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Showing 1-30 of 151 results for "Y0000557" within Papers
Sukumaran Anil et al.
Mycopathologia, 178(3-4), 207-215 (2014-08-22)
Secretion of hydrolytic enzymes such as hemolysin is considered an important virulence attribute of the opportunistic pathogenic fungus Candida. It is known that Candida spp. isolated from HIV-infected patients produce copious hemolysins. As common antifungal agents may perturb the production
Sarah G Whaley et al.
Antimicrobial agents and chemotherapy, 58(8), 4543-4554 (2014-05-29)
Candida glabrata, the second most common cause of Candida infections, is associated with high rates of mortality and often exhibits resistance to the azole class of antifungal agents. Upc2 and Ecm22 in Saccharomyces cerevisiae and Upc2 in Candida albicans are
Candida albicans prosthetic hip infection in elderly patients: is fluconazole monotherapy an option?
Theodoros Kelesidis et al.
Scandinavian journal of infectious diseases, 42(1), 12-21 (2010-01-09)
The increasing numbers of joint arthroplasties being undertaken, and the increase in patients with systemic illnesses undergoing the procedure, have contributed to a continuing increase in prosthetic joint infections. Candida prosthetic joint infection is a rare clinical entity, and only
Cristina Sgherri et al.
Biochimica et biophysica acta, 1838(1 Pt B), 465-473 (2013-11-05)
EPR spectroscopy was applied to investigate the effects of the treatment of Candida albicans cells with fluconazole (FLC) and two newly synthesized azoles (CPA18 and CPA109), in a concentration not altering yeast morphology, on the lipid organization and dynamics of
Marcio Nucci et al.
PloS one, 8(3), e59373-e59373 (2013-03-26)
The epidemiology of candidemia varies depending on the geographic region. Little is known about the epidemiology of candidemia in Latin America. We conducted a 24-month laboratory-based survey of candidemia in 20 centers of seven Latin American countries. Incidence rates were
Daisuke Sasai et al.
Japanese journal of infectious diseases, 66(2), 133-139 (2013-03-22)
The efficacy of polyene macrolides to treat experimental Trichosporon bloodstream infection was evaluated by histopathological examination and viable cell counts in the kidneys of infected mice. Viable cell counts on the 5th day after infection confirmed that liposomal amphotericin B
Lívia S Ramos et al.
The Journal of antimicrobial chemotherapy, 70(1), 111-115 (2014-08-20)
The emerging fungal pathogens comprising the Candida haemulonii complex (Candida haemulonii, Candida haemulonii var. vulnera and Candida duobushaemulonii) are notable for their antifungal resistance. Twelve isolates with phenotypic similarity to C. haemulonii were recovered from patients in Brazilian hospitals. Here
Rossana de Aguiar Cordeiro et al.
Journal of medical microbiology, 63(Pt 7), 936-944 (2014-04-12)
Candida parapsilosis complex comprises three closely related species, C. parapsilosis sensu stricto, Candida metapsilosis and Candida orthopsilosis. In the last decade, antifungal resistance to azoles and caspofungin among C. parapsilosis sensu lato strains has been considered a matter of concern
Ruwan A Silva et al.
American journal of ophthalmology, 159(2), 257-264 (2014-12-03)
To describe the isolates and susceptibilities to antifungal agents for patients with culture-proven exogenous fungal endophthalmitis. Noncomparative case series. The clinical records of all patients treated for culture-proven exogenous fungal endophthalmitis at a university referral center from 1990 to 2010
H Knoth et al.
Die Pharmazie, 67(12), 987-990 (2013-01-26)
The electrochemical reactions of the antifungal drugs itraconazole, ketoconazole, fluconazole and voriconazole have been investigated by differential pulse polarography (DPP) using a dropping mercury electrode (DME). All investigations were carried out in Britton-Robinson buffer solutions and methanol with varying pH
Diagnostic and therapeutic challenges.
Kiran Turaka et al.
Retina (Philadelphia, Pa.), 33(3), 661-665 (2013-02-07)
J A R Curvelo et al.
Journal of medical microbiology, 63(Pt 5), 697-702 (2014-02-14)
Candidiasis is a major opportunistic fungal infection in humans, and its incidence has increased steadily over the last two decades. Candida albicans, the main species of the genus, has a large arsenal of virulence attributes that contribute to successful infections
Lisa M Bean et al.
Obstetrics and gynecology, 121(2 Pt 2 Suppl 1), 452-454 (2013-02-01)
The consequences of intra-amniotic Candida infection can be devastating. Currently, standard management includes delivery. We identified only one previous case reporting intrauterine antifungal therapy, which used transcervical amphotericin B. We present two cases of intra-amniotic Candida infection treated with intra-amniotic
Christopher C Blyth et al.
Journal of paediatrics and child health, 48(9), 846-851 (2012-09-14)
To review the use of antifungal chemoprophylaxis to prevent neonatal invasive fungal infections (IFI) in very low birthweight infants (VLBW <1500 g). Systematic review of randomised controlled trials. Nine trials were identified (2029 infants), with six comparing fluconazole with placebo/no
Eric F Kong et al.
Infection and immunity, 83(2), 604-613 (2014-11-26)
The clinical significance of polymicrobial interactions, particularly those between commensal species with high pathogenic potential, remains largely understudied. Although the dimorphic fungal species Candida albicans and the bacterium Staphylococcus aureus are common cocolonizers of humans, they are considered leading opportunistic
Katsumi Shigemura et al.
The Journal of antibiotics, 67(4), 311-314 (2014-01-16)
The purpose of this study is to investigate the risk factors and susceptibilities to antifungal agents of Candida albicans and Candida non-albicans species (spp.) in candidemia cases in Kobe University Hospital. We investigated all consecutive patients with candida bloodstream infection
B Minea et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 34(2), 367-383 (2014-09-17)
This is the first multi-centre study regarding yeast infections in Romania. The aim was to determine the aetiological spectrum and susceptibility pattern to fluconazole, voriconazole and the novel compound MXP-4509. The 551 isolates were identified using routine laboratory methods, matrix-assisted
What is your diagnosis? Cryptococcal patellar osteomyelitis.
Amalia Agut et al.
Journal of the American Veterinary Medical Association, 242(6), 745-747 (2013-03-01)
Soledad Gamarra et al.
Mycopathologia, 178(3-4), 251-258 (2014-07-10)
Vulvovaginal candidiasis is one of the most common mycosis. However, the information about antifungal susceptibilities of the yeasts causing this infection is scant. We studied 121 yeasts isolated from 118 patients with vulvovaginal candidiasis. The isolates were identified by phenotypic
Raimunda Sâmia Nogueira Brilhante et al.
Journal of medical microbiology, 63(Pt 11), 1568-1572 (2014-09-06)
This study aimed to identify strains of the Candida parapsilosis complex isolated from animals, as well as to assess their in vitro antifungal susceptibility profile and in vitro production of virulence attributes. We used 28 isolates of C. parapsilosis sensu
Wei Zhao et al.
Clinical pharmacokinetics, 53(11), 1005-1018 (2014-08-27)
Selection of the first-dose-in-neonates is challenging. The objective of this proof-of-concept study was to evaluate a pharmacokinetic bridging approach to predict a neonatal dosing regimen. We selected fluconazole as a paradigm compound. We used data from studies in juvenile mice
Kyra J Barnes et al.
European journal of clinical pharmacology, 70(9), 1097-1106 (2014-06-24)
To investigate the potential inhibitory effects of uremic toxins on the major human hepatic drug-metabolising cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes in vitro. Benzyl alcohol, p-cresol, indoxyl sulfate, hippuric acid and a combination of the four uremic toxins were
Eman R Kotb et al.
Acta poloniae pharmaceutica, 70(4), 667-679 (2013-08-08)
A novel series of acyclic nucleosides 2-5 and 13a-c were synthesized by utilizing 4-phenyl-6(naphthalen-2-yl)-2-oxo-1,2-dihydropridine-3-carbonitrile (1) as a key starting material. Chlorination of 1 yielded the chloro analogue 6 that was allowed to react with urea, thiourea, thiosemicarbazide and alicyclic secondary
Nadia S El-Gohary et al.
Archiv der Pharmazie, 348(4), 283-297 (2015-03-17)
New series of [1,3,4]thiadiazoles and fused [1,3,4]thiadiazoles were synthesized. The newly synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus, Bacillus cereus, and Escherichia coli. Compounds 3b and 10a displayed the highest activity against E. coli with MIC
Shangrong Fan et al.
Mycopathologia, 179(1-2), 95-101 (2014-11-25)
Recurrent vulvovaginal candidiasis (RVVC) is a common condition that can physically and psychologically impact patients. We compared the efficacy and safety of vaginal nystatin suppositories for 14 days each month versus standard oral fluconazole regimens for the treatment for RVVC.
Sean G Chadwick et al.
Journal of medical microbiology, 62(Pt 5), 720-726 (2013-02-05)
Candida species are responsible for many opportunistic fungal infections. Fluconazole is a well-tolerated antifungal drug, commonly used in the treatment of candidiasis. However, with fluconazole resistance ever increasing, rapid detection and antifungal susceptibility testing of Candida is imperative for proper
Chin Fung Kelvin Kan et al.
Journal of lipid research, 55(8), 1657-1667 (2014-06-01)
ACSL4 is a member of the long-chain acyl-CoA synthetase (ACSL) family with a marked preference for arachidonic acid (AA) as its substrate. Although an association between elevated levels of ACSL4 and hepatosteatosis has been reported, the function of ACSL4 in
K Turner et al.
Current medicinal chemistry, 19(27), 4617-4620 (2012-08-11)
Invasive candidiasis (IC) in the premature infant population is a common infection that results in substantial morbidity and mortality. For these patients, fluconazole is among the first line therapies to treat and prevent IC, and yet few prospective studies investigating
Haiping Wang et al.
Journal of pharmaceutical sciences, 103(10), 3302-3309 (2014-08-15)
The experimental measurement of plasma protein binding is a useful in vitro Absorption Distribution Metabolism and Excretion(ADME) assay currently conducted in both screening and definitive early development candidate modes. The fraction unbound is utilized to calculate important pharmacokinetic (PK) parameters
Soňa Kucharíková et al.
The Journal of antimicrobial chemotherapy, 70(3), 846-856 (2014-11-20)
Biofilm studies have been mostly dedicated to the major human fungal pathogen Candida albicans, whereas much less is known about this virulence factor in Candida glabrata, certainly under in vivo conditions. This study provides a deeper understanding of the biofilm
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