JBIR-94 and JBIR-125, antioxidative phenolic compounds from Streptomyces sp. R56-07.

JBIR-94 and JBIR-125, antioxidative phenolic compounds from Streptomyces sp. R56-07.

Journal of natural products (2012-01-12)

Teppei Kawahara, Miho Izumikawa, Misa Otoguro, Hideki Yamamura, Masayuki Hayakawa, Motoki Takagi, Kazuo Shin-ya

ABSTRACT

Two phenolic compounds, JBIR-94 (1) and JBIR-125 (2), were isolated from the fermentation broth of strain R56-07, which was identified by phylogenetic methods as a novel species of Streptomyces. The structures of 1 and 2 were assigned on the basis of 1D and 2D NMR spectroscopy and MS analyses. Compounds 1 and 2 exhibited 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity with an IC(50) value of 11.4 and 35.1 μM, respectively. These compounds are the first examples of hydroxycinnamic acid amides containing putrescine or spermidine produced by actinomycetes.

MATERIALS

Product Number

Brand

Product Description

T3634

Sigma-Aldrich

(+)-α-Tocopherol, from vegetable oil, Type V, ~1000 IU/g

T1539

Sigma-Aldrich

(+)-α-Tocopherol, Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000 IU/g