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  • PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase.

PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase.

Bioorganic & medicinal chemistry letters (2008-12-05)
Graziella Tocco, Antonella Fais, Gabriele Meli, Michela Begala, Gianni Podda, M Benedetta Fadda, Marcella Corda, Orazio A Attanasi, Paolino Filippone, Stefano Berretta
ABSTRACT

In this work, the PEG-immobilization and the liquid phase synthesis of some coumarins derived from cardol are presented. Some preliminary results on their tyrosinase inhibitory activity are also included.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Resorcinol, ≥98%, FG
Sigma-Aldrich
4-Hexylresorcinol, 98%
Sigma-Aldrich
Resorcinol, ACS reagent, ≥99.0%
Sigma-Aldrich
Resorcinol, ReagentPlus®, 99%
Sigma-Aldrich
Resorcinol, BioXtra, ≥99%
Sigma-Aldrich
Kojic acid
Supelco
5-Pentadecylresorcinol, analytical standard