Y0001184

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Showing 1-30 of 107 results for "Y0001184" within Papers

Hepatitis C virus-induced hepatocyte cell death and protection by inhibition of apoptosis.

Eu Jin Lim et al.

The Journal of general virology, 95(Pt 10), 2204-2215 (2014-06-29)

Chronic hepatitis C virus (HCV) infection results in progressive liver fibrosis leading to cirrhosis and liver cancer. The mechanism for this remains unclear but hepatocyte apoptosis is thought to play a major role. Hepatocyte apoptosis in human liver tissue was

Human adipose-derived mesenchymal stromal cells increase endogenous neurogenesis in the rat subventricular zone acutely after 6-hydroxydopamine lesioning.

Anne Schwerk et al.

Cytotherapy, 17(2), 199-214 (2014-12-03)

In Parkinson's disease (PD), neurogenesis in the subventricular zone (SVZ)-olfactory bulb (OB) axis is affected as the result of the lack of dopaminergic innervations reaching the SVZ. This aberrant network has been related to the hyposmia of PD patients, which

Controlling and monitoring stem cell safety in vivo in an experimental rodent model.

Cindy Leten et al.

Stem cells (Dayton, Ohio), 32(11), 2833-2844 (2014-08-22)

Adult stem cells have been investigated increasingly over the past years for multiple applications. Although they have a more favorable safety profile compared to pluripotent stem cells, they are still capable of self-renewal and differentiate into several cell types. We

Endothelial cells enhance the migration of bovine meniscus cells.

Xiaoning Yuan et al.

Arthritis & rheumatology (Hoboken, N.J.), 67(1), 182-192 (2014-10-14)

To study the interactions between vascular endothelial cells and meniscal fibrochondrocytes from the inner avascular and outer vascular regions of the meniscus and to identify angiogenic factors that enhance cell migration and integrative repair. Bovine meniscal fibrochondrocytes (bMFCs) from the

Effects of synthetic alkamides on Arabidopsis fatty acid amide hydrolase activity and plant development.

Lionel Faure et al.

Phytochemistry, 110, 58-71 (2014-12-11)

Alkamides and N-acylethanolamines (NAEs) are bioactive, amide-linked lipids that influence plant development. Alkamides are restricted to several families of higher plants and some fungi, whereas NAEs are widespread signaling molecules in both plants and animals. Fatty acid amide hydrolase (FAAH)

A simian-human immunodeficiency virus carrying the rt gene from Chinese CRF01_AE strain of HIV is sensitive to nucleoside reverse transcriptase inhibitors and has a highly genetic stability in vivo.

Wei Wang et al.

Microbes and infection, 16(6), 461-471 (2014-04-09)

Human immunodeficiency virus (HIV)-1 subtype CRF01_AE is one of the major HIV-1 subtypes that dominate the global epidemic. However, its drug resistance, associated mutations, and viral fitness have not been systemically studied, because available chimeric simian-HIVs (SHIVs) usually express the

Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes.

Verónica Gómez-Pérez et al.

European journal of medicinal chemistry, 89, 362-369 (2014-12-03)

Nine novel symmetrical bispyridinium cyclophanes have been synthesized. They are rigid derivatives with an upper spacer which joins the two exocyclic amino groups, and a lower spacer joining the two positively charged nitrogen atoms. At least one of the two

Quantitative structure-retention relationships of cannabimimetic aminoalkilindole derivatives and their metabolites.

Angelo Antonio D'Archivio et al.

Journal of pharmaceutical and biomedical analysis, 109, 136-141 (2015-03-15)

Development of chromatographic analyses of synthetic cannabinoids is complicated by the lack of commercial reference standards, especially for new analogues introduced in the clandestine market to bypass legal controls and for their metabolites. In the present work, we explore the

Phosphatidylethanolamine positively regulates autophagy and longevity.

P Rockenfeller et al.

Cell death and differentiation, 22(3), 499-508 (2015-01-13)

Autophagy is a cellular recycling program that retards ageing by efficiently eliminating damaged and potentially harmful organelles and intracellular protein aggregates. Here, we show that the abundance of phosphatidylethanolamine (PE) positively regulates autophagy. Reduction of intracellular PE levels by knocking

Endothelin A receptor blocker atrasentan lowers blood pressure by the reduction of nifedipine-sensitive calcium influx in Ren-2 transgenic rats fed a high-salt diet.

Ivana Vaněčková et al.

Journal of hypertension, 33(1), 161-169 (2014-09-26)

Our previous experiments demonstrated that selective endothelin A (ETA) receptor blockade had antihypertensive effects in Ren-2 transgenic rats (TGRs), but the mechanisms responsible for this change of blood pressure (BP) have not been explored yet. Four-week-old male heterozygous TGRs and

Protic ionic liquids (PILs) nanostructure and physicochemical properties: development of high-throughput methodology for PIL creation and property screens.

Tamar L Greaves et al.

Physical chemistry chemical physics : PCCP, 17(4), 2357-2365 (2014-12-06)

A high-throughput approach was developed in order to prepare and dry a series of protic ionic liquids (PILs) from 48 Brønsted acid-base combinations. Many combinations comprised an alkyl carboxylic acid paired with an alkyl amine. Visual screens were developed to

PEGylation of microbead surfaces reduces unspecific antibody binding in glycan-based suspension array.

Tatiana Pochechueva et al.

Journal of immunological methods, 412, 42-52 (2014-07-06)

Glycan-based suspension array (SGA) is an "in-house" developed multi-target immunoassay, employing commercially available fluorescent microbeads as a solid support for unique chemically synthesized glycopolymers which capture naturally occurring human anti-glycan antibodies. SGA is a sensitive and reliable tool for the

Altered pulmonary artery endothelial-smooth muscle cell interactions in experimental congenital diaphragmatic hernia.

Shannon N Acker et al.

Pediatric research, 77(4), 511-519 (2015-01-13)

Pulmonary hypertension (PH) secondary to vascular remodeling contributes to poor outcomes in congenital diaphragmatic hernia (CDH), however mechanisms responsible are unknown. We hypothesized that pulmonary artery endothelial cell (PAEC) dysfunction contributes to smooth muscle cell (SMC) hyperplasia in experimental CDH.

Role of the rttA gene in morphogenesis, stress response, and virulence in the human pathogenic fungus Penicillium marneffei.

Sumanun Suwunnakorn et al.

Medical mycology, 53(2), 119-131 (2014-12-21)

Penicillium marneffei is a human pathogenic fungus and the only thermally dimorphic species of the genus. At 25°C, P. marneffei grows as a mycelium that produces conidia in chains. However, when incubated at 37°C or following infection of host tissue

The effects of CAMPATH-1H on cell viability do not correlate to the CD52 density on the cell surface.

Fuiyee Lee et al.

PloS one, 9(7), e103254-e103254 (2014-07-23)

Graft versus host disease (GvHD) is one of the main complications after hematological stem cell transplantation (HSCT). CAMPATH-1H is used in the pre-transplant conditioning regimen to effectively reduce GvHD by targeting CD52 antigens on T cells resulting in their depletion.

Concurrent cooperativity and substrate inhibition in the epoxidation of carbamazepine by cytochrome P450 3A4 active site mutants inspired by molecular dynamics simulations.

Christian S Müller et al.

Biochemistry, 54(3), 711-721 (2014-12-30)

Cytochrome P450 3A4 (CYP3A4) is the major human P450 responsible for the metabolism of carbamazepine (CBZ). To explore the mechanisms of interactions of CYP3A4 with this anticonvulsive drug, we carried out multiple molecular dynamics (MD) simulations, starting with the complex

Altered prostanoid metabolism contributes to impaired angiogenesis in persistent pulmonary hypertension in a fetal lamb model.

Chaitali N Mahajan et al.

Pediatric research, 77(3), 455-462 (2014-12-19)

Persistent pulmonary hypertension of the newborn (PPHN) is associated with decreased lung angiogenesis and impaired pulmonary vasodilatation at birth. Prostanoids are important modulators of vascular tone and angiogenesis. We hypothesized that altered levels of prostacyclin (PGI₂), a potent vasodilator, and

Lipopolysaccharide enhanced renal vascular response to endothelin-1 through ETA overexpression in portal hypertensive rats.

Chiao-Lin Chuang et al.

Journal of gastroenterology and hepatology, 30(1), 199-207 (2014-07-06)

Hypo-perfusion resulting from intense renal vasoconstriction is traditionally contributed to renal dysfunction in advanced liver disease, although cumulative studies demonstrated renal vasodilatation with impaired vascular contractility to endogenous vasoconstrictors in portal hypertension and compensated liver cirrhosis. The pathophysiology of altered

Association of polyalanine and polyglutamine coiled coils mediates expansion disease-related protein aggregation and dysfunction.

Ilaria Pelassa et al.

Human molecular genetics, 23(13), 3402-3420 (2014-02-06)

The expansion of homopolymeric glutamine (polyQ) or alanine (polyA) repeats in certain proteins owing to genetic mutations induces protein aggregation and toxicity, causing at least 18 human diseases. PolyQ and polyA repeats can also associate in the same proteins, but

Conformational antibody binding to a native, cell-free expressed GPCR in block copolymer membranes.

Hans-Peter M de Hoog et al.

PloS one, 9(10), e110847-e110847 (2014-10-21)

G-protein coupled receptors (GPCRs) play a key role in physiological processes and are attractive drug targets. Their biophysical characterization is, however, highly challenging because of their innate instability outside a stabilizing membrane and the difficulty of finding a suitable expression

Protective effect of quercetin in ecto-enzymes, cholinesterases, and myeloperoxidase activities in the lymphocytes of rats exposed to cadmium.

Fátima Husein Abdalla et al.

Molecular and cellular biochemistry, 396(1-2), 201-211 (2014-07-30)

The ex vivo and in vitro effects of quercetin on NTPDase, adenosine deaminase (ADA), and acetycholinesterase (AChE) activities in lymphocytes, as well as the effects of quercetin on butyrylcholinesterase (BChE) activity in serum and myeloperoxidase (MPO) activity in plasma were

Serum amyloid a truncations in type 2 diabetes mellitus.

Hussein N Yassine et al.

PloS one, 10(1), e0115320-e0115320 (2015-01-22)

Using mass spectrometric immunoassay, the abundance of SAA truncations relative to the native variants was examined in plasma of 91 participants with type 2 diabetes and chronic kidney disease and 69 participants without diabetes. The ratio of SAA 1.1 (missing

Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development.

Anthony J Donato et al.

Life sciences, 118(2), 238-243 (2014-01-15)

The role of vascular smooth muscle endothelin A receptors (ETA) in development and normal physiology remains incompletely understood. To address this, mice were generated with smooth muscle-specific knockout (KO) of ETA. Mice were homozygous for loxP-flanked exons 6-8 of the

Investigation of the interactions between the EphB2 receptor and SNEW peptide variants.

Buyong Ma et al.

Growth factors (Chur, Switzerland), 32(6), 236-246 (2014-11-21)

EphB2 interacts with cell surface-bound ephrin ligands to relay bidirectional signals. Overexpression of the EphB2 receptor protein has been linked to different types of cancer. The SNEW (SNEWIQPRLPQH) peptide binds with high selectivity and moderate affinity to EphB2, inhibiting Eph-ephrin

Electrochemical magnetoimmunosensor for the ultrasensitive determination of interleukin-6 in saliva and urine using poly-HRP streptavidin conjugates as labels for signal amplification.

I Ojeda et al.

Analytical and bioanalytical chemistry, 406(25), 6363-6371 (2014-08-02)

A novel magnetoimmunosensor design for interleukin-6 (IL-6) which involved the covalent immobilization of anti-IL-6 antibodies onto carboxyl-functionalized magnetic microparticles and a sandwich-type immunoassay with signal amplification using poly-HRP-streptavidin conjugates is reported. All the variables concerning the preparation and the electroanalytical

Development of an immunoaffinity solid phase microextraction method for the identification of penicillin binding protein 2a.

Yuhong Liu et al.

Journal of chromatography. A, 1364, 64-73 (2014-09-04)

Methicillin resistant Staphylococcus aureus (MRSA) is a bacterium that is resistant to many antibiotics. Resistance to methicillin is related to production of penicillin binding protein 2a (PBP2a). The currently presented research involves the development of antibody-linked immunoaffinity solid phase microextraction

Immobilized purine nucleoside phosphorylase from Aeromonas hydrophila as an on-line enzyme reactor for biocatalytic applications.

Enrica Calleri et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 968, 79-86 (2014-01-28)

We described the development of a biochromatographic system which uses a purine nucleoside phosphorylase from Aeromonas hydrophila (AhPNP) for the evaluation of the substrate specificity on nucleoside libraries. AhPNP has been covalently immobilized on a fused silica Open Tubular Capillary

Biochemical assays for the discovery of TDP1 inhibitors.

Christophe Marchand et al.

Molecular cancer therapeutics, 13(8), 2116-2126 (2014-07-16)

Drug screening against novel targets is warranted to generate biochemical probes and new therapeutic drug leads. TDP1 and TDP2 are two DNA repair enzymes that have yet to be successfully targeted. TDP1 repairs topoisomerase I-, alkylation-, and chain terminator-induced DNA

Scalable high-fidelity growth of semiconductor nanorod arrays with controlled geometry for photovoltaic devices using block copolymers.

Candice I Pelligra et al.

Small (Weinheim an der Bergstrasse, Germany), 10(21), 4304-4309 (2014-07-26)

Controlled density semiconducting oxide arrays are highly desirable for matching nanometer length scales specific to emerging applications. This work demonstrates a facile one-step method for templating hydrothermal growth which provides arrays with high-fidelity tuning of nanorod spacing and diameter. This

Determination of solubility parameters of ionic liquids and ionic liquid/solvent mixtures from intrinsic viscosity.

Piyarat Weerachanchai et al.

Chemphyschem : a European journal of chemical physics and physical chemistry, 15(16), 3580-3591 (2014-08-26)

The total and partial solubility parameters (dispersion, polar and hydrogen-bonding solubility parameters) of ten ionic liquids were determined. Intrinsic viscosity approaches were used that encompassed a one-dimensional method (1D-Method), and two different three-dimensional methods (3D-Method1 and 3D-Method2). The effect of

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