- Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.
Nature (1985-06-20)
C J March, B Mosley, A Larsen, D P Cerretti, G Braedt, V Price, S Gillis, C S Henney, S R Kronheim, K Grabstein
PMID2989698
ABSTRACT
Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-1 alpha and IL-1 beta), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity.
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