Alessandra Brambati et al.
Nucleic acids research, 46(3), 1227-1239 (2017-10-24)
The yeast RNA/DNA helicase Sen1, Senataxin in human, preserves the integrity of replication forks encountering transcription by removing RNA-DNA hybrids. Here we show that, in sen1 mutants, when a replication fork clashes head-on with transcription is arrested and, as a