- Pyridinylimidazole inhibitors of Tie2 kinase.
Pyridinylimidazole inhibitors of Tie2 kinase.
Bioorganic & medicinal chemistry letters (2007-07-10)
Marcus Semones, Yanhong Feng, Neil Johnson, Jerry L Adams, Jim Winkler, Michael Hansbury
PMID17618114
ABSTRACT
This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.