- Synthesis and in vivo evaluation of 3-substituted gababutins.
Synthesis and in vivo evaluation of 3-substituted gababutins.
Bioorganic & medicinal chemistry letters (2009-11-10)
David C Blakemore, Justin S Bryans, Pauline Carnell, Nicola E A Chessum, Mark J Field, Natasha Kinsella, Jack K Kinsora, Simon A Osborne, Sophie C Williams
PMID19897364
ABSTRACT
A range of 3-alkylated five-membered ring derivatives of Gabapentin were synthesized and several were found to have good levels of potency against the alpha2delta calcium subunit of a voltage-gated calcium channel. Two compounds were profiled in in vivo models of pain and anxiety.
MATERIALS