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Showing 1-30 of 86 results for "XNAT" within Papers
Zaid Mohsen et al.
Brain structure & function, 222(9), 4111-4129 (2017-06-16)
Prokineticin receptor 2 (PROKR2) is predominantly expressed in the mammalian central nervous system. Loss-of-function mutations of PROKR2 in humans are associated with Kallmann syndrome due to the disruption of gonadotropin releasing hormone neuronal migration and deficient olfactory bulb morphogenesis. PROKR2
Satvinder Kaur et al.
Nature communications, 11(1), 2769-2769 (2020-06-04)
During obstructive sleep apnea, elevation of CO2 during apneas contributes to awakening and restoring airway patency. We previously found that glutamatergic neurons in the external lateral parabrachial nucleus (PBel) containing calcitonin gene related peptide (PBelCGRP neurons) are critical for causing
Lindsay K Klofas et al.
Human molecular genetics, 29(8), 1365-1377 (2020-04-14)
Mutations in DEP domain containing 5 (DEPDC5) are increasingly appreciated as one of the most common causes of inherited focal epilepsy. Epilepsies due to DEPDC5 mutations are often associated with brain malformations, tend to be drug-resistant, and have been linked
Marcio A Torsoni et al.
Endocrinology, 157(12), 4803-4816 (2016-10-13)
A temporary and reversible inhibition of the hypothalamo-pituitary-gonadal axis is adaptive when energy reserves are diminished, allowing individual survival and energy accumulation for eventual reproduction. The AMP-activated protein kinase (AMPK) works as a cellular sensor of the AMP to ATP
Hira Raheel et al.
American journal of physiology. Lung cellular and molecular physiology, 316(5), L740-L750 (2019-02-01)
In healthy blood vessels, albumin crosses the endothelium to leave the circulation by transcytosis. However, little is known about the regulation of albumin transcytosis or how it differs in different tissues; its physiological purpose is also unclear. Using total internal
Kim M Chau et al.
Biology of reproduction, 84(1), 140-152 (2010-09-03)
The cystatin CRES (cystatin-related epididymal spermatogenic; Cst8) is the defining member of a reproductive subgroup of family 2 cystatins of cysteine protease inhibitors and is present in the epididymis and spermatozoa, suggesting roles in sperm maturation and fertilization. To elucidate
Elena Hernandez-Encinas et al.
Journal of neuroinflammation, 12, 14-14 (2015-01-27)
The CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor, which was first identified as a regulator of differentiation and inflammatory processes mainly in adipose tissue and liver; however, its function in the brain was largely unknown for many years. Previous
Megan K Ruhland et al.
Nature communications, 7, 11762-11762 (2016-06-09)
Age is a significant risk factor for the development of cancer. However, the mechanisms that drive age-related increases in cancer remain poorly understood. To determine if senescent stromal cells influence tumorigenesis, we develop a mouse model that mimics the aged
Meredith H Wilson et al.
eLife, 10 (2021-08-14)
Cytoplasmic lipid droplets are highly dynamic storage organelles that are critical for cellular lipid homeostasis. While the molecular details of lipid droplet dynamics are a very active area of investigation, this work has been primarily performed in cultured cells. Taking
Elnaz Moghimi et al.
PloS one, 10(5), e0126355-e0126355 (2015-05-29)
Dietary vitamin D3 (D3) restriction reduces paw grip endurance and motor performance in G93A mice, and increases inflammation and apoptosis in the quadríceps of females. ALS, a neuromuscular disease, causes progressive degeneration of motor neurons in the brain and spinal
Timothy B Brown et al.
Human molecular genetics, 17(20), 3095-3104 (2008-07-18)
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease caused by an expanded polyglutamine tract in the ubiquitously expressed huntingtin protein. Clinically, HD is characterized by motor, cognitive and psychiatric deficits. Striking degeneration of the striatum is observed in HD with
Luisa Ojeda-Fernández et al.
PLoS genetics, 12(3), e1005935-e1005935 (2016-03-25)
Endoglin is an auxiliary receptor for members of the TGF-β superfamily and plays an important role in the homeostasis of the vessel wall. Mutations in endoglin gene (ENG) or in the closely related TGF-β receptor type I ACVRL1/ALK1 are responsible
Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration.
Satish Bodakuntla et al.
The EMBO journal, 41(11), e111373-e111373 (2022-06-02)
Modesto Rojas et al.
PloS one, 8(12), e84357-e84357 (2013-12-21)
Diabetic retinopathy, a major cause of blindness, is characterized by increased expression of vascular endothelial growth factor (VEGF), leukocyte attachment to the vessel walls and increased vascular permeability. Previous work has shown that reactive oxygen species (ROS) produced by the
Teresa Borrás et al.
Investigative ophthalmology & visual science, 56(4), 2203-2214 (2015-02-26)
Soft tissue calcification is a pathological condition. Matrix Gla (MGP) is a potent mineralization inhibitor secreted by cartilage chondrocytes and arteries' vascular smooth muscle cells. Mgp knock-out mice die at 6 weeks due to massive arterial calcification. Arterial calcification results
Cassandra Roeske et al.
Journal of molecular endocrinology, 54(3), 277-288 (2015-04-29)
Expression of the G protein subunit Goα has been shown to be prominent in the atria of the rat heart and to be significantly associated with atrial natriuretic factor (ANF)-containing atrial-specific secretory granules by immunocytochemistry. In addition, differential expression profile
Alexandro Gianforcaro et al.
PloS one, 8(2), e30243-e30243 (2013-02-14)
We previously demonstrated that dietary vitamin D(3) at 10x the adequate intake (AI) attenuates the decline in functional capacity in the G93A mouse model of ALS. We hypothesized that higher doses would elicit more robust changes in functional and disease
Moon K Han et al.
Scientific reports, 8(1), 16220-16220 (2018-11-06)
CD98 has been implicated in the experimental model of inflammatory bowel disease. We have previously shown that IEC-specific overexpression of CD98 mediates intestinal inflammation and intestinal epithelial barrier dysfunction. Mice overexpressing CD98 exhibited severe colitis and a greater susceptibility to
Satish Bodakuntla et al.
The EMBO journal, 40(17), e108498-e108498 (2021-07-27)
Tubulin polyglutamylation is a post-translational modification of the microtubule cytoskeleton, which is generated by a variety of enzymes with different specificities. The "tubulin code" hypothesis predicts that modifications generated by specific enzymes selectively control microtubule functions. Our recent finding that
Zhangting Yao et al.
Cancer research, 80(5), 1171-1182 (2020-01-15)
Chemotherapy is important for cancer treatment, however, toxicities limit its use. While great strides have been made to ameliorate the acute toxicities induced by chemotherapy, long-term comorbidities including bone loss remain a significant problem. Chemotherapy-driven estrogen loss is postulated to
Jeffrey T Ehmsen et al.
JCI insight, 6(13) (2021-06-16)
Neurogenic muscle atrophy is the loss of skeletal muscle mass and function that occurs with nerve injury and in denervating diseases, such as amyotrophic lateral sclerosis. Aside from prompt restoration of innervation and exercise where feasible, there are currently no
Si Jie Tang et al.
Acta neuropathologica communications, 8(1), 96-96 (2020-07-03)
Accumulation of misfolded phosphorylated Tau (Tauopathy) can be triggered by mutations or by trauma, and is associated with synapse loss, gliosis, neurodegeneration and memory deficits. Fyn kinase physically associates with Tau and regulates subcellular distribution. Here, we assessed whether pharmacological
Cyrille Deboux et al.
PloS one, 8(2), e57430-e57430 (2013-03-08)
Neural precursor (NPC) based therapies are used to restore neurons or oligodendrocytes and/or provide neuroprotection in a large variety of neurological diseases. In multiple sclerosis models, intravenously (i.v) -delivered NPCs reduced clinical signs via immunomodulation. We demonstrated recently that NPCs
Marc A Mergy et al.
Neurochemistry international, 73, 56-70 (2013-12-18)
Alterations in dopamine (DA) signaling underlie the most widely held theories of molecular and circuit level perturbations that lead to risk for attention-deficit hyperactivity disorder (ADHD). The DA transporter (DAT), a presynaptic reuptake protein whose activity provides critical support for
Zhiwei Wang et al.
PloS one, 6(6), e20537-e20537 (2011-06-16)
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in the United States, suggesting that novel strategies for the prevention and treatment of PDAC are urgently needed. K-ras mutations are observed in >90% of pancreatic cancer, suggesting
David J Feith
Methods in molecular biology (Clifton, N.J.), 720, 129-141 (2011-02-15)
Polyamines are intimately linked to essential cellular processes that are required for cell growth and -proliferation, and abundant evidence links polyamine metabolism to tumor susceptibility and progression. Intensive efforts over the past 2 decades have yielded numerous mouse models of
Michael G Frantz et al.
Current biology : CB, 30(15), 2962-2973 (2020-06-27)
Disrupting binocular vision during a developmental critical period can yield enduring changes to ocular dominance (OD) in primary visual cortex (V1). Here we investigated how this experience-dependent plasticity is coordinated within the laminar circuitry of V1 by deleting separately in
Pierre-Andre Barbeau et al.
The Journal of physiology, 598(4), 683-697 (2019-12-18)
Although the role of TBC1D1 within the heart remains unknown, expression of TBC1D1 increases in the left ventricle following an acute infarction, suggesting a biological importance within this tissue. We investigated the mechanistic role of TBC1D1 within the heart, aiming
Alexandra L Cara et al.
Endocrinology, 161(8) (2020-07-02)
Disorders of androgen imbalance, such as hyperandrogenism in females or hypoandrogenism in males, increase risk of visceral adiposity, type 2 diabetes, and infertility. Androgens act upon androgen receptors (AR) which are expressed in many tissues. In the brain, AR are
Melanie C Audette et al.
Endocrinology, 152(9), 3561-3570 (2011-07-08)
Clinically, approximately 30% of women who receive synthetic glucocorticoids (sGC) for risk of preterm labor carry to term. In vitro studies have shown that sGC acutely regulate the placental system A amino acid transporter, but there are no comparable data
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