperature-pH isothermal titration calorimetric
Jigang Yu et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 69(Pt 3), 263-266 (2013-03-23)
AmyP is a raw-starch-degrading α-amylase newly identified from a marine metagenome library. It shares low sequence similarity with characterized glycoside hydrolases and was classified into a new subfamily of GH13. In particular, it showed preferential degradation to raw rice starch.
Qunyou Tan et al.
Chemical & pharmaceutical bulletin, 60(12), 1514-1521 (2012-12-05)
Pyridostigmine bromide (PTB) is a highly soluble and extremely bitter drug. Here, an economic complexation technology combined with direct tablet compression method has been developed to meet the requirements of a patient friendly dosage known as taste-masked dispersible tablets loaded
Yutaro Tsuji et al.
Lab on a chip, 13(8), 1476-1481 (2013-03-02)
This paper proposes a solution exchange of a droplet-based lipid bilayer system, in which the inner solution of a droplet is replaced for the purpose of efficient ion channel analyses. In our previous report, we successfully recorded the channel conductance
Dawei Yong et al.
Colloids and surfaces. B, Biointerfaces, 105, 31-36 (2013-01-29)
This research is aimed to develop a nano-sized supramolecular micelle delivery system of cis-dichlorodiammine platinum (II) (CDDP) in order to achieve the passive tumor targeting. Firstly, star-shaped poly (γ-benzyl-L-glutamate) was synthesized by the ring-opening polymerization of γ-benzyl-L-glutamate-N-carboxyanhydride initiated with per-6-amino-β-cyclodextrin.
Eman S Elzanfaly et al.
Acta chimica Slovenica, 60(2), 256-262 (2013-07-25)
This paper reports the construction and evaluation of two ion selective electrodes for the determination midodrine hydrochloride (MD) by direct potentiometry in pure drug substance and in tablet formulations. Precipitation based technique was used for fabrication of the first membrane
Sameena Yousuf et al.
Carbohydrate research, 365, 46-51 (2012-12-04)
Naringenin-7-O-glucoside [Prunin (Pru)] was isolated from the fruit shell of Bixa orellana L. The binding of Pru with calf thymus DNA (ctDNA) and the influence of cyclomaltoheptaose (β-cyclodextrin, β-CD) on the binding were studied by absorption and fluorescence spectroscopic techniques.
Srinivasan Damodaran et al.
Annual review of food science and technology, 4, 327-346 (2013-01-10)
Off-flavors remain a major hurdle in expanding the use of soy protein isolate (SPI) in mainstream food applications. The complexity in solving this problem arises from the presence of protein-bound precursors in SPI. Among the most predominant sources of off-flavors
Golfo G Kordopati et al.
Biochimica et biophysica acta, 1850(1), 159-168 (2014-12-03)
Cyclodextrins (CDs) in combination with therapeutic proteins and other bioactive compounds have been proposed as candidates that show enhanced chemical and enzymatic stability, better absorption, slower plasma clearance and improved dose-response curves or immunogenicity. As a result, an important number
Hanane Messiad et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 926, 21-27 (2013-03-30)
Piceatannol is one of resveratrol derivatives having health promoting potential. However, its low water-solubility and bioavailability could limit its use in both food and pharmaceutical fields. The aim of this work is the study of piceatannol complexation by β-cyclodextrin (β-CD)
Junping Zeng et al.
Colloids and surfaces. B, Biointerfaces, 105, 120-127 (2013-02-05)
This research is aimed to develop a kind of hollow nanosphere based on β-cyclodextrin-grafted α, β-poly(aspartic acid) (β-CD-graft-PAsp) as drug carrier to enhance the stability of camptothecin (CPT) in aqueous media. Firstly, mono(6-(2-aminoethyl) amino-6-deoxy)-β-cyclodextrin (β-CDen) was synthesized by a substitution
Yassin M Temerk et al.
Analytical and bioanalytical chemistry, 405(11), 3839-3846 (2013-01-22)
The binding of antitumor flavonoids, namely 3-hydroxyflavone (3HF) and hesperidin (Hesp) with dsDNA was investigated in the absence and presence of Cu(II) using cyclic voltammetry and square wave voltammetry at the hanging mercury drop electrode. The reduction currents of 3HF
Erik T Jansson et al.
Molecular pain, 9, 1-1 (2013-01-03)
The TRPV1 ion channel is expressed in nociceptors, where pharmacological modulation of its function may offer a means of alleviating pain and neurogenic inflammation processes in the human body. The aim of this study was to investigate the effects of
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