- 11-Phenyl-[b,e]-dibenzazepine compounds: novel antitumor agents.
11-Phenyl-[b,e]-dibenzazepine compounds: novel antitumor agents.
Bioorganic & medicinal chemistry letters (2008-11-26)
Raed A Al-Qawasmeh, Yoon Lee, Ming-Yu Cao, Xiaoping Gu, Stéphane Viau, Jeff Lightfoot, Jim A Wright, Aiping H Young
PMID19027297
ABSTRACT
A series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC(50) values ranging from submicromolar to micromolar concentrations. Flow cytometric analyses of several active compounds demonstrated inhibition of cell cycle progression at the G(0)-G(1) phase transition resulting in G(0)-G(1) arrest.
MATERIALS