Merck
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mRNA & LNP Contract Testing, Development, & Manufacturing Services

Operator analyzing a vial of mRNA encapsulated in a Lipid Nanoparticle

Responding to Patients Needs by Getting mRNA-Based Vaccines and Therapeutics on the Fast Track 

As part of our Millipore® CTDMO Services offering, we pave the way for robust, integrated, and consistent processes along all stages from pre-clinical to commercialization. Bringing together our capabilities, technical expertise, and regulatory know-how, we enable our clients to achieve their goals— to get mRNA-based vaccines and therapeutics on the fast track and change the life of patients.

With Millipore® CTDMO Services we offer customized services to help clients accelerate their projects, mitigate risks, and expedite time to market – all the way from mRNA through lipids​ and lipid nanoparticles (LNP) to final Fill and Finish. 

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Our Track Record

20+

Years combined track record in mRNA, Lipids and LNP manufacturing

10,000

Fold less pDNA required through next generation PCR based mRNA manufacturing

50+

Individual projects successfully delivered in synthesizing lipids

6

Commercial drug products manufactured

6+

Highly connected sites ensuring speed, scalability, quality, and flexibility


Operator holding a Eppendorf® tube

Preclinical

Our technical experts support the journey from the initial concept through mRNA synthesis, custom lipids, and screening and optimizing lipid nanoparticle (LNP) formulations for nucleic acid payloads.


Our Offering

Operator looking into a microscope

mRNA 

We specialize in the production of fully customized, functional mRNAs and provide full technical support from project design and sequence optimization to data for investigational new drug (IND) dossiers. With our proven PCR-based workflow, mRNA manufacturing is highly reproducible, and the final product has excellent properties.

  • Next generation PCR-based process for high quality mRNA
  • Fully customized mRNA manufacturing
  • Preclinical to GMP commercial scale - from mg to kg*

* We can start process and analytical development for GMP projects in Q3 2023. Transfer into GMP manufacturing facilities in Q1 2024.

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A Global Footprint

We are a single organization with a global network to deliver CDMO services across all stages of the molecule value chain.

CTDMO map

A highly connected CDMO network to ensure speed, scalability, quality, and flexibility for mRNA, lipid, and LNP manufacturing.

FPO
Darmstadt, Germany

Our Center of Excellence for Late Clinical & Commercial mRNA, manufacturing sites for our Portfolio Lipids, including Large Scale Lipid Production and Early Formulation Screening Service

Production Site - Hamburg, Germany
Hamburg, Germany

Our Center of Excellence for Early Clinical mRNA

Production Site - Schaffhausen, CH
Schaffhausen, Switzerland

Our Center of Excellence specialized for synthesizing high quality Portfolio & Custom Lipids

Vials with yellow caps
Indianapolis, United States

Our Center of Excellence for the manufacturing of Lipid Nanoparticles (incl. Fill & Finish)

Biopharma development of monoclonal antibodies in pilot plant.
St. Louis, United States

Manufacturing Site for Portfolio & Custom Lipids and Process Development for Liposomes & LNPs

Scientists performing biosafety testing and manufacturing in a laboratory setting.
Rockville, United States

Biosafety testing and manufacturing services span the product cycle from early pre-clinical development to licensed production. Services include analytical development, cell banking, cell line characterization, viral clearance, drug substance and drug product release testing, as well as rapid methods.


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