- Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4.
Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4.
Bioorganic & medicinal chemistry letters (2009-02-24)
Jie Liu, Hao Ren, Jinyi Xu, Renren Bai, Qi Yan, Wenlong Huang, Xiaoming Wu, Jihua Fu, Qiujuan Wang, Qian Wu, Rong Fu
PMID19233642
ABSTRACT
This letter describes the total synthesis, preliminary biological evaluation and mechanism studies of a novel and structurally unique isochromanone, (+/-)7,8-dihydroxy-3-methyl-isochromanone-4 (1), a nature product contained in banana (Musa sapientum L.) peel. The bioassay showed that compound 1 displays potent antihypertensive activity in renal hypertensive rats and further mechanism studies revealed that it is an ACE inhibitor.