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Showing 1-30 of 330 results for "WGA2" within Papers
Beatrice Milon et al.
BMC genomics, 15, 988-988 (2014-11-20)
Chromatin compactness has been considered a major determinant of gene activity and has been associated with specific chromatin modifications in studies on a few individual genetic loci. At the same time, genome-wide patterns of open and closed chromatin have been
Katie E Fowler et al.
BMC research notes, 5, 503-503 (2012-09-15)
The ability to transport and store DNA at room temperature in low volumes has the advantage of optimising cost, time and storage space. Blood spots on adapted filter papers are popular for this, with FTA (Flinders Technology Associates) Whatman™TM technology
Mark D Robinson et al.
Genome research, 20(12), 1719-1729 (2010-11-04)
DNA methylation is an essential epigenetic modification that plays a key role associated with the regulation of gene expression during differentiation, but in disease states such as cancer, the DNA methylation landscape is often deregulated. There are now numerous technologies
Zhihao Ding et al.
PLoS genetics, 10(11), e1004798-e1004798 (2014-11-21)
Associating genetic variation with quantitative measures of gene regulation offers a way to bridge the gap between genotype and complex phenotypes. In order to identify quantitative trait loci (QTLs) that influence the binding of a transcription factor in humans, we
Jason G Wood et al.
Aging cell, 9(6), 971-978 (2010-10-22)
Chromatin structure affects the accessibility of DNA to transcription, repair, and replication. Changes in chromatin structure occur during development, but less is known about changes during aging. We examined the state of chromatin structure and its effect on gene expression
Yixin H Ye et al.
PloS one, 8(6), e66482-e66482 (2013-07-11)
Cytosine methylation is one of several reversible epigenetic modifications of DNA that allow a greater flexibility in the relationship between genotype and phenotype. Methylation in the simplest models dampens gene expression by modifying regions of DNA critical for transcription factor
Ivan Psakhye et al.
Molecular cell, 76(4), 632-645 (2019-09-15)
Similar to ubiquitin, SUMO forms chains, but the identity of SUMO-chain-modified factors and the purpose of this modification remain largely unknown. Here, we identify the budding yeast SUMO protease Ulp2, able to disassemble SUMO chains, as a DDK interactor enriched at
Darius Juskevicius et al.
Laboratory investigation; a journal of technical methods and pathology, 98(11), 1487-1499 (2018-08-09)
Approximately 15% of patients with classical Hodgkin lymphoma (cHL) die after relapse or progressive disease. Comprehensive genetic characterization is required to better understand its molecular pathology and improve management. However, genetic information on cHL is hard to obtain mainly due
Wenzhe Liu et al.
Molecular and biochemical parasitology, 186(2), 139-142 (2012-09-25)
RNA polymerase II (RNAP-II) synthesizes the m(7)G-capped Spliced Leader (SL) RNA and most protein-coding mRNAs in trypanosomes. RNAP-II recruitment to DNA usually requires a set of transcription factors that make sequence-specific contacts near transcriptional start sites within chromosomes. In trypanosomes
Simon Mead et al.
Human mutation, 29(12), 1452-1458 (2008-06-14)
Highly accurate and high-throughput SNP genotyping platforms are increasingly popular but the performance of suboptimal DNA samples remains unclear. The aim of our study was to determine the best platform, amplification technique, and loading concentration to maximize genotype accuracy and
María-José Ferrándiz et al.
PloS one, 9(7), e101574-e101574 (2014-07-16)
The most basic level of transcription regulation in Streptococcus pneumoniae is the organization of its chromosome in topological domains. In response to drugs that caused DNA-relaxation, a global transcriptional response was observed. Several chromosomal domains were identified based on the
Marcel W Coolen et al.
Nature cell biology, 12(3), 235-246 (2010-02-23)
Silencing of individual genes can occur by genetic and epigenetic processes during carcinogenesis, but the underlying mechanisms remain unclear. By creating an integrated prostate cancer epigenome map using tiling arrays, we show that contiguous regions of gene suppression commonly occur
Johan Bélteky et al.
Genetics, selection, evolution : GSE, 50(1), 13-13 (2018-04-04)
Domestication of animals leads to large phenotypic alterations within a short evolutionary time-period. Such alterations are caused by genomic variations, yet the prevalence of modified traits is higher than expected if they were caused only by classical genetics and mutations.
Luis G Acevedo et al.
BioTechniques, 43(6), 791-797 (2008-02-07)
The technique of chromatin immunoprecipitation (ChIP) is a powerful method for identifying in vivo DNA binding sites of transcription factors and for studying chromatin modifications. Unfortunately, the large number of cells needed for the standard ChIP protocol has hindered the
Kohzoh Mitsuya et al.
PloS one, 12(10), e0186115-e0186115 (2017-10-19)
The inflammatory and metabolic derangements of obesity in pregnant women generate an adverse intrauterine environment, increase pregnancy complications and adverse fetal outcomes and program the fetus for obesity and metabolic syndrome in later life. We hypothesized that epigenetic modifications in
Caroline J Woo et al.
Cell, 140(1), 99-110 (2010-01-21)
Polycomb group (PcG) proteins are essential for accurate axial body patterning during embryonic development. PcG-mediated repression is conserved in metazoans and is targeted in Drosophila by Polycomb response elements (PREs). However, targeting sequences in humans have not been described. While
Michael Y Fessing et al.
The Journal of cell biology, 194(6), 825-839 (2011-09-21)
During development, multipotent progenitor cells establish tissue-specific programs of gene expression. In this paper, we show that p63 transcription factor, a master regulator of epidermal morphogenesis, executes its function in part by directly regulating expression of the genome organizer Satb1
James Rees Powell et al.
Scientific reports, 5, 7975-7975 (2015-01-23)
Genotoxins cause DNA damage, which can result in genomic instability. The genetic changes induced have far-reaching consequences, often leading to diseases such as cancer. A wide range of genotoxins exists, including radiations and chemicals found naturally in the environment, and
Ramji K Bhandari et al.
PloS one, 7(9), e43380-e43380 (2012-09-18)
A major event in mammalian male sex determination is the induction of the testis determining factor Sry and its downstream gene Sox9. The current study provides one of the first genome wide analyses of the downstream gene binding targets for
Duojia Zhang et al.
Fertility and sterility, 102(5), 1458-1467 (2014-08-26)
To identify aberrantly methylated candidate genes that are involved in the development of polycystic ovary syndrome (PCOS). Animal model. University-affiliated laboratory. Sprague-Dawley rats. The prenatally androgenized (PNA) rat model was established. Pregnant rats were treated with daily SC injections of
Richard Bourgon et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(8), 2080-2091 (2014-02-28)
Tailoring cancer treatment to tumor molecular characteristics promises to make personalized medicine a reality. However, reliable genetic profiling of archived clinical specimens has been hindered by limited sensitivity and high false-positive rates. Here, we describe a novel methodology, MMP-seq, which
Marek Bartkuhn et al.
The EMBO journal, 28(7), 877-888 (2009-02-21)
For the compact Drosophila genome, several factors mediating insulator function, such as su(Hw) and dCTCF, have been identified. Recent analyses showed that both these insulator-binding factors are functionally dependent on the same cofactor, CP190. Here we analysed genome-wide binding of
Mehrdad Noruzinia et al.
Asian Pacific journal of cancer prevention : APJCP, 22(8), 2371-2375 (2021-08-29)
Breast cancer is a highly diverse disease, and epigenomic alterations, as principle changes in the pathogenesis of breast cancer, have recently been noticed in epimarker research on peripheral blood. In this study, DNA samples isolated from the white blood cells
Pedro Mendez et al.
Scientific reports, 7(1), 4055-4055 (2017-06-24)
Sequencing key cancer-driver genes using formalin-fixed, paraffin-embedded (FFPE) cancer tissues is becoming the standard for identifying the best treatment regimen. However, about 25% of all samples are rejected for genetic analyses for reasons that include too little tissue to extract
Paola Merlo et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(50), 18055-18060 (2014-12-03)
DNA damage has been implicated in neurodegenerative disorders, including Alzheimer's disease and other tauopathies, but the consequences of genotoxic stress to postmitotic neurons are poorly understood. Here we demonstrate that p53, a key mediator of the DNA damage response, plays
Yu-Long Hu et al.
Molecular and cellular biology, 29(18), 5181-5192 (2009-07-22)
While investigating the mechanism of action of the HOXA9 protein, we serendipitously identified Meis1 as a HOXA9 regulatory target. Since HOXA9 and MEIS1 play key developmental roles, are cooperating DNA binding proteins and leukemic oncoproteins, and are important for normal
Michael K Skinner et al.
Environmental epigenetics, 1(1), dvv004-dvv004 (2016-05-14)
A critical transcription factor required for mammalian male sex determination is SRY (sex determining region on the Y chromosome). The expression of SRY in precursor Sertoli cells is one of the initial events in testis development. The current study was
Betül Hekimoglu-Balkan et al.
RNA biology, 9(3), 314-325 (2012-02-18)
Non-coding (nc) RNAs are involved both in recruitment of vertebrate Polycomb (PcG) proteins to chromatin, and in activation of PcG target genes. Here we investigate dynamic changes in the relationship between ncRNA transcription and recruitment of PcG proteins to chromatin
Eugen Dhimolea et al.
PloS one, 9(7), e99800-e99800 (2014-07-06)
Exposure to environmental estrogens (xenoestrogens) may play a causal role in the increased breast cancer incidence which has been observed in Europe and the US over the last 50 years. The xenoestrogen bisphenol A (BPA) leaches from plastic food/beverage containers
Juliana Mazzuchelli et al.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 19(5), 657-667 (2011-06-22)
To better understand the genomic organization and evolution of Sox genes in vertebrates, we cytogenetically mapped Sox2 and Sox14 genes in cichlid fishes and performed comparative analyses of their orthologs in several vertebrate species. The genomic regions neighboring Sox2 and
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