- 4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity.
4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity.
Bioorganic & medicinal chemistry letters (2007-11-21)
Luigi Scipione, Daniela De Vita, Alessandra Musella, Lisa Flammini, Simona Bertoni, Elisabetta Barocelli
PMID18023348
ABSTRACT
Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.