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Showing 1-30 of 84 results for "Y0001062" within Papers
Mai Shi et al.
Cellular signalling, 62, 109334-109334 (2019-06-04)
Renal aging and associated functional decline are associated with an increase in cellular senescence. Previous studies show a direct correlation between advanced glycation end products (AGEs) accumulation and renal aging, chronic kidney disease (CKD) and other nephropathies, although the underlying
Ângelo M L Denadai et al.
Materials science & engineering. C, Materials for biological applications, 33(7), 3916-3922 (2013-08-06)
Reaction of highly soluble orally active, non-peptide antihypertensive drug losartan with copper(II) leads to the spontaneous formation of a very insoluble 2:1 covalent complex, which self assembles in a hydrophobic supramolecular structure of nanometric dimensions. Thermal analysis showed that Los/Cu(II)
Losartan for progressive pulmonary vein stenosis: a possible solution?
Paul J Chai
The Journal of thoracic and cardiovascular surgery, 148(6), 2559-2559 (2014-12-01)
Jill Wylie-Sears et al.
Biochemical and biophysical research communications, 446(4), 870-875 (2014-03-19)
Adult cardiac valve endothelial cells (VEC) undergo endothelial to mesenchymal transformation (EndMT) in response to transforming growth factor-β (TGFβ). EndMT has been proposed as a mechanism to replenish interstitial cells that reside within the leaflets and further, as an adaptive
Crystal A West et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(10), R1133-R1140 (2013-09-27)
We have previously observed that many of the renal and hemodynamic adaptations seen in normal pregnancy can be induced in virgin female rats by chronic systemic vasodilation. Fourteen-day vasodilation with sodium nitrite or nifedipine (NIF) produced plasma volume expansion (PVE)
Bart F J Heijnen et al.
PloS one, 8(2), e57815-e57815 (2013-03-08)
Transient activation of the renin-angiotensin system (RAS) induces irreversible renal damage causing sustained elevation in blood pressure (BP) in Cyp1a1-Ren2 transgenic rats. In our current study we hypothesized that activation of the AT1-receptor (AT1R) leads to a T-cell response causing
Bobby V Khan
Therapeutic advances in cardiovascular disease, 5(5), 241-273 (2011-09-07)
Biomarkers are being increasingly used in the study of cardiovascular disease because they provide readily quantifiable surrogate endpoints and allow accurate assessment of the effects of therapy on particular pathological processes. However, in order to be useful, biomarkers must be
Antonio Celso S Ramos-Filho et al.
Life sciences, 93(22), 820-829 (2013-09-21)
The renin-angiotensin system (RAS) plays a major role in cardiovascular diseases in postmenopausal women, but little is known about its importance to lower urinary tract symptoms. In this study we have used the model of ovariectomized (OVX) estrogen-deficient rats to
Álvaro P S Souza et al.
Clinical science (London, England : 1979), 125(9), 449-459 (2013-05-31)
The aim of the present study was to investigate the coronary effects of Ang-(1-7) [angiotensin-(1-7)] in hypertrophic rat hearts. Heart hypertrophy was induced by abdominal aorta CoA (coarctation). Ang-(1-7) and AVE 0991, a non-peptide Mas-receptor agonist, at picomolar concentration, induced
The end of dual therapy with renin-angiotensin-aldosterone system blockade?
Dick de Zeeuw
The New England journal of medicine, 369(20), 1960-1962 (2013-11-12)
Prasanna K Santhekadur et al.
FEBS open bio, 4, 353-361 (2014-06-12)
Staphylococcal nuclease domain containing-1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) patients and promotes tumorigenesis by human HCC cells. We now document that SND1 increases angiotensin II type 1 receptor (AT1R) levels by increasing AT1R mRNA stability. This results
G B Silva et al.
Journal of biological regulators and homeostatic agents, 27(2), 569-578 (2013-07-09)
Dehydration and acute reductions of blood pressure increases ADH and Ang II levels. These hormones increase transport along the distal nephron. In the thick ascending limb (TAL) ADH increases transport via cAMP, while Ang II acts via superoxide (O2-). However
Yuji Mukai et al.
Biological & pharmaceutical bulletin, 37(9), 1550-1554 (2014-09-02)
The present study aimed to characterize the inhibitory effects of losartan, an angiotensin II receptor blocker, on CYP2C8. Inhibition experiments were based on human lymphoblast-expressed recombinant CYP2C8 (rCYP2C8) and paclitaxel as a CYP2C8 substrate. The disappearance of paclitaxel (initial concentration:
Atenolol versus Losartan in Marfan's Syndrome.
Tom Treasure et al.
The New England journal of medicine, 372(10), 978-979 (2015-03-05)
Zorana Vasilijević et al.
Srpski arhiv za celokupno lekarstvo, 141(1-2), 22-28 (2013-04-02)
Losartan, the angiotensin type 1 receptor blocker (ARB) exercises its main antihypertensive effect by vasodilatation of peripheral arteries. The aim of this study was to evaluate the antihypertensive effect and safety of losartan in patients with mild and moderate arterial
Abdu Adem et al.
PloS one, 8(3), e57806-e57806 (2013-03-22)
The objectives of this study were to investigate and compare the responses of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in the circulation of hydrated, dehydrated, and dehydrated losartan - treated camels; and to document the cardiac storage
N Inui et al.
Clinical pharmacology and therapeutics, 94(6), 702-708 (2013-08-27)
Cytochrome P450 (CYP) 1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A are major factors involved in the metabolism of clinically prescribed drugs. Because the time course after drug treatment discontinuation has received little attention, we aimed to clarify the chronological changes of
Angiotensin II mobilizes intracellular calcium and activates pannexin-1 channels in rat carotid body type II cells via AT1 receptors.
Sindhubarathi Murali et al.
The Journal of physiology, 592(21), 4747-4762 (2014-08-31)
Atenolol versus Losartan in Marfan's Syndrome.
Ronald V Lacro et al.
The New England journal of medicine, 372(10), 980-981 (2015-03-05)
Parker C Wilson et al.
The Journal of biological chemistry, 288(26), 18872-18884 (2013-05-11)
The renin-angiotensin and kallikrein-kinin systems are key regulators of vascular tone and inflammation. Angiotensin II, the principal effector of the renin-angiotensin system, promotes vasoconstriction by activating angiotensin AT1 receptors. The opposing effects of the kallikrein-kinin system are mediated by bradykinin
Songtae Kim et al.
Pancreas, 43(6), 886-890 (2014-04-11)
The aim of this study was to investigate the synergistic inhibitory effects of gemcitabine and losartan, angiotensin II type 1 (AT1) receptor blockers, on an orthotopic rat pancreatic cancer model. The rat orthotopic pancreatic cancer model was prepared using DSL-6A/C
Pasquale Piccolo et al.
European journal of human genetics : EJHG, 22(8), 988-994 (2014-01-09)
Myhre syndrome (MS, MIM 139210) is a connective tissue disorder that presents with short stature, short hands and feet, facial dysmorphic features, muscle hypertrophy, thickened skin, and deafness. Recurrent missense mutations in SMAD4 encoding for a transducer mediating transforming growth
Combined angiotensin inhibition in diabetic nephropathy.
Linda F Fried et al.
The New England journal of medicine, 370(8), 779-779 (2014-02-21)
G Agelis et al.
Biochimica et biophysica acta, 1828(8), 1846-1855 (2013-03-20)
The present work describes the drug:membrane interactions and a drug delivery system of the novel potent AT1 blocker BV6. This designed analog has most of the pharmacological segments of losartan and an additional biphenyltetrazole moiety resulting in increased lipophilicity. We
Vasiliki Mavroeidi et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 61(6), 433-443 (2013-03-05)
The AKT-mTOR pathway is activated in diabetic nephropathy. Renin-angiotensin system modulators exert beneficial effects on the diabetic kidney. We explored the action of losartan on AKT-mTOR phosphorylation in glomeruli and podocytes. Diabetes mellitus was induced to Sprague-Dawley rats by streptozotocin.
W David Knight et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(9), R1051-R1058 (2013-09-13)
Chronic intermittent hypoxia (CIH) increases mean arterial pressure (MAP) and FosB/ΔFosB staining in central autonomic nuclei. To test the role of the brain renin-angiotensin system (RAS) in CIH hypertension, rats were implanted with intracerebroventricular (icv) cannulae delivering losartan (1 μg/h)
Andrew Mackenzie et al.
Life sciences, 92(23), 1131-1137 (2013-05-07)
Rheumatoid arthritis (RA) is associated with high cardiovascular mortality. Impaired endothelial cell (EC) function and elevated angiotensin II levels may be central to the link between vascular dysfunction and RA. Here we investigated the action of angiotensin type 1 receptor
Nitro-oleic acid is a novel anti-oxidative therapy for diabetic kidney disease.
Madhav C Menon et al.
American journal of physiology. Renal physiology, 305(11), F1542-F1543 (2013-09-21)
Christiane Pees et al.
The American journal of cardiology, 112(9), 1477-1483 (2013-07-23)
Since 2008, when angiotensin II type I receptor blockade with losartan was introduced in the prevention of cardiovascular manifestation of Marfan syndrome (MFS), a specific treatment to address the cardiovascular lesions became available. The present study aimed to compare the
John J Gildea et al.
Hypertension (Dallas, Tex. : 1979), 61(5), 1021-1027 (2013-03-20)
The G protein-coupled receptor kinase 4 (GRK4) negatively regulates the dopaminergic system by desensitizing the dopamine-1-receptor. The expressional control of GRK4 has not been reported, but here we show that the transcription factor c-Myc binds to the promoter of GRK4
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