- Active thionium species mediated functionalization at the 2α-position of indole derivatives.
Active thionium species mediated functionalization at the 2α-position of indole derivatives.
Chemical communications (Cambridge, England) (2011-05-11)
Kazuhiro Higuchi, Masanori Tayu, Tomomi Kawasaki
PMID21556439
ABSTRACT
A combination of dimethyl sulfoxide (DMSO) and trifluoroacetic anhydride (TFAA) mediates functionalization at the 2α-position of indole derivatives. Carbon and heteroatom nucleophiles were directly introduced via a one-pot procedure in excellent yields.