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  • Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production.

Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production.

Bioorganic & medicinal chemistry letters (2009-01-31)
Minoru Ishikawa, Tomohisa Ninomiya, Hirotomo Akabane, Nobuaki Kushida, Go Tsujiuchi, Makoto Ohyama, Shuichi Gomi, Keiko Shito, Takashi Murata
PMID19179074
ABSTRACT

A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure-activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC(50) of 0.066 microM. An immunosuppressive activity of another natural product, synerazol was also found.