- Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir.
Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir.
Medical microbiology and immunology (2020-09-13)
Lea Patasic, Janna Seifried, Valerie Bezler, Marcell Kaljanac, Irene C Schneider, Heike Schmitz, Christiane Tondera, Jessica Hartmann, Andreas Hombach, Christian J Buchholz, Hinrich Abken, Renate König, Klaus Cichutek
PMID32918599
ABSTRACT
Chimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR engineered T cells resulting in the depletion of CD4+ target cells aiming for elimination of the human immunodeficiency virus (HIV) reservoir.