- In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.
Antimicrobial agents and chemotherapy (2009-04-15)
Victor Masseno, Steven Muriithi, Alexis Nzila
PMID19364853
ABSTRACT
We tested the effect of probenecid and verapamil in chemosensitizing Plasmodium falciparum to 14 antimalarials using the multidrug-resistant strain V1S and the drug-sensitive 3D7. Verapamil chemosensitizes V1S to quinine and chloroquine. Interestingly, probenecid profoundly chemosensitizes V1S to piperaquine. Thus, probenecid could be used to increase piperaquine efficacy in vivo.
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