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Showing 1-30 of 330 results for "WGA2" within Papers
Comparative metagenomics of viral assemblages inhabiting four phyla of marine invertebrates
Gudenkauf BM and Hewson I
Frontiers in Marine Science, 3, 23-23 (2016)
Ashley M Bushey et al.
Genes & development, 23(11), 1338-1350 (2009-05-16)
Insulators are protein-bound DNA elements that are thought to play a role in chromatin organization and the regulation of gene expression by mediating intra- and interchromosomal interactions. Suppressor of Hair-wing [Su(Hw)] and Drosophila CTCF (dCTCF) insulators are found at distinct
Tamar Sofer et al.
Epigenomics, 5(2), 147-154 (2013-04-10)
Asthma exacerbation and other respiratory symptoms are associated with exposure to air pollution. Since environment affects gene methylation, it is hypothesized that asthmatic responses to pollution are mediated through methylation. We study the possibility that airborne particulate matter affects gene
Nima Nabavizadeh et al.
Integrative biology : quantitative biosciences from nano to macro, 3(4), 490-496 (2011-03-19)
In animal and laboratory models, cancer-associated stroma, or elements of the supporting tissue surrounding a primary tumor, has been shown to be necessary for tumor evolution and progression. However, little is understood or studied regarding the properties of intact stroma
Giulia Grimaldi et al.
Molecular endocrinology (Baltimore, Md.), 25(11), 1892-1903 (2011-09-10)
Differentiation of human endometrial stromal cells (HESC) into decidual cells represents a highly coordinated process essential for embryo implantation. We show that decidualizing HESC down-regulate the histone methyltransferase enhancer of Zeste homolog 2 (EZH2), resulting in declining levels of trimethylation
Qiuyue Chen et al.
Journal of virology, 87(1), 659-665 (2012-11-02)
Hepatitis C virus (HCV) does not replicate efficiently in wild-type human hepatoma Huh-7 cells, but it replicates robustly in certain subclones of Huh-7 cells. Previously, we demonstrated that silencing of cyclic AMP (cAMP) response element binding protein 3-like 1 (CREB3L1)
Kei Fukuda et al.
Journal of human genetics, 58(7), 446-454 (2013-06-07)
Changes in gene expression have been proposed to have an important role in the evolutionary changes in phenotypes. Interspecific changes in gene expression can result not only from genetic changes in regulatory regions but also from epigenetic changes in such
Caroline J Woo et al.
Molecular and cellular biology, 33(16), 3274-3285 (2013-06-19)
Polycomb group (PcG)-mediated repression is an evolutionarily conserved process critical for cell fate determination and maintenance of gene expression during embryonic development. However, the mechanisms underlying PcG recruitment in mammals remain unclear since few regulatory sites have been identified. We
Zhenbin Chen et al.
Diseases of the colon and rectum, 55(6), 677-685 (2012-05-19)
Lymph node metastasis is an important indicator of oncologic outcome for patients with rectal cancer. Identifying predictive biomarkers of lymph node metastasis could therefore be clinically useful. The aim of this study was to assess whether chromosomal copy number alterations
Xiaosong Liu et al.
Cell research, 18(12), 1177-1189 (2008-11-26)
Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these factors regulate the developmental signaling network necessary for ES cell
Amit Sharma et al.
Clinical epigenetics, 7, 76-76 (2015-07-30)
Abnormal sex chromosome numbers in humans are observed in Turner (45,X) and Klinefelter (47,XXY) syndromes. Both syndromes are associated with several clinical phenotypes, whose molecular mechanisms are obscure, and show a range of inter-individual penetrance. In order to understand the
M Girardot et al.
Oncogene, 34(10), 1323-1332 (2014-04-01)
STAT (Signal Transducer and Activator of Transcription) transcription factors are constitutively activated in most hematopoietic cancers. We previously identified a target gene, LPP/miR-28 (LIM domain containing preferred translocation partner in lipoma), induced by constitutive activation of STAT5, but not by
Xiuwan Wang et al.
Viruses, 14(7) (2022-07-28)
Feline panleukopenia (FPL), a highly contagious and frequently fatal disease of cats, is caused by Feline parvovirus (FPV) and Canine parvovirus (CPV). We characterised the diversity of these Carnivore protoparvovirus 1 variants in 18 faecal samples collected from domestic cats
John P Thomson et al.
Nucleic acids research, 41(22), e206-e206 (2013-11-12)
The epigenetic modification of 5-hydroxymethylcytosine (5hmC) is receiving great attention due to its potential role in DNA methylation reprogramming and as a cell state identifier. Given this interest, it is important to identify reliable and cost-effective methods for the enrichment
David J VanderWeele et al.
Cancer science, 105(8), 1079-1085 (2014-06-04)
Understanding the developmental relationship between indolent and aggressive tumors is central to understanding disease progression and making treatment decisions. For example, most men diagnosed with prostate cancer have clinically indolent disease and die from other causes. Overtreatment of prostate cancer
Henryk Dreger et al.
Hypertension (Dallas, Tex. : 1979), 60(5), 1176-1183 (2012-09-12)
The histone methyltransferase enhancer of zeste homolog 2 (Ezh2) mediates trimethylation of lysine 27 in histone 3, which acts as a repressive epigenetic mark. Ezh2 is essential for maintaining pluripotency of stem cells, but information on its role in differentiated
Theresia Lassak et al.
Molecular microbiology, 82(3), 602-618 (2011-09-20)
Efg1 is a central transcriptional regulator of morphogenesis and metabolism in Candida albicans. In vivo genome-wide ChIP chip and in vitro footprint analyses revealed the Efg1 recognition sequence (EGR-box) TATGCATA in the yeast growth form of this human fungal pathogen.
Michael Korenjak et al.
Nucleic acids research, 42(14), 8939-8953 (2014-07-24)
dREAM complexes represent the predominant form of E2F/RBF repressor complexes in Drosophila. dREAM associates with thousands of sites in the fly genome but its mechanism of action is unknown. To understand the genomic context in which dREAM acts we examined
Novel cell enrichment technique for robust genetic analysis of archival classical Hodgkin lymphoma tissues
Juskevicius D, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 98, 1487-1499 (2018)
AhRam Yoon et al.
Nutrition research and practice, 11(2), 105-113 (2017-04-08)
A high-fat diet (HFD) induces obesity, which is a major risk factor for cardiovascular disease and cancer, while a calorie-restricted diet can extend life span by reducing the risk of these diseases. It is known that health effects of diet
Richard S Lee et al.
Epigenetics, 6(11), 1378-1390 (2011-11-04)
Comprehensive High-throughput Arrays for Relative Methylation (CHARM) was recently developed as an experimental platform and analytic approach to assess DNA methylation (DNAm) at a genome-wide level. Its initial implementation was for human and mouse. We adapted it for rat and
Michael B Stadler et al.
Nature, 480(7378), 490-495 (2011-12-16)
Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet the rules that govern methylation patterns remain largely elusive. To gain insights into this process, we generated base-pair-resolution mouse methylomes in stem cells and neuronal progenitors. Advanced quantitative
Joscha Muck
Genomics data, 2, 82-84 (2015-10-21)
The nuclear positioning of mammalian genes often correlates with their functional state. For instance, the human cystic fibrosis transmembrane conductance regulator (CFTR) gene associates with the nuclear periphery in its inactive state, but occupies interior positions when active. Treatment with
George Seed et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(20), 6070-6077 (2017-07-29)
Purpose: Precise detection of copy number aberrations (CNA) from tumor biopsies is critically important to the treatment of metastatic prostate cancer. The use of targeted panel next-generation sequencing (NGS) is inexpensive, high throughput, and easily feasible, allowing single-nucleotide variant calls
Silvia Peluso et al.
eLife, 6 (2017-09-28)
Sonic hedgehog (Shh) expression in the limb bud organizing centre called the zone of polarizing activity is regulated by the ZRS enhancer. Here, we examine in mouse and in a mouse limb-derived cell line the dynamic events that activate and
Identification of key genes and pathways associated with different immune statuses of hepatitis B virus infection
Jin J, et al
Journal of Cellular and Molecular Medicine, 23, 7474-7489 (2019)
Xin Chen et al.
Scientific data, 3, 160079-160079 (2016-09-14)
The molecular basis underlying the dedifferentiation of mammalian adult cardiomyocytes (ACMs) into myocyte-derived cardiac progenitor cells (mCPCs) during cardiac tissue regeneration is poorly understood. We present data integrating single-cell transcriptome and whole-genome DNA methylome analyses of mouse mCPCs to understand
Tiffany Hung et al.
Molecular cell, 33(2), 248-256 (2009-02-04)
Aberrations in chromatin dynamics play a fundamental role in tumorigenesis, yet relatively little is known of the molecular mechanisms linking histone lysine methylation to neoplastic disease. ING4 (Inhibitor of Growth 4) is a native subunit of an HBO1 histone acetyltransferase
Peter C Hollenhorst et al.
Genes & development, 21(15), 1882-1894 (2007-07-27)
The conservation of in vitro DNA-binding properties within families of transcription factors presents a challenge for achieving in vivo specificity. To uncover the mechanisms regulating specificity within the ETS gene family, we have used chromatin immunoprecipitation coupled with genome-wide promoter
Xoana Taboada et al.
Chromosoma, 123(3), 281-291 (2014-01-30)
Bacterial artificial chromosomes (BAC) have been widely used for fluorescence in situ hybridization (FISH) mapping of chromosome landmarks in different organisms, including a few in teleosts. In this study, we used BAC-FISH to consolidate the previous genetic and cytogenetic maps
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