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Showing 1-30 of 330 results for "WGA2" within Papers
Anita Minnen et al.
Molecular microbiology, 81(3), 676-688 (2011-06-10)
Segregation of replicated chromosomes is an essential process in all organisms. How bacteria, such as the oval-shaped human pathogen Streptococcus pneumoniae, efficiently segregate their chromosomes is poorly understood. Here we show that the pneumococcal homologue of the DNA-binding protein ParB
Ashley M Bushey et al.
Genes & development, 23(11), 1338-1350 (2009-05-16)
Insulators are protein-bound DNA elements that are thought to play a role in chromatin organization and the regulation of gene expression by mediating intra- and interchromosomal interactions. Suppressor of Hair-wing [Su(Hw)] and Drosophila CTCF (dCTCF) insulators are found at distinct
Katie E Fowler et al.
BMC genomics, 14, 784-784 (2013-11-15)
Obesity, excess fat tissue in the body, can underlie a variety of medical complaints including heart disease, stroke and cancer. The pig is an excellent model organism for the study of various human disorders, including obesity, as well as being
Tamar Sofer et al.
Epigenomics, 5(2), 147-154 (2013-04-10)
Asthma exacerbation and other respiratory symptoms are associated with exposure to air pollution. Since environment affects gene methylation, it is hypothesized that asthmatic responses to pollution are mediated through methylation. We study the possibility that airborne particulate matter affects gene
Solenne Dumont et al.
Oncotarget, 9(22), 15883-15894 (2018-04-18)
The PGC-1 (Peroxisome proliferator-activated receptor Gamma Coactivator-1) family of coactivators (PGC-1α, PGC-1β, and PRC) plays a central role in the transcriptional control of mitochondrial biogenesis and oxidative phosphorylation (OXPHOS) processes. These coactivators integrate mitochondrial energy production into cell metabolism using
Chiara Molinari et al.
OncoTargets and therapy, 9, 2735-2742 (2016-05-27)
Neoadjuvant chemoradiotherapy (NCRT) followed by surgery is the gold standard for the treatment of patients with locally advanced rectal cancer (LARC). However, response is variable, and no predictive markers have been validated. The amplification of 13q31-34 seemed to distinguish between
Giulia Grimaldi et al.
Molecular endocrinology (Baltimore, Md.), 25(11), 1892-1903 (2011-09-10)
Differentiation of human endometrial stromal cells (HESC) into decidual cells represents a highly coordinated process essential for embryo implantation. We show that decidualizing HESC down-regulate the histone methyltransferase enhancer of Zeste homolog 2 (EZH2), resulting in declining levels of trimethylation
Zsolt Toth et al.
PLoS pathogens, 6(7), e1001013-e1001013 (2010-07-28)
Epigenetic modifications of the herpesviral genome play a key role in the transcriptional control of latent and lytic genes during a productive viral lifecycle. In this study, we describe for the first time a comprehensive genome-wide ChIP-on-Chip analysis of the
Caroline Brossas et al.
The EMBO journal, 39(21), e99520-e99520 (2020-09-17)
Vertebrate genomes replicate according to a precise temporal program strongly correlated with their organization into A/B compartments. Until now, the molecular mechanisms underlying the establishment of early-replicating domains remain largely unknown. We defined two minimal cis-element modules containing a strong
Anna-Mia Johansson et al.
Nucleic acids research, 39(15), 6428-6439 (2011-05-10)
In Drosophila, the global increase in transcription from the male X chromosome to compensate for its monosomy is mediated by the male-specific lethal (MSL) complex consisting of five proteins and two non-coding RNAs, roX1 and roX2. After an initial sequence-dependent
Zhong Zhao et al.
Nature, 465(7301), 1089-1092 (2010-06-26)
The classic phytohormones cytokinin and auxin play essential roles in the maintenance of stem-cell systems embedded in shoot and root meristems, and exhibit complex functional interactions. Here we show that the activity of both hormones directly converges on the promoters
Belén Gómez-González et al.
The EMBO journal, 30(15), 3106-3119 (2011-06-28)
THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis and prevents transcription-associated recombination. Whether or not it has a ubiquitous role in the genome is unknown. Chromatin immunoprecipitation (ChIP)-chip studies reveal that the Hpr1 component of THO and
Koichi Suzuki et al.
PloS one, 5(8), e12422-e12422 (2010-09-25)
Identification of pathogen DNA from archaeological human remains is a powerful tool in demonstrating that the infectious disease existed in the past. However, it is very difficult to detect trace amounts of DNA remnants attached to the human skeleton, especially
Boyuan Wang et al.
FEBS letters, 592(18), 3183-3197 (2018-08-15)
Missense mutations in the p53 coding gene cause loss and gain of function. We have identified a hotspot mutation, p53N236S , which results in the aggressive progression of tumorigenesis in a knock-in mouse model. To understand the biological significance of
Y R Thorstenson et al.
Genome research, 8(8), 848-855 (1998-09-02)
An automated, inexpensive, easy-to-use, and reproducible technique for controlled, random DNA fragmentation has been developed. The technique is based on point-sink hydrodynamics that result when a DNA sample is forced through a small hole by a syringe pump. Commercially available
Maryou B Lambros et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 24(22), 5635-5644 (2018-08-11)
Purpose: Circulating tumor cells (CTCs) have clinical relevance, but their study has been limited by their low frequency.Experimental Design: We evaluated liquid biopsies by apheresis to increase CTC yield from patients suffering from metastatic prostate cancer, allow precise gene copy-number
Yu Wu et al.
The Journal of molecular diagnostics : JMD, 18(1), 131-143 (2015-11-27)
Circulating tumor cells and disseminated tumor cells (DTCs) are of great interest because they provide a minimally invasive window for assessing aspects of cancer biology, including tumor heterogeneity, a means to discover biomarkers of disease behavior, and a way to
Robert S Illingworth et al.
PloS one, 7(4), e34848-e34848 (2012-04-13)
The essential histone variant H2A.Z localises to both active and silent chromatin sites. In embryonic stem cells (ESCs), H2A.Z is also reported to co-localise with polycomb repressive complex 2 (PRC2) at developmentally silenced genes. The mechanism of H2A.Z targeting is
Lina E Lundberg et al.
G3 (Bethesda, Md.), 3(8), 1325-1334 (2013-06-05)
In Drosophila melanogaster, two chromosome-specific targeting and regulatory systems have been described. The male-specific lethal (MSL) complex supports dosage compensation by stimulating gene expression from the male X-chromosome, and the protein Painting of fourth (POF) specifically targets and stimulates expression
Ricco Lindner et al.
Scientific data, 1, 140038-140038 (2014-01-01)
The regulatory mechanisms responsible for the gene expression pattern associated with axotomy-dependent signaling affecting the neuronal phenotype, including the axonal regenerative program, remain unclear. To further this understanding, we recently performed DNA methylation temporal profiling in lumbar dorsal root ganglia
Nima Nabavizadeh et al.
Integrative biology : quantitative biosciences from nano to macro, 3(4), 490-496 (2011-03-19)
In animal and laboratory models, cancer-associated stroma, or elements of the supporting tissue surrounding a primary tumor, has been shown to be necessary for tumor evolution and progression. However, little is understood or studied regarding the properties of intact stroma
Noemí García-Romero et al.
Oncotarget, 8(1), 1416-1428 (2016-12-03)
Tumor-cell-secreted extracellular vesicles (EVs) can cross the disrupted blood-brain barrier (BBB) into the bloodstream. However, in certain gliomas, the BBB remains intact, which might limit EVs release. To evaluate the ability of tumor-derived EVs to cross the BBB, we used
Alexandre Gaspar-Maia et al.
Nature, 460(7257), 863-868 (2009-07-10)
An open chromatin largely devoid of heterochromatin is a hallmark of stem cells. It remains unknown whether an open chromatin is necessary for the differentiation potential of stem cells, and which molecules are needed to maintain open chromatin. Here we
Liqing Wang et al.
Blood, 121(18), 3631-3639 (2013-02-28)
Protocols to use Foxp3+ T-regulatory (Treg) cells for cellular therapy, especially postallogeneic stem cell transplantation, are currently being developed and tested by various groups. Inhibitors of DNA methyltransferase (Dnmt) enzymes have been advocated as a means to promote and stabilize
Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex.
Sonia V Forcales et al.
The EMBO journal, 31(2), 301-316 (2011-11-10)
Tissue-specific transcriptional activators initiate differentiation towards specialized cell types by inducing chromatin modifications permissive for transcription at target loci, through the recruitment of SWItch/Sucrose NonFermentable (SWI/SNF) chromatin-remodelling complex. However, the molecular mechanism that regulates SWI/SNF nuclear distribution in response to
Peter V Kharchenko et al.
Nature, 471(7339), 480-485 (2010-12-24)
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on
Qinglin Shen et al.
International journal of nanomedicine, 11, 2133-2146 (2016-06-09)
Selection of the optimal chemotherapy regimen for an individual cancer patient is challenging. The existing chemosensitivity tests are costly, time-consuming, and not amenable to wide utilization within a clinic. This limitation might be addressed by the recently proposed use of
Ilona N Holcomb et al.
Cancer research, 69(19), 7793-7802 (2009-09-24)
Androgen deprivation is the mainstay of therapy for progressive prostate cancer. Despite initial and dramatic tumor inhibition, most men eventually fail therapy and die of metastatic castration-resistant (CR) disease. Here, we characterize the profound degree of genomic alteration found in
John P Thomson et al.
Nucleic acids research, 41(11), 5639-5654 (2013-04-20)
Aberrant DNA methylation is a common feature of neoplastic lesions, and early detection of such changes may provide powerful mechanistic insights and biomarkers for carcinogenesis. Here, we investigate dynamic changes in the mouse liver DNA methylome associated with short (1
Savita Sankar et al.
Scientific reports, 6, 37412-37412 (2016-11-25)
Neural cell fate acquisition is mediated by transcription factors expressed in nascent neuroectoderm, including Geminin and members of the Zic transcription factor family. However, regulatory networks through which this occurs are not well defined. Here, we identified Geminin-associated chromatin locations
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