- Facile Chemoselective Modification of Thio-Ethers Generates Chiral Center-Induced Helical Peptides.
Facile Chemoselective Modification of Thio-Ethers Generates Chiral Center-Induced Helical Peptides.
Bioconjugate chemistry (2018-09-09)
Zhanfeng Hou, Chengjie Sun, Hao Geng, Kuan Hu, Mingsheng Xie, Yue Ma, Fan Jiang, Feng Yin, Zigang Li
PMID30193458
ABSTRACT
A precisely positioned sulfimide chiral center on-tether of a thio-ether tethered peptide determines the peptide secondary structure by chemoselective oxaziridine modification. This method provides a facile way to tune peptides' secondary structures and biophysical properties.
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