- Two New Isomeric Andrographolides with Anti-Inflammatory and Cytotoxic Activity.
Two New Isomeric Andrographolides with Anti-Inflammatory and Cytotoxic Activity.
Chemistry & biodiversity (2020-10-07)
Difa Liu, Zhangwei Wang, Yaoqi Liu, Yi Zhang, Eryan Guo, Mingzhen He, Junshan Liu, Shuangbing Deng, Wencai Ye, Ning Xie
PMID33022147
ABSTRACT
Two novel epimerized andrographolides, 8,17-dihydro-7,8-dehydroandrographolide and 10β-8,17-dihydro-7,8-dehydroandrographolide, were isolated from andrographolide sulfonates. Their structures were elucidated by detailed NMR analysis, single-crystal X-ray diffraction and quantum chemical ECD calculations. In addition, these compounds exhibited suppression of NO production in LPS-stimulated RAW264.7 cells over the range of 1.564 to 25.000 μg/mL.
MATERIALS